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Protein

Caskin-2

Gene

CASKIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-2
Alternative name(s):
CASK-interacting protein 2
Gene namesi
Name:CASKIN2
Synonyms:KIAA1139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000177303.9
HGNCiHGNC:18200 CASKIN2
MIMi612185 gene
neXtProtiNX_Q8WXE0

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177303
PharmGKBiPA134944093

Polymorphism and mutation databases

DMDMi296434467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669831 – 1202Caskin-2Add BLAST1202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei471PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei877PhosphoserineBy similarity1
Modified residuei878PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXE0
MaxQBiQ8WXE0
PaxDbiQ8WXE0
PeptideAtlasiQ8WXE0
PRIDEiQ8WXE0
ProteomicsDBi75016
75017 [Q8WXE0-2]

PTM databases

iPTMnetiQ8WXE0
PhosphoSitePlusiQ8WXE0
SwissPalmiQ8WXE0

Expressioni

Gene expression databases

BgeeiENSG00000177303 Expressed in 205 organ(s), highest expression level in olfactory bulb
CleanExiHS_CASKIN2
ExpressionAtlasiQ8WXE0 baseline and differential
GenevisibleiQ8WXE0 HS

Organism-specific databases

HPAiHPA071906
HPA075184

Interactioni

Subunit structurei

May not bind CASK.

Protein-protein interaction databases

BioGridi121577, 8 interactors
IntActiQ8WXE0, 3 interactors
STRINGi9606.ENSP00000325355

Structurei

Secondary structure

11202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WXE0
SMRiQ8WXE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini489 – 552SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini558 – 622SAM 2PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi685 – 1133Pro-richAdd BLAST449

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0507 Eukaryota
KOG4384 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148972
HOGENOMiHOG000049168
HOVERGENiHBG051133
InParanoidiQ8WXE0
KOiK21952
OMAiPYVFMYP
OrthoDBiEOG091G00P3
PhylomeDBiQ8WXE0
TreeFamiTF320582

Family and domain databases

CDDicd00204 ANK, 3 hits
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12063 SH3_Caskin2, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035499 Caskin2_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGREQDLILA VKNGDVTGVQ KLVAKVKATK TKLLGSTKRL NVNYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKAKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLR AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRIGYFPPG IVEVVSKRVG
360 370 380 390 400
IPAARLPSAP TPLRPGFSRT PQPPAEEPPH PLTYSQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGP GLLIENAQPL PSAGEDQVLP
460 470 480 490 500
GLHPPSLADN LSHRPLANCR SGEQIFTQDV RPEQLLEGKD AQAIHNWLSE
510 520 530 540 550
FQLEGYTAHF LQAGYDVPTI SRMTPEDLTA IGVTKPGHRK KIASEIAQLS
560 570 580 590 600
IAEWLPSYIP TDLLEWLCAL GLPQYHKQLV SSGYDSMGLV ADLTWEELQE
610 620 630 640 650
IGVNKLGHQK KLMLGVKRLA ELRRGLLQGE ALSEGGRRLA KGPELMAIEG
660 670 680 690 700
LENGEGPATA GPRLLTFQGS ELSPELQAAM AGGGPEPLPL PPARSPSQES
710 720 730 740 750
IGARSRGSGH SQEQPAPQPS GGDPSPPQER NLPEGTERPP KLCSSLPGQG
760 770 780 790 800
PPPYVFMYPQ GSPSSPAPGP PPGAPWAFSY LAGPPATPPD PPRPKRRSHS
810 820 830 840 850
LSRPGPTEGD AEGEAEGPVG STLGSYATLT RRPGRSALVR TSPSVTPTPA
860 870 880 890 900
RGTPRSQSFA LRARRKGPPP PPPKRLSSVS GPSPEPPPLD ESPGPKEGAT
910 920 930 940 950
GPRRRTLSEP AGPSEPPGPP APAGPASDTE EEEPGPEGTP PSRGSSGEGL
960 970 980 990 1000
PFAEEGNLTI KQRPKPAGPP PRETPVPPGL DFNLTESDTV KRRPKCRERE
1010 1020 1030 1040 1050
PLQTALLAFG VASATPGPAA PLPSPTPGES PPASSLPQPE PSSLPAQGVP
1060 1070 1080 1090 1100
TPLAPSPAMQ PPVPPCPGPG LESSAASRWN GETEPPAAPA ALLKVPGAGT
1110 1120 1130 1140 1150
APKPVSVACT QLAFSGPKLA PRLGPRPVPP PRPESTGTVG PGQAQQRLEQ
1160 1170 1180 1190 1200
TSSSLAAALR AAEKSIGTKE QEGTPSASTK HILDDISTMF DALADQLDAM

