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Entry version 170 (26 Feb 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Acyl-coenzyme A thioesterase 11

Gene

ACOT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 5 min(-1) for the hydrolysis of hexadecanoyl-CoA (PubMed:22897136). kcat is 3.5 min(-1) for the hydrolysis of tetradecanoyl-CoA (PubMed:22897136). kcat is 2.3 min(-1) for the hydrolysis of dodecanoyl-CoA (PubMed:22897136). kcat is 0.2 min(-1) for the hydrolysis of butanoyl-CoA (PubMed:22897136).1 Publication

      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

      This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.1 Publication
      View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei181Coenzyme ABy similarity1

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionHydrolase, Serine esterase
      Biological processFatty acid metabolism, Lipid metabolism

      Enzyme and pathway databases

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

      UniPathway: a resource for the exploration and annotation of metabolic pathways

      More...
      UniPathwayi
      UPA00199

      Chemistry databases

      SwissLipids knowledge resource for lipid biology

      More...
      SwissLipidsi
      SLP:000001186 [Q8WXI4-2]

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Acyl-coenzyme A thioesterase 111 Publication (EC:3.1.2.-1 Publication)
      Short name:
      Acyl-CoA thioesterase 111 Publication
      Alternative name(s):
      Acyl-CoA thioester hydrolase 11
      Adipose-associated thioesterase
      Brown fat-inducible thioesterase
      Short name:
      BFIT
      Palmitoyl-coenzyme A thioesterase1 Publication (EC:3.1.2.21 Publication)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:ACOT11
      Synonyms:BFIT, KIAA0707, THEA
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

      Organism-specific databases

      Human Gene Nomenclature Database

      More...
      HGNCi
      HGNC:18156 ACOT11

      Online Mendelian Inheritance in Man (OMIM)

      More...
      MIMi
      606803 gene

      neXtProt; the human protein knowledge platform

      More...
      neXtProti
      NX_Q8WXI4

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Keywords - Cellular componenti

      Cytoplasm, Mitochondrion

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Organism-specific databases

      DisGeNET

      More...
      DisGeNETi
      26027

      Open Targets

      More...
      OpenTargetsi
      ENSG00000162390

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...
      PharmGKBi
      PA38303

      Miscellaneous databases

      Pharos NIH Druggable Genome Knowledgebase

      More...
      Pharosi
      Q8WXI4 Tbio

      Polymorphism and mutation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...
      BioMutai
      ACOT11

      Domain mapping of disease mutations (DMDM)

      More...
      DMDMi
      21363000

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 13MitochondrionSequence analysisAdd BLAST13
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005381314 – 607Acyl-coenzyme A thioesterase 11Add BLAST594

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1
      Modified residuei25PhosphoserineBy similarity1

      Keywords - PTMi

      Phosphoprotein

      Proteomic databases

      jPOST - Japan Proteome Standard Repository/Database

      More...
      jPOSTi
      Q8WXI4

      MassIVE - Mass Spectrometry Interactive Virtual Environment

      More...
      MassIVEi
      Q8WXI4

      MaxQB - The MaxQuant DataBase

      More...
      MaxQBi
      Q8WXI4

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q8WXI4

      PeptideAtlas

      More...
      PeptideAtlasi
      Q8WXI4

      PRoteomics IDEntifications database

      More...
      PRIDEi
      Q8WXI4

      ProteomicsDB: a multi-organism proteome resource

      More...
      ProteomicsDBi
      75066 [Q8WXI4-1]
      75067 [Q8WXI4-2]

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      Q8WXI4

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      Q8WXI4

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

      Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.

      <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

      By cold exposure and repressed by heat exposure.

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSG00000162390 Expressed in heart left ventricle and 199 other tissues

      Genevisible search portal to normalized and curated expression data from Genevestigator

      More...
      Genevisiblei
      Q8WXI4 HS

      Organism-specific databases

      Human Protein Atlas

      More...
      HPAi
      HPA041047

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGrid)

      More...
      BioGridi
      117495, 4 interactors

      Protein interaction database and analysis system

      More...
      IntActi
      Q8WXI4, 11 interactors

      STRING: functional protein association networks

      More...
      STRINGi
      9606.ENSP00000360366

      Miscellaneous databases

      RNAct, Protein-RNA interaction predictions for model organisms.

