Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - Q8WXB4 (ZN606_HUMAN)

Entry version 170 (25 May 2022)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger protein 606

Gene

ZNF606

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a transcriptional repressor.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri289 – 311C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 344C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri400 – 422C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri736 – 758C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WXB4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WXB4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 606
Alternative name(s):
Zinc finger protein 328
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF606
Synonyms:KIAA1852, ZNF328
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25879, ZNF606

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613905, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WXB4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166704

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80095

Open Targets

More...OpenTargetsi		ENSG00000166704

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134931984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WXB4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF606

Domain mapping of disease mutations (DMDM)

More...DMDMi		30921549

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476881 – 792Zinc finger protein 606Add BLAST792

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WXB4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WXB4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WXB4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WXB4

PeptideAtlas

More...PeptideAtlasi		Q8WXB4

PRoteomics IDEntifications database

More...PRIDEi		Q8WXB4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75004

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WXB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WXB4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8WXB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult and fetal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166704, Expressed in amniotic fluid and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WXB4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WXB4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166704, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123110, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8WXB4, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343617

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WXB4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8WXB4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WXB4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 133KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri289 – 311C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 344C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST28
Zinc fingeri400 – 422C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri736 – 758C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WXB4

Identification of Orthologs from Complete Genome Data

More...OMAi		HPARVQT

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WXB4

TreeFam database of animal gene trees

More...TreeFami		TF350822

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8WXB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA 
        60         70         80         90        100
TGLPAAQVQE PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS 
       110        120        130        140        150
VGNQIAKPEV ISLLEQGEEP WSVEQACPQR TCPEWVRNLE SKALIPAQSI 
       160        170        180        190        200
FEEEQSHGMK LERYIWDDPW FSRLEVLGCK DQLEMYHMNQ STAMRQMVFM 
       210        220        230        240        250
QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP DTHAQSWRCD 
       260        270        280        290        300
SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH 
       310        320        330        340        350
IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY 
       360        370        380        390        400
ENIFYFSSFM EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY 
       410        420        430        440        450
DYNECGTSFI WSSYLIQHKK THTGEKPYEC DKCGKVFRNR SALTKHERTH 
       460        470        480        490        500
TGIKPYECNK CGKAFSWNSH LIVHKRIHTG EKPYVCNECG KSFNWNSHLI 
       510        520        530        540        550
GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF KCDECEKAFR 
       560        570        580        590        600
DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE 
       610        620        630        640        650
CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK 
       660        670        680        690        700
PYECNKCGKS FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR 
       710        720        730        740        750
THTGEKPYRC NECGKAFNES SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS 
       760        770        780        790 
LIIHQRMHSG EKRFICSECG KAFSGHSALL QHQRNHSEEK LN
Length:792
Mass (Da):91,812
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC816EB8115443E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1C8F8W1C8_HUMAN
Zinc finger protein 606
ZNF606
508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZG6F8VZG6_HUMAN
Zinc finger protein 606
ZNF606
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZC9F8VZC9_HUMAN
Zinc finger protein 606
ZNF606
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1H2F8W1H2_HUMAN
Zinc finger protein 606
ZNF606
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVX5F8VVX5_HUMAN
Zinc finger protein 606
ZNF606
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47481 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti725V → I in AAH37209 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052872141S → G. Corresponds to variant dbSNP:rs11673029Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF455357 mRNA Translation: AAL58442.1
AB058755 mRNA Translation: BAB47481.1 Different initiation.
AK293097 mRNA Translation: BAF85786.1
CH471135 Genomic DNA Translation: EAW72546.1
BC037209 mRNA Translation: AAH37209.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12968.1

Protein sequence database of the Protein Information Resource

More...PIRi		G42075

NCBI Reference Sequences

More...RefSeqi		NP_001334951.1, NM_001348022.1
NP_001334952.1, NM_001348023.1
NP_001334953.1, NM_001348024.1
NP_001334954.1, NM_001348025.1
NP_079303.2, NM_025027.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341164.9; ENSP00000343617.4; ENSG00000166704.13
ENST00000551380.7; ENSP00000446972.2; ENSG00000166704.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80095

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000551380.7; ENSP00000446972.2; NM_001348022.3; NP_001334951.1

UCSC genome browser

More...UCSCi		uc002qqw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455357 mRNA Translation: AAL58442.1
AB058755 mRNA Translation: BAB47481.1 Different initiation.
AK293097 mRNA Translation: BAF85786.1
CH471135 Genomic DNA Translation: EAW72546.1
BC037209 mRNA Translation: AAH37209.1
CCDSiCCDS12968.1
PIRiG42075
RefSeqiNP_001334951.1, NM_001348022.1
NP_001334952.1, NM_001348023.1
NP_001334953.1, NM_001348024.1
NP_001334954.1, NM_001348025.1
NP_079303.2, NM_025027.4

3D structure databases

AlphaFoldDBiQ8WXB4
SMRiQ8WXB4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123110, 7 interactors
IntActiQ8WXB4, 2 interactors
STRINGi9606.ENSP00000343617

PTM databases

iPTMnetiQ8WXB4
PhosphoSitePlusiQ8WXB4
SwissPalmiQ8WXB4

Genetic variation databases

BioMutaiZNF606
DMDMi30921549

Proteomic databases

EPDiQ8WXB4
jPOSTiQ8WXB4
MassIVEiQ8WXB4
PaxDbiQ8WXB4
PeptideAtlasiQ8WXB4
PRIDEiQ8WXB4
ProteomicsDBi75004

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19675, 132 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		80095

Genome annotation databases

EnsembliENST00000341164.9; ENSP00000343617.4; ENSG00000166704.13
ENST00000551380.7; ENSP00000446972.2; ENSG00000166704.13
GeneIDi80095
KEGGihsa:80095
MANE-SelectiENST00000551380.7; ENSP00000446972.2; NM_001348022.3; NP_001334951.1
UCSCiuc002qqw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80095
DisGeNETi80095

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF606
HGNCiHGNC:25879, ZNF606
HPAiENSG00000166704, Low tissue specificity
MIMi613905, gene
neXtProtiNX_Q8WXB4
OpenTargetsiENSG00000166704
PharmGKBiPA134931984
VEuPathDBiHostDB:ENSG00000166704

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161820
HOGENOMiCLU_002678_44_5_1
InParanoidiQ8WXB4
OMAiHPARVQT
OrthoDBi1318335at2759
PhylomeDBiQ8WXB4
TreeFamiTF350822

Enzyme and pathway databases

PathwayCommonsiQ8WXB4
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ8WXB4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80095, 12 hits in 1097 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF606, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80095
PharosiQ8WXB4, Tdark

Protein Ontology

More...PROi		PR:Q8WXB4
RNActiQ8WXB4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166704, Expressed in amniotic fluid and 201 other tissues
ExpressionAtlasiQ8WXB4, baseline and differential
GenevisibleiQ8WXB4, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN606_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXB4
Secondary accession number(s): A8KAN2, Q8NE04, Q96JH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: May 25, 2022
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again