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Entry version 167 (08 May 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Relaxin receptor 2

Gene

RXFP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418555 G alpha (s) signalling events
R-HSA-444821 Relaxin receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WXD0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Relaxin receptor 2
Alternative name(s):
G-protein coupled receptor 106
G-protein coupled receptor affecting testicular descent
Leucine-rich repeat-containing G-protein coupled receptor 8
Relaxin family peptide receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RXFP2
Synonyms:GPR106, GREAT, LGR8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17318 RXFP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606655 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXD0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 416ExtracellularSequence analysisAdd BLAST416
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei417 – 437Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini438 – 455CytoplasmicSequence analysisAdd BLAST18
Transmembranei456 – 476Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini477 – 495ExtracellularSequence analysisAdd BLAST19
Transmembranei496 – 518Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini519 – 537CytoplasmicSequence analysisAdd BLAST19
Transmembranei538 – 558Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini559 – 592ExtracellularSequence analysisAdd BLAST34
Transmembranei593 – 613Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini614 – 639CytoplasmicSequence analysisAdd BLAST26
Transmembranei640 – 660Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini661 – 670ExtracellularSequence analysis10
Transmembranei671 – 691Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini692 – 754CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cryptorchidism (CRYPTO)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionOne of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015386222T → P in CRYPTO; functionally inactive. 1 PublicationCorresponds to variant dbSNP:rs121918303EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi647D → Y: Leads to constitutive increase of basal cAMP. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
122042

MalaCards human disease database

More...
MalaCardsi
RXFP2
MIMi219050 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000133105

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918556

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1628482

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
352

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RXFP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21362625

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000697021 – 754Relaxin receptor 2Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 58By similarity
Disulfide bondi52 ↔ 71By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi65 ↔ 80By similarity
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi495 ↔ 573By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXD0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXD0

PeptideAtlas

More...
PeptideAtlasi
Q8WXD0

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXD0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75010
75011 [Q8WXD0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXD0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXD0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133105 Expressed in 38 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WXD0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125757, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000298386

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1754
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WXD0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 81LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati138 – 159LRR 1Add BLAST22
Repeati162 – 183LRR 2Add BLAST22
Repeati186 – 207LRR 3Add BLAST22
Repeati210 – 231LRR 4Add BLAST22
Repeati234 – 255LRR 5Add BLAST22
Repeati258 – 279LRR 6Add BLAST22
Repeati282 – 303LRR 7Add BLAST22
Repeati306 – 327LRR 8Add BLAST22
Repeati330 – 351LRR 9Add BLAST22
Repeati354 – 375LRR 10Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158948

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049056

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WXD0

KEGG Orthology (KO)

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KOi
K04307

Identification of Orthologs from Complete Genome Data

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OMAi
LQCRLMG

Database of Orthologous Groups

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OrthoDBi
559381at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WXD0

TreeFam database of animal gene trees

More...
TreeFami
TF326185

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 2 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR008112 Relaxin_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF13855 LRR_8, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR01739 RELAXINR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192 LDLa, 1 hit
SM00369 LRR_TYP, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS51450 LRR, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WXD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIVFLVFKHL FSLRLITMFF LLHFIVLINV KDFALTQGSM ITPSCQKGYF
60 70 80 90 100
PCGNLTKCLP RAFHCDGKDD CGNGADEENC GDTSGWATIF GTVHGNANSV
110 120 130 140 150
ALTQECFLKQ YPQCCDCKET ELECVNGDLK SVPMISNNVT LLSLKKNKIH
160 170 180 190 200
SLPDKVFIKY TKLKKIFLQH NCIRHISRKA FFGLCNLQIL YLNHNCITTL
210 220 230 240 250
RPGIFKDLHQ LTWLILDDNP ITRISQRLFT GLNSLFFLSM VNNYLEALPK
260 270 280 290 300
QMCAQMPQLN WVDLEGNRIK YLTNSTFLSC DSLTVLFLPR NQIGFVPEKT
310 320 330 340 350
FSSLKNLGEL DLSSNTITEL SPHLFKDLKL LQKLNLSSNP LMYLHKNQFE
360 370 380 390 400
SLKQLQSLDL ERIEIPNINT RMFQPMKNLS HIYFKNFRYC SYAPHVRICM
410 420 430 440 450
PLTDGISSFE DLLANNILRI FVWVIAFITC FGNLFVIGMR SFIKAENTTH
460 470 480 490 500
AMSIKILCCA DCLMGVYLFF VGIFDIKYRG QYQKYALLWM ESVQCRLMGF
510 520 530 540 550
LAMLSTEVSV LLLTYLTLEK FLVIVFPFSN IRPGKRQTSV ILICIWMAGF
560 570 580 590 600
LIAVIPFWNK DYFGNFYGKN GVCFPLYYDQ TEDIGSKGYS LGIFLGVNLL
610 620 630 640 650
AFLIIVFSYI TMFCSIQKTA LQTTEVRNCF GREVAVANRF FFIVFSDAIC
660 670 680 690 700
WIPVFVVKIL SLFRVEIPDT MTSWIVIFFL PVNSALNPIL YTLTTNFFKD
710 720 730 740 750
KLKQLLHKHQ RKSIFKIKKK SLSTSIVWIE DSSSLKLGVL NKITLGDSIM