      More...
      RNActi
      Q8WXI4 protein

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      Secondary structure

      1607
      Legend: HelixTurnBeta strandPDB Structure known for this area
      Show more details

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      Q8WXI4

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      Protein Data Bank in Europe - Knowledge Base

      More...
      PDBe-KBi
      Search...

      Miscellaneous databases

      Relative evolutionary importance of amino acids within a protein sequence

      More...
      EvolutionaryTracei
      Q8WXI4

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Domains and Repeats

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 155HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST113
      Domaini216 – 329HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST114
      Domaini375 – 585STARTPROSITE-ProRule annotationAdd BLAST211

      Region

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni91 – 93Coenzyme A bindingBy similarity3
      Regioni120 – 122Coenzyme A bindingBy similarity3
      Regioni271 – 273Coenzyme A bindingBy similarity3

      Keywords - Domaini

      Repeat, Transit peptide

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      KOG2763 Eukaryota
      COG1607 LUCA

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000156460

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      CLU_035725_0_0_1

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      Q8WXI4

      KEGG Orthology (KO)

      More...
      KOi
      K12417

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      CAGFTIW

      Database of Orthologous Groups

      More...
      OrthoDBi
      776852at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q8WXI4

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF328368

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      3.30.530.20, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR040170 Cytosol_ACT
      IPR033120 HOTDOG_ACOT
      IPR029069 HotDog_dom_sf
      IPR023393 START-like_dom_sf
      IPR002913 START_lipid-bd_dom
      IPR006683 Thioestr_dom

      The PANTHER Classification System

      More...
      PANTHERi
      PTHR11049 PTHR11049, 1 hit

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF03061 4HBT, 2 hits
      PF01852 START, 1 hit

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00234 START, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF54637 SSF54637, 2 hits

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS51770 HOTDOG_ACOT, 2 hits
      PS50848 START, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

      This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
      Isoform 1 (identifier: Q8WXI4-1) [UniParc]FASTAAdd to basket
      Also known as: BFIT1

      This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

      « Hide
              10         20         30         40         50
      MIQNVGNHLR RGLASVFSNR TSRKSALRAG NDSAMADGEG YRNPTEVQMS
      60 70 80 90 100
      QLVLPCHTNQ RGELSVGQLL KWIDTTACLS AERHAGCPCV TASMDDIYFE
      110 120 130 140 150
      HTISVGQVVN IKAKVNRAFN SSMEVGIQVA SEDLCSEKQW NVCKALATFV
      160 170 180 190 200
      ARREITKVKL KQITPRTEEE KMEHSVAAER RRMRLVYADT IKDLLANCAI
      210 220 230 240 250
      QGDLESRDCS RMVPAEKTRV ESVELVLPPH ANHQGNTFGG QIMAWMENVA
      260 270 280 290 300
      TIAASRLCRA HPTLKAIEMF HFRGPSQVGD RLVLKAIVNN AFKHSMEVGV
      310 320 330 340 350
      CVEAYRQEAE THRRHINSAF MTFVVLDADD QPQLLPWIRP QPGDGERRYR
      360 370 380 390 400
      EASARKKIRL DRKYIVSCKQ TEVPLSVPWD PSNQVYLSYN NVSSLKMLVA
      410 420 430 440 450
      KDNWVLSSEI SQVRLYTLED DKFLSFHMEM VVHVDAAQAF LLLSDLRQRP
      460 470 480 490 500
      EWDKHYRSVE LVQQVDEDDA IYHVTSPALG GHTKPQDFVI LASRRKPCDN
      510 520 530 540 550
      GDPYVIALRS VTLPTHRETP EYRRGETLCS GFCLWREGDQ LTKCCWVRVS
      560 570 580 590 600
      LTELVSASGF YSWGLESRSK GRRSDGWNGK LAGGHLSTLK AIPVAKINSR

      FGYLQDT
      Length:607
      Mass (Da):68,492
      Last modified:March 1, 2002 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12F2BCAB8AAC18EC
      GO
      Isoform 2 (identifier: Q8WXI4-2) [UniParc]FASTAAdd to basket
      Also known as: BFIT2

      The sequence of this isoform differs from the canonical sequence as follows:
           544-607: CCWVRVSLTE...NSRFGYLQDT → VSYYNQATPG...NDLAPSLQTL

      Show »
      Length:594
      Mass (Da):67,152
      Checksum:iC9CD42FB285A8B53
      GO

