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Protein

5-hydroxytryptamine receptor 3C

Gene

HTR3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3C
Short name:
5-HT3-C
Short name:
5-HT3C
Alternative name(s):
Serotonin receptor 3C
Gene namesi
Name:HTR3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178084.1
HGNCiHGNC:24003 HTR3C
MIMi610121 gene
neXtProtiNX_Q8WXA8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 248ExtracellularSequence analysisAdd BLAST221
Transmembranei249 – 269Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini270 – 282CytoplasmicSequence analysisAdd BLAST13
Transmembranei283 – 303Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini304 – 306ExtracellularSequence analysis3
Transmembranei307 – 329Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini330 – 424CytoplasmicSequence analysisAdd BLAST95
Transmembranei425 – 445Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini446 – 447ExtracellularSequence analysis2

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi170572
OpenTargetsiENSG00000178084
PharmGKBiPA134925741

Chemistry databases

ChEMBLiCHEMBL2094132
DrugBankiDB01049 Ergoloid mesylate
DB00898 Ethanol
DB13025 Tiapride

Polymorphism and mutation databases

BioMutaiHTR3C
DMDMi166198366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000031229228 – 4475-hydroxytryptamine receptor 3CAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi162 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8WXA8
PeptideAtlasiQ8WXA8
PRIDEiQ8WXA8
ProteomicsDBi74998

PTM databases

iPTMnetiQ8WXA8
PhosphoSitePlusiQ8WXA8

Expressioni

Tissue specificityi

Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.1 Publication

Gene expression databases

BgeeiENSG00000178084 Expressed in 18 organ(s), highest expression level in right lung
CleanExiHS_HTR3C
GenevisibleiQ8WXA8 HS

Interactioni

Subunit structurei

Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HTR3AP460985EBI-9008753,EBI-9008743

Protein-protein interaction databases

BioGridi128062, 85 interactors
ComplexPortaliCPX-276 5-hydroxytryptamine-3A/C receptor complex
IntActiQ8WXA8, 1 interactor
STRINGi9606.ENSP00000322617

Chemistry databases

BindingDBiQ8WXA8

Structurei

3D structure databases

ProteinModelPortaliQ8WXA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000241519
HOVERGENiHBG106638
InParanoidiQ8WXA8
KOiK04819
OMAiDIFIMES
OrthoDBiEOG091G042C
PhylomeDBiQ8WXA8
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WXA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD
60 70 80 90 100
RKAFRPFTNY SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI
110 120 130 140 150
NWNPKECVGI NKLTVLAENL WLPDIFIVES MDVDQTPSGL TAYISSEGRI
160 170 180 190 200
KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF SSFLYTVDSM LLGMDKEVWE
210 220 230 240 250
ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY VAIRRRPSLY
260 270 280 290 300
IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL
310 320 330 340 350
PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL
360 370 380 390 400
LLHCTSPGRC CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP
410 420 430 440
DGGSGWTKTQ LMELWVQFSH AMDTLLFRLY LLFMASSILT VIVLWNT
Length:447
Mass (Da):50,220
Last modified:January 15, 2008 - v2
Checksum:iE99260743598E596
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037552128V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs142791028Ensembl.1
Natural variantiVAR_037476163N → K1 PublicationCorresponds to variant dbSNP:rs6766410Ensembl.1
Natural variantiVAR_037477405G → A1 PublicationCorresponds to variant dbSNP:rs6807362Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459285 mRNA Translation: AAL66182.1
CH471052 Genomic DNA Translation: EAW78305.1
BC131799 mRNA Translation: AAI31800.1
CCDSiCCDS3250.1
RefSeqiNP_570126.2, NM_130770.2
UniGeneiHs.632579

Genome annotation databases

EnsembliENST00000318351; ENSP00000322617; ENSG00000178084
GeneIDi170572
KEGGihsa:170572
UCSCiuc003fmk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459285 mRNA Translation: AAL66182.1
CH471052 Genomic DNA Translation: EAW78305.1
BC131799 mRNA Translation: AAI31800.1
CCDSiCCDS3250.1
RefSeqiNP_570126.2, NM_130770.2
UniGeneiHs.632579

3D structure databases

ProteinModelPortaliQ8WXA8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128062, 85 interactors
ComplexPortaliCPX-276 5-hydroxytryptamine-3A/C receptor complex
IntActiQ8WXA8, 1 interactor
STRINGi9606.ENSP00000322617

Chemistry databases

BindingDBiQ8WXA8
ChEMBLiCHEMBL2094132
DrugBankiDB01049 Ergoloid mesylate
DB00898 Ethanol
DB13025 Tiapride

PTM databases

iPTMnetiQ8WXA8
PhosphoSitePlusiQ8WXA8

Polymorphism and mutation databases

BioMutaiHTR3C
DMDMi166198366

Proteomic databases

PaxDbiQ8WXA8
PeptideAtlasiQ8WXA8
PRIDEiQ8WXA8
ProteomicsDBi74998

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318351; ENSP00000322617; ENSG00000178084
GeneIDi170572
KEGGihsa:170572
UCSCiuc003fmk.4 human

Organism-specific databases

CTDi170572
DisGeNETi170572
EuPathDBiHostDB:ENSG00000178084.1
GeneCardsiHTR3C
HGNCiHGNC:24003 HTR3C
MIMi610121 gene
neXtProtiNX_Q8WXA8
OpenTargetsiENSG00000178084
PharmGKBiPA134925741
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000241519
HOVERGENiHBG106638
InParanoidiQ8WXA8
KOiK04819
OMAiDIFIMES
OrthoDBiEOG091G042C
PhylomeDBiQ8WXA8
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

Miscellaneous databases

GeneWikiiHTR3C
GenomeRNAii170572
PROiPR:Q8WXA8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178084 Expressed in 18 organ(s), highest expression level in right lung
CleanExiHS_HTR3C
GenevisibleiQ8WXA8 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT3C_HUMAN
AccessioniPrimary (citable) accession number: Q8WXA8
Secondary accession number(s): A2RRR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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