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Entry version 146 (17 Jun 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Caskin-1

Gene

CASKIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May link the scaffolding protein CASK to downstream intracellular effectors.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • signal transduction Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caskin-1
Alternative name(s):
CASK-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASKIN1
Synonyms:KIAA1306
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167971.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20879 CASKIN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612184 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXD9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000167971

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134878267

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WXD9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASKIN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61213003

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669801 – 1431Caskin-1Add BLAST1431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei253PhosphotyrosineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei398Omega-N-methylarginineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei633PhosphoserineBy similarity1
Modified residuei646PhosphoserineBy similarity1
Modified residuei719PhosphoserineBy similarity1
Modified residuei724PhosphoserineBy similarity1
Modified residuei737PhosphothreonineBy similarity1
Modified residuei787PhosphoserineCombined sources1
Modified residuei889PhosphoserineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei987PhosphoserineBy similarity1
Modified residuei1065PhosphothreonineBy similarity1
Modified residuei1067PhosphoserineBy similarity1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1266PhosphothreonineBy similarity1
Modified residuei1364PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXD9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WXD9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WXD9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WXD9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXD9

PeptideAtlas

More...
PeptideAtlasi
Q8WXD9

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXD9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75015

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167971 Expressed in cerebellum and 117 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXD9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167971 Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds the CaM kinase domain of CASK.

Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1 (By similarity). Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121585, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-34890N

Protein interaction database and analysis system

More...
IntActi
Q8WXD9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345436

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WXD9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WXD9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini472 – 535SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini541 – 605SAM 2PROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni375 – 469CASK-bindingBy similarityAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi714 – 1365Pro-richAdd BLAST652

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INAR Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003619_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXD9

KEGG Orthology (KO)

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KOi
K21952

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEDGQGP

Database of Orthologous Groups

More...
OrthoDBi
75723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXD9

TreeFam database of animal gene trees

More...
TreeFami
TF320582

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12062 SH3_Caskin1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1/2
IPR032232 Caskin1-CID
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035495 Caskin1_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF11 PTHR24174:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF16600 Caskin1-CID, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WXD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF
60 70 80 90 100
SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL
110 120 130 140 150
VLKAGSAVNI PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT
160 170 180 190 200
PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDATDPNGT SPLHLAAKNG
210 220 230 240 250
HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAHVR
260 270 280 290 300
NTYSQTALDI VHQFTTSQAS REIKQLLREA SAALQVRATK DYCNNYDLTS
310 320 330 340 350
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG
360 370 380 390 400
SRAGTEPSLP QGSSSSGPSA PPEEIWVLRK PFAGGDRSGS ISGMAGGRGS
410 420 430 440 450
GGHALHAGSE GVKLLATVLS QKSVSESGPG DSPAKPPEGS AGVARSQPPV
460 470 480 490 500
AHAGQVYGEQ PPKKLEPASE GKSSEAVSQW LTAFQLQLYA PNFISAGYDL
510 520 530 540 550
PTISRMTPED LTAIGVTKPG HRKKIAAEIS GLSIPDWLPE HKPANLAVWL
560 570 580 590 600
SMIGLAQYYK VLVDNGYENI DFITDITWED LQEIGITKLG HQKKLMLAVR
610 620 630 640 650
KLAELQKAEY AKYEGGPLRR KAPQSLEVMA IESPPPPEPT PADCQSPKMT
660 670 680 690 700
TFQDSELSDE LQAAMTGPAE VGPTTEKPSS HLPPTPRATT RQDSSLGGRA
710 720 730 740 750
RHMSSSQELL GDGPPGPSSP MSRSQEYLLD EGPAPGTPPR EARPGRHGHS
760 770 780 790 800
IKRASVPPVP GKPRQVLPPG TSHFTPPQTP TKTRPGSPQA LGGPHGPAPA
810 820 830 840 850
TAKVKPTPQL LPPTERPMSP RSLPQSPTHR GFAYVLPQPV EGEVGPAAPG
860 870 880 890 900
PAPPPVPTAV PTLCLPPEAD AEPGRPKKRA HSLNRYAASD SEPERDELLV
910 920 930 940 950
PAAAGPYATV QRRVGRSHSV RAPAGADKNV NRSQSFAVRP RKKGPPPPPP
960 970 980 990 1000
KRSSSALASA NLADEPVPDA EPEDGLLGVR AQCRRASDLA GSVDTGSAGS
1010 1020 1030 1040 1050
VKSIAAMLEL SSIGGGGRAA RRPPEGHPTP RPASPEPGRV ATVLASVKHK
1060 1070 1080 1090 1100
EAIGPGGEVV NRRRTLSGPV TGLLATARRG PGESADPGPF VEDGTGRQRP
1110 1120 1130 1140 1150
RGPSKGEAGV EGPPLAKVEA SATLKRRIRA KQNQQENVKF ILTESDTVKR
1160 1170 1180 1190 1200
RPKAKEREAG PEPPPPLSVY HNGTGTVRRR PASEQAGPPE LPPPPPPAEP
1210 1220 1230 1240 1250
PPTDLAHLPP LPPPEGEARK PAKPPVSPKP VLTQPVPKLQ GSPTPTSKKV
1260 1270 1280 1290 1300
PLPGPGSPEV KRAHGTPPPV SPKPPPPPTA PKPVKAVAGL PSGSAGPSPA
1310 1320 1330 1340 1350
PSPARQPPAA LAKPPGTPPS LGASPAKPPS PGAPALHVPA KPPRAAAAAA
1360 1370 1380 1390 1400
AAAAAPPAPP EGASPGDSAR QKLEETSACL AAALQAVEEK IRQEDAQGPR
1410 1420 1430
DSAAEKSTGS ILDDIGSMFD DLADQLDAML E
Length:1,431
Mass (Da):149,814
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDF60E68B81E884A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278R → P in BAA92544 (PubMed:10718198).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF451977 mRNA Translation: AAL49758.1
AB037727 mRNA Translation: BAA92544.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42103.1

