UniProtKB - Q8WXH5 (SOCS4_HUMAN)

BLAST

>sp|Q8WXH5|SOCS4_HUMAN Suppressor of cytokine signaling 4 OS=Homo sapiens OX=9606 GN=SOCS4 PE=1 SV=1
MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
EYHYKSKVRVLRIDAPEQQC

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History
Entry version 142 (07 Nov 2018)
Sequence version 1 (01 Mar 2002)
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Protein

Suppressor of cytokine signaling 4

Gene

SOCS4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.2 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processⁱ

intracellular signal transduction Source: InterPro
negative regulation of epidermal growth factor-activated receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15590694
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: InterPro
protein ubiquitination Source: UniProtKB-UniPathway
regulation of growth Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor
Biological process	Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SignaLinkⁱ	Q8WXH5
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Suppressor of cytokine signaling 4 Short name: SOCS-4 Alternative name(s): Suppressor of cytokine signaling 7 Short name: SOCS-7
Gene namesⁱ	Name:SOCS4 Synonyms:SOCS7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180008.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19392 SOCS4
MIMⁱ	616337 gene
neXtProtⁱ	NX_Q8WXH5

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	122809
Open Targets More...OpenTargetsⁱ	ENSG00000180008
PharmGKBⁱ	PA164742477

Polymorphism and mutation databases

BioMutaⁱ	SOCS4
DMDMⁱ	20178106

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181247	1 – 440	Suppressor of cytokine signaling 4Add BLAST		440

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WXH5
PaxDbⁱ	Q8WXH5
PeptideAtlas More...PeptideAtlasⁱ	Q8WXH5
PRIDEⁱ	Q8WXH5
ProteomicsDBⁱ	75057

PTM databases

iPTMnetⁱ	Q8WXH5
PhosphoSitePlusⁱ	Q8WXH5

Expressionⁱ

Inductionⁱ

Up-regulated by EGF.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000180008 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_SOCS4 HS_SOCS7
ExpressionAtlasⁱ	Q8WXH5 baseline and differential
Genevisibleⁱ	Q8WXH5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013478 HPA057961

HPAⁱ

CAB013478
HPA057961

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FRS3	O43559	2	EBI-3942425,EBI-725515
GRB2	P62993	3	EBI-3942425,EBI-401755
PIK3R3	Q92569	3	EBI-3942425,EBI-79893
PINK1	Q9BXM7	3	EBI-3942425,EBI-2846068
RBP7	Q96R05	3	EBI-3942425,EBI-2856326

Protein-protein interaction databases

BioGridⁱ	125796, 22 interactors
Database of interacting proteins More...DIPⁱ	DIP-29568N
IntActⁱ	Q8WXH5, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q8WXH5
STRINGⁱ	9606.ENSP00000341327

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	278 – 283	Combined sources	6
Beta strandⁱ	287 – 290	Combined sources	4
Helixⁱ	293 – 300	Combined sources	8
Beta strandⁱ	307 – 312	Combined sources	6
Beta strandⁱ	319 – 326	Combined sources	8
Beta strandⁱ	329 – 334	Combined sources	6
Beta strandⁱ	336 – 338	Combined sources	3
Beta strandⁱ	341 – 344	Combined sources	4
Beta strandⁱ	354 – 356	Combined sources	3
Helixⁱ	357 – 363	Combined sources	7
Helixⁱ	367 – 369	Combined sources	3
Helixⁱ	389 – 400	Combined sources	12
Helixⁱ	403 – 407	Combined sources	5
Beta strandⁱ	409 – 411	Combined sources	3
Helixⁱ	413 – 419	Combined sources	7
Beta strandⁱ	421 – 426	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8WXH5
SMRⁱ	Q8WXH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8WXH5

EvolutionaryTraceⁱ

Q8WXH5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	286 – 381	SH2PROSITE-ProRule annotationAdd BLAST		96
Domainⁱ	376 – 425	SOCS boxPROSITE-ProRule annotationAdd BLAST		50

Domainⁱ

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000027791
HOVERGENⁱ	HBG054138
InParanoidⁱ	Q8WXH5
KEGG Orthology (KO) More...KOⁱ	K04697
OMAⁱ	ESCSDAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EQ0
PhylomeDBⁱ	Q8WXH5
TreeFamⁱ	TF321368

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10385 SH2_SOCS4, 1 hit cd03738 SOCS_SOCS4, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028416 SOCS4 IPR022252 SOCS4/SOCS5_dom IPR035864 SOCS4_SH2 IPR037342 SOCS4_SOCS IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44282:SF2 PTHR44282:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF12610 SOCS, 1 hit PF07525 SOCS_box, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WXH5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE 
        60         70         80         90        100
TVNGIEKTEV SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG 
       110        120        130        140        150
QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH 
       160        170        180        190        200
TAPINSKSDE WVSTDLSQTE LRDGQLKRRN MEENINCFSH TNVQPCVITT 
       210        220        230        240        250
DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS SRKRNKPKWD 
       260        270        280        290        300
LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL 
       310        320        330        340        350
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC 
       360        370        380        390        400
VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC 
       410        420        430        440
TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC

Length:440

Mass (Da):50,623

Last modified:March 1, 2002 - v1

Checksum:ⁱA4A747AB7F6FF08C

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF424815 mRNA Translation: AAL60517.1 BC060790 mRNA Translation: AAH60790.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9722.1
NCBI Reference Sequences More...RefSeqⁱ	NP_543143.1, NM_080867.2 NP_955453.1, NM_199421.1 XP_011534727.1, XM_011536425.1 XP_011534728.1, XM_011536426.1
UniGeneⁱ	Hs.744302

Genome annotation databases

Ensemblⁱ	ENST00000339298; ENSP00000341327; ENSG00000180008 ENST00000395472; ENSP00000378855; ENSG00000180008 ENST00000555846; ENSP00000452522; ENSG00000180008
GeneIDⁱ	122809
KEGGⁱ	hsa:122809
UCSC genome browser More...UCSCⁱ	uc001xbo.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q8WXH5	Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens (human)		HUMAN		440	UniRef100_Q8WXH5

Protein	Similar proteins		Species	Score	Length	Source
Q8WXH5	Suppressor of cytokine signaling 4		PONAB		440	UniRef90_Q8WXH5
Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens (human)		HUMAN		440
Suppressor of cytokine signaling 4		MYOBR		441
Uncharacterized protein		MYOLU		441
Uncharacterized protein		RABIT		441
+31

Protein	Similar proteins		Species	Score	Length	Source
Q8WXH5	Suppressor of cytokine signaling 4		PONAB		440	UniRef50_Q8WXH5
Suppressor of cytokine signaling 4		MOUSE		436
Suppressor of cytokine signaling 4		BOVIN		440
Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens (human)		HUMAN		440
Uncharacterized protein		MYOLU		441
+219

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF424815 mRNA Translation: AAL60517.1 BC060790 mRNA Translation: AAH60790.1
CCDSⁱ	CCDS9722.1
RefSeqⁱ	NP_543143.1, NM_080867.2 NP_955453.1, NM_199421.1 XP_011534727.1, XM_011536425.1 XP_011534728.1, XM_011536426.1
UniGeneⁱ	Hs.744302

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IZV	X-ray	2.55	A	274-437	[»]
ProteinModelPortalⁱ	Q8WXH5
SMRⁱ	Q8WXH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125796, 22 interactors
DIPⁱ	DIP-29568N
IntActⁱ	Q8WXH5, 15 interactors
MINTⁱ	Q8WXH5
STRINGⁱ	9606.ENSP00000341327

PTM databases

iPTMnetⁱ	Q8WXH5
PhosphoSitePlusⁱ	Q8WXH5

Polymorphism and mutation databases

BioMutaⁱ	SOCS4
DMDMⁱ	20178106

Proteomic databases

MaxQBⁱ	Q8WXH5
PaxDbⁱ	Q8WXH5
PeptideAtlasⁱ	Q8WXH5
PRIDEⁱ	Q8WXH5
ProteomicsDBⁱ	75057

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	122809
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000339298; ENSP00000341327; ENSG00000180008 ENST00000395472; ENSP00000378855; ENSG00000180008 ENST00000555846; ENSP00000452522; ENSG00000180008
GeneIDⁱ	122809
KEGGⁱ	hsa:122809
UCSCⁱ	uc001xbo.4 human

Organism-specific databases

CTDⁱ	122809
DisGeNETⁱ	122809
EuPathDBⁱ	HostDB:ENSG00000180008.8
GeneCardsⁱ	SOCS4
HGNCⁱ	HGNC:19392 SOCS4
HPAⁱ	CAB013478 HPA057961
MIMⁱ	616337 gene
neXtProtⁱ	NX_Q8WXH5
OpenTargetsⁱ	ENSG00000180008
PharmGKBⁱ	PA164742477
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000027791
HOVERGENⁱ	HBG054138
InParanoidⁱ	Q8WXH5
KOⁱ	K04697
OMAⁱ	ESCSDAE
OrthoDBⁱ	EOG091G0EQ0
PhylomeDBⁱ	Q8WXH5
TreeFamⁱ	TF321368

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SignaLinkⁱ	Q8WXH5

Miscellaneous databases

ChiTaRSⁱ	SOCS4 human
EvolutionaryTraceⁱ	Q8WXH5
GenomeRNAiⁱ	122809
Protein Ontology More...PROⁱ	PR:Q8WXH5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180008 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_SOCS4 HS_SOCS7
ExpressionAtlasⁱ	Q8WXH5 baseline and differential
Genevisibleⁱ	Q8WXH5 HS

Family and domain databases

CDDⁱ	cd10385 SH2_SOCS4, 1 hit cd03738 SOCS_SOCS4, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028416 SOCS4 IPR022252 SOCS4/SOCS5_dom IPR035864 SOCS4_SH2 IPR037342 SOCS4_SOCS IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44282:SF2 PTHR44282:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF12610 SOCS, 1 hit PF07525 SOCS_box, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOCS4_HUMAN
Accessionⁱ	Q8WXH5Primary (citable) accession number: Q8WXH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q8WXH5 (SOCS4_HUMAN)

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Suppressor of cytokine signaling 4

SOCS4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