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Protein

Secretogranin-3

Gene

SCG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
Secretogranin III
Short name:
SgIII
Gene namesi
Name:SCG3
ORF Names:UNQ2502/PRO5990
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104112.8
HGNCiHGNC:13707 SCG3
MIMi611796 gene
neXtProtiNX_Q8WXD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi29106
OpenTargetsiENSG00000104112
PharmGKBiPA34988

Polymorphism and mutation databases

BioMutaiSCG3
DMDMi46397796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000546120 – 468Secretogranin-3Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Glycosylationi216O-linked (GalNAc...) threonine1 Publication1
Glycosylationi231O-linked (GalNAc...) threonine1 Publication1
Glycosylationi359O-linked (GalNAc...) serine1 Publication1
Modified residuei362PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8WXD2
PaxDbiQ8WXD2
PeptideAtlasiQ8WXD2
PRIDEiQ8WXD2
ProteomicsDBi75012
75013 [Q8WXD2-2]

PTM databases

GlyConnecti732
iPTMnetiQ8WXD2
PhosphoSitePlusiQ8WXD2
UniCarbKBiQ8WXD2

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000104112 Expressed in 110 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_SCG3
ExpressionAtlasiQ8WXD2 baseline and differential
GenevisibleiQ8WXD2 HS

Organism-specific databases

HPAiCAB033274
HPA006880
HPA053715

Interactioni

Subunit structurei

Interacts with CHGA.By similarity

Protein-protein interaction databases

BioGridi118874, 6 interactors
DIPiDIP-29451N
IntActiQ8WXD2, 3 interactors
STRINGi9606.ENSP00000220478

Structurei

3D structure databases

ProteinModelPortaliQ8WXD2
SMRiQ8WXD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUH Eukaryota
ENOG4110KQ3 LUCA
GeneTreeiENSGT00390000005488
HOGENOMiHOG000247064
HOVERGENiHBG057085
InParanoidiQ8WXD2
OMAiENKPGQS
OrthoDBiEOG091G06X3
PhylomeDBiQ8WXD2
TreeFamiTF331266

Family and domain databases

InterProiView protein in InterPro
IPR026197 SCG3
PANTHERiPTHR17388 PTHR17388, 1 hit
PfamiView protein in Pfam
PF15467 SGIII, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE
60 70 80 90 100
EDKIKKTYPP ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD
110 120 130 140 150
NKLNVEDVDS TKNRKLIDDY DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED
160 170 180 190 200
IVHKIAARIY EENDRAVFDK IVSKLLNLGL ITESQAHTLE DEVAEVLQKL
210 220 230 240 250
ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL AKGENDETVS
260 270 280 290 300
NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI
310 320 330 340 350
TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN
360 370 380 390 400
ISKLFPAPSE KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE
410 420 430 440 450
PKGKTEAYLE AIRKNIEWLK KHDKKGNKED YDLSKMRDFI NKQADAYVEK
460
GILDKEEAEA IKRIYSSL
Length:468
Mass (Da):53,005
Last modified:April 13, 2004 - v3
Checksum:i5E6BBDDFFF3B8D82
GO
Isoform 2 (identifier: Q8WXD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):26,909
Checksum:i8B855AF34EBA3A0E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKC2H0YKC2_HUMAN
Secretogranin-3
SCG3
57Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79K → R in AAD44483 (Ref. 1) Curated1
Sequence conflicti150D → G in BAG52108 (PubMed:14702039).Curated1
Sequence conflicti272 – 274EEL → RDF in AAD44483 (Ref. 1) Curated3
Sequence conflicti421K → R in BAG59111 (PubMed:14702039).Curated1

Polymorphismi

Polymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013827125S → N. Corresponds to variant dbSNP:rs2305710Ensembl.1
Natural variantiVAR_067273167V → A1 PublicationCorresponds to variant dbSNP:rs17851186Ensembl.1
Natural variantiVAR_034484233M → V. Corresponds to variant dbSNP:rs35664837Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428761 – 232Missing in isoform 2. 1 PublicationAdd BLAST232