      <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

      The sequence BAA31682 differs from that shown. Reason: Erroneous initiation.Curated

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti255S → R in AAH01517 (PubMed:15489334).Curated1
      Sequence conflicti348R → W in BAD97290 (Ref. 4) Curated1

      Natural variant

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04819011R → W. Corresponds to variant dbSNP:rs34630746Ensembl.1
      Natural variantiVAR_022119165P → L. Corresponds to variant dbSNP:rs2304306Ensembl.1
      Natural variantiVAR_022120202G → D1 PublicationCorresponds to variant dbSNP:rs1702003Ensembl.1
      Natural variantiVAR_022121212M → I. Corresponds to variant dbSNP:rs2304305Ensembl.1
      Natural variantiVAR_048191536R → H. Corresponds to variant dbSNP:rs12403630Ensembl.1

      Alternative sequence

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000160544 – 607CCWVR…YLQDT → VSYYNQATPGVLNYVTTNVA GLSSEFYTTFKACEQFLLDN RNDLAPSLQTL in isoform 2. 4 PublicationsAdd BLAST64

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AF416921 mRNA Translation: AAL40937.1
      AF416922 mRNA Translation: AAL40938.1
      AB014607 mRNA Translation: BAA31682.1 Different initiation.
      AK023937 mRNA Translation: BAB14734.1
      AK223570 mRNA Translation: BAD97290.1
      AC099796 Genomic DNA No translation available.
      AL590093 Genomic DNA No translation available.
      CH471059 Genomic DNA Translation: EAX06682.1
      CH471059 Genomic DNA Translation: EAX06683.1
      CH471059 Genomic DNA Translation: EAX06684.1
      BC001517 mRNA Translation: AAH01517.1
      BC093844 mRNA Translation: AAH93844.1
      BC093846 mRNA Translation: AAH93846.1

      The Consensus CDS (CCDS) project

      More...
      CCDSi
      CCDS592.1 [Q8WXI4-1]
      CCDS593.1 [Q8WXI4-2]

      Protein sequence database of the Protein Information Resource

      More...
      PIRi
      T00351

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_056362.1, NM_015547.3 [Q8WXI4-1]
      NP_671517.1, NM_147161.3 [Q8WXI4-2]

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENST00000343744; ENSP00000340260; ENSG00000162390 [Q8WXI4-2]
      ENST00000371316; ENSP00000360366; ENSG00000162390 [Q8WXI4-1]

      Database of genes from NCBI RefSeq genomes

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      GeneIDi
      26027

      KEGG: Kyoto Encyclopedia of Genes and Genomes

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      KEGGi
      hsa:26027

      UCSC genome browser

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      UCSCi
      uc001cxl.3 human [Q8WXI4-1]

      Keywords - Coding sequence diversityi

      Alternative splicing, Polymorphism

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AF416921 mRNA Translation: AAL40937.1
      AF416922 mRNA Translation: AAL40938.1
      AB014607 mRNA Translation: BAA31682.1 Different initiation.
      AK023937 mRNA Translation: BAB14734.1
      AK223570 mRNA Translation: BAD97290.1
      AC099796 Genomic DNA No translation available.
      AL590093 Genomic DNA No translation available.
      CH471059 Genomic DNA Translation: EAX06682.1
      CH471059 Genomic DNA Translation: EAX06683.1
      CH471059 Genomic DNA Translation: EAX06684.1
      BC001517 mRNA Translation: AAH01517.1
      BC093844 mRNA Translation: AAH93844.1
      BC093846 mRNA Translation: AAH93846.1
      CCDSiCCDS592.1 [Q8WXI4-1]
      CCDS593.1 [Q8WXI4-2]
      PIRiT00351
      RefSeqiNP_056362.1, NM_015547.3 [Q8WXI4-1]
      NP_671517.1, NM_147161.3 [Q8WXI4-2]

      3D structure databases

      Select the link destinations:

      Protein Data Bank Europe

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      PDBei

      Protein Data Bank RCSB

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      RCSB PDBi

      Protein Data Bank Japan

      More...
      PDBji
      Links Updated
      PDB entryMethodResolution (Å)ChainPositionsPDBsum
      3FO5X-ray2.00A/B339-543[»]
      SMRiQ8WXI4
      ModBaseiSearch...
      PDBe-KBiSearch...

