Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 154 (16 Oct 2019)
Sequence version 2 (18 May 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Caskin-2

Gene

CASKIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caskin-2
Alternative name(s):
CASK-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASKIN2
Synonyms:KIAA1139
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18200 CASKIN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612185 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXE0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57513

Open Targets

More...
OpenTargetsi
ENSG00000177303

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944093

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WXE0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASKIN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434467

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669831 – 1202Caskin-2Add BLAST1202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei253PhosphotyrosineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei471PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei877PhosphoserineBy similarity1
Modified residuei878PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXE0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WXE0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WXE0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WXE0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXE0

PeptideAtlas

More...
PeptideAtlasi
Q8WXE0

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXE0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75016 [Q8WXE0-1]
75017 [Q8WXE0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXE0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXE0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WXE0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177303 Expressed in 205 organ(s), highest expression level in olfactory bulb

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WXE0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXE0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071906
HPA075184

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May not bind CASK.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121577, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WXE0, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325355

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WXE0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini489 – 552SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini558 – 622SAM 2PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi685 – 1133Pro-richAdd BLAST449

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0507 Eukaryota
KOG4384 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049168

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXE0

KEGG Orthology (KO)

More...
KOi
K21952

Identification of Orthologs from Complete Genome Data

More...
OMAi
AEAIYNW

Database of Orthologous Groups

More...
OrthoDBi
75723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXE0

TreeFam database of animal gene trees

More...
TreeFami
TF320582

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12063 SH3_Caskin2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1/2
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035499 Caskin2_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF7 PTHR24174:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGREQDLILA VKNGDVTGVQ KLVAKVKATK TKLLGSTKRL NVNYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKAKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLR AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRIGYFPPG IVEVVSKRVG
360 370 380 390 400
IPAARLPSAP TPLRPGFSRT PQPPAEEPPH PLTYSQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGP GLLIENAQPL PSAGEDQVLP
460 470 480 490 500
GLHPPSLADN LSHRPLANCR SGEQIFTQDV RPEQLLEGKD AQAIHNWLSE
510 520 530 540 550
FQLEGYTAHF LQAGYDVPTI SRMTPEDLTA IGVTKPGHRK KIASEIAQLS
560 570 580 590 600
IAEWLPSYIP TDLLEWLCAL GLPQYHKQLV SSGYDSMGLV ADLTWEELQE
610 620 630 640 650
IGVNKLGHQK KLMLGVKRLA ELRRGLLQGE ALSEGGRRLA KGPELMAIEG
660 670 680 690 700
LENGEGPATA GPRLLTFQGS ELSPELQAAM AGGGPEPLPL PPARSPSQES
710 720 730 740 750
IGARSRGSGH SQEQPAPQPS GGDPSPPQER NLPEGTERPP KLCSSLPGQG
760 770 780 790 800
PPPYVFMYPQ GSPSSPAPGP PPGAPWAFSY LAGPPATPPD PPRPKRRSHS
810 820 830 840 850
LSRPGPTEGD AEGEAEGPVG STLGSYATLT RRPGRSALVR TSPSVTPTPA
860 870 880 890 900
RGTPRSQSFA LRARRKGPPP PPPKRLSSVS GPSPEPPPLD ESPGPKEGAT
910 920 930 940 950
GPRRRTLSEP AGPSEPPGPP APAGPASDTE EEEPGPEGTP PSRGSSGEGL
960 970 980 990 1000
PFAEEGNLTI KQRPKPAGPP PRETPVPPGL DFNLTESDTV KRRPKCRERE
1010 1020 1030 1040 1050
PLQTALLAFG VASATPGPAA PLPSPTPGES PPASSLPQPE PSSLPAQGVP
1060 1070 1080 1090 1100
TPLAPSPAMQ PPVPPCPGPG LESSAASRWN GETEPPAAPA ALLKVPGAGT
1110 1120 1130 1140 1150
APKPVSVACT QLAFSGPKLA PRLGPRPVPP PRPESTGTVG PGQAQQRLEQ
1160 1170 1180 1190 1200
TSSSLAAALR AAEKSIGTKE QEGTPSASTK HILDDISTMF DALADQLDAM

