MADD

Functionⁱ

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.6 Publications

Miscellaneous

Overexpression of MADD activates the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase (ERK). Expression of the MADD death domain stimulates both the ERK and c-JUN N-terminal kinase MAP kinases and induces the phosphorylation of cytosolic phospholipase A2.1 Publication

GO - Molecular functionⁱ

death receptor binding
Source: ProtInc
Traceable author statementⁱ
- 9115275
protein kinase activator activity
Source: UniProtKB
Traceable author statementⁱ
- 9115275
Rab guanyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20937701

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9115275
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9115275
execution phase of apoptosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14735464
regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11577081
regulation of cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14735464
regulation of extrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11577081
regulation of extrinsic apoptotic signaling pathway via death domain receptors
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9115275
regulation of Rab protein signal transduction
Source: FlyBase
Inferred from direct assayⁱ
- 20937701
regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5357905 Regulation of TNFR1 signaling R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAP kinase-activating death domain protein Alternative name(s): Differentially expressed in normal and neoplastic cells Insulinoma glucagonoma clone 20 Rab3 GDP/GTP exchange factor
Gene namesⁱ	Name:MADDImported Synonyms:DENNImported, IG20Imported, KIAA0358Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110514.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6766 MADD
MIMⁱ	603584 gene+phenotype
neXtProtⁱ	NX_Q8WXG6

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8567
MIMⁱ	603584 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000110514
PharmGKBⁱ	PA30523

Polymorphism and mutation databases

BioMutaⁱ	MADD
DMDMⁱ	126215742

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278138	1 – 1647	MAP kinase-activating death domain proteinBy similarityAdd BLAST		1647

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	156	PhosphoserineCombined sources	1
Modified residueⁱ	689	PhosphoserineBy similarity	1
Modified residueⁱ	692	PhosphoserineCombined sources	1
Modified residueⁱ	813	PhosphoserineBy similarity	1
Modified residueⁱ	818	PhosphoserineCombined sources	1
Modified residueⁱ	820	PhosphoserineCombined sources	1
Modified residueⁱ	858	PhosphoserineCombined sources	1
Modified residueⁱ	862	PhosphoserineCombined sources	1
Modified residueⁱ	916	PhosphoserineCombined sources	1
Modified residueⁱ	921	PhosphoserineCombined sources	1
Modified residueⁱ	930	PhosphoserineBy similarity	1
Modified residueⁱ	1059	PhosphoserineCombined sources	1
Modified residueⁱ	1061	PhosphothreonineBy similarity	1
Modified residueⁱ	1066	PhosphothreonineBy similarity	1
Modified residueⁱ	1110	PhosphoserineBy similarity	1
Modified residueⁱ	1237	PhosphothreonineCombined sources	1
Modified residueⁱ	1239	PhosphoserineCombined sources	1
Modified residueⁱ	1270	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8WXG6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WXG6
PaxDbⁱ	Q8WXG6
PeptideAtlas More...PeptideAtlasⁱ	Q8WXG6
PRIDEⁱ	Q8WXG6
ProteomicsDBⁱ	75032 75033 [Q8WXG6-2] 75034 [Q8WXG6-3] 75035 [Q8WXG6-4] 75036 [Q8WXG6-5] 75037 [Q8WXG6-6] 75038 [Q8WXG6-7]

PTM databases

iPTMnetⁱ	Q8WXG6
PhosphoSitePlusⁱ	Q8WXG6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000110514 Expressed in 222 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	Q8WXG6 baseline and differential
Genevisibleⁱ	Q8WXG6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038568

HPAⁱ

HPA038568

Interactionⁱ

Subunit structureⁱ

Interacts with the death domain of TNFRSF1A through its own death domain. Interacts with PIDD1.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POT1	Q9NUX5	2	EBI-310528,EBI-752420
PTPRN	Q16849	4	EBI-310528,EBI-728153

GO - Molecular functionⁱ

death receptor binding
Source: ProtInc
Traceable author statementⁱ
- 9115275
Rab guanyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20937701

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114136, 30 interactors
ELMⁱ	Q8WXG6
IntActⁱ	Q8WXG6, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q8WXG6
STRINGⁱ	9606.ENSP00000310933

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WXG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	14 – 268	uDENNPROSITE-ProRule annotationAdd BLAST	255
Domainⁱ	289 – 429	cDENNPROSITE-ProRule annotationAdd BLAST	141
Domainⁱ	431 – 565	dDENNPROSITE-ProRule annotationAdd BLAST	135
Domainⁱ	1340 – 1415	DeathSequence analysisAdd BLAST	76

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1157 – 1250	Ser-richSequence analysisAdd BLAST		94

Sequence similaritiesⁱ

Belongs to the MADD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3570 Eukaryota ENOG410XP23 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118819
HOGENOMⁱ	HOG000231438
HOVERGENⁱ	HBG079455
InParanoidⁱ	Q8WXG6
OMAⁱ	KRLVDCC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00AV
PhylomeDBⁱ	Q8WXG6
TreeFamⁱ	TF318583

Family and domain databases

InterProⁱ	View protein in InterPro IPR001194 cDENN_dom IPR005112 dDENN_dom IPR037516 Tripartite_DENN IPR005113 uDENN_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02141 DENN, 1 hit PF03456 uDENN, 1 hit
SMARTⁱ	View protein in SMART SM00801 dDENN, 1 hit SM00799 DENN, 1 hit SM00800 uDENN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50211 DENN, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: Q8WXG6-1) [UniParc]FASTA Add to basket

