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Protein

Acyl-coenzyme A thioesterase 11

Gene

ACOT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei181Coenzyme ABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Chemistry databases

SwissLipids knowledge resource for lipid biology

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SwissLipidsi
SLP:000001186 [Q8WXI4-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 11 (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 11
Alternative name(s):
Acyl-CoA thioester hydrolase 11
Adipose-associated thioesterase
Brown fat-inducible thioesterase
Short name:
BFIT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOT11
Synonyms:BFIT, KIAA0707, THEA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162390.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18156 ACOT11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606803 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXI4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26027

Open Targets

More...
OpenTargetsi
ENSG00000162390

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38303

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACOT11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21363000

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538131 – 607Acyl-coenzyme A thioesterase 11Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXI4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WXI4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WXI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXI4

PeptideAtlas

More...
PeptideAtlasi
Q8WXI4

PRoteomics IDEntifications database

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PRIDEi
Q8WXI4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75066
75067 [Q8WXI4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By cold exposure and repressed by heat exposure.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162390 Expressed in 200 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACOT11

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WXI4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041047

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117495, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WXI4, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360366

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FO5X-ray2.00A/B339-543[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WXI4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WXI4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WXI4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 155HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST113
Domaini216 – 329HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST114
Domaini375 – 585STARTPROSITE-ProRule annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni91 – 93Coenzyme A bindingBy similarity3
Regioni120 – 122Coenzyme A bindingBy similarity3
Regioni271 – 273Coenzyme A bindingBy similarity3

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2763 Eukaryota
COG1607 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156460

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG023847

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WXI4

KEGG Orthology (KO)

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KOi
K12417

Identification of Orthologs from Complete Genome Data

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OMAi
FHMEMLV

Database of Orthologous Groups

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OrthoDBi
776852at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXI4

TreeFam database of animal gene trees

More...
TreeFami
TF328368

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040170 Cytosol_ACT
IPR033120 HOTDOG_ACOT
IPR029069 HotDog_dom_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
IPR006683 Thioestr_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11049 PTHR11049, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03061 4HBT, 2 hits
PF01852 START, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00234 START, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54637 SSF54637, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51770 HOTDOG_ACOT, 2 hits
PS50848 START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WXI4-1) [UniParc]FASTAAdd to basket
Also known as: BFIT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIQNVGNHLR RGLASVFSNR TSRKSALRAG NDSAMADGEG YRNPTEVQMS
60 70 80 90 100
QLVLPCHTNQ RGELSVGQLL KWIDTTACLS AERHAGCPCV TASMDDIYFE
110 120 130 140 150
HTISVGQVVN IKAKVNRAFN SSMEVGIQVA SEDLCSEKQW NVCKALATFV
160 170 180 190 200
ARREITKVKL KQITPRTEEE KMEHSVAAER RRMRLVYADT IKDLLANCAI
210 220 230 240 250
QGDLESRDCS RMVPAEKTRV ESVELVLPPH ANHQGNTFGG QIMAWMENVA
260 270 280 290 300
TIAASRLCRA HPTLKAIEMF HFRGPSQVGD RLVLKAIVNN AFKHSMEVGV
310 320 330 340 350
CVEAYRQEAE THRRHINSAF MTFVVLDADD QPQLLPWIRP QPGDGERRYR
360 370 380 390 400
EASARKKIRL DRKYIVSCKQ TEVPLSVPWD PSNQVYLSYN NVSSLKMLVA
410 420 430 440 450
KDNWVLSSEI SQVRLYTLED DKFLSFHMEM VVHVDAAQAF LLLSDLRQRP
460 470 480 490 500
EWDKHYRSVE LVQQVDEDDA IYHVTSPALG GHTKPQDFVI LASRRKPCDN
510 520 530 540 550
GDPYVIALRS VTLPTHRETP EYRRGETLCS GFCLWREGDQ LTKCCWVRVS
560 570 580 590 600
LTELVSASGF YSWGLESRSK GRRSDGWNGK LAGGHLSTLK AIPVAKINSR

FGYLQDT
Length:607
Mass (Da):68,492
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12F2BCAB8AAC18EC
GO
Isoform 2 (identifier: Q8WXI4-2) [UniParc]FASTAAdd to basket
Also known as: BFIT2

The sequence of this isoform differs from the canonical sequence as follows:
     544-607: CCWVRVSLTE...NSRFGYLQDT → VSYYNQATPG...NDLAPSLQTL

