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Entry version 156 (17 Jun 2020)
Sequence version 2 (20 Feb 2007)
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Protein

Ankyrin repeat and SOCS box protein 10

Gene

ASB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 10
Short name:
ASB-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASB10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146926.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17185 ASB10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615054 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXI3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glaucoma 1, open angle, F (GLC1F)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06986748T → S in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344615EnsemblClinVar.1
Natural variantiVAR_06986865G → E in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886491EnsemblClinVar.1
Natural variantiVAR_06986967V → M in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344616EnsemblClinVar.1
Natural variantiVAR_06987072R → H in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886488EnsemblClinVar.1
Natural variantiVAR_06987394R → Q in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs147737381EnsemblClinVar.1
Natural variantiVAR_06987497D → E in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344619EnsemblClinVar.1
Natural variantiVAR_069876183R → C in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344605EnsemblClinVar.1
Natural variantiVAR_069878197A → V in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344607EnsemblClinVar.1
Natural variantiVAR_069879207V → L in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886474EnsemblClinVar.1
Natural variantiVAR_069881272R → H in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs140602973EnsemblClinVar.1
Natural variantiVAR_069882295Q → L in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344609EnsemblClinVar.1
Natural variantiVAR_069884320A → T in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344610EnsemblClinVar.1
Natural variantiVAR_069886332H → Q in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886482EnsemblClinVar.1
Natural variantiVAR_069887356H → Y in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344611EnsemblClinVar.1
Natural variantiVAR_069888360R → H in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344612EnsemblClinVar.1
Natural variantiVAR_069891440S → G in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886487EnsemblClinVar.1
Isoform 3 (identifier: Q8WXI3-3)
Natural variantiVAR_08279619P → S in GLC1F, uncertain pathological significance. 1 Publication1
Natural variantiVAR_08279732R → S in GLC1F, uncertain pathological significance. 1 Publication1
Natural variantiVAR_08279839R → Q in GLC1F, uncertain pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation, Glaucoma

Organism-specific databases

DisGeNET

More...
DisGeNETi
136371

MalaCards human disease database

More...
MalaCardsi
ASB10
MIMi603383 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000146926

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
353225 NON RARE IN EUROPE: Primary adult open-angle glaucoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25028

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WXI3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASB10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302522

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669421 – 467Ankyrin repeat and SOCS box protein 10Add BLAST467

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXI3

PeptideAtlas

More...
PeptideAtlasi
Q8WXI3

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXI3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75063 [Q8WXI3-1]
75064 [Q8WXI3-2]
75065 [Q8WXI3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXI3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146926 Expressed in muscle of leg and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WXI3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXI3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146926 Group enriched (heart muscle, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
126459, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WXI3, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8WXI3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000391137

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WXI3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WXI3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati115 – 144ANK 1Add BLAST30
Repeati147 – 176ANK 2Add BLAST30
Repeati180 – 209ANK 3Add BLAST30
Repeati214 – 243ANK 4Add BLAST30
Repeati247 – 289ANK 5Add BLAST43
Repeati293 – 322ANK 6Add BLAST30
Repeati326 – 361ANK 7Add BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini412 – 464SOCS boxPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035721_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXI3

KEGG Orthology (KO)

More...
KOi
K10332

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHLCQGA

Database of Orthologous Groups

More...
OrthoDBi
540084at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXI3

TreeFam database of animal gene trees

More...
TreeFami
TF323921

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 3 hits
PF07525 SOCS_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 7 hits
SM00969 SOCS_box, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50225 SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLMSWSPEEC KGQGEPLDDR HPLCARLVEK PSRGSEEHLK SGPGPIVTRT
60 70 80 90 100
ASGPALAFWQ AVLAGDVGCV SRILADSSTG LAPDSVFDTS DPERWRDFRF
110 120 130 140 150
NIRALRLWSL TYEEELTTPL HVAASRGHTE VLRLLLRRRA RPDSAPGGRT
160 170 180 190 200
ALHEACAAGH TACVHVLLVA GADPNIADQD GKRPLHLCRG PGTLECAELL
210 220 230 240 250
LRFGARVDGR SEEEEETPLH VAARLGHVEL ADLLLRRGAC PDARNAEGWT
260 270 280 290 300
PLLAACDVRC QSITDAEATT ARCLQLCSLL LSAGADADAA DQDKQRPLHL
310 320 330 340 350
ACRRGHAAVV ELLLSCGVSA NTMDYGGHTP LHCALQGPAA ALAQSPEHVV
360 370 380 390 400
RALLNHGAVR VWPGALPKVL ERWSTCPRTI EVLMNTYSVV QLPEEAVGLV
410 420 430 440 450
TPETLQKHQR FYSSLFALVR QPRSLQHLSR CALRSHLEGS LPQALPRLPL
460
PPRLLRYLQL DFEGVLY
Length:467
Mass (Da):50,894
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C92C07B154479DE
GO
Isoform 2 (identifier: Q8WXI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-406: Missing.