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078851 mRNA Translation: AAD44483.1
AF453583 mRNA Translation: AAL67431.1
AY359093 mRNA Translation: AAQ89451.1
AK075314 mRNA Translation: BAG52108.1
AK290175 mRNA Translation: BAF82864.1
AK296466 mRNA Translation: BAG59111.1
AC020892 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77426.1
BC009511 mRNA Translation: AAH09511.2
BC014539 mRNA Translation: AAH14539.1
CCDSiCCDS10142.1 [Q8WXD2-1]
CCDS53947.1 [Q8WXD2-2]
RefSeqiNP_001158729.1, NM_001165257.1 [Q8WXD2-2]
NP_037375.2, NM_013243.3 [Q8WXD2-1]
UniGeneiHs.232618

Genome annotation databases

EnsembliENST00000220478; ENSP00000220478; ENSG00000104112 [Q8WXD2-1]
ENST00000542355; ENSP00000445205; ENSG00000104112 [Q8WXD2-2]
GeneIDi29106
KEGGihsa:29106
UCSCiuc002abh.4 human [Q8WXD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078851 mRNA Translation: AAD44483.1
AF453583 mRNA Translation: AAL67431.1
AY359093 mRNA Translation: AAQ89451.1
AK075314 mRNA Translation: BAG52108.1
AK290175 mRNA Translation: BAF82864.1
AK296466 mRNA Translation: BAG59111.1
AC020892 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77426.1
BC009511 mRNA Translation: AAH09511.2
BC014539 mRNA Translation: AAH14539.1
CCDSiCCDS10142.1 [Q8WXD2-1]
CCDS53947.1 [Q8WXD2-2]
RefSeqiNP_001158729.1, NM_001165257.1 [Q8WXD2-2]
NP_037375.2, NM_013243.3 [Q8WXD2-1]
UniGeneiHs.232618

3D structure databases

ProteinModelPortaliQ8WXD2
SMRiQ8WXD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118874, 6 interactors
DIPiDIP-29451N
IntActiQ8WXD2, 3 interactors
STRINGi9606.ENSP00000220478

PTM databases

GlyConnecti732
iPTMnetiQ8WXD2
PhosphoSitePlusiQ8WXD2
UniCarbKBiQ8WXD2

Polymorphism and mutation databases

BioMutaiSCG3
DMDMi46397796

Proteomic databases

EPDiQ8WXD2
PaxDbiQ8WXD2
PeptideAtlasiQ8WXD2
PRIDEiQ8WXD2
ProteomicsDBi75012
75013 [Q8WXD2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220478; ENSP00000220478; ENSG00000104112 [Q8WXD2-1]
ENST00000542355; ENSP00000445205; ENSG00000104112 [Q8WXD2-2]
GeneIDi29106
KEGGihsa:29106
UCSCiuc002abh.4 human [Q8WXD2-1]

Organism-specific databases

CTDi29106
DisGeNETi29106
EuPathDBiHostDB:ENSG00000104112.8
GeneCardsiSCG3
HGNCiHGNC:13707 SCG3
HPAiCAB033274
HPA006880
HPA053715
MIMi611796 gene
neXtProtiNX_Q8WXD2
OpenTargetsiENSG00000104112
PharmGKBiPA34988
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUH Eukaryota
ENOG4110KQ3 LUCA
GeneTreeiENSGT00390000005488
HOGENOMiHOG000247064
HOVERGENiHBG057085
InParanoidiQ8WXD2
OMAiENKPGQS
OrthoDBiEOG091G06X3
PhylomeDBiQ8WXD2
TreeFamiTF331266

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiSCG3 human
GeneWikiiSCG3
GenomeRNAii29106
PROiPR:Q8WXD2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104112 Expressed in 110 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_SCG3
ExpressionAtlasiQ8WXD2 baseline and differential
GenevisibleiQ8WXD2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026197 SCG3
PANTHERiPTHR17388 PTHR17388, 1 hit
PfamiView protein in Pfam
PF15467 SGIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG3_HUMAN
AccessioniPrimary (citable) accession number: Q8WXD2
Secondary accession number(s): A8K2B0
, B3KQP6, B4DK99, F5H3R8, Q96C83, Q96GE8, Q9Y6G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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