      Protein-protein interaction databases

      BioGridi117495, 4 interactors
      IntActiQ8WXI4, 11 interactors
      STRINGi9606.ENSP00000360366

      Chemistry databases

      SwissLipidsiSLP:000001186 [Q8WXI4-2]

      PTM databases

      iPTMnetiQ8WXI4
      PhosphoSitePlusiQ8WXI4

      Polymorphism and mutation databases

      BioMutaiACOT11
      DMDMi21363000

      Proteomic databases

      jPOSTiQ8WXI4
      MassIVEiQ8WXI4
      MaxQBiQ8WXI4
      PaxDbiQ8WXI4
      PeptideAtlasiQ8WXI4
      PRIDEiQ8WXI4
      ProteomicsDBi75066 [Q8WXI4-1]
      75067 [Q8WXI4-2]

      Genome annotation databases

      EnsembliENST00000343744; ENSP00000340260; ENSG00000162390 [Q8WXI4-2]
      ENST00000371316; ENSP00000360366; ENSG00000162390 [Q8WXI4-1]
      GeneIDi26027
      KEGGihsa:26027
      UCSCiuc001cxl.3 human [Q8WXI4-1]

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      26027
      DisGeNETi26027

      GeneCards: human genes, protein and diseases

      More...
      GeneCardsi
      ACOT11
      HGNCiHGNC:18156 ACOT11
      HPAiHPA041047
      MIMi606803 gene
      neXtProtiNX_Q8WXI4
      OpenTargetsiENSG00000162390
      PharmGKBiPA38303

      Human Unidentified Gene-Encoded large proteins database

      More...
      HUGEi
      Search...

      GenAtlas: human gene database

      More...
      GenAtlasi
      Search...

      Phylogenomic databases

      eggNOGiKOG2763 Eukaryota
      COG1607 LUCA
      GeneTreeiENSGT00940000156460
      HOGENOMiCLU_035725_0_0_1
      InParanoidiQ8WXI4
      KOiK12417
      OMAiCAGFTIW
      OrthoDBi776852at2759
      PhylomeDBiQ8WXI4
      TreeFamiTF328368

      Enzyme and pathway databases

      UniPathwayiUPA00199
      ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

      Miscellaneous databases

      ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

      More...
      ChiTaRSi
      ACOT11 human
      EvolutionaryTraceiQ8WXI4

      The Gene Wiki collection of pages on human genes and proteins

      More...
      GeneWikii
      ACOT11

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...
      GenomeRNAii
      26027
      PharosiQ8WXI4 Tbio

      Protein Ontology

      More...
      PROi
      PR:Q8WXI4
      RNActiQ8WXI4 protein

      The Stanford Online Universal Resource for Clones and ESTs

      More...
      SOURCEi
      Search...

      Gene expression databases

      BgeeiENSG00000162390 Expressed in heart left ventricle and 199 other tissues
      GenevisibleiQ8WXI4 HS

      Family and domain databases

      Gene3Di3.30.530.20, 1 hit
      InterProiView protein in InterPro
      IPR040170 Cytosol_ACT
      IPR033120 HOTDOG_ACOT
      IPR029069 HotDog_dom_sf
      IPR023393 START-like_dom_sf
      IPR002913 START_lipid-bd_dom
      IPR006683 Thioestr_dom
      PANTHERiPTHR11049 PTHR11049, 1 hit
      PfamiView protein in Pfam
      PF03061 4HBT, 2 hits
      PF01852 START, 1 hit
      SMARTiView protein in SMART
      SM00234 START, 1 hit
      SUPFAMiSSF54637 SSF54637, 2 hits
      PROSITEiView protein in PROSITE
      PS51770 HOTDOG_ACOT, 2 hits
      PS50848 START, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACO11_HUMAN
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXI4
      Secondary accession number(s): B1AQ22
      , D3DQ50, O75187, Q52LP1, Q53ER9, Q96DI1, Q9H883
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
      Last sequence update: March 1, 2002
      Last modified: February 26, 2020
      This is version 170 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      3D-structure, Reference proteome

      Documents

      1. PATHWAY comments
        Index of metabolic and biosynthesis pathways
      2. PDB cross-references
        Index of Protein Data Bank (PDB) cross-references
      3. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
      4. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      5. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      6. Human chromosome 1
        Human chromosome 1: entries, gene names and cross-references to MIM
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