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Protein

ATR-interacting protein

Gene

ATRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.1 Publication

Caution

The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.Curated

GO - Molecular functioni

  • K63-linked polyubiquitin modification-dependent protein binding Source: UniProtKB

GO - Biological processi

  • DNA damage checkpoint Source: UniProtKB
  • DNA replication Source: Reactome
  • interstrand cross-link repair Source: Reactome

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiQ8WXE1

Names & Taxonomyi

Protein namesi
Recommended name:
ATR-interacting protein
Alternative name(s):
ATM and Rad3-related-interacting protein
Gene namesi
Name:ATRIP
Synonyms:AGS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164053.18
HostDB:ENSG00000282827.1
HGNCiHGNC:33499 ATRIP
MIMi606605 gene
neXtProtiNX_Q8WXE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi769 – 770EE → AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage. 1 Publication2
Mutagenesisi774 – 775DD → AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage. 1 Publication2

Organism-specific databases

DisGeNETi84126
GeneReviewsiATRIP
MalaCardsiATRIP
OpenTargetsiENSG00000164053
Orphaneti808 Seckel syndrome
PharmGKBiPA162377290

Polymorphism and mutation databases

DMDMi48428109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647401 – 791ATR-interacting proteinAdd BLAST791

Post-translational modificationi

Phosphorylated by ATR.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXE1
MaxQBiQ8WXE1
PaxDbiQ8WXE1
PeptideAtlasiQ8WXE1
PRIDEiQ8WXE1
ProteomicsDBi75018
75019 [Q8WXE1-2]
75020 [Q8WXE1-3]

PTM databases

iPTMnetiQ8WXE1
PhosphoSitePlusiQ8WXE1

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000164053
CleanExiHS_ATRIP
ExpressionAtlasiQ8WXE1 baseline and differential
GenevisibleiQ8WXE1 HS

Organism-specific databases

HPAiCAB033109
HPA047590

Interactioni

Subunit structurei

Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • K63-linked polyubiquitin modification-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi313463, 61 interactors
CORUMiQ8WXE1
DIPiDIP-46495N
ELMiQ8WXE1
IntActiQ8WXE1, 32 interactors
MINTiQ8WXE1
STRINGi9606.ENSP00000323099

Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 63Combined sources7

3D structure databases

ProteinModelPortaliQ8WXE1
SMRiQ8WXE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 156Interaction with CINP1 PublicationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 217Sequence analysisAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi769 – 776EEXXXDL motif8

Domaini

The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.1 Publication

Sequence similaritiesi

Belongs to the ATRIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHIV Eukaryota
ENOG41107QS LUCA
GeneTreeiENSGT00390000012850
HOGENOMiHOG000273897
HOVERGENiHBG050618
InParanoidiQ8WXE1
KOiK10905
OMAiGSNCQCN
OrthoDBiEOG091G03DF
PhylomeDBiQ8WXE1
TreeFamiTF324417

Family and domain databases

InterProiView protein in InterPro
IPR033349 ATRIP
PANTHERiPTHR28594 PTHR28594, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WXE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTSAPGSK RRSEPPAPRP GPPPGTGHPP SKRARGFSAA AAPDPDDPFG
60 70 80 90 100
AHGDFTADDL EELDTLASQA LSQCPAAARD VSSDHKVHRL LDGMSKNPSG
110 120 130 140 150
KNRETVPIKD NFELEVLQAQ YKELKEKMKV MEEEVLIKNG EIKILRDSLH
160 170 180 190 200
QTESVLEEQR RSHFLLEQEK TQALSDKEKE FSKKLQSLQS ELQFKDAEMN
210 220 230 240 250
ELRTKLQTSE RANKLAAPSV SHVSPRKNPS VVIKPEACSP QFGKTSFPTK
260 270 280 290 300
ESFSANMSLP HPCQTESGYK PLVGREDSKP HSLRGDSIKQ EEAQKSFVDS
310 320 330 340 350
WRQRSNTQGS ILINLLLKQP LIPGSSLSLC HLLSSSSESP AGTPLQPPGF
360 370 380 390 400
GSTLAGMSGL RTTGSYDGSF SLSALREAQN LAFTGLNLVA RNECSRDGDP
410 420 430 440 450
AEGGRRAFPL CQLPGAVHFL PLVQFFIGLH CQALQDLAAA KRSGAPGDSP
460 470 480 490 500
THSSCVSSGV ETNPEDSVCI LEGFSVTALS ILQHLVCHSG AVVSLLLSGV
510 520 530 540 550
GADSAAGEGN RSLVHRLSDG DMTSALRGVA DDQGQHPLLK MLLHLLAFSS
560 570 580 590 600
AATGHLQASV LTQCLKVLVK LAENTSCDFL PRFQCVFQVL PKCLSPETPL
610 620 630 640 650
PSVLLAVELL SLLADHDQLA PQLCSHSEGC LLLLLYMYIT SRPDRVALET
660 670 680 690 700
QWLQLEQEVV WLLAKLGVQS PLPPVTGSNC QCNVEVVRAL TVMLHRQWLT
710 720 730 740 750
VRRAGGPPRT DQQRRTVRCL RDTVLLLHGL SQKDKLFMMH CVEVLHQFDQ
760 770 780 790
VMPGVSMLIR GLPDVTDCEE AALDDLCAAE TDVEDPEVEC G
Length:791
Mass (Da):85,838
Last modified:March 1, 2002 - v1
Checksum:i58981602F7961756
GO
Isoform 2 (identifier: Q8WXE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-687: Missing.

