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Protein

Adhesion G-protein coupled receptor V1

Gene

ADGRV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism.By similarity
Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1.By similarity

Miscellaneous

By far is the largest known cell surface protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Hydrolase, Receptor, Transducer
Biological processSensory transduction, Vision
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.19.3.6 the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor V1Curated (EC:3.4.-.-By similarity)
Short name:
ADGRV1Curated
Alternative name(s):
G-protein coupled receptor 98
Monogenic audiogenic seizure susceptibility protein 1 homolog
Usher syndrome type-2C protein
Very large G-protein coupled receptor 1
Cleaved into the following 2 chains:
ADGRV1 subunit alphaBy similarity
ADGRV1 subunit betaBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRV1Imported
Synonyms:GPR98, KIAA0686, KIAA1943, MASS1, VLGR11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164199.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17416 ADGRV1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602851 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXG9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 5908ExtracellularSequence analysisAdd BLAST5879
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5909 – 5929HelicalSequence analysisAdd BLAST21
Topological domaini5930 – 5939CytoplasmicSequence analysis10
Transmembranei5940 – 5960HelicalSequence analysisAdd BLAST21
Topological domaini5961 – 5979ExtracellularSequence analysisAdd BLAST19
Transmembranei5980 – 6000HelicalSequence analysisAdd BLAST21
Topological domaini6001 – 6010CytoplasmicSequence analysis10
Transmembranei6011 – 6031HelicalSequence analysisAdd BLAST21
Topological domaini6032 – 6059ExtracellularSequence analysisAdd BLAST28
Transmembranei6060 – 6080HelicalSequence analysisAdd BLAST21
Topological domaini6081 – 6104CytoplasmicSequence analysisAdd BLAST24
Transmembranei6105 – 6125HelicalSequence analysisAdd BLAST21
Topological domaini6126 – 6133ExtracellularSequence analysis8
Transmembranei6134 – 6154HelicalSequence analysisAdd BLAST21
Topological domaini6155 – 6306CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Usher syndrome 2C (USH2C)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionUSH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
See also OMIM:605472
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0680324789R → W in USH2C. 1 PublicationCorresponds to variant dbSNP:rs1131691924Ensembl.1
Natural variantiVAR_0680335978H → R in USH2C. 1 PublicationCorresponds to variant dbSNP:rs756460900EnsemblClinVar.1
Febrile seizures, familial, 4 (FEB4)
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionSeizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
See also OMIM:604352

Keywords - Diseasei

Deafness, Retinitis pigmentosa, Usher syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
84059

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ADGRV1

MalaCards human disease database

More...
MalaCardsi
ADGRV1
MIMi604352 phenotype
605472 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164199

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
36387 Generalized epilepsy with febrile seizures-plus
231178 Usher syndrome type 2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR98

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023273530 – 6306Adhesion G-protein coupled receptor V1Add BLAST6277
ChainiPRO_000044573130 – 5890ADGRV1 subunit alphaBy similarityAdd BLAST5861
ChainiPRO_00004457325891 – 6306ADGRV1 subunit betaBy similarityAdd BLAST416

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei5890 – 5891CleavageBy similarity2

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXG9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXG9

PeptideAtlas

More...
PeptideAtlasi
Q8WXG9

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXG9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75040
75041 [Q8WXG9-2]
75042 [Q8WXG9-3]
75043 [Q8WXG9-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1289

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXG9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in adult tissues.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164199 Expressed in 142 organ(s), highest expression level in adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_GPR98

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WXG9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXG9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN. Interacts with USH2A and WHRN (PubMed:16434480). Interacts (via the cytoplasmic region) with PDZD7 (PubMed:20440071). Interacts (via the cytoplasmic region) with MYO7A (via MyTH4-FERM domains) (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123854, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WXG9

