UniProtKB - Q8WXA9 (SREK1_HUMAN)

BLAST

>sp|Q8WXA9|SREK1_HUMAN Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1
MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK
IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP
RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE
SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK
KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD
RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK
SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE
KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA
PRTEENKIQHNGNCQLNEENLSTKTEAV

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History
Entry version 153 (12 Sep 2018)
Sequence version 1 (01 Mar 2002)
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Protein

Splicing regulatory glutamine/lysine-rich protein 1

Gene

SREK1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).By similarity

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW
regulation of alternative mRNA splicing, via spliceosome Source: InterPro
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Splicing regulatory glutamine/lysine-rich protein 1 Alternative name(s): Serine/arginine-rich-splicing regulatory protein 86 Short name: SRrp86 Splicing factor, arginine/serine-rich 12 Splicing regulatory protein 508 Short name: SRrp508
Gene namesⁱ	Name:SREK1 Synonyms:SFRS12, SRRP86
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153914.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17882 SREK1
MIMⁱ	609268 gene
neXtProtⁱ	NX_Q8WXA9

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	140890
Open Targets More...OpenTargetsⁱ	ENSG00000153914
PharmGKBⁱ	PA38255

Polymorphism and mutation databases

BioMutaⁱ	SREK1
DMDMⁱ	37537968

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081940	1 – 508	Splicing regulatory glutamine/lysine-rich protein 1Add BLAST		508

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	171	PhosphoserineCombined sources	1
Modified residueⁱ	184	PhosphoserineCombined sources	1
Modified residueⁱ	363	PhosphothreonineCombined sources	1
Cross-linkⁱ	504	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8WXA9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WXA9
PaxDbⁱ	Q8WXA9
PeptideAtlas More...PeptideAtlasⁱ	Q8WXA9
PRIDEⁱ	Q8WXA9
ProteomicsDBⁱ	74999 75000 [Q8WXA9-2]

PTM databases

iPTMnetⁱ	Q8WXA9
PhosphoSitePlusⁱ	Q8WXA9
SwissPalmⁱ	Q8WXA9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000153914 Expressed in 228 organ(s), highest expression level in kidney
CleanExⁱ	HS_SFRS12
ExpressionAtlasⁱ	Q8WXA9 baseline and differential
Genevisibleⁱ	Q8WXA9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037673 HPA037674 HPA059332

HPAⁱ

HPA037673
HPA037674
HPA059332

Interactionⁱ

Subunit structureⁱ

Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome (By similarity). Interacts with SREK1IP1.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SRSF11	Q05519	3	EBI-1044237,EBI-1051785
SRSF11	Q05519-2	4	EBI-1044237,EBI-11975029

Protein-protein interaction databases

BioGridⁱ	126754, 87 interactors
IntActⁱ	Q8WXA9, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q8WXA9
STRINGⁱ	9606.ENSP00000334538

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WXA9
SMRⁱ	Q8WXA9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	66 – 142	RRMPROSITE-ProRule annotationAdd BLAST		77

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	190 – 474	Arg/Glu/Lys/Ser-richAdd BLAST		285

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4676 Eukaryota ENOG410YYIR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110872
HOVERGENⁱ	HBG079174
InParanoidⁱ	Q8WXA9
KEGG Orthology (KO) More...KOⁱ	K13165
OMAⁱ	VCYIKFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QKH
PhylomeDBⁱ	Q8WXA9
TreeFamⁱ	TF106266

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12260 RRM2_SREK1, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR033568 Srek1 IPR034192 SREK1_RRM2
PANTHERⁱ	PTHR32343:SF7 PTHR32343:SF7, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WXA9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP 
        60         70         80         90        100
PLMGNVDPSK IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG 
       110        120        130        140        150
DETQPTRFAF VEFADQNSVP RALAFNGVMF GDRPLKINHS NNAIVKPPEM 
       160        170        180        190        200
TPQAAAKELE EVMKRVREAQ SFISAAIEPE SGKSNERKGG RSRSHTRSKS 
       210        220        230        240        250
RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK KRSKSRERRK 
       260        270        280        290        300
SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD 
       310        320        330        340        350
RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE 
       360        370        380        390        400
IDEKRKKDKK SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK 
       410        420        430        440        450
RKSSRSPSPR SRNKKDKKRE KERDHISERR ERERSTSMRK SSNDRDGKEK 
       460        470        480        490        500
LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA PRTEENKIQH NGNCQLNEEN 

LSTKTEAV

Length:508

Mass (Da):59,380

Last modified:March 1, 2002 - v1

Checksum:ⁱ878DC088B642EC3F

Isoform 2 (identifier: Q8WXA9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MNSGGGFGLG...LSLLAPAPTM