KPVS
Length:754
Mass (Da):86,453
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2088ECD204C6A6C5
GO
Isoform 2 (identifier: Q8WXD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-309: Missing.

Note: No experimental confirmation available.
Show »
Length:730
Mass (Da):83,736
Checksum:i36274984AF9314E9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015386222T → P in CRYPTO; functionally inactive. 1 PublicationCorresponds to variant dbSNP:rs121918303EnsemblClinVar.1
Natural variantiVAR_015387604I → V1 PublicationCorresponds to variant dbSNP:rs17076657Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042831286 – 309Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF403384 mRNA Translation: AAL69324.2
AF453828 mRNA Translation: AAL73946.1
AY899851 mRNA Translation: AAX85199.1
AL138708 Genomic DNA No translation available.
AL159161 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08484.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53862.1 [Q8WXD0-2]
CCDS9342.1 [Q8WXD0-1]

NCBI Reference Sequences

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RefSeqi
NP_001159530.1, NM_001166058.1 [Q8WXD0-2]
NP_570718.1, NM_130806.4 [Q8WXD0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298386; ENSP00000298386; ENSG00000133105 [Q8WXD0-1]
ENST00000380314; ENSP00000369670; ENSG00000133105 [Q8WXD0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
122042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:122042

UCSC genome browser

More...
UCSCi
uc001utt.4 human [Q8WXD0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403384 mRNA Translation: AAL69324.2
AF453828 mRNA Translation: AAL73946.1
AY899851 mRNA Translation: AAX85199.1
AL138708 Genomic DNA No translation available.
AL159161 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08484.1
CCDSiCCDS53862.1 [Q8WXD0-2]
CCDS9342.1 [Q8WXD0-1]
RefSeqiNP_001159530.1, NM_001166058.1 [Q8WXD0-2]
NP_570718.1, NM_130806.4 [Q8WXD0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M96NMR-A38-81[»]
SMRiQ8WXD0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125757, 1 interactor
STRINGi9606.ENSP00000298386

Chemistry databases

ChEMBLiCHEMBL1628482
GuidetoPHARMACOLOGYi352

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiQ8WXD0
PhosphoSitePlusiQ8WXD0

Polymorphism and mutation databases

BioMutaiRXFP2
DMDMi21362625

Proteomic databases

EPDiQ8WXD0
PaxDbiQ8WXD0
PeptideAtlasiQ8WXD0
PRIDEiQ8WXD0
ProteomicsDBi75010
75011 [Q8WXD0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
122042
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298386; ENSP00000298386; ENSG00000133105 [Q8WXD0-1]
ENST00000380314; ENSP00000369670; ENSG00000133105 [Q8WXD0-2]
GeneIDi122042
KEGGihsa:122042
UCSCiuc001utt.4 human [Q8WXD0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
122042
DisGeNETi122042

GeneCards: human genes, protein and diseases

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GeneCardsi
RXFP2
HGNCiHGNC:17318 RXFP2
MalaCardsiRXFP2
MIMi219050 phenotype
606655 gene
neXtProtiNX_Q8WXD0
OpenTargetsiENSG00000133105
PharmGKBiPA134918556

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158948
HOGENOMiHOG000049056
InParanoidiQ8WXD0
KOiK04307
OMAiLQCRLMG
OrthoDBi559381at2759
PhylomeDBiQ8WXD0
TreeFamiTF326185

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-444821 Relaxin receptors
SIGNORiQ8WXD0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RXFP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Relaxin/insulin-like_family_peptide_receptor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
122042

Protein Ontology

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PROi
PR:Q8WXD0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000133105 Expressed in 38 organ(s), highest expression level in leukocyte
GenevisibleiQ8WXD0 HS

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di3.80.10.10, 2 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR008112 Relaxin_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF13855 LRR_8, 3 hits
PRINTSiPR00237 GPCRRHODOPSN
PR01739 RELAXINR
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00369 LRR_TYP, 10 hits
SUPFAMiSSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS51450 LRR, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRXFP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXD0
Secondary accession number(s): B1ALE9, Q3KU23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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