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Protein

Ankyrin repeat and SOCS box protein 11

Gene

ASB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 11
Short name:
ASB-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASB11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000165192.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17186 ASB11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300626 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXH4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165192

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25029

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASB11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20531990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669441 – 323Ankyrin repeat and SOCS box protein 11Add BLAST323

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXH4

PeptideAtlas

More...
PeptideAtlasi
Q8WXH4

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXH4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75055
75056 [Q8WXH4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165192 Expressed in 41 organ(s), highest expression level in muscle of leg

CleanEx database of gene expression profiles

More...
CleanExi
HS_ASB11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WXH4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXH4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000238

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126610, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417914

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WXH4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WXH4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 126ANK 2Add BLAST30
Repeati130 – 159ANK 3Add BLAST30
Repeati162 – 191ANK 4Add BLAST30
Repeati195 – 224ANK 5Add BLAST30
Repeati227 – 256ANK 6Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini273 – 323SOCS boxPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160592

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231513

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001376

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXH4

KEGG Orthology (KO)

More...
KOi
K10333

Identification of Orthologs from Complete Genome Data

More...
OMAi
YGANLKC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0DYR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXH4

TreeFam database of animal gene trees

More...
TreeFami
TF331945

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits
cd03728 SOCS_ASB_9_11, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037333 ASB9/11_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR
60 70 80 90 100
IAEEIYGGIS DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS
110 120 130 140 150
SLHEACLGGH VACAKALLEN GAHVNGVTVH GATPLFNACC SGSAACVNVL
160 170 180 190 200
LEFGAKAQLE VHLASPIHEA VKRGHRECME ILLANNVNID HEVPQLGTPL
210 220 230 240 250
YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN VEVIHLLTDY
260 270 280 290 300
GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG
310 320
RACHQAIHKL HLPEPLERFL LYQ
Length:323
Mass (Da):35,367
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF95A40184C5BBF4E
GO
Isoform 2 (identifier: Q8WXH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-104: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):33,534
Checksum:i2C83F1E160D3AAD2
GO
Isoform 3 (identifier: Q8WXH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MEDGPVFYGF...IAEEIYGGIS → MLQLTGENEK...GDYICHTFQG

Note: Gene prediction based on EST data.
Show »
Length:302
Mass (Da):32,952
Checksum:i0D33F8E4E0A400FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF31F8WF31_HUMAN
Ankyrin repeat and SOCS box protein...
ASB11
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069428165S → L1 PublicationCorresponds to variant dbSNP:rs144572145Ensembl.1
Natural variantiVAR_048286249D → N. Corresponds to variant dbSNP:rs34025595Ensembl.1
Natural variantiVAR_048287263S → G. Corresponds to variant dbSNP:rs35859007Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471271 – 60MEDGP…YGGIS → MLQLTGENEKNCEVSERIRR SGPWKEISFGDYICHTFQG in isoform 3. CuratedAdd BLAST60
Alternative sequenceiVSP_04308788 – 104Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF425642 mRNA Translation: AAL60519.1
BX537857 mRNA Translation: CAD97864.1
AC095351 Genomic DNA No translation available.
BC069340 mRNA Translation: AAH69340.1
BC103874 mRNA Translation: AAI03875.1
BC103875 mRNA Translation: AAI03876.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14164.1 [Q8WXH4-1]
CCDS35209.1 [Q8WXH4-3]
CCDS56596.1 [Q8WXH4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001012428.1, NM_001012428.2 [Q8WXH4-3]
NP_001188512.1, NM_001201583.1 [Q8WXH4-2]
NP_543149.1, NM_080873.2 [Q8WXH4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.352183

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344384; ENSP00000343408; ENSG00000165192 [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192 [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192 [Q8WXH4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
140456

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140456

UCSC genome browser

More...
UCSCi
uc004cwo.3 human [Q8WXH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425642 mRNA Translation: AAL60519.1
BX537857 mRNA Translation: CAD97864.1
AC095351 Genomic DNA No translation available.
BC069340 mRNA Translation: AAH69340.1
BC103874 mRNA Translation: AAI03875.1
BC103875 mRNA Translation: AAI03876.1
CCDSiCCDS14164.1 [Q8WXH4-1]
CCDS35209.1 [Q8WXH4-3]
CCDS56596.1 [Q8WXH4-2]
RefSeqiNP_001012428.1, NM_001012428.2 [Q8WXH4-3]
NP_001188512.1, NM_001201583.1 [Q8WXH4-2]
NP_543149.1, NM_080873.2 [Q8WXH4-1]
UniGeneiHs.352183

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UUCX-ray1.80A64-287[»]
ProteinModelPortaliQ8WXH4
SMRiQ8WXH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126610, 14 interactors
STRINGi9606.ENSP00000417914

PTM databases

iPTMnetiQ8WXH4
PhosphoSitePlusiQ8WXH4

Polymorphism and mutation databases

BioMutaiASB11
DMDMi20531990

Proteomic databases

PaxDbiQ8WXH4
PeptideAtlasiQ8WXH4
PRIDEiQ8WXH4
ProteomicsDBi75055
75056 [Q8WXH4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344384; ENSP00000343408; ENSG00000165192 [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192 [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192 [Q8WXH4-1]
GeneIDi140456
KEGGihsa:140456
UCSCiuc004cwo.3 human [Q8WXH4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140456
EuPathDBiHostDB:ENSG00000165192.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ASB11
HGNCiHGNC:17186 ASB11
HPAiHPA000238
MIMi300626 gene
neXtProtiNX_Q8WXH4
OpenTargetsiENSG00000165192
PharmGKBiPA25029

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000160592
HOGENOMiHOG000231513
HOVERGENiHBG001376
InParanoidiQ8WXH4
KOiK10333
OMAiYGANLKC
OrthoDBiEOG091G0DYR
PhylomeDBiQ8WXH4
TreeFamiTF331945

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140456

Protein Ontology

More...
PROi
PR:Q8WXH4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165192 Expressed in 41 organ(s), highest expression level in muscle of leg
CleanExiHS_ASB11
ExpressionAtlasiQ8WXH4 baseline and differential
GenevisibleiQ8WXH4 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03728 SOCS_ASB_9_11, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037333 ASB9/11_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASB11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXH4
Secondary accession number(s): E9PEN1, Q3SYC4, Q7Z667
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: December 5, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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