Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Splicing regulatory glutamine/lysine-rich protein 1

Gene

SREK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing regulatory glutamine/lysine-rich protein 1
Alternative name(s):
Serine/arginine-rich-splicing regulatory protein 86
Short name:
SRrp86
Splicing factor, arginine/serine-rich 12
Splicing regulatory protein 508
Short name:
SRrp508
Gene namesi
Name:SREK1
Synonyms:SFRS12, SRRP86
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153914.15
HGNCiHGNC:17882 SREK1
MIMi609268 gene
neXtProtiNX_Q8WXA9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi140890
OpenTargetsiENSG00000153914
PharmGKBiPA38255

Polymorphism and mutation databases

BioMutaiSREK1
DMDMi37537968

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819401 – 508Splicing regulatory glutamine/lysine-rich protein 1Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei363PhosphothreonineCombined sources1
Cross-linki504Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WXA9
MaxQBiQ8WXA9
PaxDbiQ8WXA9
PeptideAtlasiQ8WXA9
PRIDEiQ8WXA9
ProteomicsDBi74999
75000 [Q8WXA9-2]

PTM databases

iPTMnetiQ8WXA9
PhosphoSitePlusiQ8WXA9
SwissPalmiQ8WXA9

Expressioni

Gene expression databases

BgeeiENSG00000153914 Expressed in 228 organ(s), highest expression level in kidney
CleanExiHS_SFRS12
ExpressionAtlasiQ8WXA9 baseline and differential
GenevisibleiQ8WXA9 HS

Organism-specific databases

HPAiHPA037673
HPA037674
HPA059332

Interactioni

Subunit structurei

Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome (By similarity). Interacts with SREK1IP1.By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi126754, 87 interactors
IntActiQ8WXA9, 19 interactors
MINTiQ8WXA9
STRINGi9606.ENSP00000334538

Structurei

3D structure databases

ProteinModelPortaliQ8WXA9
SMRiQ8WXA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 142RRMPROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi190 – 474Arg/Glu/Lys/Ser-richAdd BLAST285

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGiKOG4676 Eukaryota
ENOG410YYIR LUCA
GeneTreeiENSGT00730000110872
HOVERGENiHBG079174
InParanoidiQ8WXA9
KOiK13165
OMAiVCYIKFR
OrthoDBiEOG091G0QKH
PhylomeDBiQ8WXA9
TreeFamiTF106266

Family and domain databases

CDDicd12260 RRM2_SREK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033568 Srek1
IPR034192 SREK1_RRM2
PANTHERiPTHR32343:SF7 PTHR32343:SF7, 2 hits
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP
60 70 80 90 100
PLMGNVDPSK IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG
110 120 130 140 150
DETQPTRFAF VEFADQNSVP RALAFNGVMF GDRPLKINHS NNAIVKPPEM
160 170 180 190 200
TPQAAAKELE EVMKRVREAQ SFISAAIEPE SGKSNERKGG RSRSHTRSKS
210 220 230 240 250
RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK KRSKSRERRK
260 270 280 290 300
SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD
310 320 330 340 350
RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE
360 370 380 390 400
IDEKRKKDKK SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK
410 420 430 440 450
RKSSRSPSPR SRNKKDKKRE KERDHISERR ERERSTSMRK SSNDRDGKEK
460 470 480 490 500
LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA PRTEENKIQH NGNCQLNEEN

LSTKTEAV
Length:508
Mass (Da):59,380
Last modified:March 1, 2002 - v1
Checksum:i878DC088B642EC3F
GO
Isoform 2 (identifier: Q8WXA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNSGGGFGLG...LSLLAPAPTM

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):71,649
Checksum:i86DBE20EDCF3EC6F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJ76E5RJ76_HUMAN
Splicing regulatory glutamine/lysin...
SREK1
76Annotation score:
E5RFV3E5RFV3_HUMAN
Splicing regulatory glutamine/lysin...
SREK1
132Annotation score:
A0A087WY03A0A087WY03_HUMAN
Splicing regulatory glutamine/lysin...
SREK1
100Annotation score:
H0YC47H0YC47_HUMAN
Splicing regulatory glutamine/lysin...
SREK1
60Annotation score:
E5RK30E5RK30_HUMAN
Splicing regulatory glutamine/lysin...
SREK1
42Annotation score:

Sequence cautioni

The sequence AAH47322 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0083991M → MNSGGGFGLGLGFGLTPTSV IQVTNLSSAVTSEQMRTLFS FLGEIEELRLYPPDNAPLAF SSKVCYVKFRDPSSVGVAQH LTNTVFIDRALIVVPCAEGK IPEESKALSLLAPAPTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459094 mRNA Translation: AAL67778.1
BC047322 mRNA Translation: AAH47322.1 Sequence problems.
BC067770 mRNA Translation: AAH67770.1
BC112343 mRNA Translation: AAI12344.1
CCDSiCCDS3991.1 [Q8WXA9-1]
CCDS43323.1 [Q8WXA9-2]
RefSeqiNP_001070667.1, NM_001077199.2 [Q8WXA9-2]
NP_001257421.1, NM_001270492.1
NP_001310456.1, NM_001323527.1 [Q8WXA9-1]
NP_631907.1, NM_139168.3 [Q8WXA9-1]
XP_011541473.1, XM_011543171.2 [Q8WXA9-1]
UniGeneiHs.49367

Genome annotation databases

EnsembliENST00000334121; ENSP00000334538; ENSG00000153914 [Q8WXA9-2]
ENST00000380918; ENSP00000370305; ENSG00000153914 [Q8WXA9-1]
GeneIDi140890
KEGGihsa:140890
UCSCiuc003jun.5 human [Q8WXA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459094 mRNA Translation: AAL67778.1
BC047322 mRNA Translation: AAH47322.1 Sequence problems.
BC067770 mRNA Translation: AAH67770.1
BC112343 mRNA Translation: AAI12344.1
CCDSiCCDS3991.1 [Q8WXA9-1]
CCDS43323.1 [Q8WXA9-2]
RefSeqiNP_001070667.1, NM_001077199.2 [Q8WXA9-2]
NP_001257421.1, NM_001270492.1
NP_001310456.1, NM_001323527.1 [Q8WXA9-1]
NP_631907.1, NM_139168.3 [Q8WXA9-1]
XP_011541473.1, XM_011543171.2 [Q8WXA9-1]
UniGeneiHs.49367

3D structure databases

ProteinModelPortaliQ8WXA9
SMRiQ8WXA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126754, 87 interactors
IntActiQ8WXA9, 19 interactors
MINTiQ8WXA9
STRINGi9606.ENSP00000334538

PTM databases

iPTMnetiQ8WXA9
PhosphoSitePlusiQ8WXA9
SwissPalmiQ8WXA9

Polymorphism and mutation databases

BioMutaiSREK1
DMDMi37537968

Proteomic databases

EPDiQ8WXA9
MaxQBiQ8WXA9
PaxDbiQ8WXA9
PeptideAtlasiQ8WXA9
PRIDEiQ8WXA9
ProteomicsDBi74999
75000 [Q8WXA9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334121; ENSP00000334538; ENSG00000153914 [Q8WXA9-2]
ENST00000380918; ENSP00000370305; ENSG00000153914 [Q8WXA9-1]
GeneIDi140890
KEGGihsa:140890
UCSCiuc003jun.5 human [Q8WXA9-1]

Organism-specific databases

CTDi140890
DisGeNETi140890
EuPathDBiHostDB:ENSG00000153914.15
GeneCardsiSREK1
HGNCiHGNC:17882 SREK1
HPAiHPA037673
HPA037674
HPA059332
MIMi609268 gene
neXtProtiNX_Q8WXA9
OpenTargetsiENSG00000153914
PharmGKBiPA38255
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4676 Eukaryota
ENOG410YYIR LUCA
GeneTreeiENSGT00730000110872
HOVERGENiHBG079174
InParanoidiQ8WXA9
KOiK13165
OMAiVCYIKFR
OrthoDBiEOG091G0QKH
PhylomeDBiQ8WXA9
TreeFamiTF106266

Miscellaneous databases

ChiTaRSiSREK1 human
GeneWikiiSFRS12
GenomeRNAii140890
PROiPR:Q8WXA9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153914 Expressed in 228 organ(s), highest expression level in kidney
CleanExiHS_SFRS12
ExpressionAtlasiQ8WXA9 baseline and differential
GenevisibleiQ8WXA9 HS

Family and domain databases

CDDicd12260 RRM2_SREK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033568 Srek1
IPR034192 SREK1_RRM2
PANTHERiPTHR32343:SF7 PTHR32343:SF7, 2 hits
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSREK1_HUMAN
AccessioniPrimary (citable) accession number: Q8WXA9
Secondary accession number(s): A4FTW3, Q2M1J0, Q86X37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again