Also known as: IG201 Publication, IG20-FL1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP PEEDEDEQGE SYTPRFSQHV 
       810        820        830        840        850
SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST EGFGGIMSFA 
       860        870        880        890        900
SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKVFGLNT LMEIVTEAGP 
       910        920        930        940        950
GSGEGNRRAL VDQKSSVIKH SPTVKREPPS PQGRSSNSSE NQQFLKEVVH 
       960        970        980        990       1000
SVLDGQGVGW LNMKKVRRLL ESEQLRVFVL SKLNRMVQSE DDARQDIIPD 
      1010       1020       1030       1040       1050
VEISRKVYKG MLDLLKCTVL SLEQSYAHAG LGGMASIFGL LEIAQTHYYS 
      1060       1070       1080       1090       1100
KEPDKRKRSP TESVNTPVGK DPGLAGRGDP KAMAQLRVPQ LGPRAPSATG 
      1110       1120       1130       1140       1150
KGPKELDTRS LKEENFIASI ELWNKHQEVK KQKALEKQRP EVIKPVFDLG 
      1160       1170       1180       1190       1200
ETEEKKSQIS ADSGVSLTSS SQRTDQDSVI GVSPAVMIRS SSQDSEVSTV 
      1210       1220       1230       1240       1250
VSNSSGETLG ADSDLSSNAG DGPGGEGSVH LASSRGTLSD SEIETNSATS 
      1260       1270       1280       1290       1300
TIFGKAHSLK PSIKEKLAGS PIRTSEDVSQ RVYLYEGLLG RDKGSMWDQL 
      1310       1320       1330       1340       1350
EDAAMETFSI SKERSTLWDQ MQFWEDAFLD AVMLEREGMG MDQGPQEMID 
      1360       1370       1380       1390       1400
RYLSLGEHDR KRLEDDEDRL LATLLHNLIS YMLLMKVNKN DIRKKVRRLM 
      1410       1420       1430       1440       1450
GKSHIGLVYS QQINEVLDQL ANLNGRDLSI WSSGSRHMKK QTFVVHAGTD 
      1460       1470       1480       1490       1500
TNGDIFFMEV CDDCVVLRSN IGTVYERWWY EKLINMTYCP KTKVLCLWRR 
      1510       1520       1530       1540       1550
NGSETQLNKF YTKKCRELYY CVKDSMERAA ARQQSIKPGP ELGGEFPVQD 
      1560       1570       1580       1590       1600
LKTGEGGLLQ VTLEGINLKF MHNQVFIELN HIKKCNTVRG VFVLEEFVPE 
      1610       1620       1630       1640 
IKEVVSHKYK TPMAHEICYS VLCLFSYVAA VHSSEEDLRT PPRPVSS

Length:1,647

Mass (Da):183,303

Last modified:February 20, 2007 - v2

Checksum:ⁱ2CA9A3519269757E

GO

Isoform 21 Publication (identifier: Q8WXG6-2) [UniParc]FASTA Add to basket

Also known as: IG201 Publication, IG20-PA1 Publication, IG20-PASV1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1121-1139: ELWNKHQEVKKQKALEKQR → G
1291-1311: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP PEEDEDEQGE SYTPRFSQHV 
       810        820        830        840        850
SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST EGFGGIMSFA 
       860        870        880        890        900
SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKVFGLNT LMEIVTEAGP 
       910        920        930        940        950
GSGEGNRRAL VDQKSSVIKH SPTVKREPPS PQGRSSNSSE NQQFLKEVVH 
       960        970        980        990       1000
SVLDGQGVGW LNMKKVRRLL ESEQLRVFVL SKLNRMVQSE DDARQDIIPD 
      1010       1020       1030       1040       1050
VEISRKVYKG MLDLLKCTVL SLEQSYAHAG LGGMASIFGL LEIAQTHYYS 
      1060       1070       1080       1090       1100
KEPDKRKRSP TESVNTPVGK DPGLAGRGDP KAMAQLRVPQ LGPRAPSATG 
      1110       1120       1130       1140       1150
KGPKELDTRS LKEENFIASI GPEVIKPVFD LGETEEKKSQ ISADSGVSLT 
      1160       1170       1180       1190       1200
SSSQRTDQDS VIGVSPAVMI RSSSQDSEVS TVVSNSSGET LGADSDLSSN 
      1210       1220       1230       1240       1250
AGDGPGGEGS VHLASSRGTL SDSEIETNSA TSTIFGKAHS LKPSIKEKLA 
      1260       1270       1280       1290       1300
GSPIRTSEDV SQRVYLYEGL LGKERSTLWD QMQFWEDAFL DAVMLEREGM 
      1310       1320       1330       1340       1350
GMDQGPQEMI DRYLSLGEHD RKRLEDDEDR LLATLLHNLI SYMLLMKVNK 
      1360       1370       1380       1390       1400
NDIRKKVRRL MGKSHIGLVY SQQINEVLDQ LANLNGRDLS IWSSGSRHMK 
      1410       1420       1430       1440       1450
KQTFVVHAGT DTNGDIFFME VCDDCVVLRS NIGTVYERWW YEKLINMTYC 
      1460       1470       1480       1490       1500
PKTKVLCLWR RNGSETQLNK FYTKKCRELY YCVKDSMERA AARQQSIKPG 
      1510       1520       1530       1540       1550
PELGGEFPVQ DLKTGEGGLL QVTLEGINLK FMHNQVFIEL NHIKKCNTVR 
      1560       1570       1580       1590       1600
GVFVLEEFVP EIKEVVSHKY KTPMAHEICY SVLCLFSYVA AVHSSEEDLR 

TPPRPVSS

Show »