Show »
Length:429
Mass (Da):46,609
Checksum:i56019889B7BD50DE
GO
Isoform 3 (identifier: Q8WXI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MLMSWSPEEC...DFRFNIRALR → MPWGKNSSPH...EPRWSSHQRG

Show »
Length:452
Mass (Da):49,565
Checksum:i50FF121D0A2B4A2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WB38F8WB38_HUMAN
Ankyrin repeat and SOCS box protein...
ASB10
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti421Q → R in BAC86204 (PubMed:14702039).Curated1
Sequence conflicti433L → P in BAC86204 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06986748T → S in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344615EnsemblClinVar.1
Natural variantiVAR_06986865G → E in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886491EnsemblClinVar.1
Natural variantiVAR_06986967V → M in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344616EnsemblClinVar.1
Natural variantiVAR_06987072R → H in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886488EnsemblClinVar.1
Natural variantiVAR_06987188D → V1 PublicationCorresponds to variant dbSNP:rs151344617EnsemblClinVar.1
Natural variantiVAR_06987291D → Y1 PublicationCorresponds to variant dbSNP:rs104886490EnsemblClinVar.1
Natural variantiVAR_06987394R → Q in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs147737381EnsemblClinVar.1
Natural variantiVAR_06987497D → E in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344619EnsemblClinVar.1
Natural variantiVAR_069875172A → V1 PublicationCorresponds to variant dbSNP:rs151344604EnsemblClinVar.1
Natural variantiVAR_069876183R → C in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344605EnsemblClinVar.1
Natural variantiVAR_069877189R → W1 PublicationCorresponds to variant dbSNP:rs104886473EnsemblClinVar.1
Natural variantiVAR_069878197A → V in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344607EnsemblClinVar.1
Natural variantiVAR_069879207V → L in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886474EnsemblClinVar.1
Natural variantiVAR_069880237R → G1 PublicationCorresponds to variant dbSNP:rs61735708Ensembl.1
Natural variantiVAR_069881272R → H in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs140602973EnsemblClinVar.1
Natural variantiVAR_069882295Q → L in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344609EnsemblClinVar.1
Natural variantiVAR_069883304R → C1 PublicationCorresponds to variant dbSNP:rs61735130EnsemblClinVar.1
Natural variantiVAR_069884320A → T in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344610EnsemblClinVar.1
Natural variantiVAR_069885329T → M1 PublicationCorresponds to variant dbSNP:rs104886481EnsemblClinVar.1
Natural variantiVAR_069886332H → Q in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886482EnsemblClinVar.1
Natural variantiVAR_069887356H → Y in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344611EnsemblClinVar.1
Natural variantiVAR_069888360R → H in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151344612EnsemblClinVar.1
Natural variantiVAR_069889372R → C1 PublicationCorresponds to variant dbSNP:rs62489646Ensembl.1
Natural variantiVAR_069890402P → T1 PublicationCorresponds to variant dbSNP:rs919533Ensembl.1
Natural variantiVAR_069891440S → G in GLC1F; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104886487EnsemblClinVar.1
Natural variantiVAR_022090453R → C1 PublicationCorresponds to variant dbSNP:rs3800791Ensembl.1
Isoform 3 (identifier: Q8WXI3-3)
Natural variantiVAR_08279619P → S in GLC1F, uncertain pathological significance. 1 Publication1
Natural variantiVAR_08279732R → S in GLC1F, uncertain pathological significance. 1 Publication1
Natural variantiVAR_08279839R → Q in GLC1F, uncertain pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389971 – 106MLMSW…IRALR → MPWGKNSSPHWGHHLGCLPS APACRIWRPHSRPAWEPPRP SPLLCQDMALQNALYTGDLA RLQELFPPHSTADLLLESRA AEPRWSSHQRG in isoform 3. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_023357369 – 406Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF417920 mRNA Translation: AAL59159.1
AK125565 mRNA Translation: BAC86204.1
AC010973 Genomic DNA No translation available.
BC126351 mRNA Translation: AAI26352.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47749.2 [Q8WXI3-2]
CCDS47750.2 [Q8WXI3-1]
CCDS5921.2 [Q8WXI3-3]