Protein interaction database and analysis system

More...
IntActi
Q8WXG9, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8WXG9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WXG9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 117Calx-beta 1Sequence analysisAdd BLAST88
Domaini133 – 237Calx-beta 2Sequence analysisAdd BLAST105
Domaini262 – 362Calx-beta 31 PublicationAdd BLAST101
Domaini388 – 488Calx-beta 41 PublicationAdd BLAST101
Domaini645 – 745Calx-beta 51 PublicationAdd BLAST101
Domaini763 – 861Calx-beta 6Sequence analysisAdd BLAST99
Domaini876 – 979Calx-beta 7Sequence analysisAdd BLAST104
Domaini993 – 1093Calx-beta 8Sequence analysisAdd BLAST101
Domaini1108 – 1208Calx-beta 91 PublicationAdd BLAST101
Domaini1444 – 1544Calx-beta 101 PublicationAdd BLAST101
Domaini1564 – 1665Calx-beta 11Sequence analysisAdd BLAST102
Domaini1710 – 1809Calx-beta 12Sequence analysisAdd BLAST100
Domaini1850 – 1952Calx-beta 13Sequence analysisAdd BLAST103
Domaini1966 – 2079Calx-beta 14Sequence analysisAdd BLAST114
Domaini2107 – 2206Calx-beta 15Sequence analysisAdd BLAST100
Domaini2222 – 2324Calx-beta 16Sequence analysisAdd BLAST103
Domaini2441 – 2541Calx-beta 171 PublicationAdd BLAST101
Domaini2584 – 2676Calx-beta 18Sequence analysisAdd BLAST93
Domaini2689 – 2789Calx-beta 191 PublicationAdd BLAST101
Domaini2814 – 2925Calx-beta 20Sequence analysisAdd BLAST112
Domaini2947 – 3048Calx-beta 21Sequence analysisAdd BLAST102
Domaini3063 – 3172Calx-beta 22Sequence analysisAdd BLAST110
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3255 – 3296EAR 1PROSITE-ProRule annotationAdd BLAST42
Repeati3297 – 3345EAR 2PROSITE-ProRule annotationAdd BLAST49
Repeati3348 – 3393EAR 3PROSITE-ProRule annotationAdd BLAST46
Repeati3395 – 3439EAR 4PROSITE-ProRule annotationAdd BLAST45
Repeati3441 – 3488EAR 5PROSITE-ProRule annotationAdd BLAST48
Repeati3492 – 3534EAR 6PROSITE-ProRule annotationAdd BLAST43
Domaini3525 – 3625Calx-beta 231 PublicationAdd BLAST101
Domaini3639 – 3739Calx-beta 241 PublicationAdd BLAST101
Domaini3775 – 3875Calx-beta 251 PublicationAdd BLAST101
Domaini3899 – 4006Calx-beta 26Sequence analysisAdd BLAST108
Domaini4020 – 4123Calx-beta 27Sequence analysisAdd BLAST104
Domaini4139 – 4239Calx-beta 281 PublicationAdd BLAST101
Domaini4255 – 4354Calx-beta 29Sequence analysisAdd BLAST100
Domaini4387 – 4489Calx-beta 30Sequence analysisAdd BLAST103
Domaini4512 – 4612Calx-beta 311 PublicationAdd BLAST101
Domaini4634 – 4734Calx-beta 321 PublicationAdd BLAST101
Domaini4992 – 5095Calx-beta 33Sequence analysisAdd BLAST104
Domaini5288 – 5332Calx-beta 34Sequence analysisAdd BLAST45
Domaini5368 – 5468Calx-beta 351 PublicationAdd BLAST101
Domaini5853 – 5902GPSPROSITE-ProRule annotationAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 7 transmembrane domain is required in hair cells for the hair bundle ankle formation.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUBQ Eukaryota
ENOG410XT0U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088618

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081572

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXG9

KEGG Orthology (KO)

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KOi
K18263

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEHFVCT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G031A

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXG9

TreeFam database of animal gene trees

More...
TreeFami
TF331149

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 34 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013320 ConA-like_dom_sf
IPR009039 EAR
IPR005492 EPTP
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR026919 GPR98
IPR000203 GPS