Length:1,608

Mass (Da):178,558

Checksum:ⁱFE1C240F2B74E284

GO

Isoform 33 Publications (identifier: Q8WXG6-3) [UniParc]FASTA Add to basket

Also known as: DENN2 Publications, IG20-SV11 Publication, MADD1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     885-904: Missing.
     1121-1139: ELWNKHQEVKKQKALEKQR → G
     1201-1201: Missing.
     1291-1311: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP PEEDEDEQGE SYTPRFSQHV 
       810        820        830        840        850
SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST EGFGGIMSFA 
       860        870        880        890        900
SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKGNRRAL VDQKSSVIKH 
       910        920        930        940        950
SPTVKREPPS PQGRSSNSSE NQQFLKEVVH SVLDGQGVGW LNMKKVRRLL 
       960        970        980        990       1000
ESEQLRVFVL SKLNRMVQSE DDARQDIIPD VEISRKVYKG MLDLLKCTVL 
      1010       1020       1030       1040       1050
SLEQSYAHAG LGGMASIFGL LEIAQTHYYS KEPDKRKRSP TESVNTPVGK 
      1060       1070       1080       1090       1100
DPGLAGRGDP KAMAQLRVPQ LGPRAPSATG KGPKELDTRS LKEENFIASI 
      1110       1120       1130       1140       1150
GPEVIKPVFD LGETEEKKSQ ISADSGVSLT SSSQRTDQDS VIGVSPAVMI 
      1160       1170       1180       1190       1200
RSSSQDSEVS TVSNSSGETL GADSDLSSNA GDGPGGEGSV HLASSRGTLS 
      1210       1220       1230       1240       1250
DSEIETNSAT STIFGKAHSL KPSIKEKLAG SPIRTSEDVS QRVYLYEGLL 
      1260       1270       1280       1290       1300
GKERSTLWDQ MQFWEDAFLD AVMLEREGMG MDQGPQEMID RYLSLGEHDR 
      1310       1320       1330       1340       1350
KRLEDDEDRL LATLLHNLIS YMLLMKVNKN DIRKKVRRLM GKSHIGLVYS 
      1360       1370       1380       1390       1400
QQINEVLDQL ANLNGRDLSI WSSGSRHMKK QTFVVHAGTD TNGDIFFMEV 
      1410       1420       1430       1440       1450
CDDCVVLRSN IGTVYERWWY EKLINMTYCP KTKVLCLWRR NGSETQLNKF 
      1460       1470       1480       1490       1500
YTKKCRELYY CVKDSMERAA ARQQSIKPGP ELGGEFPVQD LKTGEGGLLQ 
      1510       1520       1530       1540       1550
VTLEGINLKF MHNQVFIELN HIKKCNTVRG VFVLEEFVPE IKEVVSHKYK 
      1560       1570       1580 
TPMAHEICYS VLCLFSYVAA VHSSEEDLRT PPRPVSS

Show »

Length:1,587

Mass (Da):176,455

Checksum:ⁱ400BBDE0D2BD704E

GO

Isoform 43 Publications (identifier: Q8WXG6-4) [UniParc]FASTA Add to basket

Also known as: IG20-SV21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     762-804: Missing.
     1121-1139: ELWNKHQEVKKQKALEKQR → G
     1291-1311: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GAQKLLRPNS LRLASDSDAE SDSRASSPNS TVSNTSTEGF 
       810        820        830        840        850
GGIMSFASSL YRNHSTSFSL SNLTLPTKGA REKATPFPSL KVFGLNTLME 
       860        870        880        890        900
IVTEAGPGSG EGNRRALVDQ KSSVIKHSPT VKREPPSPQG RSSNSSENQQ 
       910        920        930        940        950
FLKEVVHSVL DGQGVGWLNM KKVRRLLESE QLRVFVLSKL NRMVQSEDDA 
       960        970        980        990       1000
RQDIIPDVEI SRKVYKGMLD LLKCTVLSLE QSYAHAGLGG MASIFGLLEI 
      1010       1020       1030       1040       1050
AQTHYYSKEP DKRKRSPTES VNTPVGKDPG LAGRGDPKAM AQLRVPQLGP 
      1060       1070       1080       1090       1100
RAPSATGKGP KELDTRSLKE ENFIASIGPE VIKPVFDLGE TEEKKSQISA 
      1110       1120       1130       1140       1150
DSGVSLTSSS QRTDQDSVIG VSPAVMIRSS SQDSEVSTVV SNSSGETLGA 
      1160       1170       1180       1190       1200
DSDLSSNAGD GPGGEGSVHL ASSRGTLSDS EIETNSATST IFGKAHSLKP 
      1210       1220       1230       1240       1250
SIKEKLAGSP IRTSEDVSQR VYLYEGLLGK ERSTLWDQMQ FWEDAFLDAV 
      1260       1270       1280       1290       1300
MLEREGMGMD QGPQEMIDRY LSLGEHDRKR LEDDEDRLLA TLLHNLISYM 
      1310       1320       1330       1340       1350
LLMKVNKNDI RKKVRRLMGK SHIGLVYSQQ INEVLDQLAN LNGRDLSIWS 
      1360       1370       1380       1390       1400
SGSRHMKKQT FVVHAGTDTN GDIFFMEVCD DCVVLRSNIG TVYERWWYEK 
      1410       1420       1430       1440       1450
LINMTYCPKT KVLCLWRRNG SETQLNKFYT KKCRELYYCV KDSMERAAAR 
      1460       1470       1480       1490       1500
QQSIKPGPEL GGEFPVQDLK TGEGGLLQVT LEGINLKFMH NQVFIELNHI 
      1510       1520       1530       1540       1550
KKCNTVRGVF VLEEFVPEIK EVVSHKYKTP MAHEICYSVL CLFSYVAAVH 
      1560 
SSEEDLRTPP RPVSS

Show »

