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Entry version 160 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Stonin-2

Gene

STON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WXE9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8WXE9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stonin-2
Alternative name(s):
Stoned B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STON2
Synonyms:STN2, STNB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140022.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30652, STON2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608467, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXE9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi738W → A: Reduces interaction with SYT1. 1 Publication1
Mutagenesisi740K → A: Reduces interaction with SYT1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
85439

Open Targets

More...
OpenTargetsi
ENSG00000140022

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485624

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WXE9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STON2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34098614

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857321 – 905Stonin-2Add BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei255PhosphothreonineBy similarity1
Modified residuei281PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by PKD.1 Publication
Neddylated; deneddylated via its interaction with the COP9 signalosome (CSN) complex through TOR1A and COPS4.1 Publication
Ubiquitinated; leading to its degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXE9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WXE9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WXE9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WXE9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXE9

PeptideAtlas

More...
PeptideAtlasi
Q8WXE9

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXE9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32734
75021 [Q8WXE9-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8WXE9

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8WXE9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140022, Expressed in kidney and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WXE9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXE9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140022, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2.

Interacts with EPS15, EPS15R and ITSN1.

Interacts indirectly with the AP-2 adapter complex.

Interacts with TOR1A and COPS4; the interaction controls STON2 protein stability.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124526, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8WXE9

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8WXE9

Protein interaction database and analysis system

More...
IntActi
Q8WXE9, 46 interactors

Molecular INTeraction database

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MINTi
Q8WXE9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000450857

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WXE9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1905
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WXE9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WXE9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 560SHDPROSITE-ProRule annotationAdd BLAST134
Domaini568 – 878MHDPROSITE-ProRule annotationAdd BLAST311

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi313 – 315NPF 13
Motifi329 – 331NPF 23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of SYT1, SYT2, EPS15, EPS15R and ITSN1.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Stoned B family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2677, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159392

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016541_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXE9

KEGG Orthology (KO)

More...
KOi
K20067

Identification of Orthologs from Complete Genome Data

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OMAi
WIELDDH

Database of Orthologous Groups

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OrthoDBi
1059322at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXE9

TreeFam database of animal gene trees

More...
TreeFami
TF300393

Family and domain databases

Database of protein disorder

More...
DisProti
DP01368

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR028565, MHD
IPR012320, SHD_dom
IPR031228, STON2
IPR017110, Stonin
IPR022699, Stonin2_N

The PANTHER Classification System

More...
PANTHERi
PTHR10529:SF345, PTHR10529:SF345, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PF12016, Stonin2_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037099, Stonin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447, SSF49447, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51072, MHD, 1 hit
PS51070, SHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTLDHVIAT HQSEWVSFNE EPPFPAHSQG GTEEHLPGLS SSPDQSESSS
60 70 80 90 100
GENHVVDGGS QDHSHSEQDD SSEKMGLISE AASPPGSPEQ PPPDLASAIS
110 120 130 140 150
NWVQFEDDTP WASTSPPHQE TAETALPLTM PCWTCPSFDS LGRCPLTSES
160 170 180 190 200
SWTTHSEDTS SPSFGCSYTD LQLINAEEQT SGQASGADST DNSSSLQEDE
210 220 230 240 250
EVEMEAISWQ ASSPAMNGHP APPVTSARFP SWVTFDDNEV SCPLPPVTSP
260 270 280 290 300
LKPNTPPSAS VIPDVPYNSM GSFKKRDRPK STLMNFSKVQ KLDISSLNRT
310 320 330 340 350
PSVTEASPWR ATNPFLNETL QDVQPSPINP FSAFFEEQER RSQNSSISST
360 370 380 390 400
TGKSQRDSLI VIYQDAISFD DSSKTQSHSD AVEKLKQLQI DDPDHFGSAT
410 420 430 440 450
LPDDDPVAWI ELDAHPPGSA RSQPRDGWPM MLRIPEKKNI MSSRHWGPIF
460 470 480 490 500
VKLTDTGYLQ LYYEQGLEKP FREFKLEICH EISEPRLQNY DENGRIHSLR
510 520 530 540 550
IDRVTYKEKK KYQPKPAVAH TAEREQVIKL GTTNYDDFLS FIHAVQDRLM
560 570 580 590 600
DLPVLSMDLS TVGLNYLEEE ITVDVRDEFS GIVSKGDNQI LQHHVLTRIH
610 620 630 640 650
ILSFLSGLAE CRLGLNDILV KGNEIVLRQD IMPTTTTKWI KLHECRFHGC
660 670 680 690 700
VDEDVFHNSR VILFNPLDAC RFELMRFRTV FAEKTLPFTL RTATSVNGAE
710 720 730 740 750
VEVQSWLRMS TGFSANRDPL TQVPCENVMI RYPVPSEWVK NFRRESVLGE
760 770 780 790 800
KSLKAKVNRG ASFGSTSVSG SEPVMRVTLG TAKYEHAFNS IVWRINRLPD
810 820 830 840 850
KNSASGHPHC FFCHLELGSD REVPSRFANH VNVEFSMPTT SASKASVRSI
860 870 880 890 900
SVEDKTDVRK WVNYSAHYSY QVALGSIWLM LPTPFVHPTT LPLLFLLAML

TMFAW
Length:905
Mass (Da):101,165
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59F5810DEC540CA3
GO
Isoform 2 (identifier: Q8WXE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-905: VALGSIWLMLPTPFVHPTTLPLLFLLAMLTMFAW → TTETDNLPNP...PLASSIRTMV

