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Protein

Relaxin-3

Gene

RLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).

GO - Molecular functioni

  • G protein-coupled receptor binding Source: GO_Central
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444821 Relaxin receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Prorelaxin H3
Cleaved into the following 2 chains:
Gene namesi
Name:RLN3
Synonyms:INSL7, RXN3, ZINS4
ORF Names:UNQ6188/PRO20213
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171136.6
HGNCiHGNC:17135 RLN3
MIMi606855 gene
neXtProtiNX_Q8WXF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi117579
OpenTargetsiENSG00000171136
PharmGKBiPA34401

Polymorphism and mutation databases

BioMutaiRLN3
DMDMi37999891

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
PeptideiPRO_000001608226 – 52Relaxin-3 B chainBy similarityAdd BLAST27
PropeptideiPRO_000001608355 – 118Connecting peptideBy similarityAdd BLAST64
PeptideiPRO_0000016084119 – 142Relaxin-3 A chainBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 129Interchain (between B and A chains)1 Publication
Disulfide bondi47 ↔ 142Interchain (between B and A chains)1 Publication
Disulfide bondi128 ↔ 1331 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ8WXF3
PeptideAtlasiQ8WXF3
PRIDEiQ8WXF3
ProteomicsDBi75025

PTM databases

iPTMnetiQ8WXF3
PhosphoSitePlusiQ8WXF3

Expressioni

Gene expression databases

BgeeiENSG00000171136 Expressed in 37 organ(s), highest expression level in right testis
CleanExiHS_RLN3
ExpressionAtlasiQ8WXF3 baseline and differential
GenevisibleiQ8WXF3 HS

Organism-specific databases

HPAiHPA043731

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Binary interactionsi

WithEntry#Exp.IntActNotes
RXFP4Q8TDU99EBI-9519546,EBI-9519524

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125590, 3 interactors
IntActiQ8WXF3, 1 interactor
MINTiQ8WXF3
STRINGi9606.ENSP00000397415

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WXF3
SMRiQ8WXF3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXF3

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZRS Eukaryota
ENOG41121Z2 LUCA
GeneTreeiENSGT00510000048203
HOGENOMiHOG000111888
HOVERGENiHBG045048
InParanoidiQ8WXF3
KOiK22000
OMAiEARASPY
OrthoDBiEOG091G0Y3D
PhylomeDBiQ8WXF3
TreeFamiTF333404

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WXF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARYMLLLLL AVWVLTGELW PGAEARAAPY GVRLCGREFI RAVIFTCGGS
60 70 80 90 100
RWRRSDILAH EAMGDTFPDA DADEDSLAGE LDEAMGSSEW LALTKSPQAF
110 120 130 140
YRGRPSWQGT PGVLRGSRDV LAGLSSSCCK WGCSKSEISS LC
Length:142
Mass (Da):15,451
Last modified:March 1, 2002 - v1
Checksum:i23A3E095034B31E4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENX1K7ENX1_HUMAN
Relaxin-3
RLN3
109Annotation score:

Sequence cautioni

The sequence AAQ88548 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447451 mRNA Translation: AAL40345.1
AB076563 mRNA Translation: BAC53758.1
AY358181 mRNA Translation: AAQ88548.1 Different initiation.
CCDSiCCDS12302.1
RefSeqiNP_001298126.1, NM_001311197.1
NP_543140.1, NM_080864.3
UniGeneiHs.352155

Genome annotation databases

EnsembliENST00000431365; ENSP00000397415; ENSG00000171136
GeneIDi117579
KEGGihsa:117579
UCSCiuc002mxw.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447451 mRNA Translation: AAL40345.1
AB076563 mRNA Translation: BAC53758.1
AY358181 mRNA Translation: AAQ88548.1 Different initiation.
CCDSiCCDS12302.1
RefSeqiNP_001298126.1, NM_001311197.1
NP_543140.1, NM_080864.3
UniGeneiHs.352155

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FHWNMR-A119-142[»]
B26-52[»]
2K1VNMR-B26-52[»]
ProteinModelPortaliQ8WXF3
SMRiQ8WXF3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125590, 3 interactors
IntActiQ8WXF3, 1 interactor
MINTiQ8WXF3
STRINGi9606.ENSP00000397415

PTM databases

iPTMnetiQ8WXF3
PhosphoSitePlusiQ8WXF3

Polymorphism and mutation databases

BioMutaiRLN3
DMDMi37999891

Proteomic databases

PaxDbiQ8WXF3
PeptideAtlasiQ8WXF3
PRIDEiQ8WXF3
ProteomicsDBi75025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431365; ENSP00000397415; ENSG00000171136
GeneIDi117579
KEGGihsa:117579
UCSCiuc002mxw.2 human

Organism-specific databases

CTDi117579
DisGeNETi117579
EuPathDBiHostDB:ENSG00000171136.6
GeneCardsiRLN3
HGNCiHGNC:17135 RLN3
HPAiHPA043731
MIMi606855 gene
neXtProtiNX_Q8WXF3
OpenTargetsiENSG00000171136
PharmGKBiPA34401
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZRS Eukaryota
ENOG41121Z2 LUCA
GeneTreeiENSGT00510000048203
HOGENOMiHOG000111888
HOVERGENiHBG045048
InParanoidiQ8WXF3
KOiK22000
OMAiEARASPY
OrthoDBiEOG091G0Y3D
PhylomeDBiQ8WXF3
TreeFamiTF333404

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444821 Relaxin receptors

Miscellaneous databases

EvolutionaryTraceiQ8WXF3
GenomeRNAii117579
PROiPR:Q8WXF3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171136 Expressed in 37 organ(s), highest expression level in right testis
CleanExiHS_RLN3
ExpressionAtlasiQ8WXF3 baseline and differential
GenevisibleiQ8WXF3 HS

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREL3_HUMAN
AccessioniPrimary (citable) accession number: Q8WXF3
Secondary accession number(s): Q6UXW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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