Length:1,565

Mass (Da):173,395

Checksum:ⁱBF80481B41A4E680

GO

Isoform 52 Publications (identifier: Q8WXG6-5) [UniParc]FASTA Add to basket

Also known as: DENN-SV1 Publication, IG20-SV31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     762-804: Missing.
     885-904: Missing.
     1121-1139: ELWNKHQEVKKQKALEKQR → G
     1291-1311: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GAQKLLRPNS LRLASDSDAE SDSRASSPNS TVSNTSTEGF 
       810        820        830        840        850
GGIMSFASSL YRNHSTSFSL SNLTLPTKGA REKATPFPSL KGNRRALVDQ 
       860        870        880        890        900
KSSVIKHSPT VKREPPSPQG RSSNSSENQQ FLKEVVHSVL DGQGVGWLNM 
       910        920        930        940        950
KKVRRLLESE QLRVFVLSKL NRMVQSEDDA RQDIIPDVEI SRKVYKGMLD 
       960        970        980        990       1000
LLKCTVLSLE QSYAHAGLGG MASIFGLLEI AQTHYYSKEP DKRKRSPTES 
      1010       1020       1030       1040       1050
VNTPVGKDPG LAGRGDPKAM AQLRVPQLGP RAPSATGKGP KELDTRSLKE 
      1060       1070       1080       1090       1100
ENFIASIGPE VIKPVFDLGE TEEKKSQISA DSGVSLTSSS QRTDQDSVIG 
      1110       1120       1130       1140       1150
VSPAVMIRSS SQDSEVSTVV SNSSGETLGA DSDLSSNAGD GPGGEGSVHL 
      1160       1170       1180       1190       1200
ASSRGTLSDS EIETNSATST IFGKAHSLKP SIKEKLAGSP IRTSEDVSQR 
      1210       1220       1230       1240       1250
VYLYEGLLGK ERSTLWDQMQ FWEDAFLDAV MLEREGMGMD QGPQEMIDRY 
      1260       1270       1280       1290       1300
LSLGEHDRKR LEDDEDRLLA TLLHNLISYM LLMKVNKNDI RKKVRRLMGK 
      1310       1320       1330       1340       1350
SHIGLVYSQQ INEVLDQLAN LNGRDLSIWS SGSRHMKKQT FVVHAGTDTN 
      1360       1370       1380       1390       1400
GDIFFMEVCD DCVVLRSNIG TVYERWWYEK LINMTYCPKT KVLCLWRRNG 
      1410       1420       1430       1440       1450
SETQLNKFYT KKCRELYYCV KDSMERAAAR QQSIKPGPEL GGEFPVQDLK 
      1460       1470       1480       1490       1500
TGEGGLLQVT LEGINLKFMH NQVFIELNHI KKCNTVRGVF VLEEFVPEIK 
      1510       1520       1530       1540 
EVVSHKYKTP MAHEICYSVL CLFSYVAAVH SSEEDLRTPP RPVSS

Show »

Length:1,545

Mass (Da):171,392

Checksum:ⁱ30610743419A2E69

GO

Isoform 61 Publication (identifier: Q8WXG6-6) [UniParc]FASTA Add to basket

Also known as: IG20-SV41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     762-804: Missing.
     885-904: Missing.
     1121-1139: ELWNKHQEVKKQKALEKQR → G
     1291-1311: Missing.
     1575-1582: VFIELNHI → FLKLKKW
     1583-1647: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GAQKLLRPNS LRLASDSDAE SDSRASSPNS TVSNTSTEGF 
       810        820        830        840        850
GGIMSFASSL YRNHSTSFSL SNLTLPTKGA REKATPFPSL KGNRRALVDQ 
       860        870        880        890        900
KSSVIKHSPT VKREPPSPQG RSSNSSENQQ FLKEVVHSVL DGQGVGWLNM 
       910        920        930        940        950
KKVRRLLESE QLRVFVLSKL NRMVQSEDDA RQDIIPDVEI SRKVYKGMLD 
       960        970        980        990       1000
LLKCTVLSLE QSYAHAGLGG MASIFGLLEI AQTHYYSKEP DKRKRSPTES 
      1010       1020       1030       1040       1050
VNTPVGKDPG LAGRGDPKAM AQLRVPQLGP RAPSATGKGP KELDTRSLKE 
      1060       1070       1080       1090       1100
ENFIASIGPE VIKPVFDLGE TEEKKSQISA DSGVSLTSSS QRTDQDSVIG 
      1110       1120       1130       1140       1150
VSPAVMIRSS SQDSEVSTVV SNSSGETLGA DSDLSSNAGD GPGGEGSVHL 
      1160       1170       1180       1190       1200
ASSRGTLSDS EIETNSATST IFGKAHSLKP SIKEKLAGSP IRTSEDVSQR 
      1210       1220       1230       1240       1250
VYLYEGLLGK ERSTLWDQMQ FWEDAFLDAV MLEREGMGMD QGPQEMIDRY 
      1260       1270       1280       1290       1300
LSLGEHDRKR LEDDEDRLLA TLLHNLISYM LLMKVNKNDI RKKVRRLMGK 
      1310       1320       1330       1340       1350
SHIGLVYSQQ INEVLDQLAN LNGRDLSIWS SGSRHMKKQT FVVHAGTDTN 
      1360       1370       1380       1390       1400
GDIFFMEVCD DCVVLRSNIG TVYERWWYEK LINMTYCPKT KVLCLWRRNG 
      1410       1420       1430       1440       1450
SETQLNKFYT KKCRELYYCV KDSMERAAAR QQSIKPGPEL GGEFPVQDLK 
      1460       1470 
TGEGGLLQVT LEGINLKFMH NQFLKLKKW

Show »

