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UniProtKB - Q8WXB4 (ZN606_HUMAN)
Protein
Zinc finger protein 606
Gene
ZNF606
Organism
Homo sapiens (Human)
Status
Functioni
May act as a transcriptional repressor.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 289 – 311 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 344 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 400 – 422 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 512 – 534 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 540 – 562 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 568 – 590 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 596 – 618 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 624 – 646 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 652 – 674 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 680 – 702 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 708 – 730 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 736 – 758 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 764 – 786 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8WXB4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q8WXB4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 606Alternative name(s): Zinc finger protein 328 |
Gene namesi | Name:ZNF606 Synonyms:KIAA1852, ZNF328 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25879, ZNF606 |
MIMi | 613905, gene |
neXtProti | NX_Q8WXB4 |
VEuPathDBi | HostDB:ENSG00000166704 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 80095 |
OpenTargetsi | ENSG00000166704 |
PharmGKBi | PA134931984 |
Miscellaneous databases
Pharosi | Q8WXB4, Tdark |
Genetic variation databases
BioMutai | ZNF606 |
DMDMi | 30921549 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047688 | 1 – 792 | Zinc finger protein 606Add BLAST | 792 |
Proteomic databases
EPDi | Q8WXB4 |
jPOSTi | Q8WXB4 |
MassIVEi | Q8WXB4 |
PaxDbi | Q8WXB4 |
PeptideAtlasi | Q8WXB4 |
PRIDEi | Q8WXB4 |
ProteomicsDBi | 75004 |
PTM databases
iPTMneti | Q8WXB4 |
PhosphoSitePlusi | Q8WXB4 |
SwissPalmi | Q8WXB4 |
Expressioni
Tissue specificityi
Widely expressed in adult and fetal tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000166704, Expressed in amniotic fluid and 201 other tissues |
ExpressionAtlasi | Q8WXB4, baseline and differential |
Genevisiblei | Q8WXB4, HS |
Organism-specific databases
HPAi | ENSG00000166704, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123110, 7 interactors |
IntActi | Q8WXB4, 2 interactors |
STRINGi | 9606.ENSP00000343617 |
Miscellaneous databases
RNActi | Q8WXB4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 133 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 289 – 311 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 344 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 400 – 422 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 512 – 534 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 540 – 562 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 568 – 590 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 596 – 618 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 624 – 646 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 652 – 674 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 680 – 702 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 708 – 730 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 736 – 758 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 764 – 786 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161820 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q8WXB4 |
OMAi | HPARVQT |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8WXB4 |
TreeFami | TF350822 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 16 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8WXB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA
60 70 80 90 100
TGLPAAQVQE PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS
110 120 130 140 150
VGNQIAKPEV ISLLEQGEEP WSVEQACPQR TCPEWVRNLE SKALIPAQSI
160 170 180 190 200
FEEEQSHGMK LERYIWDDPW FSRLEVLGCK DQLEMYHMNQ STAMRQMVFM
210 220 230 240 250
QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP DTHAQSWRCD
260 270 280 290 300
SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH
310 320 330 340 350
IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY
360 370 380 390 400
ENIFYFSSFM EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY
410 420 430 440 450
DYNECGTSFI WSSYLIQHKK THTGEKPYEC DKCGKVFRNR SALTKHERTH
460 470 480 490 500
TGIKPYECNK CGKAFSWNSH LIVHKRIHTG EKPYVCNECG KSFNWNSHLI
510 520 530 540 550
GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF KCDECEKAFR
560 570 580 590 600
DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE
610 620 630 640 650
CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK
660 670 680 690 700
PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR
710 720 730 740 750
THTGEKPYRC NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS
760 770 780 790
LIIHQRMHSG EKRFICSECG KAFSGHSALL QHQRNHSEEK LN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W1C8 | F8W1C8_HUMAN | Zinc finger protein 606 | ZNF606 | 508 | Annotation score: | ||
F8VZG6 | F8VZG6_HUMAN | Zinc finger protein 606 | ZNF606 | 58 | Annotation score: | ||
F8VZC9 | F8VZC9_HUMAN | Zinc finger protein 606 | ZNF606 | 88 | Annotation score: | ||
F8W1H2 | F8W1H2_HUMAN | Zinc finger protein 606 | ZNF606 | 66 | Annotation score: | ||
F8VVX5 | F8VVX5_HUMAN | Zinc finger protein 606 | ZNF606 | 69 | Annotation score: |
Sequence cautioni
The sequence BAB47481 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 725 | V → I in AAH37209 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052872 | 141 | S → G. Corresponds to variant dbSNP:rs11673029Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF455357 mRNA Translation: AAL58442.1 AB058755 mRNA Translation: BAB47481.1 Different initiation. AK293097 mRNA Translation: BAF85786.1 CH471135 Genomic DNA Translation: EAW72546.1 BC037209 mRNA Translation: AAH37209.1 |
CCDSi | CCDS12968.1 |
PIRi | G42075 |
RefSeqi | NP_001334951.1, NM_001348022.1 NP_001334952.1, NM_001348023.1 NP_001334953.1, NM_001348024.1 NP_001334954.1, NM_001348025.1 NP_079303.2, NM_025027.4 |
Genome annotation databases
Ensembli | ENST00000341164.9; ENSP00000343617.4; ENSG00000166704.13 ENST00000551380.7; ENSP00000446972.2; ENSG00000166704.13 |
GeneIDi | 80095 |
KEGGi | hsa:80095 |
MANE-Selecti | ENST00000551380.7; ENSP00000446972.2; NM_001348022.3; NP_001334951.1 |
UCSCi | uc002qqw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF455357 mRNA Translation: AAL58442.1 AB058755 mRNA Translation: BAB47481.1 Different initiation. AK293097 mRNA Translation: BAF85786.1 CH471135 Genomic DNA Translation: EAW72546.1 BC037209 mRNA Translation: AAH37209.1 |
CCDSi | CCDS12968.1 |
PIRi | G42075 |
RefSeqi | NP_001334951.1, NM_001348022.1 NP_001334952.1, NM_001348023.1 NP_001334953.1, NM_001348024.1 NP_001334954.1, NM_001348025.1 NP_079303.2, NM_025027.4 |
3D structure databases
AlphaFoldDBi | Q8WXB4 |
SMRi | Q8WXB4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123110, 7 interactors |
IntActi | Q8WXB4, 2 interactors |
STRINGi | 9606.ENSP00000343617 |
PTM databases
iPTMneti | Q8WXB4 |
PhosphoSitePlusi | Q8WXB4 |
SwissPalmi | Q8WXB4 |
Genetic variation databases
BioMutai | ZNF606 |
DMDMi | 30921549 |
Proteomic databases
EPDi | Q8WXB4 |
jPOSTi | Q8WXB4 |
MassIVEi | Q8WXB4 |
PaxDbi | Q8WXB4 |
PeptideAtlasi | Q8WXB4 |
PRIDEi | Q8WXB4 |
ProteomicsDBi | 75004 |
Protocols and materials databases
Antibodypediai | 19675, 132 antibodies from 20 providers |
DNASUi | 80095 |
Genome annotation databases
Ensembli | ENST00000341164.9; ENSP00000343617.4; ENSG00000166704.13 ENST00000551380.7; ENSP00000446972.2; ENSG00000166704.13 |
GeneIDi | 80095 |
KEGGi | hsa:80095 |
MANE-Selecti | ENST00000551380.7; ENSP00000446972.2; NM_001348022.3; NP_001334951.1 |
UCSCi | uc002qqw.4, human |
Organism-specific databases
CTDi | 80095 |
DisGeNETi | 80095 |
GeneCardsi | ZNF606 |
HGNCi | HGNC:25879, ZNF606 |
HPAi | ENSG00000166704, Low tissue specificity |
MIMi | 613905, gene |
neXtProti | NX_Q8WXB4 |
OpenTargetsi | ENSG00000166704 |
PharmGKBi | PA134931984 |
VEuPathDBi | HostDB:ENSG00000166704 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161820 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q8WXB4 |
OMAi | HPARVQT |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8WXB4 |
TreeFami | TF350822 |
Enzyme and pathway databases
PathwayCommonsi | Q8WXB4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q8WXB4 |
Miscellaneous databases
BioGRID-ORCSi | 80095, 12 hits in 1097 CRISPR screens |
ChiTaRSi | ZNF606, human |
GenomeRNAii | 80095 |
Pharosi | Q8WXB4, Tdark |
PROi | PR:Q8WXB4 |
RNActi | Q8WXB4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166704, Expressed in amniotic fluid and 201 other tissues |
ExpressionAtlasi | Q8WXB4, baseline and differential |
Genevisiblei | Q8WXB4, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 16 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN606_HUMAN | |
Accessioni | Q8WXB4Primary (citable) accession number: Q8WXB4 Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families