LD
Length:1,202
Mass (Da):126,783
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i881E6BAEEBDF3DC5
GO
Isoform 2 (identifier: Q8WXE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:1,120
Mass (Da):118,157
Checksum:iF120B5C26DAD308B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRN1J3QRN1_HUMAN
Caskin-2
CASKIN2
323Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKS3J3QKS3_HUMAN
Caskin-2
CASKIN2
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti640A → G in BAH14307 (PubMed:14702039).Curated1
Sequence conflicti1093L → P in BAH14307 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060244891E → GCombined sources4 PublicationsCorresponds to variant dbSNP:rs7503373Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0405681 – 82Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF451976 mRNA Translation: AAL49757.1
AK300354 mRNA Translation: BAG62095.1
AK315936 mRNA Translation: BAH14307.1
AC100787 Genomic DNA No translation available.
BC066643 mRNA Translation: AAH66643.1
AB032965 mRNA Translation: BAA86453.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11723.1 [Q8WXE0-1]
CCDS45775.1 [Q8WXE0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001136115.1, NM_001142643.2 [Q8WXE0-2]
NP_065804.2, NM_020753.4 [Q8WXE0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321617; ENSP00000325355; ENSG00000177303 [Q8WXE0-1]
ENST00000433559; ENSP00000406963; ENSG00000177303 [Q8WXE0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57513

UCSC genome browser

More...
UCSCi
uc002joc.5 human [Q8WXE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451976 mRNA Translation: AAL49757.1
AK300354 mRNA Translation: BAG62095.1
AK315936 mRNA Translation: BAH14307.1
AC100787 Genomic DNA No translation available.
BC066643 mRNA Translation: AAH66643.1
AB032965 mRNA Translation: BAA86453.1
CCDSiCCDS11723.1 [Q8WXE0-1]
CCDS45775.1 [Q8WXE0-2]
RefSeqiNP_001136115.1, NM_001142643.2 [Q8WXE0-2]
NP_065804.2, NM_020753.4 [Q8WXE0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KE9NMR-A284-348[»]
4IS7X-ray2.75A483-633[»]
5L1MX-ray2.75A483-633[»]
SMRiQ8WXE0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121577, 12 interactors
IntActiQ8WXE0, 5 interactors
STRINGi9606.ENSP00000325355

PTM databases

iPTMnetiQ8WXE0
PhosphoSitePlusiQ8WXE0
SwissPalmiQ8WXE0

Polymorphism and mutation databases

BioMutaiCASKIN2
DMDMi296434467

Proteomic databases

EPDiQ8WXE0
jPOSTiQ8WXE0
MassIVEiQ8WXE0
MaxQBiQ8WXE0
PaxDbiQ8WXE0
PeptideAtlasiQ8WXE0
PRIDEiQ8WXE0
ProteomicsDBi75016 [Q8WXE0-1]
75017 [Q8WXE0-2]

Genome annotation databases

EnsembliENST00000321617; ENSP00000325355; ENSG00000177303 [Q8WXE0-1]
ENST00000433559; ENSP00000406963; ENSG00000177303 [Q8WXE0-2]
GeneIDi57513
KEGGihsa:57513
UCSCiuc002joc.5 human [Q8WXE0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57513
DisGeNETi57513

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASKIN2
HGNCiHGNC:18200 CASKIN2
HPAiHPA071906
HPA075184
MIMi612185 gene
neXtProtiNX_Q8WXE0
OpenTargetsiENSG00000177303
PharmGKBiPA134944093

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0507 Eukaryota
KOG4384 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000158256
HOGENOMiHOG000049168
InParanoidiQ8WXE0
KOiK21952
OMAiAEAIYNW
OrthoDBi75723at2759
PhylomeDBiQ8WXE0
TreeFamiTF320582

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CASKIN2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57513
PharosiQ8WXE0

Protein Ontology

More...
PROi
PR:Q8WXE0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177303 Expressed in 205 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiQ8WXE0 baseline and differential
GenevisibleiQ8WXE0 HS

Family and domain databases

CDDicd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12063 SH3_Caskin2, 1 hit
Gene3Di1.10.150.50, 2 hits
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1/2
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035499 Caskin2_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24174:SF7 PTHR24174:SF7, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSKI2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXE0
Secondary accession number(s): B4DTT3
, B7Z9H1, Q7LG69, Q9ULT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again