Show »
Length:594
Mass (Da):67,152
Checksum:iC9CD42FB285A8B53
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31682 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti255S → R in AAH01517 (PubMed:15489334).Curated1
Sequence conflicti348R → W in BAD97290 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04819011R → W. Corresponds to variant dbSNP:rs34630746Ensembl.1
Natural variantiVAR_022119165P → L. Corresponds to variant dbSNP:rs2304306Ensembl.1
Natural variantiVAR_022120202G → D1 PublicationCorresponds to variant dbSNP:rs1702003Ensembl.1
Natural variantiVAR_022121212M → I. Corresponds to variant dbSNP:rs2304305Ensembl.1
Natural variantiVAR_048191536R → H. Corresponds to variant dbSNP:rs12403630Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000160544 – 607CCWVR…YLQDT → VSYYNQATPGVLNYVTTNVA GLSSEFYTTFKACEQFLLDN RNDLAPSLQTL in isoform 2. 4 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF416921 mRNA Translation: AAL40937.1
AF416922 mRNA Translation: AAL40938.1
AB014607 mRNA Translation: BAA31682.1 Different initiation.
AK023937 mRNA Translation: BAB14734.1
AK223570 mRNA Translation: BAD97290.1
AC099796 Genomic DNA No translation available.
AL590093 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06682.1
CH471059 Genomic DNA Translation: EAX06683.1
CH471059 Genomic DNA Translation: EAX06684.1
BC001517 mRNA Translation: AAH01517.1
BC093844 mRNA Translation: AAH93844.1
BC093846 mRNA Translation: AAH93846.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS592.1 [Q8WXI4-1]
CCDS593.1 [Q8WXI4-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00351

NCBI Reference Sequences

More...
RefSeqi
NP_056362.1, NM_015547.3 [Q8WXI4-1]
NP_671517.1, NM_147161.3 [Q8WXI4-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.745173

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343744; ENSP00000340260; ENSG00000162390 [Q8WXI4-2]
ENST00000371316; ENSP00000360366; ENSG00000162390 [Q8WXI4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26027

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26027

UCSC genome browser

More...
UCSCi
uc001cxl.3 human [Q8WXI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416921 mRNA Translation: AAL40937.1
AF416922 mRNA Translation: AAL40938.1
AB014607 mRNA Translation: BAA31682.1 Different initiation.
AK023937 mRNA Translation: BAB14734.1
AK223570 mRNA Translation: BAD97290.1
AC099796 Genomic DNA No translation available.
AL590093 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06682.1
CH471059 Genomic DNA Translation: EAX06683.1
CH471059 Genomic DNA Translation: EAX06684.1
BC001517 mRNA Translation: AAH01517.1
BC093844 mRNA Translation: AAH93844.1
BC093846 mRNA Translation: AAH93846.1
CCDSiCCDS592.1 [Q8WXI4-1]
CCDS593.1 [Q8WXI4-2]
PIRiT00351
RefSeqiNP_056362.1, NM_015547.3 [Q8WXI4-1]
NP_671517.1, NM_147161.3 [Q8WXI4-2]
UniGeneiHs.745173

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FO5X-ray2.00A/B339-543[»]
ProteinModelPortaliQ8WXI4
SMRiQ8WXI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117495, 4 interactors
IntActiQ8WXI4, 8 interactors
STRINGi9606.ENSP00000360366

Chemistry databases

SwissLipidsiSLP:000001186 [Q8WXI4-2]

PTM databases

iPTMnetiQ8WXI4
PhosphoSitePlusiQ8WXI4

Polymorphism and mutation databases

BioMutaiACOT11
DMDMi21363000

Proteomic databases

EPDiQ8WXI4
jPOSTiQ8WXI4
MaxQBiQ8WXI4
PaxDbiQ8WXI4
PeptideAtlasiQ8WXI4
PRIDEiQ8WXI4
ProteomicsDBi75066
75067 [Q8WXI4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343744; ENSP00000340260; ENSG00000162390 [Q8WXI4-2]
ENST00000371316; ENSP00000360366; ENSG00000162390 [Q8WXI4-1]
GeneIDi26027
KEGGihsa:26027
UCSCiuc001cxl.3 human [Q8WXI4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26027
DisGeNETi26027
EuPathDBiHostDB:ENSG00000162390.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ACOT11
HGNCiHGNC:18156 ACOT11
HPAiHPA041047
MIMi606803 gene
neXtProtiNX_Q8WXI4
OpenTargetsiENSG00000162390
PharmGKBiPA38303

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2763 Eukaryota
COG1607 LUCA
GeneTreeiENSGT00940000156460
HOVERGENiHBG023847
InParanoidiQ8WXI4
KOiK12417
OMAiFHMEMLV
OrthoDBi776852at2759
PhylomeDBiQ8WXI4
TreeFamiTF328368

Enzyme and pathway databases

ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACOT11 human
EvolutionaryTraceiQ8WXI4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ACOT11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26027

Protein Ontology

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PROi
PR:Q8WXI4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162390 Expressed in 200 organ(s), highest expression level in heart left ventricle
CleanExiHS_ACOT11
GenevisibleiQ8WXI4 HS

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR040170 Cytosol_ACT
IPR033120 HOTDOG_ACOT
IPR029069 HotDog_dom_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
IPR006683 Thioestr_dom
PANTHERiPTHR11049 PTHR11049, 1 hit
PfamiView protein in Pfam
PF03061 4HBT, 2 hits
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00234 START, 1 hit
SUPFAMiSSF54637 SSF54637, 2 hits
PROSITEiView protein in PROSITE
PS51770 HOTDOG_ACOT, 2 hits
PS50848 START, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACO11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXI4
Secondary accession number(s): B1AQ22
, D3DQ50, O75187, Q52LP1, Q53ER9, Q96DI1, Q9H883
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: January 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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