Show »
Length:920
Mass (Da):102,835
Checksum:i85140C1E96940A27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IU55A0A3B3IU55_HUMAN
Stonin-2
STON2
977Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V322G3V322_HUMAN
Stonin-2
STON2
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ05H0YJ05_HUMAN
Stonin-2
STON2
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK57558 differs from that shown. Intron retention.Curated
The sequence AAK57558 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAK76362 differs from that shown. Reason: Frameshift.Curated
The sequence BAD92185 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121 – 122TA → NS in AAK76362 (PubMed:11454741).Curated2
Isoform 2 (identifier: Q8WXE9-3)
Sequence conflicti899V → L in BAD92185 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020182307S → P3 PublicationsCorresponds to variant dbSNP:rs3813535Ensembl.1
Natural variantiVAR_046643646R → H. Corresponds to variant dbSNP:rs34323725Ensembl.1
Natural variantiVAR_046644694T → A. Corresponds to variant dbSNP:rs35689202Ensembl.1
Natural variantiVAR_021912851S → A. Corresponds to variant dbSNP:rs2241621Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044863872 – 905VALGS…TMFAW → TTETDNLPNPLYCSCLPHTD LKRGSKRVVKIRWNASLEVP LASSIRTMV in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF380833 mRNA Translation: AAK76362.1 Frameshift.
AF449430 mRNA Translation: AAL47008.1
AB208948 mRNA Translation: BAD92185.1 Different initiation.
AL121769 Genomic DNA No translation available.
AL136040 Genomic DNA No translation available.
BC069389 mRNA Translation: AAH69389.1
BC117493 mRNA Translation: AAI17494.1
AF255309 mRNA Translation: AAK57558.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS58332.1 [Q8WXE9-3]

NCBI Reference Sequences

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RefSeqi
NP_001243359.1, NM_001256430.1 [Q8WXE9-3]
NP_149095.2, NM_033104.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000555447; ENSP00000450857; ENSG00000140022 [Q8WXE9-3]
ENST00000614646; ENSP00000477736; ENSG00000140022 [Q8WXE9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85439

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85439

UCSC genome browser

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UCSCi
uc001xvk.3, human [Q8WXE9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380833 mRNA Translation: AAK76362.1 Frameshift.
AF449430 mRNA Translation: AAL47008.1
AB208948 mRNA Translation: BAD92185.1 Different initiation.
AL121769 Genomic DNA No translation available.
AL136040 Genomic DNA No translation available.
BC069389 mRNA Translation: AAH69389.1
BC117493 mRNA Translation: AAI17494.1
AF255309 mRNA Translation: AAK57558.1 Sequence problems.
CCDSiCCDS58332.1 [Q8WXE9-3]
RefSeqiNP_001243359.1, NM_001256430.1 [Q8WXE9-3]
NP_149095.2, NM_033104.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JXCNMR-B301-340[»]
SMRiQ8WXE9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124526, 58 interactors
CORUMiQ8WXE9
ELMiQ8WXE9
IntActiQ8WXE9, 46 interactors
MINTiQ8WXE9
STRINGi9606.ENSP00000450857

PTM databases

CarbonylDBiQ8WXE9
iPTMnetiQ8WXE9
PhosphoSitePlusiQ8WXE9

Polymorphism and mutation databases

BioMutaiSTON2
DMDMi34098614

Proteomic databases

EPDiQ8WXE9
jPOSTiQ8WXE9
MassIVEiQ8WXE9
MaxQBiQ8WXE9
PaxDbiQ8WXE9
PeptideAtlasiQ8WXE9
PRIDEiQ8WXE9
ProteomicsDBi32734
75021 [Q8WXE9-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q8WXE9, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
164, 22 antibodies

The DNASU plasmid repository

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DNASUi
85439

Genome annotation databases

EnsembliENST00000555447; ENSP00000450857; ENSG00000140022 [Q8WXE9-3]
ENST00000614646; ENSP00000477736; ENSG00000140022 [Q8WXE9-3]
GeneIDi85439
KEGGihsa:85439
UCSCiuc001xvk.3, human [Q8WXE9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85439
DisGeNETi85439
EuPathDBiHostDB:ENSG00000140022.9

GeneCards: human genes, protein and diseases

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GeneCardsi
STON2
HGNCiHGNC:30652, STON2
HPAiENSG00000140022, Low tissue specificity
MIMi608467, gene
neXtProtiNX_Q8WXE9
OpenTargetsiENSG00000140022
PharmGKBiPA143485624

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2677, Eukaryota
GeneTreeiENSGT00940000159392
HOGENOMiCLU_016541_0_0_1
InParanoidiQ8WXE9
KOiK20067
OMAiWIELDDH
OrthoDBi1059322at2759
PhylomeDBiQ8WXE9
TreeFamiTF300393

Enzyme and pathway databases

PathwayCommonsiQ8WXE9
ReactomeiR-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SignaLinkiQ8WXE9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
85439, 6 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STON2, human
EvolutionaryTraceiQ8WXE9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85439
PharosiQ8WXE9, Tbio

Protein Ontology

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PROi
PR:Q8WXE9
RNActiQ8WXE9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140022, Expressed in kidney and 196 other tissues
ExpressionAtlasiQ8WXE9, baseline and differential
GenevisibleiQ8WXE9, HS

Family and domain databases

DisProtiDP01368
InterProiView protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR028565, MHD
IPR012320, SHD_dom
IPR031228, STON2
IPR017110, Stonin
IPR022699, Stonin2_N
PANTHERiPTHR10529:SF345, PTHR10529:SF345, 1 hit
PfamiView protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PF12016, Stonin2_N, 1 hit
PIRSFiPIRSF037099, Stonin, 1 hit
SUPFAMiSSF49447, SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS51072, MHD, 1 hit
PS51070, SHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTON2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXE9
Secondary accession number(s): G3V2T7
, Q17R24, Q59H11, Q6NT47, Q96RI7, Q96RU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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