« Hide

        10         20         30         40         50
MNSGGGFGLG LGFGLTPTSV IQVTNLSSAV TSEQMRTLFS FLGEIEELRL 
        60         70         80         90        100
YPPDNAPLAF SSKVCYVKFR DPSSVGVAQH LTNTVFIDRA LIVVPCAEGK 
       110        120        130        140        150
IPEESKALSL LAPAPTMTSL MPGAGLLPIP TPNPLTTLGV SLSSLGAIPA 
       160        170        180        190        200
AALDPNIATL GEIPQPPLMG NVDPSKIDEI RRTVYVGNLN SQTTTADQLL 
       210        220        230        240        250
EFFKQVGEVK FVRMAGDETQ PTRFAFVEFA DQNSVPRALA FNGVMFGDRP 
       260        270        280        290        300
LKINHSNNAI VKPPEMTPQA AAKELEEVMK RVREAQSFIS AAIEPESGKS 
       310        320        330        340        350
NERKGGRSRS HTRSKSRSSS KSHSRRKRSQ SKHRSRSHNR SRSRQKDRRR 
       360        370        380        390        400
SKSPHKKRSK SRERRKSRSR SHSRDKRKDT REKIKEKERV KEKDREKERE 
       410        420        430        440        450
REKEREKEKE RGKNKDRDKE REKDREKDKE KDREREREKE HEKDRDKEKE 
       460        470        480        490        500
KEQDKEKERE KDRSKEIDEK RKKDKKSRTP PRSYNASRRS RSSSRERRRR 
       510        520        530        540        550
RSRSSSRSPR TSKTIKRKSS RSPSPRSRNK KDKKREKERD HISERRERER 
       560        570        580        590        600
STSMRKSSND RDGKEKLEKN STSLKEKEHN KEPDSSVSKE VDDKDAPRTE 
       610        620 
ENKIQHNGNC QLNEENLSTK TEAV

Note: No experimental confirmation available.

Show »

Length:624

Mass (Da):71,649

Checksum:ⁱ86DBE20EDCF3EC6F

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RJ76	E5RJ76_HUMAN	Splicing regulatory glutamine/lysin... Splicing regulatory glutamine/lysine-rich protein 1	SREK1	76	Annotation score:
E5RFV3	E5RFV3_HUMAN	Splicing regulatory glutamine/lysin... Splicing regulatory glutamine/lysine-rich protein 1	SREK1	132	Annotation score:
A0A087WY03	A0A087WY03_HUMAN	Splicing regulatory glutamine/lysin... Splicing regulatory glutamine/lysine-rich protein 1	SREK1	100	Annotation score:
H0YC47	H0YC47_HUMAN	Splicing regulatory glutamine/lysin... Splicing regulatory glutamine/lysine-rich protein 1	SREK1	60	Annotation score:
E5RK30	E5RK30_HUMAN	Splicing regulatory glutamine/lysin... Splicing regulatory glutamine/lysine-rich protein 1	SREK1	42	Annotation score:

Sequence cautionⁱ

The sequence AAH47322 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008399	1	M → MNSGGGFGLGLGFGLTPTSV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNAPLAF SSKVCYVKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEESKALSLLAPAPTM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF459094 mRNA Translation: AAL67778.1 BC047322 mRNA Translation: AAH47322.1 Sequence problems. BC067770 mRNA Translation: AAH67770.1 BC112343 mRNA Translation: AAI12344.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3991.1 [Q8WXA9-1] CCDS43323.1 [Q8WXA9-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001070667.1, NM_001077199.2 [Q8WXA9-2] NP_001257421.1, NM_001270492.1 NP_001310456.1, NM_001323527.1 [Q8WXA9-1] NP_631907.1, NM_139168.3 [Q8WXA9-1] XP_011541473.1, XM_011543171.2 [Q8WXA9-1]
UniGeneⁱ	Hs.49367

Genome annotation databases

Ensemblⁱ	ENST00000334121; ENSP00000334538; ENSG00000153914 [Q8WXA9-2] ENST00000380918; ENSP00000370305; ENSG00000153914 [Q8WXA9-1]
GeneIDⁱ	140890
KEGGⁱ	hsa:140890
UCSC genome browser More...UCSCⁱ	uc003jun.5 human [Q8WXA9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WXA9	Isoform 2 of Splicing regulatory glutamine/lysine-rich protein 1		HUMAN		624	UniRef100_Q8WXA9
Uncharacterized protein DKFZp667P103 (Fragment)		HUMAN		331
UPI000387C2EA		HUMAN		359

Protein	Similar proteins		Species	Score	Length	Source
Q8WXA9	Isoform 2 of Splicing regulatory glutamine/lysine-rich protein 1		HUMAN		624	UniRef90_Q8WXA9
Uncharacterized protein		SHEEP		632
Uncharacterized protein		PROCO		630
Uncharacterized protein		CALJA		630
Uncharacterized protein		Cebus capucinus imitator		630
+222

Protein	Similar proteins		Species	Score	Length	Source
Q8WXA9	Splicing regulatory glutamine/lysine-rich protein 1		MOUSE		494	UniRef50_Q8WXA9
Isoform 2 of Splicing regulatory glutamine/lysine-rich protein 1		HUMAN		624
Uncharacterized protein		SHEEP		632
Uncharacterized protein		Cebus capucinus imitator		630
Uncharacterized protein		AOTNA		630
+507

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF459094 mRNA Translation: AAL67778.1 BC047322 mRNA Translation: AAH47322.1 Sequence problems. BC067770 mRNA Translation: AAH67770.1 BC112343 mRNA Translation: AAI12344.1
CCDSⁱ	CCDS3991.1 [Q8WXA9-1] CCDS43323.1 [Q8WXA9-2]
RefSeqⁱ	NP_001070667.1, NM_001077199.2 [Q8WXA9-2] NP_001257421.1, NM_001270492.1 NP_001310456.1, NM_001323527.1 [Q8WXA9-1] NP_631907.1, NM_139168.3 [Q8WXA9-1] XP_011541473.1, XM_011543171.2 [Q8WXA9-1]
UniGeneⁱ	Hs.49367

3D structure databases

ProteinModelPortalⁱ	Q8WXA9
SMRⁱ	Q8WXA9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126754, 87 interactors
IntActⁱ	Q8WXA9, 19 interactors
MINTⁱ	Q8WXA9
STRINGⁱ	9606.ENSP00000334538

PTM databases

iPTMnetⁱ	Q8WXA9
PhosphoSitePlusⁱ	Q8WXA9
SwissPalmⁱ	Q8WXA9

Polymorphism and mutation databases

BioMutaⁱ	SREK1
DMDMⁱ	37537968

Proteomic databases

EPDⁱ	Q8WXA9
MaxQBⁱ	Q8WXA9
PaxDbⁱ	Q8WXA9
PeptideAtlasⁱ	Q8WXA9
PRIDEⁱ	Q8WXA9
ProteomicsDBⁱ	74999 75000 [Q8WXA9-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000334121; ENSP00000334538; ENSG00000153914 [Q8WXA9-2] ENST00000380918; ENSP00000370305; ENSG00000153914 [Q8WXA9-1]
GeneIDⁱ	140890
KEGGⁱ	hsa:140890
UCSCⁱ	uc003jun.5 human [Q8WXA9-1]

Organism-specific databases

CTDⁱ	140890
DisGeNETⁱ	140890
EuPathDBⁱ	HostDB:ENSG00000153914.15
GeneCardsⁱ	SREK1
HGNCⁱ	HGNC:17882 SREK1
HPAⁱ	HPA037673 HPA037674 HPA059332
MIMⁱ	609268 gene
neXtProtⁱ	NX_Q8WXA9
OpenTargetsⁱ	ENSG00000153914
PharmGKBⁱ	PA38255
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4676 Eukaryota ENOG410YYIR LUCA
GeneTreeⁱ	ENSGT00730000110872
HOVERGENⁱ	HBG079174
InParanoidⁱ	Q8WXA9
KOⁱ	K13165
OMAⁱ	VCYIKFR
OrthoDBⁱ	EOG091G0QKH
PhylomeDBⁱ	Q8WXA9
TreeFamⁱ	TF106266

Miscellaneous databases

ChiTaRSⁱ	SREK1 human
GeneWikiⁱ	SFRS12
GenomeRNAiⁱ	140890
Protein Ontology More...PROⁱ	PR:Q8WXA9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153914 Expressed in 228 organ(s), highest expression level in kidney
CleanExⁱ	HS_SFRS12
ExpressionAtlasⁱ	Q8WXA9 baseline and differential
Genevisibleⁱ	Q8WXA9 HS

Family and domain databases

CDDⁱ	cd12260 RRM2_SREK1, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR033568 Srek1 IPR034192 SREK1_RRM2
PANTHERⁱ	PTHR32343:SF7 PTHR32343:SF7, 2 hits
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SREK1_HUMAN
Accessionⁱ	Q8WXA9Primary (citable) accession number: Q8WXA9 Secondary accession number(s): A4FTW3, Q2M1J0, Q86X37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
	Last sequence update:	March 1, 2002
	Last modified:	September 12, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WXA9 (SREK1_HUMAN)

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Splicing regulatory glutamine/lysine-rich protein 1

SREK1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