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Protein

Epididymal-specific lipocalin-9

Gene

LCN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-804914 Transport of fatty acids

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-9
Alternative name(s):
MUP-like lipocalin
Gene namesi
Name:LCN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148386.9
HGNCiHGNC:17442 LCN9
MIMi612903 gene
neXtProtiNX_Q8WX39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879860

Chemistry databases

DrugBankiDB03087 2-(Sec-Butyl)Thiazole
DB04512 2-Isobutyl-3-Methoxypyrazine
DB01760 2-Methoxy-3-Isopropylpyrazine
DB03711 6-Hydroxy-6-Methyl-Heptan-3-One

Polymorphism and mutation databases

BioMutaiLCN9
DMDMi338817980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000001791816 – 176Epididymal-specific lipocalin-9Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 161By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WX39
PeptideAtlasiQ8WX39
PRIDEiQ8WX39
ProteomicsDBi74975

PTM databases

iPTMnetiQ8WX39
PhosphoSitePlusiQ8WX39

Expressioni

Gene expression databases

BgeeiENSG00000148386
CleanExiHS_LCN9
ExpressionAtlasiQ8WX39 baseline and differential

Organism-specific databases

HPAiHPA060941

Interactioni

Protein-protein interaction databases

IntActiQ8WX39, 1 interactor
STRINGi9606.ENSP00000277526

Structurei

3D structure databases

ProteinModelPortaliQ8WX39
SMRiQ8WX39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBWS Eukaryota
ENOG4111AS1 LUCA
GeneTreeiENSGT00530000063356
HOGENOMiHOG000231458
HOVERGENiHBG000215
InParanoidiQ8WX39
OMAiWYSIFMA
TreeFamiTF338197

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002971 Maj_urinary
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01221 MAJORURINARY
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WX39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLLSLGL SLIAAQEFDP HTVMQRNYNV ARVSGVWYSI FMASDDLNRI
60 70 80 90 100
KENGDLRVFV RNIEHLKNGS LIFDFEYMVQ GECVAVVVVC EKTEKNGEYS
110 120 130 140 150
INYEGQNTVA VSETDYRLFI TFHLQNFRNG TETHTLALYE TCEKYGLGSQ
160 170
NIIDLTNKDP CYSKHYRSPP RPPMRW
Length:176
Mass (Da):20,285
Last modified:June 28, 2011 - v3
Checksum:iF15525B66B909180
GO

Sequence cautioni

The sequence CAD13244 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05616765H → Y. Corresponds to variant dbSNP:rs12352552Ensembl.1
Natural variantiVAR_05616890C → F. Corresponds to variant dbSNP:rs7875283Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301270 mRNA Translation: AAQ81975.1
AL158822 Genomic DNA Translation: CAD13244.1 Sequence problems.
CCDSiCCDS56593.1
RefSeqiNP_001001676.1, NM_001001676.1
UniGeneiHs.532679

Genome annotation databases

EnsembliENST00000277526; ENSP00000277526; ENSG00000148386
GeneIDi392399
KEGGihsa:392399

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLCN9_HUMAN
AccessioniPrimary (citable) accession number: Q8WX39
Secondary accession number(s): C9J5F0, Q6JVE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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