UniProtKB - Q8WXA9 (SREK1_HUMAN)
Splicing regulatory glutamine/lysine-rich protein 1
SREK1
Functioni
Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).
By similarityGO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- RNA splicing Source: UniProtKB-KW
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q8WXA9 |
SignaLinki | Q8WXA9 |
Names & Taxonomyi
Protein namesi | Recommended name: Splicing regulatory glutamine/lysine-rich protein 1Alternative name(s): Serine/arginine-rich-splicing regulatory protein 86 Short name: SRrp86 Splicing factor, arginine/serine-rich 12 Splicing regulatory protein 508 Short name: SRrp508 |
Gene namesi | Name:SREK1 Synonyms:SFRS12, SRRP86 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17882, SREK1 |
MIMi | 609268, gene |
neXtProti | NX_Q8WXA9 |
VEuPathDBi | HostDB:ENSG00000153914 |
Subcellular locationi
Nucleus
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- spliceosomal complex Source: UniProtKB-KW
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 140890 |
OpenTargetsi | ENSG00000153914 |
PharmGKBi | PA38255 |
Miscellaneous databases
Pharosi | Q8WXA9, Tbio |
Genetic variation databases
BioMutai | SREK1 |
DMDMi | 37537968 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081940 | 1 – 508 | Splicing regulatory glutamine/lysine-rich protein 1Add BLAST | 508 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 171 | PhosphoserineCombined sources | 1 | |
Modified residuei | 184 | PhosphoserineCombined sources | 1 | |
Modified residuei | 363 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 504 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8WXA9 |
jPOSTi | Q8WXA9 |
MassIVEi | Q8WXA9 |
MaxQBi | Q8WXA9 |
PaxDbi | Q8WXA9 |
PeptideAtlasi | Q8WXA9 |
PRIDEi | Q8WXA9 |
ProteomicsDBi | 74999 [Q8WXA9-1] 75000 [Q8WXA9-2] |
PTM databases
GlyGeni | Q8WXA9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WXA9 |
PhosphoSitePlusi | Q8WXA9 |
SwissPalmi | Q8WXA9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153914, Expressed in sural nerve and 239 other tissues |
ExpressionAtlasi | Q8WXA9, baseline and differential |
Genevisiblei | Q8WXA9, HS |
Organism-specific databases
HPAi | ENSG00000153914, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6.
Interacts with the spliceosome (By similarity).
Interacts with SREK1IP1.
By similarity2 PublicationsBinary interactionsi
Q8WXA9
Protein-protein interaction databases
BioGRIDi | 126754, 151 interactors |
IntActi | Q8WXA9, 34 interactors |
MINTi | Q8WXA9 |
STRINGi | 9606.ENSP00000334538 |
Miscellaneous databases
RNActi | Q8WXA9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 142 | RRMPROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 508 | DisorderedSequence analysisAdd BLAST | 336 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 192 – 258 | Basic residuesSequence analysisAdd BLAST | 67 | |
Compositional biasi | 259 – 365 | Basic and acidic residuesSequence analysisAdd BLAST | 107 | |
Compositional biasi | 376 – 408 | Basic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 409 – 486 | Basic and acidic residuesSequence analysisAdd BLAST | 78 | |
Compositional biasi | 487 – 508 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4676, Eukaryota |
GeneTreei | ENSGT00730000110872 |
HOGENOMi | CLU_030029_2_0_1 |
InParanoidi | Q8WXA9 |
OMAi | NCQPNDE |
OrthoDBi | 1460556at2759 |
PhylomeDBi | Q8WXA9 |
TreeFami | TF106266 |
Family and domain databases
CDDi | cd12260, RRM2_SREK1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034192, SREK1_RRM2 |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP
60 70 80 90 100
PLMGNVDPSK IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG
110 120 130 140 150
DETQPTRFAF VEFADQNSVP RALAFNGVMF GDRPLKINHS NNAIVKPPEM
160 170 180 190 200
TPQAAAKELE EVMKRVREAQ SFISAAIEPE SGKSNERKGG RSRSHTRSKS
210 220 230 240 250
RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK KRSKSRERRK
260 270 280 290 300
SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD
310 320 330 340 350
RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE
360 370 380 390 400
IDEKRKKDKK SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK
410 420 430 440 450
RKSSRSPSPR SRNKKDKKRE KERDHISERR ERERSTSMRK SSNDRDGKEK
460 470 480 490 500
LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA PRTEENKIQH NGNCQLNEEN
LSTKTEAV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RJ76 | E5RJ76_HUMAN | Splicing regulatory glutamine/lysin... | SREK1 | 76 | Annotation score: | ||
E5RFV3 | E5RFV3_HUMAN | Splicing regulatory glutamine/lysin... | SREK1 | 132 | Annotation score: | ||
A0A087WY03 | A0A087WY03_HUMAN | Splicing regulatory glutamine/lysin... | SREK1 | 100 | Annotation score: | ||
H0YC47 | H0YC47_HUMAN | Splicing regulatory glutamine/lysin... | SREK1 | 60 | Annotation score: | ||
E5RK30 | E5RK30_HUMAN | Splicing regulatory glutamine/lysin... | SREK1 | 42 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008399 | 1 | M → MNSGGGFGLGLGFGLTPTSV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNAPLAF SSKVCYVKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEESKALSLLAPAPTM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF459094 mRNA Translation: AAL67778.1 BC047322 mRNA Translation: AAH47322.1 Sequence problems. BC067770 mRNA Translation: AAH67770.1 BC112343 mRNA Translation: AAI12344.1 |
CCDSi | CCDS3991.1 [Q8WXA9-1] CCDS43323.1 [Q8WXA9-2] |
RefSeqi | NP_001070667.1, NM_001077199.2 [Q8WXA9-2] NP_001257421.1, NM_001270492.1 NP_001310456.1, NM_001323527.1 [Q8WXA9-1] NP_631907.1, NM_139168.3 [Q8WXA9-1] XP_011541473.1, XM_011543171.2 [Q8WXA9-1] |
Genome annotation databases
Ensembli | ENST00000334121; ENSP00000334538; ENSG00000153914 [Q8WXA9-2] ENST00000380918; ENSP00000370305; ENSG00000153914 |
GeneIDi | 140890 |
KEGGi | hsa:140890 |
MANE-Selecti | ENST00000334121.11; ENSP00000334538.6; NM_001077199.3; NP_001070667.1 [Q8WXA9-2] |
UCSCi | uc003jun.5, human [Q8WXA9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF459094 mRNA Translation: AAL67778.1 BC047322 mRNA Translation: AAH47322.1 Sequence problems. BC067770 mRNA Translation: AAH67770.1 BC112343 mRNA Translation: AAI12344.1 |
CCDSi | CCDS3991.1 [Q8WXA9-1] CCDS43323.1 [Q8WXA9-2] |
RefSeqi | NP_001070667.1, NM_001077199.2 [Q8WXA9-2] NP_001257421.1, NM_001270492.1 NP_001310456.1, NM_001323527.1 [Q8WXA9-1] NP_631907.1, NM_139168.3 [Q8WXA9-1] XP_011541473.1, XM_011543171.2 [Q8WXA9-1] |
3D structure databases
SMRi | Q8WXA9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126754, 151 interactors |
IntActi | Q8WXA9, 34 interactors |
MINTi | Q8WXA9 |
STRINGi | 9606.ENSP00000334538 |
PTM databases
GlyGeni | Q8WXA9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WXA9 |
PhosphoSitePlusi | Q8WXA9 |
SwissPalmi | Q8WXA9 |
Genetic variation databases
BioMutai | SREK1 |
DMDMi | 37537968 |
Proteomic databases
EPDi | Q8WXA9 |
jPOSTi | Q8WXA9 |
MassIVEi | Q8WXA9 |
MaxQBi | Q8WXA9 |
PaxDbi | Q8WXA9 |
PeptideAtlasi | Q8WXA9 |
PRIDEi | Q8WXA9 |
ProteomicsDBi | 74999 [Q8WXA9-1] 75000 [Q8WXA9-2] |
Protocols and materials databases
Antibodypediai | 23829, 87 antibodies from 21 providers |
DNASUi | 140890 |
Genome annotation databases
Ensembli | ENST00000334121; ENSP00000334538; ENSG00000153914 [Q8WXA9-2] ENST00000380918; ENSP00000370305; ENSG00000153914 |
GeneIDi | 140890 |
KEGGi | hsa:140890 |
MANE-Selecti | ENST00000334121.11; ENSP00000334538.6; NM_001077199.3; NP_001070667.1 [Q8WXA9-2] |
UCSCi | uc003jun.5, human [Q8WXA9-1] |
Organism-specific databases
CTDi | 140890 |
DisGeNETi | 140890 |
GeneCardsi | SREK1 |
HGNCi | HGNC:17882, SREK1 |
HPAi | ENSG00000153914, Low tissue specificity |
MIMi | 609268, gene |
neXtProti | NX_Q8WXA9 |
OpenTargetsi | ENSG00000153914 |
PharmGKBi | PA38255 |
VEuPathDBi | HostDB:ENSG00000153914 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4676, Eukaryota |
GeneTreei | ENSGT00730000110872 |
HOGENOMi | CLU_030029_2_0_1 |
InParanoidi | Q8WXA9 |
OMAi | NCQPNDE |
OrthoDBi | 1460556at2759 |
PhylomeDBi | Q8WXA9 |
TreeFami | TF106266 |
Enzyme and pathway databases
PathwayCommonsi | Q8WXA9 |
SignaLinki | Q8WXA9 |
Miscellaneous databases
BioGRID-ORCSi | 140890, 140 hits in 1052 CRISPR screens |
ChiTaRSi | SREK1, human |
GeneWikii | SFRS12 |
GenomeRNAii | 140890 |
Pharosi | Q8WXA9, Tbio |
PROi | PR:Q8WXA9 |
RNActi | Q8WXA9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153914, Expressed in sural nerve and 239 other tissues |
ExpressionAtlasi | Q8WXA9, baseline and differential |
Genevisiblei | Q8WXA9, HS |
Family and domain databases
CDDi | cd12260, RRM2_SREK1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034192, SREK1_RRM2 |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SREK1_HUMAN | |
Accessioni | Q8WXA9Primary (citable) accession number: Q8WXA9 Secondary accession number(s): A4FTW3, Q2M1J0, Q86X37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families