The PANTHER Classification System

More...
PANTHERi
PTHR11878:SF20 PTHR11878:SF20, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF03160 Calx-beta, 35 hits
PF03736 EPTP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 38 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50912 EAR, 6 hits
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXG9-1) [UniParc]FASTAAdd to basket
Also known as: VLGR1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSVFLGPGMP SASLLVNLLS ALLILFVFGE TEIRFTGQTE FVVNETSTTV
60 70 80 90 100
IRLIIERIGE PANVTAIVSL YGEDAGDFFD TYAAAFIPAG ETNRTVYIAV
110 120 130 140 150
CDDDLPEPDE TFIFHLTLQK PSANVKLGWP RTVTVTILSN DNAFGIISFN
160 170 180 190 200
MLPSIAVSEP KGRNESMPLT LIREKGTYGM VMVTFEVEGG PNPPDEDLSP
210 220 230 240 250
VKGNITFPPG RATVIYNLTV LDDEVPENDE IFLIQLKSVE GGAEINTSRN
260 270 280 290 300
SIEIIIKKND SPVRFLQSIY LVPEEDHILI IPVVRGKDNN GNLIGSDEYE
310 320 330 340 350
VSISYAVTTG NSTAHAQQNL DFIDLQPNTT VVFPPFIHES HLKFQIVDDT
360 370 380 390 400
IPEIAESFHI MLLKDTLQGD AVLISPSVVQ VTIKPNDKPY GVLSFNSVLF
410 420 430 440 450
ERTVIIDEDR ISRYEEITVV RNGGTHGNVS ANWVLTRNST DPSPVTADIR
460 470 480 490 500
PSSGVLHFAQ GQMLATIPLT VVDDDLPEEA EAYLLQILPH TIRGGAEVSE
510 520 530 540 550
PAELLFYIQD SDDVYGLITF FPMENQKIES SPGERYLSLS FTRLGGTKGD
560 570 580 590 600
VRLLYSVLYI PAGAVDPLQA KEGILNISRR NDLIFPEQKT QVTTKLPIRN
610 620 630 640 650
DAFLQNGAHF LVQLETVELL NIIPLIPPIS PRFGEICNIS LLVTPAIANG
660 670 680 690 700
EIGFLSNLPI ILHEPEDFAA EVVYIPLHRD GTDGQATVYW SLKPSGFNSK
710 720 730 740 750
AVTPDDIGPF NGSVLFLSGQ SDTTINITIK GDDIPEMNET VTLSLDRVNV
760 770 780 790 800
ENQVLKSGYT SRDLIILEND DPGGVFEFSP ASRGPYVIKE GESVELHIIR
810 820 830 840 850
SRGSLVKQFL HYRVEPRDSN EFYGNTGVLE FKPGEREIVI TLLARLDGIP
860 870 880 890 900
ELDEHYWVVL SSHGERESKL GSATIVNITI LKNDDPHGII EFVSDGLIVM
910 920 930 940 950
INESKGDAIY SAVYDVVRNR GNFGDVSVSW VVSPDFTQDV FPVQGTVVFG
960 970 980 990 1000
DQEFSKNITI YSLPDEIPEE MEEFTVILLN GTGGAKVGNR TTATLRIRRN
1010 1020 1030 1040 1050
DDPIYFAEPR VVRVQEGETA NFTVLRNGSV DVTCMVQYAT KDGKATARER
1060 1070 1080 1090 1100
DFIPVEKGET LIFEVGSRQQ SISIFVNEDG IPETDEPFYI ILLNSTGDTV
1110 1120 1130 1140 1150
VYQYGVATVI IEANDDPNGI FSLEPIDKAV EEGKTNAFWI LRHRGYFGSV
1160 1170 1180 1190 1200
SVSWQLFQND SALQPGQEFY ETSGTVNFMD GEEAKPIILH AFPDKIPEFN
1210 1220 1230 1240 1250
EFYFLKLVNI SGGSPGPGGQ LAETNLQVTV MVPFNDDPFG VFILDPECLE
1260 1270 1280 1290 1300
REVAEDVLSE DDMSYITNFT ILRQQGVFGD VQLGWEILSS EFPAGLPPMI
1310 1320 1330 1340 1350
DFLLVGIFPT TVHLQQHMRR HHSGTDALYF TGLEGAFGTV NPKYHPSRNN
1360 1370 1380 1390 1400
TIANFTFSAW VMPNANTNGF IIAKDDGNGS IYYGVKIQTN ESHVTLSLHY
1410 1420 1430 1440 1450
KTLGSNATYI AKTTVMKYLE ESVWLHLLII LEDGIIEFYL DGNAMPRGIK
1460 1470 1480 1490 1500
SLKGEAITDG PGILRIGAGI NGNDRFTGLM QDVRSYERKL TLEEIYELHA
1510 1520 1530 1540 1550
MPAKSDLHPI SGYLEFRQGE TNKSFIISAR DDNDEEGEEL FILKLVSVYG
1560 1570 1580 1590 1600
GARISEENTT ARLTIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR
1610 1620 1630 1640 1650
GALDYVHVFY TISQIETDGI NYLVDDFANA SGTITFLPWQ RSEVLNIYVL
1660 1670 1680 1690 1700
DDDIPELNEY FRVTLVSAIP GDGKLGSTPT SGASIDPEKE TTDITIKASD
1710 1720 1730 1740 1750
HPYGLLQFST GLPPQPKDAM TLPASSVPHI TVEEEDGEIR LLVIRAQGLL
1760 1770 1780 1790 1800
GRVTAEFRTV SLTAFSPEDY QNVAGTLEFQ PGERYKYIFI NITDNSIPEL
1810 1820 1830 1840 1850
EKSFKVELLN LEGGVAELFR VDGSGSGDGD MEFFLPTIHK RASLGVASQI
1860 1870 1880 1890 1900
LVTIAASDHA HGVFEFSPES LFVSGTEPED GYSTVTLNVI RHHGTLSPVT
1910 1920 1930 1940 1950
LHWNIDSDPD GDLAFTSGNI TFEIGQTSAN ITVEILPDED PELDKAFSVS
1960 1970 1980 1990 2000
VLSVSSGSLG AHINATLTVL ASDDPYGIFI FSEKNRPVKV EEATQNITLS
2010 2020 2030 2040 2050
IIRLKGLMGK VLVSYATLDD MEKPPYFPPN LARATQGRDY IPASGFALFG
2060 2070 2080 2090 2100
ANQSEATIAI SILDDDEPER SESVFIELLN STLVAKVQSR SIPNSPRLGP
2110 2120 2130 2140 2150
KVETIAQLII IANDDAFGTL QLSAPIVRVA ENHVGPIINV TRTGGAFADV
2160 2170 2180 2190 2200
SVKFKAVPIT AIAGEDYSIA SSDVVLLEGE TSKAVPIYVI NDIYPELEES
2210 2220 2230 2240 2250
FLVQLMNETT GGARLGALTE AVIIIEASDD PYGLFGFQIT KLIVEEPEFN
2260 2270 2280 2290 2300
SVKVNLPIIR NSGTLGNVTV QWVATINGQL ATGDLRVVSG NVTFAPGETI
2310 2320 2330 2340 2350
QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRIANI IIPANDDPYG
2360 2370 2380 2390 2400
TVAFAQMVYR VQEPLERSSC ANITVRRSGG HFGRLLLFYS TSDIDVVALA
2410 2420 2430 2440 2450
MEEGQDLLSY YESPIQGVPD PLWRTWMNVS AVGEPLYTCA TLCLKEQACS
2460 2470 2480 2490 2500
AFSFFSASEG PQCFWMTSWI SPAVNNSDFW TYRKNMTRVA SLFSGQAVAG
2510 2520 2530 2540 2550
SDYEPVTRQW AIMQEGDEFA NLTVSILPDD FPEMDESFLI SLLEVHLMNI
2560 2570 2580 2590 2600
SASLKNQPTI GQPNISTVVI ALNGDAFGVF VIYNISPNTS EDGLFVEVQE
2610 2620 2630 2640 2650
QPQTLVELMI HRTGGSLGQV AVEWRVVGGT ATEGLDFIGA GEILTFAEGE
2660 2670 2680 2690 2700
TKKTVILTIL DDSEPEDDES IIVSLVYTEG GSRILPSSDT VRVNILANDN
2710 2720 2730 2740 2750
VAGIVSFQTA SRSVIGHEGE ILQFHVIRTF PGRGNVTVNW KIIGQNLELN
2760 2770 2780 2790 2800
FANFSGQLFF PEGSLNTTLF VHLLDDNIPE EKEVYQVILY DVRTQGVPPA
2810 2820 2830 2840 2850
GIALLDAQGY AAVLTVEASD EPHGVLNFAL SSRFVLLQEA NITIQLFINR
2860 2870 2880 2890 2900
EFGSLGAINV TYTTVPGMLS LKNQTVGNLA EPEVDFVPII GFLILEEGET
2910 2920 2930 2940 2950
AAAINITILE DDVPELEEYF LVNLTYVGLT MAASTSFPPR LDSEGLTAQV
2960 2970 2980 2990 3000
IIDANDGARG VIEWQQSRFE VNETHGSLTL VAQRSREPLG HVSLFVYAQN
3010 3020 3030 3040 3050
LEAQVGLDYI FTPMILHFAD GERYKNVNIM ILDDDIPEGD EKFQLILTNP
3060 3070 3080 3090 3100
SPGLELGKNT IALIIVLAND DGPGVLSFNN SEHFFLREPT ALYVQESVAV
3110 3120 3130 3140 3150
LYIVREPAQG LFGTVTVQFI VTEVNSSNES KDLTPSKGYI VLEEGVRFKA
3160 3170 3180 3190 3200
LQISAILDTE PEMDEYFVCT LFNPTGGARL GVHVQTLITV LQNQAPLGLF
3210 3220 3230 3240 3250
SISAVENRAT SIDIEEANRT VYLNVSRTNG IDLAVSVQWE TVSETAFGMR
3260 3270 3280 3290 3300
GMDVVFSVFQ SFLDESASGW CFFTLENLIY GIMLRKSSVT VYRWQGIFIP
3310 3320 3330 3340 3350
VEDLNIENPK TCEAFNIGFS PYFVITHEER NEEKPSLNSV FTFTSGFKLF
3360 3370 3380 3390 3400
LVQTIIILES SQVRYFTSDS QDYLIIASQR DDSELTQVFR WNGGSFVLHQ
3410 3420 3430 3440 3450
KLPVRGVLTV ALFNKGGSVF LAISQANARL NSLLFRWSGS GFINFQEVPV
3460 3470 3480 3490 3500
SGTTEVEALS SANDIYLIFA ENVFLGDQNS IDIFIWEMGQ SSFRYFQSVD
3510 3520 3530 3540 3550
FAAVNRIHSF TPASGIAHIL LIGQDMSALY CWNSERNQFS FVLEVPSAYD
3560 3570 3580 3590 3600
VASVTVKSLN SSKNLIALVG AHSHIYELAY ISSHSDFIPS SGELIFEPGE
3610 3620 3630 3640 3650
REATIAVNIL DDTVPEKEES FKVQLKNPKG GAEIGINDSV TITILSNDDA
3660 3670 3680 3690 3700
YGIVAFAQNS LYKQVEEMEQ DSLVTLNVER LKGTYGRITI AWEADGSISD
3710 3720 3730 3740 3750
IFPTSGVILF TEGQVLSTIT LTILADNIPE LSEVVIVTLT RITTEGVEDS
3760 3770 3780 3790 3800
YKGATIDQDR SKSVITTLPN DSPFGLVGWR AASVFIRVAE PKENTTTLQL
3810 3820 3830 3840 3850
QIARDKGLLG DIAIHLRAQP NFLLHVDNQA TENEDYVLQE TIIIMKENIK
3860 3870 3880 3890 3900
EAHAEVSILP DDLPELEEGF IVTITEVNLV NSDFSTGQPS VRRPGMEIAE
3910 3920 3930 3940 3950
IMIEENDDPR GIFMFHVTRG AGEVITAYEV PPPLNVLQVP VVRLAGSFGA
3960 3970 3980 3990 4000
VNVYWKASPD SAGLEDFKPS HGILEFADKQ VTAMIEITII DDAEFELTET
4010 4020 4030 4040 4050
FNISLISVAG GGRLGDDVVV TVVIPQNDSP FGVFGFEEKT VMIDESLSSD
4060 4070 4080 4090 4100
DPDSYVTLTV VRSPGGKGTV RLEWTIDEKA KHNLSPLNGT LHFDETESQK
4110 4120 4130 4140 4150
TIVLHTLQDT VLEEDRRFTI QLISIDEVEI SPVKGSASII IRGDKRASGE
4160 4170 4180 4190 4200
VGIAPSSRHI LIGEPSAKYN GTAIISLVRG PGILGEVTVF WRIFPPSVGE
4210 4220 4230 4240 4250
FAETSGKLTM RDEQSAVIVV IQALNDDIPE EKSFYEFQLT AVSEGGVLSE
4260 4270 4280 4290 4300
SSSTANITVV ASDSPYGRFA FSHEQLRVSE AQRVNITIIR SSGDFGHVRL
4310 4320 4330 4340 4350
WYKTMSGTAE AGLDFVPAAG ELLFEAGEMR KSLHVEILDD DYPEGPEEFS
4360 4370 4380 4390 4400
LTITKVELQG RGYDFTIQEN GLQIDQPPEI GNISIVRIII MKNDNAEGII
4410 4420 4430 4440 4450
EFDPKYTAFE VEEDVGLIMI PVVRLHGTYG YVTADFISQS SSASPGGVDY
4460 4470 4480 4490 4500
ILHGSTVTFQ HGQNLSFINI SIIDDNESEF EEPIEILLTG ATGGAVLGRH
4510 4520 4530 4540 4550
LVSRIIIAKS DSPFGVIRFL NQSKISIANP NSTMILSLVL ERTGGLLGEI
4560 4570 4580 4590 4600
QVNWETVGPN SQEALLPQNR DIADPVSGLF YFGEGEGGVR TIILTIYPHE
4610 4620 4630 4640 4650
EIEVEETFII KLHLVKGEAK LDSRAKDVTL TIQEFGDPNG VVQFAPETLS
4660 4670 4680 4690 4700
KKTYSEPLAL EGPLLITFFV RRVKGTFGEI MVYWELSSEF DITEDFLSTS
4710 4720 4730 4740 4750
GFFTIADGES EASFDVHLLP DEVPEIEEDY VIQLVSVEGG AELDLEKSIT
4760 4770 4780 4790 4800
WFSVYANDDP HGVFALYSDR QSILIGQNLI RSIQINITRL AGTFGDVAVG
4810 4820 4830 4840 4850
LRISSDHKEQ PIVTENAERQ LVVKDGATYK VDVVPIKNQV FLSLGSNFTL
4860 4870 4880 4890 4900
QLVTVMLVGG RFYGMPTILQ EAKSAVLPVS EKAANSQVGF ESTAFQLMNI
4910 4920 4930 4940 4950
TAGTSHVMIS RRGTYGALSV AWTTGYAPGL EIPEFIVVGN MTPTLGSLSF
4960 4970 4980 4990 5000
SHGEQRKGVF LWTFPSPGWP EAFVLHLSGV QSSAPGGAQL RSGFIVAEIE
5010 5020 5030 5040 5050
PMGVFQFSTS SRNIIVSEDT QMIRLHVQRL FGFHSDLIKV SYQTTAGSAK
5060 5070 5080 5090 5100
PLEDFEPVQN GELFFQKFQT EVDFEITIIN DQLSEIEEFF YINLTSVEIR
5110 5120 5130 5140 5150
GLQKFDVNWS PRLNLDFSVA VITILDNDDL AGMDISFPET TVAVAVDTTL
5160 5170 5180 5190 5200
IPVETESTTY LSTSKTTTIL QPTNVVAIVT EATGVSAIPE KLVTLHGTPA
5210 5220 5230 5240 5250
VSEKPDVATV TANVSIHGTF SLGPSIVYIE EEMKNGTFNT AEVLIRRTGG
5260 5270 5280 5290 5300
FTGNVSITVK TFGERCAQME PNALPFRGIY GISNLTWAVE EEDFEEQTLT
5310 5320 5330 5340 5350
LIFLDGERER KVSVQILDDD EPEGQEFFYV FLTNPQGGAQ IVEEKDDTGF
5360 5370 5380 5390 5400
AAFAMVIITG SDLHNGIIGF SEESQSGLEL REGAVMRRLH LIVTRQPNRA
5410 5420 5430 5440 5450
FEDVKVFWRV TLNKTVVVLQ KDGVNLVEEL QSVSGTTTCT MGQTKCFISI
5460 5470 5480 5490 5500
ELKPEKVPQV EVYFFVELYE ATAGAAINNS ARFAQIKILE SDESQSLVYF
5510 5520 5530 5540 5550
SVGSRLAVAH KKATLISLQV ARDSGTGLMM SVNFSTQELR SAETIGRTII
5560 5570 5580 5590 5600
SPAISGKDFV ITEGTLVFEP GQRSTVLDVI LTPETGSLNS FPKRFQIVLF
5610 5620 5630 5640 5650
DPKGGARIDK VYGTANITLV SDADSQAIWG LADQLHQPVN DDILNRVLHT
5660 5670 5680 5690 5700
ISMKVATENT DEQLSAMMHL IEKITTEGKI QAFSVASRTL FYEILCSLIN
5710 5720 5730 5740 5750
PKRKDTRGFS HFAEVTENFA FSLLTNVTCG SPGEKSKTIL DSCPYLSILA
5760 5770 5780 5790 5800
LHWYPQQING HKFEGKEGDY IRIPERLLDV QDAEIMAGKS TCKLVQFTEY
5810 5820 5830 5840 5850
SSQQWFISGN NLPTLKNKVL SLSVKGQSSQ LLTNDNEVLY RIYAAEPRII
5860 5870 5880 5890 5900
PQTSLCLLWN QAAASWLSDS QFCKVVEETA DYVECACSHM SVYAVYARTD
5910 5920 5930 5940 5950
NLSSYNEAFF TSGFICISGL CLAVLSHIFC ARYSMFAAKL LTHMMAASLG
5960 5970 5980 5990 6000
TQILFLASAY ASPQLAEESC SAMAAVTHYL YLCQFSWMLI QSVNFWYVLV
6010 6020 6030 6040 6050
MNDEHTERRY LLFFLLSWGL PAFVVILLIV ILKGIYHQSM SQIYGLIHGD
6060 6070 6080 6090 6100
LCFIPNVYAA LFTAALVPLT CLVVVFVVFI HAYQVKPQWK AYDDVFRGRT
6110 6120 6130 6140 6150
NAAEIPLILY LFALISVTWL WGGLHMAYRH FWMLVLFVIF NSLQGLYVFM
6160 6170 6180 6190 6200
VYFILHNQMC CPMKASYTVE MNGHPGPSTA FFTPGSGMPP AGGEISKSTQ
6210 6220 6230 6240 6250
NLIGAMEEVP PDWERASFQQ GSQASPDLKP SPQNGATFPS SGGYGQGSLI
6260 6270 6280 6290 6300
ADEESQEFDD LIFALKTGAG LSVSDNESGQ GSQEGGTLTD SQIVELRRIP

IADTHL
Length:6,306
Mass (Da):693,069
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30168F374ACEEF24
GO
Isoform 2 (identifier: Q8WXG9-2) [UniParc]FASTAAdd to basket
Also known as: VLGR1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-4339: Missing.
     4340-4359: DDYPEGPEEFSLTITKVELQ → MQLCIFCCCCILFYFDLYDF

Note: May be due to intron retention.
Show »
Length:1,967
Mass (Da):217,183
Checksum:iFB25C8F0D003EB47
GO
Isoform 3 (identifier: Q8WXG9-3) [UniParc]FASTAAdd to basket
Also known as: VLGR1c

The sequence of this isoform differs from the canonical sequence as follows:
     2296-2306: PGETIQTLLLE → RVVSGYPSATN
     2307-6306: Missing.

Note: Dubious isoform produced through aberrant splice sites.1 Publication
Show »
Length:2,306
Mass (Da):252,843
Checksum:i0D3B4F197CF169D8
GO
Isoform 4 (identifier: Q8WXG9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1461-1466: PGILRI → EGHHHN
     1467-6306: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:1,466
Mass (Da):162,038
Checksum:iD213A1B3948A9453
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1X7SBU6A0A1X7SBU6_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
2,624Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQK7A0A1W2PQK7_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQP9A0A1W2PQP9_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQU5A0A1W2PQU5_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIF0D6RIF0_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PR84A0A1W2PR84_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRC7A0A1W2PRC7_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
2,038Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNS5A0A1W2PNS5_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPA4A0A1W2PPA4_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
938Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRR5A0A1W2PRR5_HUMAN
Adhesion G protein-coupled receptor...
ADGRV1
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL30811 differs from that shown. Reason: Frameshift at positions 3524 and 3532.Curated
The sequence CAB66476 differs from that shown. Reason: Erroneous translation. Wrong genetic code use for translating the sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107E → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti219T → A in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti257K → E in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti435 – 437LTR → VTP in AAL30811 (PubMed:11606593).Curated3
Sequence conflicti471 – 472VV → GG in AAL30811 (PubMed:11606593).Curated2
Sequence conflicti534E → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti747R → W in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1096T → P in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1099T → P in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1232V → A in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1320R → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti1340 – 1342VNP → GNS in AAL30811 (PubMed:11606593).Curated3
Sequence conflicti1347S → F in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti3230G → D in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti3528A → T in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti3552A → V in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti4244E → G in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti5427V → M in AAD55586 (PubMed:10976914).Curated1
Sequence conflicti5427V → M in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti5427V → M in BAA31661 (PubMed:9734811).Curated1
Sequence conflicti5876V → I in AAD55586 (PubMed:10976914).Curated1
Sequence conflicti5876V → I in AAL30811 (PubMed:11606593).Curated1
Sequence conflicti5876V → I in BAA31661 (PubMed:9734811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025995127L → R1 PublicationCorresponds to variant dbSNP:rs41311333EnsemblClinVar.1
Natural variantiVAR_025996249R → K1 PublicationCorresponds to variant dbSNP:rs41303344EnsemblClinVar.1
Natural variantiVAR_046346551V → A. Corresponds to variant dbSNP:rs6889939EnsemblClinVar.1
Natural variantiVAR_0259971093L → F2 PublicationsCorresponds to variant dbSNP:rs2366777EnsemblClinVar.1
Natural variantiVAR_0463471187I → V. Corresponds to variant dbSNP:rs16868935EnsemblClinVar.1
Natural variantiVAR_0463481916T → I. Corresponds to variant dbSNP:rs35791889EnsemblClinVar.1
Natural variantiVAR_0259981927T → M1 PublicationCorresponds to variant dbSNP:rs17544552EnsemblClinVar.1
Natural variantiVAR_0259991951V → I1 PublicationCorresponds to variant dbSNP:rs4916684EnsemblClinVar.1
Natural variantiVAR_0260001985N → D1 PublicationCorresponds to variant dbSNP:rs41303352EnsemblClinVar.1
Natural variantiVAR_0260011987P → L1 PublicationCorresponds to variant dbSNP:rs4916685EnsemblClinVar.1
Natural variantiVAR_0260022004L → F1 PublicationCorresponds to variant dbSNP:rs16868972EnsemblClinVar.1
Natural variantiVAR_0463492097R → C. Corresponds to variant dbSNP:rs16868974EnsemblClinVar.1
Natural variantiVAR_0260032232Y → C1 PublicationCorresponds to variant dbSNP:rs10037067EnsemblClinVar.1
Natural variantiVAR_0260042345N → S1 PublicationCorresponds to variant dbSNP:rs2366926EnsemblClinVar.1
Natural variantiVAR_0260052379G → A1 Publication1
Natural variantiVAR_0260062584N → S2 PublicationsCorresponds to variant dbSNP:rs1878878EnsemblClinVar.1
Natural variantiVAR_0260072764S → L1 PublicationCorresponds to variant dbSNP:rs16869016EnsemblClinVar.1
Natural variantiVAR_0260082803A → T1 PublicationCorresponds to variant dbSNP:rs111033530EnsemblClinVar.1
Natural variantiVAR_0463503094V → I. Corresponds to variant dbSNP:rs13157270EnsemblClinVar.1
Natural variantiVAR_0260093217A → V1 PublicationCorresponds to variant dbSNP:rs114137750EnsemblClinVar.1
Natural variantiVAR_0260103248G → D1 PublicationCorresponds to variant dbSNP:rs16869032EnsemblClinVar.1
Natural variantiVAR_0463513347F → L. Corresponds to variant dbSNP:rs10067636EnsemblClinVar.1
Natural variantiVAR_0260113471E → K2 PublicationsCorresponds to variant dbSNP:rs2366928EnsemblClinVar.1
Natural variantiVAR_0463523867E → A. Corresponds to variant dbSNP:rs16869088Ensembl.1
Natural variantiVAR_0559333868E → A. Corresponds to variant dbSNP:rs16869088Ensembl.1
Natural variantiVAR_0680324789R → W in USH2C. 1 PublicationCorresponds to variant dbSNP:rs1131691924Ensembl.1
Natural variantiVAR_0260125344E → G4 PublicationsCorresponds to variant dbSNP:rs2438374EnsemblClinVar.1
Natural variantiVAR_0260135437T → A. Corresponds to variant dbSNP:rs770471921Ensembl.1
Natural variantiVAR_0680335978H → R in USH2C. 1 PublicationCorresponds to variant dbSNP:rs756460900EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179471 – 4339Missing in isoform 2. 2 PublicationsAdd BLAST4339
Alternative sequenceiVSP_0353131461 – 1466PGILRI → EGHHHN in isoform 4. 1 Publication6
Alternative sequenceiVSP_0353141467 – 6306Missing in isoform 4. 1 PublicationAdd BLAST4840
Alternative sequenceiVSP_0179482296 – 2306PGETIQTLLLE → RVVSGYPSATN in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0179492307 – 6306Missing in isoform 3. 1 PublicationAdd BLAST4000
Alternative sequenceiVSP_0179504340 – 4359DDYPE…KVELQ → MQLCIFCCCCILFYFDLYDF in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF055084 mRNA Translation: AAD55586.1
AF435925 mRNA Translation: AAL30811.1 Frameshift.
AC027323 Genomic DNA No translation available.
AC034215 Genomic DNA No translation available.
AC074132 Genomic DNA No translation available.
AC093281 Genomic DNA No translation available.
AC093529 Genomic DNA No translation available.
AC094109 Genomic DNA No translation available.
AC099512 Genomic DNA No translation available.
AB075823 mRNA Translation: BAB85529.1
AL136541 mRNA Translation: CAB66476.2 Sequence problems.
AB014586 mRNA Translation: BAA31661.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47246.1 [Q8WXG9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_115495.3, NM_032119.3 [Q8WXG9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.591777

