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UniProtKB - Q8WXB1 (MT21A_HUMAN)

Entry version 134 (10 Feb 2021)
Sequence version 2 (26 Jun 2007)
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Protein

Protein N-lysine methyltransferase METTL21A

Gene

METTL21A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei47S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei94S-adenosyl-L-methionine1 Publication1
Binding sitei125S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei143S-adenosyl-L-methionine; via carbonyl oxygen1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WXB1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8876725, Protein methylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein N-lysine methyltransferase METTL21A (EC:2.1.1.-)
Alternative name(s):
HSPA lysine methyltransferase
HSPA-KMT
Hepatocellular carcinoma-associated antigen 557b
Methyltransferase-like protein 21A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:METTL21A
Synonyms:FAM119A, HCA557B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30476, METTL21A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615257, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WXB1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144401.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi94D → A: Abolishes methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		151194

Open Targets

More...OpenTargetsi		ENSG00000144401

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145008433

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WXB1, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3588741

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		METTL21A

Domain mapping of disease mutations (DMDM)

More...DMDMi		150382834

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002920331 – 218Protein N-lysine methyltransferase METTL21AAdd BLAST218

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WXB1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WXB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WXB1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WXB1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WXB1

PeptideAtlas

More...PeptideAtlasi		Q8WXB1

PRoteomics IDEntifications database

More...PRIDEi		Q8WXB1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75001 [Q8WXB1-1]
75002 [Q8WXB1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WXB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WXB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144401, Expressed in oocyte and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WXB1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WXB1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144401, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with heat shock protein 70 family members; at least some of these proteins are methylation substrates (PubMed:23349634 and PubMed:23921388).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127352, 31 interactors

Protein interaction database and analysis system

More...IntActi		Q8WXB1, 16 interactors

Molecular INTeraction database

More...MINTi		Q8WXB1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000415115

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WXB1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WXB1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 75S-adenosyl-L-methionine binding1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily. METTL21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2793, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157249

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055721_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WXB1

Database of Orthologous Groups

More...OrthoDBi		1588190at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WXB1

TreeFam database of animal gene trees

More...TreeFami		TF313206

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019410, Methyltransf_16
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR14614, PTHR14614, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10294, Methyltransf_16, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVPYEETT EFGLQKFHKP LATFSFANHT IQIRQDWRHL GVAAVVWDAA 
        60         70         80         90        100
IVLSTYLEMG AVELRGRSAV ELGAGTGLVG IVAALLGAHV TITDRKVALE 
       110        120        130        140        150
FLKSNVQANL PPHIQTKTVV KELTWGQNLG SFSPGEFDLI LGADIIYLEE 
       160        170        180        190        200
TFTDLLQTLE HLCSNHSVIL LACRIRYERD NNFLAMLERQ FTVRKVHYDP 
       210 
EKDVHIYEAQ KRNQKEDL
Length:218
Mass (Da):24,600
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18E7E39A1CDCC56E
GO
Isoform 2 (identifier: Q8WXB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: AHV → GGI
     91-218: Missing.

Show »
Length:90
Mass (Da):9,609
Checksum:i4A8C7FFF7CDB4C1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JES0C9JES0_HUMAN
Protein N-lysine methyltransferase ...
METTL21A LOC151194, hCG_15462
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXH9H7BXH9_HUMAN
Protein N-lysine methyltransferase ...
METTL21A
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSX1C9JSX1_HUMAN
Protein N-lysine methyltransferase ...
METTL21A
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33I → T in BAC04229 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032935192T → I3 PublicationsCorresponds to variant dbSNP:rs2551949Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02637988 – 90AHV → GGI in isoform 2. 1 Publication3
Alternative sequenceiVSP_02638091 – 218Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF455817 mRNA Translation: AAL66295.1
AK093812 mRNA Translation: BAC04229.1
AC079767 Genomic DNA Translation: AAX93175.1
BC009462 mRNA Translation: AAH09462.1
BC033720 mRNA Translation: AAH33720.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2376.1 [Q8WXB1-1]
CCDS82562.1 [Q8WXB1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001120867.1, NM_001127395.3 [Q8WXB1-1]
NP_001294950.1, NM_001308021.2
NP_001317059.1, NM_001330130.1 [Q8WXB1-1]
NP_001317060.1, NM_001330131.1 [Q8WXB1-2]
NP_001317062.1, NM_001330133.1 [Q8WXB1-2]
NP_001317063.1, NM_001330134.1 [Q8WXB1-1]
NP_001317064.1, NM_001330135.1 [Q8WXB1-2]
NP_660323.3, NM_145280.6 [Q8WXB1-1]
XP_005246396.1, XM_005246339.3 [Q8WXB1-1]
XP_005246397.1, XM_005246340.3 [Q8WXB1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000406927; ENSP00000385481; ENSG00000144401 [Q8WXB1-1]
ENST00000411432; ENSP00000415115; ENSG00000144401 [Q8WXB1-1]
ENST00000425132; ENSP00000400730; ENSG00000144401 [Q8WXB1-2]
ENST00000426075; ENSP00000403317; ENSG00000144401 [Q8WXB1-1]
ENST00000442521; ENSP00000392062; ENSG00000144401 [Q8WXB1-1]
ENST00000448007; ENSP00000407622; ENSG00000144401 [Q8WXB1-1]
ENST00000458426; ENSP00000389684; ENSG00000144401 [Q8WXB1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		151194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:151194

