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UniProtKB - Q8WXG8 (S100Z_HUMAN)
Protein
Protein S100-Z
Gene
S100Z
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
This protein binds two calcium ions.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 28 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 33 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 63 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 65 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 67 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 69 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 74 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- calcium ion binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WXG8 |
SignaLinki | Q8WXG8 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-ZCuratedAlternative name(s): S100 calcium-binding protein ZImported |
Gene namesi | Name:S100ZImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30367, S100Z |
MIMi | 610103, gene |
neXtProti | NX_Q8WXG8 |
VEuPathDBi | HostDB:ENSG00000171643 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 170591 |
OpenTargetsi | ENSG00000171643 |
PharmGKBi | PA134902118 |
Miscellaneous databases
Pharosi | Q8WXG8, Tbio |
Genetic variation databases
BioMutai | S100Z |
DMDMi | 296453019 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000144033 | 2 – 99 | Protein S100-ZAdd BLAST | 98 |
Proteomic databases
MassIVEi | Q8WXG8 |
PaxDbi | Q8WXG8 |
PRIDEi | Q8WXG8 |
Expressioni
Tissue specificityi
Highest level of expression in spleen and leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000171643, Expressed in monocyte and 88 other tissues |
Genevisiblei | Q8WXG8, HS |
Organism-specific databases
HPAi | ENSG00000171643, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
Q8WXG8
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 128065, 10 interactors |
IntActi | Q8WXG8, 11 interactors |
STRINGi | 9606.ENSP00000320430 |
Miscellaneous databases
RNActi | Q8WXG8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q8WXG8 |
SMRi | Q8WXG8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 48 | EF-hand 1CuratedAdd BLAST | 36 | |
Domaini | 50 – 85 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the S-100 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S17E, Eukaryota |
GeneTreei | ENSGT00940000161125 |
HOGENOMi | CLU_138624_2_1_1 |
InParanoidi | Q8WXG8 |
OMAi | MSQKDPM |
OrthoDBi | 1495576at2759 |
PhylomeDBi | Q8WXG8 |
TreeFami | TF332727 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub IPR028490, S100Z |
PANTHERi | PTHR11639:SF72, PTHR11639:SF72, 1 hit |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8WXG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPTQLEMAMD TMIRIFHRYS GKERKRFKLS KGELKLLLQR ELTEFLSCQK
60 70 80 90
ETQLVDKIVQ DLDANKDNEV DFNEFVVMVA ALTVACNDYF VEQLKKKGK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060484 | 23 | E → A2 PublicationsCorresponds to variant dbSNP:rs1320308Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF437876 mRNA Translation: AAL30893.1 AC114962 Genomic DNA No translation available. BC022320 mRNA Translation: AAH22320.1 |
CCDSi | CCDS43333.1 |
RefSeqi | NP_570128.2, NM_130772.3 XP_011541541.1, XM_011543239.2 XP_011541542.1, XM_011543240.2 XP_011541543.1, XM_011543241.2 XP_011541546.1, XM_011543244.2 XP_011541547.1, XM_011543245.2 XP_016864660.1, XM_017009171.1 XP_016864661.1, XM_017009172.1 XP_016864662.1, XM_017009173.1 |
Genome annotation databases
Ensembli | ENST00000317593.9; ENSP00000320430.4; ENSG00000171643.14 ENST00000513010.5; ENSP00000426768.1; ENSG00000171643.14 ENST00000613039.1; ENSP00000483535.1; ENSG00000171643.14 |
GeneIDi | 170591 |
KEGGi | hsa:170591 |
MANE-Selecti | ENST00000317593.9; ENSP00000320430.4; NM_130772.4; NP_570128.2 |
UCSCi | uc003kep.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF437876 mRNA Translation: AAL30893.1 AC114962 Genomic DNA No translation available. BC022320 mRNA Translation: AAH22320.1 |
CCDSi | CCDS43333.1 |
RefSeqi | NP_570128.2, NM_130772.3 XP_011541541.1, XM_011543239.2 XP_011541542.1, XM_011543240.2 XP_011541543.1, XM_011543241.2 XP_011541546.1, XM_011543244.2 XP_011541547.1, XM_011543245.2 XP_016864660.1, XM_017009171.1 XP_016864661.1, XM_017009172.1 XP_016864662.1, XM_017009173.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5HYD | X-ray | 2.30 | A/B/C/D | 2-97 | [»] | |
AlphaFoldDBi | Q8WXG8 | |||||
SMRi | Q8WXG8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128065, 10 interactors |
IntActi | Q8WXG8, 11 interactors |
STRINGi | 9606.ENSP00000320430 |
Genetic variation databases
BioMutai | S100Z |
DMDMi | 296453019 |
Proteomic databases
MassIVEi | Q8WXG8 |
PaxDbi | Q8WXG8 |
PRIDEi | Q8WXG8 |
Protocols and materials databases
Antibodypediai | 54566, 131 antibodies from 22 providers |
DNASUi | 170591 |
Genome annotation databases
Ensembli | ENST00000317593.9; ENSP00000320430.4; ENSG00000171643.14 ENST00000513010.5; ENSP00000426768.1; ENSG00000171643.14 ENST00000613039.1; ENSP00000483535.1; ENSG00000171643.14 |
GeneIDi | 170591 |
KEGGi | hsa:170591 |
MANE-Selecti | ENST00000317593.9; ENSP00000320430.4; NM_130772.4; NP_570128.2 |
UCSCi | uc003kep.1, human |
Organism-specific databases
CTDi | 170591 |
DisGeNETi | 170591 |
GeneCardsi | S100Z |
HGNCi | HGNC:30367, S100Z |
HPAi | ENSG00000171643, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 610103, gene |
neXtProti | NX_Q8WXG8 |
OpenTargetsi | ENSG00000171643 |
PharmGKBi | PA134902118 |
VEuPathDBi | HostDB:ENSG00000171643 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S17E, Eukaryota |
GeneTreei | ENSGT00940000161125 |
HOGENOMi | CLU_138624_2_1_1 |
InParanoidi | Q8WXG8 |
OMAi | MSQKDPM |
OrthoDBi | 1495576at2759 |
PhylomeDBi | Q8WXG8 |
TreeFami | TF332727 |
Enzyme and pathway databases
PathwayCommonsi | Q8WXG8 |
SignaLinki | Q8WXG8 |
Miscellaneous databases
BioGRID-ORCSi | 170591, 13 hits in 1070 CRISPR screens |
ChiTaRSi | S100Z, human |
GenomeRNAii | 170591 |
Pharosi | Q8WXG8, Tbio |
PROi | PR:Q8WXG8 |
RNActi | Q8WXG8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171643, Expressed in monocyte and 88 other tissues |
Genevisiblei | Q8WXG8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub IPR028490, S100Z |
PANTHERi | PTHR11639:SF72, PTHR11639:SF72, 1 hit |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S100Z_HUMAN | |
Accessioni | Q8WXG8Primary (citable) accession number: Q8WXG8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families