UniProtKB - Q8WXH5 (SOCS4_HUMAN)
Protein
Suppressor of cytokine signaling 4
Gene
SOCS4
Organism
Homo sapiens (Human)
Status
Functioni
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.2 Publications
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- intracellular signal transduction Source: InterPro
- negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: InterPro
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of growth Source: UniProtKB-KW
Keywordsi
Molecular function | Signal transduction inhibitor |
Biological process | Growth regulation, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
SignaLinki | Q8WXH5 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of cytokine signaling 4Short name: SOCS-4 Alternative name(s): Suppressor of cytokine signaling 7 Short name: SOCS-7 |
Gene namesi | Name:SOCS4 Synonyms:SOCS7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180008.8 |
HGNCi | HGNC:19392 SOCS4 |
MIMi | 616337 gene |
neXtProti | NX_Q8WXH5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 122809 |
OpenTargetsi | ENSG00000180008 |
PharmGKBi | PA164742477 |
Polymorphism and mutation databases
BioMutai | SOCS4 |
DMDMi | 20178106 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181247 | 1 – 440 | Suppressor of cytokine signaling 4Add BLAST | 440 |
Proteomic databases
jPOSTi | Q8WXH5 |
MaxQBi | Q8WXH5 |
PaxDbi | Q8WXH5 |
PeptideAtlasi | Q8WXH5 |
PRIDEi | Q8WXH5 |
ProteomicsDBi | 75057 |
PTM databases
iPTMneti | Q8WXH5 |
PhosphoSitePlusi | Q8WXH5 |
Expressioni
Inductioni
Up-regulated by EGF.1 Publication
Gene expression databases
Bgeei | ENSG00000180008 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas |
ExpressionAtlasi | Q8WXH5 baseline and differential |
Genevisiblei | Q8WXH5 HS |
Organism-specific databases
HPAi | CAB013478 HPA057961 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 125796, 22 interactors |
DIPi | DIP-29568N |
IntActi | Q8WXH5, 15 interactors |
MINTi | Q8WXH5 |
STRINGi | 9606.ENSP00000341327 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2IZV | X-ray | 2.55 | A | 274-437 | [»] | |
ProteinModelPortali | Q8WXH5 | |||||
SMRi | Q8WXH5 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WXH5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 286 – 381 | SH2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 376 – 425 | SOCS boxPROSITE-ProRule annotationAdd BLAST | 50 |
Domaini
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG4566 Eukaryota ENOG4111V4J LUCA |
GeneTreei | ENSGT00940000161456 |
HOGENOMi | HOG000027791 |
HOVERGENi | HBG054138 |
InParanoidi | Q8WXH5 |
KOi | K04697 |
OMAi | ESCSDAE |
OrthoDBi | 722019at2759 |
PhylomeDBi | Q8WXH5 |
TreeFami | TF321368 |
Family and domain databases
CDDi | cd10385 SH2_SOCS4, 1 hit cd03738 SOCS_SOCS4, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028416 SOCS4 IPR022252 SOCS4/SOCS5_dom IPR035864 SOCS4_SH2 IPR037342 SOCS4_SOCS IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf |
PANTHERi | PTHR44282:SF2 PTHR44282:SF2, 1 hit |
Pfami | View protein in Pfam PF00017 SH2, 1 hit PF12610 SOCS, 1 hit PF07525 SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit |
SUPFAMi | SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WXH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE
60 70 80 90 100
TVNGIEKTEV SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG
110 120 130 140 150
QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH
160 170 180 190 200
TAPINSKSDE WVSTDLSQTE LRDGQLKRRN MEENINCFSH TNVQPCVITT
210 220 230 240 250
DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS SRKRNKPKWD
260 270 280 290 300
LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
310 320 330 340 350
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC
360 370 380 390 400
VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC
410 420 430 440
TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF424815 mRNA Translation: AAL60517.1 BC060790 mRNA Translation: AAH60790.1 |
CCDSi | CCDS9722.1 |
RefSeqi | NP_543143.1, NM_080867.2 NP_955453.1, NM_199421.1 XP_011534727.1, XM_011536425.1 XP_011534728.1, XM_011536426.1 |
UniGenei | Hs.744302 |
Genome annotation databases
Ensembli | ENST00000339298; ENSP00000341327; ENSG00000180008 ENST00000395472; ENSP00000378855; ENSG00000180008 ENST00000555846; ENSP00000452522; ENSG00000180008 |
GeneIDi | 122809 |
KEGGi | hsa:122809 |
UCSCi | uc001xbo.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF424815 mRNA Translation: AAL60517.1 BC060790 mRNA Translation: AAH60790.1 |
CCDSi | CCDS9722.1 |
RefSeqi | NP_543143.1, NM_080867.2 NP_955453.1, NM_199421.1 XP_011534727.1, XM_011536425.1 XP_011534728.1, XM_011536426.1 |
UniGenei | Hs.744302 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2IZV | X-ray | 2.55 | A | 274-437 | [»] | |
ProteinModelPortali | Q8WXH5 | |||||
SMRi | Q8WXH5 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 125796, 22 interactors |
DIPi | DIP-29568N |
IntActi | Q8WXH5, 15 interactors |
MINTi | Q8WXH5 |
STRINGi | 9606.ENSP00000341327 |
PTM databases
iPTMneti | Q8WXH5 |
PhosphoSitePlusi | Q8WXH5 |
Polymorphism and mutation databases
BioMutai | SOCS4 |
DMDMi | 20178106 |
Proteomic databases
jPOSTi | Q8WXH5 |
MaxQBi | Q8WXH5 |
PaxDbi | Q8WXH5 |
PeptideAtlasi | Q8WXH5 |
PRIDEi | Q8WXH5 |
ProteomicsDBi | 75057 |
Protocols and materials databases
DNASUi | 122809 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000339298; ENSP00000341327; ENSG00000180008 ENST00000395472; ENSP00000378855; ENSG00000180008 ENST00000555846; ENSP00000452522; ENSG00000180008 |
GeneIDi | 122809 |
KEGGi | hsa:122809 |
UCSCi | uc001xbo.4 human |
Organism-specific databases
CTDi | 122809 |
DisGeNETi | 122809 |
EuPathDBi | HostDB:ENSG00000180008.8 |
GeneCardsi | SOCS4 |
HGNCi | HGNC:19392 SOCS4 |
HPAi | CAB013478 HPA057961 |
MIMi | 616337 gene |
neXtProti | NX_Q8WXH5 |
OpenTargetsi | ENSG00000180008 |
PharmGKBi | PA164742477 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4566 Eukaryota ENOG4111V4J LUCA |
GeneTreei | ENSGT00940000161456 |
HOGENOMi | HOG000027791 |
HOVERGENi | HBG054138 |
InParanoidi | Q8WXH5 |
KOi | K04697 |
OMAi | ESCSDAE |
OrthoDBi | 722019at2759 |
PhylomeDBi | Q8WXH5 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
SignaLinki | Q8WXH5 |
Miscellaneous databases
ChiTaRSi | SOCS4 human |
EvolutionaryTracei | Q8WXH5 |
GenomeRNAii | 122809 |
PROi | PR:Q8WXH5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180008 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas |
ExpressionAtlasi | Q8WXH5 baseline and differential |
Genevisiblei | Q8WXH5 HS |
Family and domain databases
CDDi | cd10385 SH2_SOCS4, 1 hit cd03738 SOCS_SOCS4, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028416 SOCS4 IPR022252 SOCS4/SOCS5_dom IPR035864 SOCS4_SH2 IPR037342 SOCS4_SOCS IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf |
PANTHERi | PTHR44282:SF2 PTHR44282:SF2, 1 hit |
Pfami | View protein in Pfam PF00017 SH2, 1 hit PF12610 SOCS, 1 hit PF07525 SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit |
SUPFAMi | SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | SOCS4_HUMAN | |
Accessioni | Q8WXH5Primary (citable) accession number: Q8WXH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways