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Protein

Suppressor of cytokine signaling 4

Gene

SOCS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SignaLinkiQ8WXH5
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Alternative name(s):
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:SOCS4
Synonyms:SOCS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000180008.8
HGNCiHGNC:19392 SOCS4
MIMi616337 gene
neXtProtiNX_Q8WXH5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi122809
OpenTargetsiENSG00000180008
PharmGKBiPA164742477

Polymorphism and mutation databases

BioMutaiSOCS4
DMDMi20178106

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812471 – 440Suppressor of cytokine signaling 4Add BLAST440

Proteomic databases

MaxQBiQ8WXH5
PaxDbiQ8WXH5
PeptideAtlasiQ8WXH5
PRIDEiQ8WXH5
ProteomicsDBi75057

PTM databases

iPTMnetiQ8WXH5
PhosphoSitePlusiQ8WXH5

Expressioni

Inductioni

Up-regulated by EGF.1 Publication

Gene expression databases

BgeeiENSG00000180008 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_SOCS4
HS_SOCS7
ExpressionAtlasiQ8WXH5 baseline and differential
GenevisibleiQ8WXH5 HS

Organism-specific databases

HPAiCAB013478
HPA057961

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi125796, 22 interactors
DIPiDIP-29568N
IntActiQ8WXH5, 15 interactors
MINTiQ8WXH5
STRINGi9606.ENSP00000341327

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WXH5
SMRiQ8WXH5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXH5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 381SH2PROSITE-ProRule annotationAdd BLAST96
Domaini376 – 425SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiQ8WXH5
KOiK04697
OMAiESCSDAE
OrthoDBiEOG091G0EQ0
PhylomeDBiQ8WXH5
TreeFamiTF321368

Family and domain databases

CDDicd10385 SH2_SOCS4, 1 hit
cd03738 SOCS_SOCS4, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028416 SOCS4
IPR022252 SOCS4/SOCS5_dom
IPR035864 SOCS4_SH2
IPR037342 SOCS4_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF2 PTHR44282:SF2, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WXH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE
60 70 80 90 100
TVNGIEKTEV SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG
110 120 130 140 150
QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH
160 170 180 190 200
TAPINSKSDE WVSTDLSQTE LRDGQLKRRN MEENINCFSH TNVQPCVITT
210 220 230 240 250
DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS SRKRNKPKWD
260 270 280 290 300
LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
310 320 330 340 350
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC
360 370 380 390 400
VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC
410 420 430 440
TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC
Length:440
Mass (Da):50,623
Last modified:March 1, 2002 - v1
Checksum:iA4A747AB7F6FF08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424815 mRNA Translation: AAL60517.1
BC060790 mRNA Translation: AAH60790.1
CCDSiCCDS9722.1
RefSeqiNP_543143.1, NM_080867.2
NP_955453.1, NM_199421.1
XP_011534727.1, XM_011536425.1
XP_011534728.1, XM_011536426.1
UniGeneiHs.744302

Genome annotation databases

EnsembliENST00000339298; ENSP00000341327; ENSG00000180008
ENST00000395472; ENSP00000378855; ENSG00000180008
ENST00000555846; ENSP00000452522; ENSG00000180008
GeneIDi122809
KEGGihsa:122809
UCSCiuc001xbo.4 human

Similar proteinsi

Entry informationi

Entry nameiSOCS4_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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