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Protein

Ankyrin repeat and SOCS box protein 15

Gene

ASB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 15
Short name:
ASB-15
Gene namesi
Name:ASB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146809.12
HGNCiHGNC:19767 ASB15
neXtProtiNX_Q8WXK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi142685
OpenTargetsiENSG00000146809
PharmGKBiPA134977130

Polymorphism and mutation databases

BioMutaiASB15
DMDMi296439431

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669541 – 588Ankyrin repeat and SOCS box protein 15Add BLAST588

Proteomic databases

PaxDbiQ8WXK1
PRIDEiQ8WXK1
ProteomicsDBi75072

PTM databases

iPTMnetiQ8WXK1
PhosphoSitePlusiQ8WXK1

Expressioni

Gene expression databases

BgeeiENSG00000146809 Expressed in 40 organ(s), highest expression level in muscle of leg
CleanExiHS_ASB15
ExpressionAtlasiQ8WXK1 baseline and differential
GenevisibleiQ8WXK1 HS

Interactioni

Protein-protein interaction databases

BioGridi126774, 19 interactors
IntActiQ8WXK1, 13 interactors
STRINGi9606.ENSP00000275699

Structurei

3D structure databases

ProteinModelPortaliQ8WXK1
SMRiQ8WXK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati110 – 142ANK 1Add BLAST33
Repeati143 – 174ANK 2Add BLAST32
Repeati176 – 208ANK 3Add BLAST33
Repeati209 – 241ANK 4Add BLAST33
Repeati242 – 274ANK 5Add BLAST33
Repeati307 – 339ANK 6Add BLAST33
Repeati349 – 380ANK 7Add BLAST32
Repeati381 – 413ANK 8Add BLAST33
Repeati416 – 444ANK 9Add BLAST29
Domaini524 – 579SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150873
HOGENOMiHOG000034086
HOVERGENiHBG023406
InParanoidiQ8WXK1
KOiK10337
OMAiHYLALKY
OrthoDBiEOG091G03QP
PhylomeDBiQ8WXK1
TreeFamiTF315127

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 4 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 9 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 7 hits
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8WXK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA
60 70 80 90 100
IKQGHIPELQ EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY
110 120 130 140 150
KTLWEFKTCD GETPLTLAVK AGLVENVRTL LEKGVWPNTK NDKGETPLLI
160 170 180 190 200
AVKKGSYDMV STLIKHNTSL DQPCVKRWSA MHEAAKQGRK DIVALLLKHG
210 220 230 240 250
GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA DDGASVLFEA
260 270 280 290 300
AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
310 320 330 340 350
KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER
360 370 380 390 400
KTALYFGVSN NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL
410 420 430 440 450
SHGANVNCYF MHVNDTRFPS VIQYALNDEV MLRLLLNNGY QVEMCFDCMH
460 470 480 490 500
GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP FCEFITVPWM KHLVGRVTRV
510 520 530 540 550
LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL CRLKIRRLMG
560 570 580
LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT
Length:588
Mass (Da):65,799
Last modified:May 18, 2010 - v3
Checksum:iB3FD2435776B343D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z4V1Q7Z4V1_HUMAN
Ankyrin repeat and SOCS box protein...
ASB15
249Annotation score:
A0A0C4DG46A0A0C4DG46_HUMAN
Ankyrin repeat and SOCS box protein...
ASB15
241Annotation score:
C9J956C9J956_HUMAN
Ankyrin repeat and SOCS box protein...
ASB15
97Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346Y → C in BAC86146 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06046657P → L2 PublicationsCorresponds to variant dbSNP:rs6962756Ensembl.1
Natural variantiVAR_060467357G → A2 PublicationsCorresponds to variant dbSNP:rs4731112Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125360 mRNA Translation: BAC86146.1
AC006333 Genomic DNA No translation available.
BC100874 mRNA Translation: AAI00875.1
BC100875 mRNA Translation: AAI00876.1
BC100876 mRNA Translation: AAI00877.1
BC100877 mRNA Translation: AAI00878.1
CR749595 mRNA Translation: CAH18393.1
AF403033 mRNA Translation: AAL57352.1
CCDSiCCDS34742.1
RefSeqiNP_001277187.1, NM_001290258.1
NP_563616.3, NM_080928.4
XP_005250203.1, XM_005250146.4
XP_011514119.1, XM_011515817.2
XP_011514120.1, XM_011515818.2
XP_011514121.1, XM_011515819.2
XP_011514122.1, XM_011515820.2
XP_016867245.1, XM_017011756.1
XP_016867246.1, XM_017011757.1
UniGeneiHs.83916

