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Protein

Caskin-1

Gene

CASKIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May link the scaffolding protein CASK to downstream intracellular effectors.By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • signal transduction Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-1
Alternative name(s):
CASK-interacting protein 1
Gene namesi
Name:CASKIN1
Synonyms:KIAA1306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000167971.15
HGNCiHGNC:20879 CASKIN1
MIMi612184 gene
neXtProtiNX_Q8WXD9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167971
PharmGKBiPA134878267

Polymorphism and mutation databases

BioMutaiCASKIN1
DMDMi61213003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669801 – 1431Caskin-1Add BLAST1431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei398Omega-N-methylarginineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei633PhosphoserineBy similarity1
Modified residuei646PhosphoserineBy similarity1
Modified residuei719PhosphoserineBy similarity1
Modified residuei724PhosphoserineBy similarity1
Modified residuei737PhosphothreonineBy similarity1
Modified residuei787PhosphoserineCombined sources1
Modified residuei889PhosphoserineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei987PhosphoserineBy similarity1
Modified residuei1065PhosphothreonineBy similarity1
Modified residuei1067PhosphoserineBy similarity1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1266PhosphothreonineBy similarity1
Modified residuei1364PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8WXD9
MaxQBiQ8WXD9
PaxDbiQ8WXD9
PeptideAtlasiQ8WXD9
PRIDEiQ8WXD9
ProteomicsDBi75015

PTM databases

iPTMnetiQ8WXD9
PhosphoSitePlusiQ8WXD9

Expressioni

Gene expression databases

BgeeiENSG00000167971 Expressed in 118 organ(s), highest expression level in cerebellum
CleanExiHS_CASKIN1
GenevisibleiQ8WXD9 HS

Organism-specific databases

HPAiCAB079050
HPA055990

Interactioni

Subunit structurei

Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1 (By similarity). Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121585, 3 interactors
DIPiDIP-34890N
IntActiQ8WXD9, 1 interactor
STRINGi9606.ENSP00000345436

Structurei

Secondary structure

11431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WXD9
SMRiQ8WXD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini472 – 535SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini541 – 605SAM 2PROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 469CASK-bindingBy similarityAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi714 – 1365Pro-richAdd BLAST652

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410INAR Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148972
HOGENOMiHOG000049168
HOVERGENiHBG051133
InParanoidiQ8WXD9
KOiK21952
OMAiKIQGSPT
OrthoDBiEOG091G00P3
PhylomeDBiQ8WXD9
TreeFamiTF320582

