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Protein

Ankyrin repeat and SOCS box protein 11

Gene

ASB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 11
Short name:
ASB-11
Gene namesi
Name:ASB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000165192.13
HGNCiHGNC:17186 ASB11
MIMi300626 gene
neXtProtiNX_Q8WXH4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165192
PharmGKBiPA25029

Polymorphism and mutation databases

BioMutaiASB11
DMDMi20531990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669441 – 323Ankyrin repeat and SOCS box protein 11Add BLAST323

Proteomic databases

PaxDbiQ8WXH4
PeptideAtlasiQ8WXH4
PRIDEiQ8WXH4
ProteomicsDBi75055
75056 [Q8WXH4-2]

PTM databases

iPTMnetiQ8WXH4
PhosphoSitePlusiQ8WXH4

Expressioni

Gene expression databases

BgeeiENSG00000165192
CleanExiHS_ASB11
ExpressionAtlasiQ8WXH4 baseline and differential
GenevisibleiQ8WXH4 HS

Organism-specific databases

HPAiHPA000238

Interactioni

Protein-protein interaction databases

BioGridi126610, 14 interactors
STRINGi9606.ENSP00000417914

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi68 – 75Combined sources8
Helixi78 – 87Combined sources10
Helixi101 – 107Combined sources7
Helixi111 – 119Combined sources9
Helixi134 – 141Combined sources8
Helixi144 – 152Combined sources9
Helixi166 – 172Combined sources7
Helixi176 – 184Combined sources9
Turni194 – 196Combined sources3
Helixi199 – 205Combined sources7
Helixi209 – 217Combined sources9
Helixi231 – 236Combined sources6
Helixi241 – 249Combined sources9
Helixi264 – 267Combined sources4
Helixi273 – 281Combined sources9

3D structure databases

ProteinModelPortaliQ8WXH4
SMRiQ8WXH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 126ANK 2Add BLAST30
Repeati130 – 159ANK 3Add BLAST30
Repeati162 – 191ANK 4Add BLAST30
Repeati195 – 224ANK 5Add BLAST30
Repeati227 – 256ANK 6Add BLAST30
Domaini273 – 323SOCS boxPROSITE-ProRule annotationAdd BLAST51

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148951
HOGENOMiHOG000231513
HOVERGENiHBG001376
InParanoidiQ8WXH4
KOiK10333
OMAiYGANLKC
OrthoDBiEOG091G0DYR
PhylomeDBiQ8WXH4
TreeFamiTF331945

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03728 SOCS_ASB_9_11, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037333 ASB9/11_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR
60 70 80 90 100
IAEEIYGGIS DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS
110 120 130 140 150
SLHEACLGGH VACAKALLEN GAHVNGVTVH GATPLFNACC SGSAACVNVL
160 170 180 190 200
LEFGAKAQLE VHLASPIHEA VKRGHRECME ILLANNVNID HEVPQLGTPL
210 220 230 240 250
YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN VEVIHLLTDY
260 270 280 290 300
GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG
310 320
RACHQAIHKL HLPEPLERFL LYQ
Length:323
Mass (Da):35,367
Last modified:March 1, 2002 - v1
Checksum:iF95A40184C5BBF4E
GO
Isoform 2 (identifier: Q8WXH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-104: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):33,534
Checksum:i2C83F1E160D3AAD2
GO
Isoform 3 (identifier: Q8WXH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MEDGPVFYGF...IAEEIYGGIS → MLQLTGENEK...GDYICHTFQG

Note: Gene prediction based on EST data.
Show »
Length:302
Mass (Da):32,952
Checksum:i0D33F8E4E0A400FB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069428165S → L1 PublicationCorresponds to variant dbSNP:rs144572145Ensembl.1
Natural variantiVAR_048286249D → N. Corresponds to variant dbSNP:rs34025595Ensembl.1
Natural variantiVAR_048287263S → G. Corresponds to variant dbSNP:rs35859007Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471271 – 60MEDGP…YGGIS → MLQLTGENEKNCEVSERIRR SGPWKEISFGDYICHTFQG in isoform 3. CuratedAdd BLAST60
Alternative sequenceiVSP_04308788 – 104Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425642 mRNA Translation: AAL60519.1
BX537857 mRNA Translation: CAD97864.1
AC095351 Genomic DNA No translation available.
BC069340 mRNA Translation: AAH69340.1
BC103874 mRNA Translation: AAI03875.1
BC103875 mRNA Translation: AAI03876.1
CCDSiCCDS14164.1 [Q8WXH4-1]
CCDS35209.1 [Q8WXH4-3]
CCDS56596.1 [Q8WXH4-2]
RefSeqiNP_001012428.1, NM_001012428.2 [Q8WXH4-3]
NP_001188512.1, NM_001201583.1 [Q8WXH4-2]
NP_543149.1, NM_080873.2 [Q8WXH4-1]
UniGeneiHs.352183

Genome annotation databases

EnsembliENST00000344384; ENSP00000343408; ENSG00000165192 [Q8WXH4-3]
ENST00000380470; ENSP00000369837; ENSG00000165192 [Q8WXH4-2]
ENST00000480796; ENSP00000417914; ENSG00000165192 [Q8WXH4-1]
GeneIDi140456
KEGGihsa:140456
UCSCiuc004cwo.3 human [Q8WXH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiASB11_HUMAN
AccessioniPrimary (citable) accession number: Q8WXH4
Secondary accession number(s): E9PEN1, Q3SYC4, Q7Z667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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