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000405460; ENSP00000384582; ENSG00000164199 [Q8WXG9-1]
ENST00000645211; ENSP00000495777; ENSG00000164199 [Q8WXG9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84059

UCSC genome browser

More...
UCSCi
uc003kju.4 human [Q8WXG9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055084 mRNA Translation: AAD55586.1
AF435925 mRNA Translation: AAL30811.1 Frameshift.
AC027323 Genomic DNA No translation available.
AC034215 Genomic DNA No translation available.
AC074132 Genomic DNA No translation available.
AC093281 Genomic DNA No translation available.
AC093529 Genomic DNA No translation available.
AC094109 Genomic DNA No translation available.
AC099512 Genomic DNA No translation available.
AB075823 mRNA Translation: BAB85529.1
AL136541 mRNA Translation: CAB66476.2 Sequence problems.
AB014586 mRNA Translation: BAA31661.2
CCDSiCCDS47246.1 [Q8WXG9-1]
RefSeqiNP_115495.3, NM_032119.3 [Q8WXG9-1]
UniGeneiHs.591777

3D structure databases

ProteinModelPortaliQ8WXG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123854, 38 interactors
CORUMiQ8WXG9
IntActiQ8WXG9, 3 interactors
MINTiQ8WXG9
STRINGi9606.ENSP00000384582

Protein family/group databases

TCDBi2.A.19.3.6 the ca(2+):cation antiporter (caca) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyConnecti1289
iPTMnetiQ8WXG9
PhosphoSitePlusiQ8WXG9

Polymorphism and mutation databases

BioMutaiGPR98
DMDMi327478512

Proteomic databases

EPDiQ8WXG9
PaxDbiQ8WXG9
PeptideAtlasiQ8WXG9
PRIDEiQ8WXG9
ProteomicsDBi75040
75041 [Q8WXG9-2]
75042 [Q8WXG9-3]
75043 [Q8WXG9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405460; ENSP00000384582; ENSG00000164199 [Q8WXG9-1]
ENST00000645211; ENSP00000495777; ENSG00000164199 [Q8WXG9-1]
GeneIDi84059
KEGGihsa:84059
UCSCiuc003kju.4 human [Q8WXG9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84059
DisGeNETi84059
EuPathDBiHostDB:ENSG00000164199.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRV1
GeneReviewsiADGRV1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005029
HGNCiHGNC:17416 ADGRV1
HPAiHPA067503
MalaCardsiADGRV1
MIMi602851 gene
604352 phenotype
605472 phenotype
neXtProtiNX_Q8WXG9
OpenTargetsiENSG00000164199
Orphaneti36387 Generalized epilepsy with febrile seizures-plus
231178 Usher syndrome type 2

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUBQ Eukaryota
ENOG410XT0U LUCA
GeneTreeiENSGT00940000154880
HOGENOMiHOG000088618
HOVERGENiHBG081572
InParanoidiQ8WXG9
KOiK18263
OMAiDEHFVCT
OrthoDBiEOG091G031A
PhylomeDBiQ8WXG9
TreeFamiTF331149

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRV1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR98

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84059

Protein Ontology

More...
PROi
PR:Q8WXG9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164199 Expressed in 142 organ(s), highest expression level in adrenal gland
CleanExiHS_GPR98
ExpressionAtlasiQ8WXG9 baseline and differential
GenevisibleiQ8WXG9 HS

Family and domain databases

Gene3Di2.60.40.2030, 34 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013320 ConA-like_dom_sf
IPR009039 EAR
IPR005492 EPTP
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR026919 GPR98
IPR000203 GPS
PANTHERiPTHR11878:SF20 PTHR11878:SF20, 5 hits
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF03160 Calx-beta, 35 hits
PF03736 EPTP, 1 hit
SMARTiView protein in SMART
SM00237 Calx_beta, 19 hits
SUPFAMiSSF141072 SSF141072, 38 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 6 hits
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRV1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXG9
Secondary accession number(s): O75171
, Q8TF58, Q9H0X5, Q9UL61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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