NCBI Reference Sequences

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RefSeqi
NP_001135931.2, NM_001142459.1 [Q8WXI3-1]
NP_001135932.2, NM_001142460.1 [Q8WXI3-2]
NP_543147.2, NM_080871.3 [Q8WXI3-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275838; ENSP00000275838; ENSG00000146926 [Q8WXI3-2]
ENST00000377867; ENSP00000367098; ENSG00000146926 [Q8WXI3-3]
ENST00000420175; ENSP00000391137; ENSG00000146926 [Q8WXI3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
136371

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:136371

UCSC genome browser

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UCSCi
uc003wjl.1 human [Q8WXI3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417920 mRNA Translation: AAL59159.1
AK125565 mRNA Translation: BAC86204.1
AC010973 Genomic DNA No translation available.
BC126351 mRNA Translation: AAI26352.1
CCDSiCCDS47749.2 [Q8WXI3-2]
CCDS47750.2 [Q8WXI3-1]
CCDS5921.2 [Q8WXI3-3]
RefSeqiNP_001135931.2, NM_001142459.1 [Q8WXI3-1]
NP_001135932.2, NM_001142460.1 [Q8WXI3-2]
NP_543147.2, NM_080871.3 [Q8WXI3-3]

3D structure databases

SMRiQ8WXI3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126459, 27 interactors
IntActiQ8WXI3, 8 interactors
MINTiQ8WXI3
STRINGi9606.ENSP00000391137

PTM databases

iPTMnetiQ8WXI3
PhosphoSitePlusiQ8WXI3

Polymorphism and mutation databases

BioMutaiASB10
DMDMi126302522

Proteomic databases

PaxDbiQ8WXI3
PeptideAtlasiQ8WXI3
PRIDEiQ8WXI3
ProteomicsDBi75063 [Q8WXI3-1]
75064 [Q8WXI3-2]
75065 [Q8WXI3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32988 132 antibodies

The DNASU plasmid repository

More...
DNASUi
136371

Genome annotation databases

EnsembliENST00000275838; ENSP00000275838; ENSG00000146926 [Q8WXI3-2]
ENST00000377867; ENSP00000367098; ENSG00000146926 [Q8WXI3-3]
ENST00000420175; ENSP00000391137; ENSG00000146926 [Q8WXI3-1]
GeneIDi136371
KEGGihsa:136371
UCSCiuc003wjl.1 human [Q8WXI3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
136371
DisGeNETi136371
EuPathDBiHostDB:ENSG00000146926.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ASB10
HGNCiHGNC:17185 ASB10
HPAiENSG00000146926 Group enriched (heart muscle, skeletal muscle, tongue)
MalaCardsiASB10
MIMi603383 phenotype
615054 gene
neXtProtiNX_Q8WXI3
OpenTargetsiENSG00000146926
Orphaneti353225 NON RARE IN EUROPE: Primary adult open-angle glaucoma
PharmGKBiPA25028

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000158974
HOGENOMiCLU_035721_0_0_1
InParanoidiQ8WXI3
KOiK10332
OMAiLHLCQGA
OrthoDBi540084at2759
PhylomeDBiQ8WXI3
TreeFamiTF323921

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
136371 1 hit in 786 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
136371
PharosiQ8WXI3 Tbio

Protein Ontology

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PROi
PR:Q8WXI3
RNActiQ8WXI3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146926 Expressed in muscle of leg and 36 other tissues
ExpressionAtlasiQ8WXI3 baseline and differential
GenevisibleiQ8WXI3 HS

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50225 SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASB10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXI3
Secondary accession number(s): A0AVH0, Q6ZUL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: February 20, 2007
Last modified: June 17, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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