Family and domain databases

CDDicd00204 ANK, 2 hits
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12062 SH3_Caskin1, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1
IPR032232 Caskin1-CID
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035495 Caskin1_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24177:SF12 PTHR24177:SF12, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF16600 Caskin1-CID, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WXD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF
60 70 80 90 100
SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL
110 120 130 140 150
VLKAGSAVNI PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT
160 170 180 190 200
PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDATDPNGT SPLHLAAKNG
210 220 230 240 250
HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAHVR
260 270 280 290 300
NTYSQTALDI VHQFTTSQAS REIKQLLREA SAALQVRATK DYCNNYDLTS
310 320 330 340 350
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG
360 370 380 390 400
SRAGTEPSLP QGSSSSGPSA PPEEIWVLRK PFAGGDRSGS ISGMAGGRGS
410 420 430 440 450
GGHALHAGSE GVKLLATVLS QKSVSESGPG DSPAKPPEGS AGVARSQPPV
460 470 480 490 500
AHAGQVYGEQ PPKKLEPASE GKSSEAVSQW LTAFQLQLYA PNFISAGYDL
510 520 530 540 550
PTISRMTPED LTAIGVTKPG HRKKIAAEIS GLSIPDWLPE HKPANLAVWL
560 570 580 590 600
SMIGLAQYYK VLVDNGYENI DFITDITWED LQEIGITKLG HQKKLMLAVR
610 620 630 640 650
KLAELQKAEY AKYEGGPLRR KAPQSLEVMA IESPPPPEPT PADCQSPKMT
660 670 680 690 700
TFQDSELSDE LQAAMTGPAE VGPTTEKPSS HLPPTPRATT RQDSSLGGRA
710 720 730 740 750
RHMSSSQELL GDGPPGPSSP MSRSQEYLLD EGPAPGTPPR EARPGRHGHS
760 770 780 790 800
IKRASVPPVP GKPRQVLPPG TSHFTPPQTP TKTRPGSPQA LGGPHGPAPA
810 820 830 840 850
TAKVKPTPQL LPPTERPMSP RSLPQSPTHR GFAYVLPQPV EGEVGPAAPG
860 870 880 890 900
PAPPPVPTAV PTLCLPPEAD AEPGRPKKRA HSLNRYAASD SEPERDELLV
910 920 930 940 950
PAAAGPYATV QRRVGRSHSV RAPAGADKNV NRSQSFAVRP RKKGPPPPPP
960 970 980 990 1000
KRSSSALASA NLADEPVPDA EPEDGLLGVR AQCRRASDLA GSVDTGSAGS
1010 1020 1030 1040 1050
VKSIAAMLEL SSIGGGGRAA RRPPEGHPTP RPASPEPGRV ATVLASVKHK
1060 1070 1080 1090 1100
EAIGPGGEVV NRRRTLSGPV TGLLATARRG PGESADPGPF VEDGTGRQRP
1110 1120 1130 1140 1150
RGPSKGEAGV EGPPLAKVEA SATLKRRIRA KQNQQENVKF ILTESDTVKR
1160 1170 1180 1190 1200
RPKAKEREAG PEPPPPLSVY HNGTGTVRRR PASEQAGPPE LPPPPPPAEP
1210 1220 1230 1240 1250
PPTDLAHLPP LPPPEGEARK PAKPPVSPKP VLTQPVPKLQ GSPTPTSKKV
1260 1270 1280 1290 1300
PLPGPGSPEV KRAHGTPPPV SPKPPPPPTA PKPVKAVAGL PSGSAGPSPA
1310 1320 1330 1340 1350
PSPARQPPAA LAKPPGTPPS LGASPAKPPS PGAPALHVPA KPPRAAAAAA
1360 1370 1380 1390 1400
AAAAAPPAPP EGASPGDSAR QKLEETSACL AAALQAVEEK IRQEDAQGPR
1410 1420 1430
DSAAEKSTGS ILDDIGSMFD DLADQLDAML E
Length:1,431
Mass (Da):149,814
Last modified:March 1, 2002 - v1
Checksum:iCDF60E68B81E884A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278R → P in BAA92544 (PubMed:10718198).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451977 mRNA Translation: AAL49758.1
AB037727 mRNA Translation: BAA92544.1
CCDSiCCDS42103.1
RefSeqiNP_065815.1, NM_020764.3
UniGeneiHs.643537

Genome annotation databases

EnsembliENST00000343516; ENSP00000345436; ENSG00000167971
GeneIDi57524
KEGGihsa:57524
UCSCiuc010bsg.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451977 mRNA Translation: AAL49758.1
AB037727 mRNA Translation: BAA92544.1
CCDSiCCDS42103.1
RefSeqiNP_065815.1, NM_020764.3
UniGeneiHs.643537

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SEIX-ray2.40A/B470-605[»]
3SENX-ray3.10A/B/C/D470-613[»]
ProteinModelPortaliQ8WXD9
SMRiQ8WXD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121585, 3 interactors
DIPiDIP-34890N
IntActiQ8WXD9, 1 interactor
STRINGi9606.ENSP00000345436

PTM databases

iPTMnetiQ8WXD9
PhosphoSitePlusiQ8WXD9

Polymorphism and mutation databases

BioMutaiCASKIN1
DMDMi61213003

Proteomic databases

EPDiQ8WXD9
MaxQBiQ8WXD9
PaxDbiQ8WXD9
PeptideAtlasiQ8WXD9
PRIDEiQ8WXD9
ProteomicsDBi75015

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343516; ENSP00000345436; ENSG00000167971
GeneIDi57524
KEGGihsa:57524
UCSCiuc010bsg.2 human

Organism-specific databases

CTDi57524
EuPathDBiHostDB:ENSG00000167971.15
GeneCardsiCASKIN1
HGNCiHGNC:20879 CASKIN1
HPAiCAB079050
HPA055990
MIMi612184 gene
neXtProtiNX_Q8WXD9
OpenTargetsiENSG00000167971
PharmGKBiPA134878267
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INAR Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148972
HOGENOMiHOG000049168
HOVERGENiHBG051133
InParanoidiQ8WXD9
KOiK21952
OMAiKIQGSPT
OrthoDBiEOG091G00P3
PhylomeDBiQ8WXD9
TreeFamiTF320582

Miscellaneous databases

ChiTaRSiCASKIN1 human
GenomeRNAii57524
PROiPR:Q8WXD9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167971 Expressed in 118 organ(s), highest expression level in cerebellum
CleanExiHS_CASKIN1
GenevisibleiQ8WXD9 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12062 SH3_Caskin1, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1
IPR032232 Caskin1-CID
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035495 Caskin1_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24177:SF12 PTHR24177:SF12, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF16600 Caskin1-CID, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSKI1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXD9
Secondary accession number(s): Q9P2P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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