Genome annotation databases

EnsembliENST00000275699; ENSP00000275699; ENSG00000146809
ENST00000434204; ENSP00000390963; ENSG00000146809
ENST00000451215; ENSP00000416433; ENSG00000146809
ENST00000451558; ENSP00000397655; ENSG00000146809
GeneIDi142685
KEGGihsa:142685
UCSCiuc003vku.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125360 mRNA Translation: BAC86146.1
AC006333 Genomic DNA No translation available.
BC100874 mRNA Translation: AAI00875.1
BC100875 mRNA Translation: AAI00876.1
BC100876 mRNA Translation: AAI00877.1
BC100877 mRNA Translation: AAI00878.1
CR749595 mRNA Translation: CAH18393.1
AF403033 mRNA Translation: AAL57352.1
CCDSiCCDS34742.1
RefSeqiNP_001277187.1, NM_001290258.1
NP_563616.3, NM_080928.4
XP_005250203.1, XM_005250146.4
XP_011514119.1, XM_011515817.2
XP_011514120.1, XM_011515818.2
XP_011514121.1, XM_011515819.2
XP_011514122.1, XM_011515820.2
XP_016867245.1, XM_017011756.1
XP_016867246.1, XM_017011757.1
UniGeneiHs.83916

3D structure databases

ProteinModelPortaliQ8WXK1
SMRiQ8WXK1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126774, 19 interactors
IntActiQ8WXK1, 13 interactors
STRINGi9606.ENSP00000275699

PTM databases

iPTMnetiQ8WXK1
PhosphoSitePlusiQ8WXK1

Polymorphism and mutation databases

BioMutaiASB15
DMDMi296439431

Proteomic databases

PaxDbiQ8WXK1
PRIDEiQ8WXK1
ProteomicsDBi75072

Protocols and materials databases

DNASUi142685
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275699; ENSP00000275699; ENSG00000146809
ENST00000434204; ENSP00000390963; ENSG00000146809
ENST00000451215; ENSP00000416433; ENSG00000146809
ENST00000451558; ENSP00000397655; ENSG00000146809
GeneIDi142685
KEGGihsa:142685
UCSCiuc003vku.1 human

Organism-specific databases

CTDi142685
DisGeNETi142685
EuPathDBiHostDB:ENSG00000146809.12
GeneCardsiASB15
H-InvDBiHIX0025283
HGNCiHGNC:19767 ASB15
neXtProtiNX_Q8WXK1
OpenTargetsiENSG00000146809
PharmGKBiPA134977130
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150873
HOGENOMiHOG000034086
HOVERGENiHBG023406
InParanoidiQ8WXK1
KOiK10337
OMAiHYLALKY
OrthoDBiEOG091G03QP
PhylomeDBiQ8WXK1
TreeFamiTF315127

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

GenomeRNAii142685
PROiPR:Q8WXK1

Gene expression databases

BgeeiENSG00000146809 Expressed in 40 organ(s), highest expression level in muscle of leg
CleanExiHS_ASB15
ExpressionAtlasiQ8WXK1 baseline and differential
GenevisibleiQ8WXK1 HS

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 4 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 9 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 7 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB15_HUMAN
AccessioniPrimary (citable) accession number: Q8WXK1
Secondary accession number(s): Q3ZCP3, Q3ZCP5, Q68D37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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