LD
Length:1,202
Mass (Da):126,783
Last modified:May 18, 2010 - v2
Checksum:i881E6BAEEBDF3DC5
GO
Isoform 2 (identifier: Q8WXE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:1,120
Mass (Da):118,157
Checksum:iF120B5C26DAD308B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRN1J3QRN1_HUMAN
Caskin-2
CASKIN2
323Annotation score:
J3QKS3J3QKS3_HUMAN
Caskin-2
CASKIN2
25Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti640A → G in BAH14307 (PubMed:14702039).Curated1
Sequence conflicti1093L → P in BAH14307 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060244891E → GCombined sources4 PublicationsCorresponds to variant dbSNP:rs7503373Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0405681 – 82Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451976 mRNA Translation: AAL49757.1
AK300354 mRNA Translation: BAG62095.1
AK315936 mRNA Translation: BAH14307.1
AC100787 Genomic DNA No translation available.
BC066643 mRNA Translation: AAH66643.1
AB032965 mRNA Translation: BAA86453.1
CCDSiCCDS11723.1 [Q8WXE0-1]
CCDS45775.1 [Q8WXE0-2]
RefSeqiNP_001136115.1, NM_001142643.2 [Q8WXE0-2]
NP_065804.2, NM_020753.4 [Q8WXE0-1]
UniGeneiHs.274408
Hs.745460

Genome annotation databases

EnsembliENST00000321617; ENSP00000325355; ENSG00000177303 [Q8WXE0-1]
ENST00000433559; ENSP00000406963; ENSG00000177303 [Q8WXE0-2]
GeneIDi57513
KEGGihsa:57513
UCSCiuc002joc.5 human [Q8WXE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451976 mRNA Translation: AAL49757.1
AK300354 mRNA Translation: BAG62095.1
AK315936 mRNA Translation: BAH14307.1
AC100787 Genomic DNA No translation available.
BC066643 mRNA Translation: AAH66643.1
AB032965 mRNA Translation: BAA86453.1
CCDSiCCDS11723.1 [Q8WXE0-1]
CCDS45775.1 [Q8WXE0-2]
RefSeqiNP_001136115.1, NM_001142643.2 [Q8WXE0-2]
NP_065804.2, NM_020753.4 [Q8WXE0-1]
UniGeneiHs.274408
Hs.745460

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KE9NMR-A284-348[»]
4IS7X-ray2.75A483-633[»]
5L1MX-ray2.75A483-633[»]
ProteinModelPortaliQ8WXE0
SMRiQ8WXE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121577, 8 interactors
IntActiQ8WXE0, 3 interactors
STRINGi9606.ENSP00000325355

PTM databases

iPTMnetiQ8WXE0
PhosphoSitePlusiQ8WXE0
SwissPalmiQ8WXE0

Polymorphism and mutation databases

DMDMi296434467

Proteomic databases

EPDiQ8WXE0
MaxQBiQ8WXE0
PaxDbiQ8WXE0
PeptideAtlasiQ8WXE0
PRIDEiQ8WXE0
ProteomicsDBi75016
75017 [Q8WXE0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321617; ENSP00000325355; ENSG00000177303 [Q8WXE0-1]
ENST00000433559; ENSP00000406963; ENSG00000177303 [Q8WXE0-2]
GeneIDi57513
KEGGihsa:57513
UCSCiuc002joc.5 human [Q8WXE0-1]

Organism-specific databases

CTDi57513
EuPathDBiHostDB:ENSG00000177303.9
GeneCardsiCASKIN2
H-InvDBiHIX0020291
HGNCiHGNC:18200 CASKIN2
HPAiHPA071906
HPA075184
MIMi612185 gene
neXtProtiNX_Q8WXE0
OpenTargetsiENSG00000177303
PharmGKBiPA134944093
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0507 Eukaryota
KOG4384 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148972
HOGENOMiHOG000049168
HOVERGENiHBG051133
InParanoidiQ8WXE0
KOiK21952
OMAiPYVFMYP
OrthoDBiEOG091G00P3
PhylomeDBiQ8WXE0
TreeFamiTF320582

Miscellaneous databases

GenomeRNAii57513
PROiPR:Q8WXE0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177303 Expressed in 205 organ(s), highest expression level in olfactory bulb
CleanExiHS_CASKIN2
ExpressionAtlasiQ8WXE0 baseline and differential
GenevisibleiQ8WXE0 HS

Family and domain databases

CDDicd00204 ANK, 3 hits
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12063 SH3_Caskin2, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035499 Caskin2_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSKI2_HUMAN
AccessioniPrimary (citable) accession number: Q8WXE0
Secondary accession number(s): B4DTT3
, B7Z9H1, Q7LG69, Q9ULT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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