Length:1,479

Mass (Da):164,006

Checksum:ⁱ7D5CECD86F93B07D

GO

Isoform 71 Publication (identifier: Q8WXG6-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1575-1582: VFIELNHI → FLKLKKW
1583-1647: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP PEEDEDEQGE SYTPRFSQHV 
       810        820        830        840        850
SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST EGFGGIMSFA 
       860        870        880        890        900
SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKVFGLNT LMEIVTEAGP 
       910        920        930        940        950
GSGEGNRRAL VDQKSSVIKH SPTVKREPPS PQGRSSNSSE NQQFLKEVVH 
       960        970        980        990       1000
SVLDGQGVGW LNMKKVRRLL ESEQLRVFVL SKLNRMVQSE DDARQDIIPD 
      1010       1020       1030       1040       1050
VEISRKVYKG MLDLLKCTVL SLEQSYAHAG LGGMASIFGL LEIAQTHYYS 
      1060       1070       1080       1090       1100
KEPDKRKRSP TESVNTPVGK DPGLAGRGDP KAMAQLRVPQ LGPRAPSATG 
      1110       1120       1130       1140       1150
KGPKELDTRS LKEENFIASI ELWNKHQEVK KQKALEKQRP EVIKPVFDLG 
      1160       1170       1180       1190       1200
ETEEKKSQIS ADSGVSLTSS SQRTDQDSVI GVSPAVMIRS SSQDSEVSTV 
      1210       1220       1230       1240       1250
VSNSSGETLG ADSDLSSNAG DGPGGEGSVH LASSRGTLSD SEIETNSATS 
      1260       1270       1280       1290       1300
TIFGKAHSLK PSIKEKLAGS PIRTSEDVSQ RVYLYEGLLG RDKGSMWDQL 
      1310       1320       1330       1340       1350
EDAAMETFSI SKERSTLWDQ MQFWEDAFLD AVMLEREGMG MDQGPQEMID 
      1360       1370       1380       1390       1400
RYLSLGEHDR KRLEDDEDRL LATLLHNLIS YMLLMKVNKN DIRKKVRRLM 
      1410       1420       1430       1440       1450
GKSHIGLVYS QQINEVLDQL ANLNGRDLSI WSSGSRHMKK QTFVVHAGTD 
      1460       1470       1480       1490       1500
TNGDIFFMEV CDDCVVLRSN IGTVYERWWY EKLINMTYCP KTKVLCLWRR 
      1510       1520       1530       1540       1550
NGSETQLNKF YTKKCRELYY CVKDSMERAA ARQQSIKPGP ELGGEFPVQD 
      1560       1570       1580 
LKTGEGGLLQ VTLEGINLKF MHNQFLKLKK W

Show »

Length:1,581

Mass (Da):175,917

Checksum:ⁱ8E2F7CD03C349AC5

GO

Isoform 8 (identifier: Q8WXG6-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     762-804: Missing.
     885-904: Missing.
     1121-1139: ELWNKHQEVKKQKALEKQR → G
     1197-1200: Missing.
     1291-1311: Missing.

« Hide

        10         20         30         40         50
MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP 
        60         70         80         90        100
DVVFFCQPEG CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS 
       110        120        130        140        150
FQKRISKEKG EGGAGSRGKE GTHATCASEE GGTESSESGS SLQPLSADST 
       160        170        180        190        200
PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL SHYPFFSTFR ECLYTLKRLV 
       210        220        230        240        250
DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL LHDLREIEAW 
       260        270        280        290        300
IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
       310        320        330        340        350
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF 
       360        370        380        390        400
PVIPLLPTCM ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD 
       410        420        430        440        450
SNRVIAPTNA EVLPILPEPE SLELKKHLKQ ALASMSLNTQ PILNLEKFHE 
       460        470        480        490        500
GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN DVDSVDVATR VAMVRFFNSA 
       510        520        530        540        550
NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE KLARTQAVEY 
       560        570        580        590        600
FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
       610        620        630        640        650
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI 
       660        670        680        690        700
NGDTPNVDPL THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS 
       710        720        730        740        750
SSSTTASSSP STVIHGANSE PADSTEMDDK AAVGVSKPLP SVPPSIGKSN 
       760        770        780        790        800
VDRRQAEIGE GAQKLLRPNS LRLASDSDAE SDSRASSPNS TVSNTSTEGF 
       810        820        830        840        850
GGIMSFASSL YRNHSTSFSL SNLTLPTKGA REKATPFPSL KGNRRALVDQ 
       860        870        880        890        900
KSSVIKHSPT VKREPPSPQG RSSNSSENQQ FLKEVVHSVL DGQGVGWLNM 
       910        920        930        940        950
KKVRRLLESE QLRVFVLSKL NRMVQSEDDA RQDIIPDVEI SRKVYKGMLD 
       960        970        980        990       1000
LLKCTVLSLE QSYAHAGLGG MASIFGLLEI AQTHYYSKEP DKRKRSPTES 
      1010       1020       1030       1040       1050
VNTPVGKDPG LAGRGDPKAM AQLRVPQLGP RAPSATGKGP KELDTRSLKE 
      1060       1070       1080       1090       1100
ENFIASIGPE VIKPVFDLGE TEEKKSQISA DSGVSLTSSS QRTDQDSVIG 
      1110       1120       1130       1140       1150
VSPAVMIRSS SQDSEVSNSS GETLGADSDL SSNAGDGPGG EGSVHLASSR 
      1160       1170       1180       1190       1200
GTLSDSEIET NSATSTIFGK AHSLKPSIKE KLAGSPIRTS EDVSQRVYLY 
      1210       1220       1230       1240       1250
EGLLGKERST LWDQMQFWED AFLDAVMLER EGMGMDQGPQ EMIDRYLSLG 
      1260       1270       1280       1290       1300
EHDRKRLEDD EDRLLATLLH NLISYMLLMK VNKNDIRKKV RRLMGKSHIG 
      1310       1320       1330       1340       1350
LVYSQQINEV LDQLANLNGR DLSIWSSGSR HMKKQTFVVH AGTDTNGDIF 
      1360       1370       1380       1390       1400
FMEVCDDCVV LRSNIGTVYE RWWYEKLINM TYCPKTKVLC LWRRNGSETQ 
      1410       1420       1430       1440       1450
LNKFYTKKCR ELYYCVKDSM ERAAARQQSI KPGPELGGEF PVQDLKTGEG 
      1460       1470       1480       1490       1500
GLLQVTLEGI NLKFMHNQVF IELNHIKKCN TVRGVFVLEE FVPEIKEVVS 
      1510       1520       1530       1540 
HKYKTPMAHE ICYSVLCLFS YVAAVHSSEE DLRTPPRPVS S

Note: No experimental confirmation available.