UCSC genome browser

More...UCSCi		uc002vce.4, human [Q8WXB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455817 mRNA Translation: AAL66295.1
AK093812 mRNA Translation: BAC04229.1
AC079767 Genomic DNA Translation: AAX93175.1
BC009462 mRNA Translation: AAH09462.1
BC033720 mRNA Translation: AAH33720.1
CCDSiCCDS2376.1 [Q8WXB1-1]
CCDS82562.1 [Q8WXB1-2]
RefSeqiNP_001120867.1, NM_001127395.3 [Q8WXB1-1]
NP_001294950.1, NM_001308021.2
NP_001317059.1, NM_001330130.1 [Q8WXB1-1]
NP_001317060.1, NM_001330131.1 [Q8WXB1-2]
NP_001317062.1, NM_001330133.1 [Q8WXB1-2]
NP_001317063.1, NM_001330134.1 [Q8WXB1-1]
NP_001317064.1, NM_001330135.1 [Q8WXB1-2]
NP_660323.3, NM_145280.6 [Q8WXB1-1]
XP_005246396.1, XM_005246339.3 [Q8WXB1-1]
XP_005246397.1, XM_005246340.3 [Q8WXB1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LECX-ray2.28A/B8-218[»]
SMRiQ8WXB1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127352, 31 interactors
IntActiQ8WXB1, 16 interactors
MINTiQ8WXB1
STRINGi9606.ENSP00000415115

Chemistry databases

ChEMBLiCHEMBL3588741

PTM databases

iPTMnetiQ8WXB1
PhosphoSitePlusiQ8WXB1

Genetic variation databases

BioMutaiMETTL21A
DMDMi150382834

Proteomic databases

EPDiQ8WXB1
jPOSTiQ8WXB1
MassIVEiQ8WXB1
MaxQBiQ8WXB1
PaxDbiQ8WXB1
PeptideAtlasiQ8WXB1
PRIDEiQ8WXB1
ProteomicsDBi75001 [Q8WXB1-1]
75002 [Q8WXB1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34188, 165 antibodies

The DNASU plasmid repository

More...DNASUi		151194

Genome annotation databases

EnsembliENST00000406927; ENSP00000385481; ENSG00000144401 [Q8WXB1-1]
ENST00000411432; ENSP00000415115; ENSG00000144401 [Q8WXB1-1]
ENST00000425132; ENSP00000400730; ENSG00000144401 [Q8WXB1-2]
ENST00000426075; ENSP00000403317; ENSG00000144401 [Q8WXB1-1]
ENST00000442521; ENSP00000392062; ENSG00000144401 [Q8WXB1-1]
ENST00000448007; ENSP00000407622; ENSG00000144401 [Q8WXB1-1]
ENST00000458426; ENSP00000389684; ENSG00000144401 [Q8WXB1-2]
GeneIDi151194
KEGGihsa:151194
UCSCiuc002vce.4, human [Q8WXB1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		151194
DisGeNETi151194

GeneCards: human genes, protein and diseases

More...GeneCardsi		METTL21A
HGNCiHGNC:30476, METTL21A
HPAiENSG00000144401, Low tissue specificity
MIMi615257, gene
neXtProtiNX_Q8WXB1
OpenTargetsiENSG00000144401
PharmGKBiPA145008433
VEuPathDBiHostDB:ENSG00000144401.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2793, Eukaryota
GeneTreeiENSGT00940000157249
HOGENOMiCLU_055721_4_2_1
InParanoidiQ8WXB1
OrthoDBi1588190at2759
PhylomeDBiQ8WXB1
TreeFamiTF313206

Enzyme and pathway databases

PathwayCommonsiQ8WXB1
ReactomeiR-HSA-8876725, Protein methylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		151194, 4 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		METTL21A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		151194
PharosiQ8WXB1, Tbio

Protein Ontology

More...PROi		PR:Q8WXB1
RNActiQ8WXB1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144401, Expressed in oocyte and 201 other tissues
ExpressionAtlasiQ8WXB1, baseline and differential
GenevisibleiQ8WXB1, HS

Family and domain databases

InterProiView protein in InterPro
IPR019410, Methyltransf_16
IPR029063, SAM-dependent_MTases
PANTHERiPTHR14614, PTHR14614, 1 hit
PfamiView protein in Pfam
PF10294, Methyltransf_16, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMT21A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXB1
Secondary accession number(s): Q53RV0, Q8N1Z9, Q96GH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: February 10, 2021
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  7. Human entries with genetic variants
    List of human entries with genetic variants
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