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Protein

Ankyrin repeat and SOCS box protein 13

Gene

ASB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 13
Short name:
ASB-13
Gene namesi
Name:ASB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000196372.12
HGNCiHGNC:19765 ASB13
MIMi615055 gene
neXtProtiNX_Q8WXK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi79754
OpenTargetsiENSG00000196372
PharmGKBiPA134992129

Polymorphism and mutation databases

BioMutaiASB13
DMDMi20531995

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669491 – 278Ankyrin repeat and SOCS box protein 13Add BLAST278

Proteomic databases

EPDiQ8WXK3
MaxQBiQ8WXK3
PaxDbiQ8WXK3
PeptideAtlasiQ8WXK3
PRIDEiQ8WXK3
ProteomicsDBi75073
75074 [Q8WXK3-2]

Expressioni

Gene expression databases

BgeeiENSG00000196372 Expressed in 207 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_ASB13
GenevisibleiQ8WXK3 HS

Organism-specific databases

HPAiHPA048293
HPA061742

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122865, 18 interactors
IntActiQ8WXK3, 15 interactors
MINTiQ8WXK3
STRINGi9606.ENSP00000350331

Structurei

3D structure databases

ProteinModelPortaliQ8WXK3
SMRiQ8WXK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 47ANK 1Add BLAST30
Repeati51 – 80ANK 2Add BLAST30
Repeati84 – 113ANK 3Add BLAST30
Repeati116 – 145ANK 4Add BLAST30
Repeati149 – 178ANK 5Add BLAST30
Repeati181 – 210ANK 6Add BLAST30
Domaini229 – 278SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150865
HOGENOMiHOG000231513
HOVERGENiHBG001376
InParanoidiQ8WXK3
KOiK10335
OMAiMEAHDCH
OrthoDBiEOG091G0DYR
PhylomeDBiQ8WXK3
TreeFamiTF331945

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03729 SOCS_ASB13, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037334 ASB13_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WXK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRAADGCF LGDVGFWVER TPVHEAAQRG ESLQLQQLIE SGACVNQVTV
60 70 80 90 100
DSITPLHAAS LQGQARCVQL LLAAGAQVDA RNIDGSTPLC DACASGSIEC
110 120 130 140 150
VKLLLSYGAK VNPPLYTASP LHEACMSGSS ECVRLLIDVG ANLEAHDCHF
160 170 180 190 200
GTPLHVACAR EHLDCVKVLL NAGANVNAAK LHETALHHAA KVKNVDLIEM
210 220 230 240 250
LIEFGGNIYA RDNRGKKPSD YTWSSSAPAK CFEYYEKTPL TLSQLCRVNL
260 270
RKATGVRGLE KIAKLNIPPR LIDYLSYN
Length:278
Mass (Da):30,007
Last modified:May 10, 2002 - v2
Checksum:i6E54725A70AB32EF
GO
Isoform 2 (identifier: Q8WXK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: G → A
     174-278: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):18,205
Checksum:i8F7BD794962D4AF4
GO

Sequence cautioni

The sequence AAL57350 differs from that shown. Reason: Frameshift at position 14.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → S in BAB14456 (PubMed:14702039).Curated1
Sequence conflicti129S → D in AAL57350 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000272173G → A in isoform 2. 1 Publication1
Alternative sequenceiVSP_000273174 – 278Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403031 mRNA Translation: AAL57350.1 Frameshift.
AK023196 mRNA Translation: BAB14456.1
AK292071 mRNA Translation: BAF84760.1
CR457302 mRNA Translation: CAG33583.1
AL365356 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86435.1
CH471072 Genomic DNA Translation: EAW86436.1
BC012056 mRNA Translation: AAH12056.1
CCDSiCCDS7070.1 [Q8WXK3-1]
RefSeqiNP_078977.2, NM_024701.3 [Q8WXK3-1]
UniGeneiHs.445899

Genome annotation databases

EnsembliENST00000357700; ENSP00000350331; ENSG00000196372 [Q8WXK3-1]
ENST00000459912; ENSP00000433358; ENSG00000196372 [Q8WXK3-2]
GeneIDi79754
KEGGihsa:79754
UCSCiuc001iig.3 human [Q8WXK3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403031 mRNA Translation: AAL57350.1 Frameshift.
AK023196 mRNA Translation: BAB14456.1
AK292071 mRNA Translation: BAF84760.1
CR457302 mRNA Translation: CAG33583.1
AL365356 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86435.1
CH471072 Genomic DNA Translation: EAW86436.1
BC012056 mRNA Translation: AAH12056.1
CCDSiCCDS7070.1 [Q8WXK3-1]
RefSeqiNP_078977.2, NM_024701.3 [Q8WXK3-1]
UniGeneiHs.445899

3D structure databases

ProteinModelPortaliQ8WXK3
SMRiQ8WXK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122865, 18 interactors
IntActiQ8WXK3, 15 interactors
MINTiQ8WXK3
STRINGi9606.ENSP00000350331

Polymorphism and mutation databases

BioMutaiASB13
DMDMi20531995

Proteomic databases

EPDiQ8WXK3
MaxQBiQ8WXK3
PaxDbiQ8WXK3
PeptideAtlasiQ8WXK3
PRIDEiQ8WXK3
ProteomicsDBi75073
75074 [Q8WXK3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357700; ENSP00000350331; ENSG00000196372 [Q8WXK3-1]
ENST00000459912; ENSP00000433358; ENSG00000196372 [Q8WXK3-2]
GeneIDi79754
KEGGihsa:79754
UCSCiuc001iig.3 human [Q8WXK3-1]

Organism-specific databases

CTDi79754
DisGeNETi79754
EuPathDBiHostDB:ENSG00000196372.12
GeneCardsiASB13
HGNCiHGNC:19765 ASB13
HPAiHPA048293
HPA061742
MIMi615055 gene
neXtProtiNX_Q8WXK3
OpenTargetsiENSG00000196372
PharmGKBiPA134992129
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150865
HOGENOMiHOG000231513
HOVERGENiHBG001376
InParanoidiQ8WXK3
KOiK10335
OMAiMEAHDCH
OrthoDBiEOG091G0DYR
PhylomeDBiQ8WXK3
TreeFamiTF331945

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiASB13 human
GeneWikiiASB13
GenomeRNAii79754
PROiPR:Q8WXK3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196372 Expressed in 207 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_ASB13
GenevisibleiQ8WXK3 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03729 SOCS_ASB13, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037334 ASB13_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB13_HUMAN
AccessioniPrimary (citable) accession number: Q8WXK3
Secondary accession number(s): A8K7Q6
, D3DRR2, Q96EP7, Q9H8Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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