Show »

Length:1,541

Mass (Da):171,006

Checksum:ⁱF717C904CE01ADE1

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MRB5	A0A0A0MRB5_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	1,588	Annotation score:
F8W8U2	F8W8U2_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	439	Annotation score:
C9J6B0	C9J6B0_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	154	Annotation score:
C9JLZ9	C9JLZ9_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	135	Annotation score:
C9JM97	C9JM97_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	75	Annotation score:
C9K0L0	C9K0L0_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	136	Annotation score:
A0A0U1RR25	A0A0U1RR25_HUMAN	MAP kinase-activating death domain ... MAP kinase-activating death domain protein	MADD	199	Annotation score:

Sequence cautionⁱ

The sequence BAA20814 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	108	E → G in AAL40265 (PubMed:11577081).Curated	1
Sequence conflictⁱ	108	E → G in AAL40266 (PubMed:11577081).Curated	1
Sequence conflictⁱ	108	E → G in AAL40267 (PubMed:11577081).Curated	1
Sequence conflictⁱ	108	E → G in AAL40268 (PubMed:11577081).Curated	1
Sequence conflictⁱ	108	E → G in AAL35261 (PubMed:11577081).Curated	1
Sequence conflictⁱ	145	L → F in AAL40265 (PubMed:11577081).Curated	1
Sequence conflictⁱ	145	L → F in AAL40266 (PubMed:11577081).Curated	1
Sequence conflictⁱ	145	L → F in AAL40267 (PubMed:11577081).Curated	1
Sequence conflictⁱ	145	L → F in AAL40268 (PubMed:11577081).Curated	1
Sequence conflictⁱ	145	L → F in AAL35261 (PubMed:11577081).Curated	1
Sequence conflictⁱ	205	E → G in BAF85131 (PubMed:14702039).Curated	1
Sequence conflictⁱ	312	V → L in AAL40265 (PubMed:11577081).Curated	1
Sequence conflictⁱ	312	V → L in AAL40266 (PubMed:11577081).Curated	1
Sequence conflictⁱ	312	V → L in AAL40267 (PubMed:11577081).Curated	1
Sequence conflictⁱ	312	V → L in AAL40268 (PubMed:11577081).Curated	1
Sequence conflictⁱ	312	V → L in AAL35261 (PubMed:11577081).Curated	1
Sequence conflictⁱ	482	V → A in AAL40265 (PubMed:11577081).Curated	1
Sequence conflictⁱ	482	V → A in AAL40266 (PubMed:11577081).Curated	1
Sequence conflictⁱ	482	V → A in AAL40267 (PubMed:11577081).Curated	1
Sequence conflictⁱ	482	V → A in AAL40268 (PubMed:11577081).Curated	1
Sequence conflictⁱ	482	V → A in AAL35261 (PubMed:11577081).Curated	1
Sequence conflictⁱ	500	A → V in BAF85131 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1262	S → C in AAL40265 (PubMed:11577081).Curated	1
Sequence conflictⁱ	1262	S → C in AAL40266 (PubMed:11577081).Curated	1
Sequence conflictⁱ	1262	S → C in AAL40267 (PubMed:11577081).Curated	1
Sequence conflictⁱ	1262	S → C in AAL40268 (PubMed:11577081).Curated	1
Sequence conflictⁱ	1262	S → C in AAL35261 (PubMed:11577081).Curated	1
Sequence conflictⁱ	1592	F → S in BAF85131 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1639	R → G in BAF85131 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030666	696	P → T1 PublicationCorresponds to variant dbSNP:rs17854007Ensembl.	1
Natural variantⁱVAR_030667	751	V → M1 PublicationCorresponds to variant dbSNP:rs1051006Ensembl.	1
Natural variantⁱVAR_051148	765	R → Q. Corresponds to variant dbSNP:rs3736101Ensembl.	1
Natural variantⁱVAR_030668	968	R → G1 PublicationCorresponds to variant dbSNP:rs17854008Ensembl.	1
Natural variantⁱVAR_030669	1040	L → F1 PublicationCorresponds to variant dbSNP:rs17854009Ensembl.	1
Natural variantⁱVAR_051149	1518	L → P. Corresponds to variant dbSNP:rs34534575Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_052293	762 – 804	Missing in isoform 4, isoform 5, isoform 6 and isoform 8. 5 PublicationsAdd BLAST	43
Alternative sequenceⁱVSP_052294	885 – 904	Missing in isoform 3, isoform 5, isoform 6 and isoform 8. 6 PublicationsAdd BLAST	20
Alternative sequenceⁱVSP_052295	1121 – 1139	ELWNK…LEKQR → G in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8. 6 PublicationsAdd BLAST	19
Alternative sequenceⁱVSP_044848	1197 – 1200	Missing in isoform 8. 1 Publication	4
Alternative sequenceⁱVSP_055676	1201	Missing in isoform 3. 3 Publications	1
Alternative sequenceⁱVSP_052296	1291 – 1311	Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8. 6 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_052297	1575 – 1582	VFIELNHI → FLKLKKW in isoform 6 and isoform 7. 2 Publications	8
Alternative sequenceⁱVSP_052298	1583 – 1647	Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST	65

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44953 mRNA Translation: AAD12154.1 U77352 mRNA Translation: AAB57735.1 AF440100 mRNA Translation: AAL40265.1 AF440101 mRNA Translation: AAL40266.1 AF440102 mRNA Translation: AAL40267.1 AF440103 mRNA Translation: AAL40268.1 AF440434 mRNA Translation: AAL35261.1 AB002356 mRNA Translation: BAA20814.2 Different initiation. AK292442 mRNA Translation: BAF85131.1 AC018410 Genomic DNA No translation available. AC090582 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW67931.1 CH471064 Genomic DNA Translation: EAW67932.1 BC040484 mRNA Translation: AAH40484.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41642.1 [Q8WXG6-7] CCDS44586.1 [Q8WXG6-3] CCDS44587.1 [Q8WXG6-4] CCDS44588.1 [Q8WXG6-5] CCDS44589.1 [Q8WXG6-8] CCDS44590.1 [Q8WXG6-6] CCDS7930.1 [Q8WXG6-1] CCDS7932.1 [Q8WXG6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001129415.1, NM_001135943.1 NP_001129416.1, NM_001135944.1 [Q8WXG6-8] NP_003673.3, NM_003682.3 [Q8WXG6-1] NP_569826.2, NM_130470.2 NP_569827.2, NM_130471.2 [Q8WXG6-4] NP_569828.2, NM_130472.2 [Q8WXG6-5] NP_569829.2, NM_130473.2 [Q8WXG6-2] NP_569830.2, NM_130474.2 [Q8WXG6-6] NP_569831.1, NM_130475.2 [Q8WXG6-7] NP_569832.2, NM_130476.2 [Q8WXG6-3] XP_005253246.1, XM_005253189.2 [Q8WXG6-1] XP_005253253.1, XM_005253196.2 [Q8WXG6-2] XP_005253256.1, XM_005253199.2 XP_005253258.1, XM_005253201.2 [Q8WXG6-4] XP_005253260.1, XM_005253203.2 [Q8WXG6-5] XP_005253261.1, XM_005253204.2 [Q8WXG6-8] XP_005253262.1, XM_005253205.1 [Q8WXG6-6]
UniGeneⁱ	Hs.82548

Genome annotation databases

Ensemblⁱ	ENST00000311027; ENSP00000310933; ENSG00000110514 [Q8WXG6-1] ENST00000349238; ENSP00000304505; ENSG00000110514 [Q8WXG6-2] ENST00000395336; ENSP00000378745; ENSG00000110514 [Q8WXG6-7] ENST00000395344; ENSP00000378753; ENSG00000110514 [Q8WXG6-8] ENST00000402192; ENSP00000384287; ENSG00000110514 [Q8WXG6-3] ENST00000402799; ENSP00000385585; ENSG00000110514 [Q8WXG6-5] ENST00000406482; ENSP00000384435; ENSG00000110514 [Q8WXG6-6] ENST00000407859; ENSP00000384204; ENSG00000110514 [Q8WXG6-4]
GeneIDⁱ	8567
KEGGⁱ	hsa:8567
UCSC genome browser More...UCSCⁱ	uc001ner.2 human [Q8WXG6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WXG6	MAP kinase-activating death domain protein		MOUSE		1577	UniRef90_Q8WXG6
MAP kinase-activating death domain protein		TARSY		1651
MAP kinase-activating death domain protein isoform X1		DELLE		1650
Uncharacterized protein		Cebus capucinus imitator		1650
MAP kinase activating death domain		RABIT		1649
+419
Q8WXG6-2	MAP kinase-activating death domain protein isoform X8		DELLE		1629	UniRef90_Q8WXG6-2
MAP kinase-activating death domain protein isoform X1		Yangtze finless porpoise		1617
MAP kinase-activating death domain protein isoform X1		PHYCD		1617
MADD isoform 4		PANTR		1608
Uncharacterized protein		PROCO		1608
+165
Q8WXG6-3	MAP kinase activating death domain		SHEEP		1677	UniRef90_Q8WXG6-3
MAP kinase-activating death domain protein isoform X4		PHYCD		1597
MAP kinase-activating death domain protein isoform X6		Yangtze finless porpoise		1597
Uncharacterized protein		PIG		1589
MAP kinase activating death domain		CANLF		1589
+202
Q8WXG6-4	MAP kinase-activating death domain protein isoform X9		Yangtze finless porpoise		1574	UniRef90_Q8WXG6-4
MAP-kinase activating death domain		PANTR		1565
Uncharacterized protein		COLAP		1565
MAP kinase-activating death domain protein isoform X7		ODORO		1565
MAP kinase-activating death domain protein isoform X17		DELLE		1565
+60
Q8WXG6-5	MAP kinase-activating death domain protein isoform c		MACMU		1545	UniRef90_Q8WXG6-5
MADD isoform 2		PANTR		1545
MADD isoform 2		PONAB		1545
Uncharacterized protein		COLAP		1541
Isoform 8 of MAP kinase-activating death domain protein		HUMAN		1541
+104
Q8WXG6-6	MAP kinase-activating death domain protein isoform g		MACMU		1496	UniRef90_Q8WXG6-6
MADD isoform 5		PANTR		1479
Uncharacterized protein		COLAP		1479
MAP kinase-activating death domain protein isoform X22		DELLE		1479
MADD isoform 4		PONAB		1479
+50
Q8WXG6-8	Isoform 5 of MAP kinase-activating death domain protein		HUMAN		1545	UniRef90_Q8WXG6-5
MAP kinase-activating death domain protein isoform c		MACMU		1545
MADD isoform 2		PANTR		1545
MADD isoform 2		PONAB		1545
Uncharacterized protein		COLAP		1541
+104

