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Protein

Pyrin domain-containing protein 1

Gene

PYDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.2 Publications

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrin domain-containing protein 1Curated
Alternative name(s):
PAAD-only protein 11 Publication
Pyrin-only protein 11 Publication
cellular POP11 Publication
Short name:
cPOP11 Publication
Gene namesi
Name:PYDC1Imported
Synonyms:ASC21 Publication, ASCI, POP11 Publication, PYC1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169900.7
HGNCiHGNC:30261 PYDC1
MIMi615700 gene
neXtProtiNX_Q8WXC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi260434
OpenTargetsiENSG00000169900
PharmGKBiPA142671111

Polymorphism and mutation databases

BioMutaiPYDC1
DMDMi74730989

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805931 – 89Pyrin domain-containing protein 1Add BLAST89

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WXC3
PaxDbiQ8WXC3
PeptideAtlasiQ8WXC3
PRIDEiQ8WXC3
ProteomicsDBi75005

Expressioni

Tissue specificityi

Predominantly expressed in monocytes, macrophages and granulocytes.1 Publication

Gene expression databases

BgeeiENSG00000169900 Expressed in 67 organ(s), highest expression level in cerebellum
CleanExiHS_POP1
HS_PYDC1
GenevisibleiQ8WXC3 HS

Interactioni

Subunit structurei

Interacts with PYCARD/ASC (via pyrin domain).2 Publications

Protein-protein interaction databases

BioGridi129281, 1 interactor
IntActiQ8WXC3, 1 interactor
STRINGi9606.ENSP00000304336

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WXC3
SMRiQ8WXC3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WXC3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 89PyrinPROSITE-ProRule annotationAdd BLAST89

Phylogenomic databases

eggNOGiENOG410JDCM Eukaryota
ENOG4111636 LUCA
GeneTreeiENSGT00440000033973
HOGENOMiHOG000059575
InParanoidiQ8WXC3
KOiK12802
OMAiLRDIGMQ
OrthoDBiEOG091G0OWO
PhylomeDBiQ8WXC3

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WXC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTKREAILK VLENLTPEEL KKFKMKLGTV PLREGFERIP RGALGQLDIV
60 70 80
DLTDKLVASY YEDYAAELVV AVLRDMRMLE EAARLQRAA
Length:89
Mass (Da):10,107
Last modified:March 1, 2002 - v1
Checksum:i4CDF6D672DDDD98E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37E → G in AAN03745 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454669 mRNA Translation: AAL58439.1
AY163727 mRNA Translation: AAO23114.1
AF467809 mRNA Translation: AAN03745.1
AK313418 mRNA Translation: BAG36211.1
CH471192 Genomic DNA Translation: EAW52147.1
BC105033 mRNA Translation: AAI05034.1
BC105035 mRNA Translation: AAI05036.1
CCDSiCCDS10710.1
RefSeqiNP_690865.1, NM_152901.3
UniGeneiHs.58314

Genome annotation databases

EnsembliENST00000302964; ENSP00000304336; ENSG00000169900
GeneIDi260434
KEGGihsa:260434
UCSCiuc002ebo.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454669 mRNA Translation: AAL58439.1
AY163727 mRNA Translation: AAO23114.1
AF467809 mRNA Translation: AAN03745.1
AK313418 mRNA Translation: BAG36211.1
CH471192 Genomic DNA Translation: EAW52147.1
BC105033 mRNA Translation: AAI05034.1
BC105035 mRNA Translation: AAI05036.1
CCDSiCCDS10710.1
RefSeqiNP_690865.1, NM_152901.3
UniGeneiHs.58314

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HM2NMR-Q1-89[»]
4QOBX-ray2.70A/B1-89[»]
ProteinModelPortaliQ8WXC3
SMRiQ8WXC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129281, 1 interactor
IntActiQ8WXC3, 1 interactor
STRINGi9606.ENSP00000304336

Polymorphism and mutation databases

BioMutaiPYDC1
DMDMi74730989

Proteomic databases

EPDiQ8WXC3
PaxDbiQ8WXC3
PeptideAtlasiQ8WXC3
PRIDEiQ8WXC3
ProteomicsDBi75005

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302964; ENSP00000304336; ENSG00000169900
GeneIDi260434
KEGGihsa:260434
UCSCiuc002ebo.4 human

Organism-specific databases

CTDi260434
DisGeNETi260434
EuPathDBiHostDB:ENSG00000169900.7
GeneCardsiPYDC1
HGNCiHGNC:30261 PYDC1
MIMi615700 gene
neXtProtiNX_Q8WXC3
OpenTargetsiENSG00000169900
PharmGKBiPA142671111
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDCM Eukaryota
ENOG4111636 LUCA
GeneTreeiENSGT00440000033973
HOGENOMiHOG000059575
InParanoidiQ8WXC3
KOiK12802
OMAiLRDIGMQ
OrthoDBiEOG091G0OWO
PhylomeDBiQ8WXC3

Miscellaneous databases

EvolutionaryTraceiQ8WXC3
GenomeRNAii260434
PROiPR:Q8WXC3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169900 Expressed in 67 organ(s), highest expression level in cerebellum
CleanExiHS_POP1
HS_PYDC1
GenevisibleiQ8WXC3 HS

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYDC1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXC3
Secondary accession number(s): B2R8L4, Q8NFP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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