Show »
Length:764
Mass (Da):83,003
Checksum:i94E7E31A6BCAAC1D
GO
Isoform 3 (identifier: Q8WXE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):76,336
Checksum:i417F5811408F2799
GO
Isoform 4 (identifier: Q8WXE1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:664
Mass (Da):72,362
Checksum:i460E7E097BCA1C30
GO

Sequence cautioni

The sequence BAB14029 differs from that shown. Reason: Frameshift at position 650.Curated
The sequence BAB14029 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF84257 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280P → L in AAH14153 (PubMed:15489334).Curated1
Sequence conflicti343T → A in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti492V → I in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti647A → T in BAG62254 (PubMed:14702039).Curated1
Sequence conflicti683N → D in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti687V → I in AAH30597 (PubMed:15489334).Curated1
Sequence conflicti712Q → K in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti777C → G in BAF84257 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050683125K → Q. Corresponds to variant dbSNP:rs11925638Ensembl.1
Natural variantiVAR_050684240P → L. Corresponds to variant dbSNP:rs35240314Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470111 – 127Missing in isoform 4. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_0105011 – 93Missing in isoform 3. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_010504661 – 687Missing in isoform 2. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451323 mRNA Translation: AAL38042.1
AK022405 mRNA Translation: BAB14029.1 Sequence problems.
AK291568 mRNA Translation: BAF84257.1 Different initiation.
AK291829 mRNA Translation: BAF84518.1
AK315075 mRNA Translation: BAG37544.1
AK300548 mRNA Translation: BAG62254.1
AC104448 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64876.1
CH471055 Genomic DNA Translation: EAW64878.1
BC014153 mRNA Translation: AAH14153.2
BC020563 mRNA Translation: AAH20563.1
BC030597 mRNA Translation: AAH30597.1
AL832917 mRNA Translation: CAH10621.1
CCDSiCCDS2767.1 [Q8WXE1-2]
CCDS2768.1 [Q8WXE1-1]
CCDS59449.1 [Q8WXE1-3]
CCDS59450.1 [Q8WXE1-5]
RefSeqiNP_001257951.1, NM_001271022.1 [Q8WXE1-5]
NP_001257952.1, NM_001271023.1 [Q8WXE1-3]
NP_115542.2, NM_032166.3 [Q8WXE1-2]
NP_569055.1, NM_130384.2 [Q8WXE1-1]
UniGeneiHs.694840

Genome annotation databases

EnsembliENST00000320211; ENSP00000323099; ENSG00000164053 [Q8WXE1-1]
ENST00000346691; ENSP00000302338; ENSG00000164053 [Q8WXE1-2]
ENST00000357105; ENSP00000349620; ENSG00000164053 [Q8WXE1-5]
ENST00000412052; ENSP00000400930; ENSG00000164053 [Q8WXE1-3]
GeneIDi84126
KEGGihsa:84126
UCSCiuc003ctf.3 human [Q8WXE1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATRIP_HUMAN
AccessioniPrimary (citable) accession number: Q8WXE1
Secondary accession number(s): A8K6A3
, A8K714, B2RCE7, B4DU92, B5MEB7, Q69YK9, Q8NHQ2, Q8WUG7, Q96CL3, Q9HA30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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