Protein	Similar proteins		Species	Score	Length	Source
Q8WXG6	MAP kinase-activating death domain protein		MOUSE		1577	UniRef50_Q8WXG6
MAP kinase-activating death domain protein		RAT		1602
MAP kinase-activating death domain protein		TARSY		1651
Uncharacterized protein		Cebus capucinus imitator		1650
MAP kinase-activating death domain protein isoform X1		DELLE		1650
+2033
Q8WXG6-4	MAP kinase-activating death domain protein isoform X9		Yangtze finless porpoise		1574	UniRef50_Q8WXG6-4
MADD isoform 6		PANTR		1565
MAP kinase-activating death domain protein isoform X5		LIPVE		1565
MAP kinase activating death domain		HORSE		1565
MAP kinase-activating death domain protein isoform X17		DELLE		1565
+87
Q8WXG6-6	MAP kinase-activating death domain protein isoform g		MACMU		1496	UniRef50_Q8WXG6-6
MAP kinase-activating death domain protein isoform X22		DELLE		1479
MADD isoform 4		PONAB		1479
MAP kinase-activating death domain protein isoform X17		Yangtze finless porpoise		1479
MADD isoform 5		PANTR		1479
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44953 mRNA Translation: AAD12154.1 U77352 mRNA Translation: AAB57735.1 AF440100 mRNA Translation: AAL40265.1 AF440101 mRNA Translation: AAL40266.1 AF440102 mRNA Translation: AAL40267.1 AF440103 mRNA Translation: AAL40268.1 AF440434 mRNA Translation: AAL35261.1 AB002356 mRNA Translation: BAA20814.2 Different initiation. AK292442 mRNA Translation: BAF85131.1 AC018410 Genomic DNA No translation available. AC090582 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW67931.1 CH471064 Genomic DNA Translation: EAW67932.1 BC040484 mRNA Translation: AAH40484.1
CCDSⁱ	CCDS41642.1 [Q8WXG6-7] CCDS44586.1 [Q8WXG6-3] CCDS44587.1 [Q8WXG6-4] CCDS44588.1 [Q8WXG6-5] CCDS44589.1 [Q8WXG6-8] CCDS44590.1 [Q8WXG6-6] CCDS7930.1 [Q8WXG6-1] CCDS7932.1 [Q8WXG6-2]
RefSeqⁱ	NP_001129415.1, NM_001135943.1 NP_001129416.1, NM_001135944.1 [Q8WXG6-8] NP_003673.3, NM_003682.3 [Q8WXG6-1] NP_569826.2, NM_130470.2 NP_569827.2, NM_130471.2 [Q8WXG6-4] NP_569828.2, NM_130472.2 [Q8WXG6-5] NP_569829.2, NM_130473.2 [Q8WXG6-2] NP_569830.2, NM_130474.2 [Q8WXG6-6] NP_569831.1, NM_130475.2 [Q8WXG6-7] NP_569832.2, NM_130476.2 [Q8WXG6-3] XP_005253246.1, XM_005253189.2 [Q8WXG6-1] XP_005253253.1, XM_005253196.2 [Q8WXG6-2] XP_005253256.1, XM_005253199.2 XP_005253258.1, XM_005253201.2 [Q8WXG6-4] XP_005253260.1, XM_005253203.2 [Q8WXG6-5] XP_005253261.1, XM_005253204.2 [Q8WXG6-8] XP_005253262.1, XM_005253205.1 [Q8WXG6-6]
UniGeneⁱ	Hs.82548

3D structure databases

ProteinModelPortalⁱ	Q8WXG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114136, 30 interactors
ELMⁱ	Q8WXG6
IntActⁱ	Q8WXG6, 9 interactors
MINTⁱ	Q8WXG6
STRINGⁱ	9606.ENSP00000310933

PTM databases

iPTMnetⁱ	Q8WXG6
PhosphoSitePlusⁱ	Q8WXG6

Polymorphism and mutation databases

BioMutaⁱ	MADD
DMDMⁱ	126215742

Proteomic databases

EPDⁱ	Q8WXG6
MaxQBⁱ	Q8WXG6
PaxDbⁱ	Q8WXG6
PeptideAtlasⁱ	Q8WXG6
PRIDEⁱ	Q8WXG6
ProteomicsDBⁱ	75032 75033 [Q8WXG6-2] 75034 [Q8WXG6-3] 75035 [Q8WXG6-4] 75036 [Q8WXG6-5] 75037 [Q8WXG6-6] 75038 [Q8WXG6-7]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000311027; ENSP00000310933; ENSG00000110514 [Q8WXG6-1] ENST00000349238; ENSP00000304505; ENSG00000110514 [Q8WXG6-2] ENST00000395336; ENSP00000378745; ENSG00000110514 [Q8WXG6-7] ENST00000395344; ENSP00000378753; ENSG00000110514 [Q8WXG6-8] ENST00000402192; ENSP00000384287; ENSG00000110514 [Q8WXG6-3] ENST00000402799; ENSP00000385585; ENSG00000110514 [Q8WXG6-5] ENST00000406482; ENSP00000384435; ENSG00000110514 [Q8WXG6-6] ENST00000407859; ENSP00000384204; ENSG00000110514 [Q8WXG6-4]
GeneIDⁱ	8567
KEGGⁱ	hsa:8567
UCSCⁱ	uc001ner.2 human [Q8WXG6-1]

Organism-specific databases

CTDⁱ	8567
DisGeNETⁱ	8567
EuPathDBⁱ	HostDB:ENSG00000110514.19
GeneCardsⁱ	MADD
HGNCⁱ	HGNC:6766 MADD
HPAⁱ	HPA038568
MIMⁱ	603584 gene+phenotype
neXtProtⁱ	NX_Q8WXG6
OpenTargetsⁱ	ENSG00000110514
PharmGKBⁱ	PA30523
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3570 Eukaryota ENOG410XP23 LUCA
GeneTreeⁱ	ENSGT00760000118819
HOGENOMⁱ	HOG000231438
HOVERGENⁱ	HBG079455
InParanoidⁱ	Q8WXG6
OMAⁱ	KRLVDCC
OrthoDBⁱ	EOG091G00AV
PhylomeDBⁱ	Q8WXG6
TreeFamⁱ	TF318583

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5357905 Regulation of TNFR1 signaling R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	MADD human
GeneWikiⁱ	MADD_(gene)
GenomeRNAiⁱ	8567
Protein Ontology More...PROⁱ	PR:Q8WXG6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110514 Expressed in 222 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	Q8WXG6 baseline and differential
Genevisibleⁱ	Q8WXG6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001194 cDENN_dom IPR005112 dDENN_dom IPR037516 Tripartite_DENN IPR005113 uDENN_dom
Pfamⁱ	View protein in Pfam PF02141 DENN, 1 hit PF03456 uDENN, 1 hit
SMARTⁱ	View protein in SMART SM00801 dDENN, 1 hit SM00799 DENN, 1 hit SM00800 uDENN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50211 DENN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MADD_HUMAN
Accessionⁱ	Q8WXG6Primary (citable) accession number: Q8WXG6 Secondary accession number(s): A8K8S7 Q8WZ63
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q8WXG6 (MADD_HUMAN)

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MAP kinase-activating death domain protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

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Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