NCBI Reference Sequences

More...
RefSeqi
NP_065815.1, NM_020764.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343516; ENSP00000345436; ENSG00000167971

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57524

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57524

UCSC genome browser

More...
UCSCi
uc010bsg.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451977 mRNA Translation: AAL49758.1
AB037727 mRNA Translation: BAA92544.1
CCDSiCCDS42103.1
RefSeqiNP_065815.1, NM_020764.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SEIX-ray2.40A/B470-605[»]
3SENX-ray3.10A/B/C/D470-613[»]
SMRiQ8WXD9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121585, 3 interactors
DIPiDIP-34890N
IntActiQ8WXD9, 3 interactors
STRINGi9606.ENSP00000345436

PTM databases

iPTMnetiQ8WXD9
PhosphoSitePlusiQ8WXD9

Polymorphism and mutation databases

BioMutaiCASKIN1
DMDMi61213003

Proteomic databases

EPDiQ8WXD9
jPOSTiQ8WXD9
MassIVEiQ8WXD9
MaxQBiQ8WXD9
PaxDbiQ8WXD9
PeptideAtlasiQ8WXD9
PRIDEiQ8WXD9
ProteomicsDBi75015

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
61351 25 antibodies

Genome annotation databases

EnsembliENST00000343516; ENSP00000345436; ENSG00000167971
GeneIDi57524
KEGGihsa:57524
UCSCiuc010bsg.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57524
EuPathDBiHostDB:ENSG00000167971.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CASKIN1
HGNCiHGNC:20879 CASKIN1
HPAiENSG00000167971 Tissue enriched (brain)
MIMi612184 gene
neXtProtiNX_Q8WXD9
OpenTargetsiENSG00000167971
PharmGKBiPA134878267

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410INAR Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000158025
HOGENOMiCLU_003619_1_1_1
InParanoidiQ8WXD9
KOiK21952
OMAiQEDGQGP
OrthoDBi75723at2759
PhylomeDBiQ8WXD9
TreeFamiTF320582

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57524 1 hit in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CASKIN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57524
PharosiQ8WXD9 Tdark

Protein Ontology

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PROi
PR:Q8WXD9
RNActiQ8WXD9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167971 Expressed in cerebellum and 117 other tissues
GenevisibleiQ8WXD9 HS

Family and domain databases

CDDicd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12062 SH3_Caskin1, 1 hit
Gene3Di1.10.150.50, 2 hits
1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1/2
IPR032232 Caskin1-CID
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035495 Caskin1_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24174:SF11 PTHR24174:SF11, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF16600 Caskin1-CID, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSKI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXD9
Secondary accession number(s): Q9P2P0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2002
Last modified: June 17, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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