ATP-binding cassette sub-family A member 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
• ATP binding Source: UniProtKB-KW
• lipid transporter activity Source: Reactome

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cholesterol efflux Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 20382126
• high-density lipoprotein particle remodeling Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 20382126
• lipid transport Source: GO_Central
• negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 20382126
• reverse cholesterol transport Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 20382126
• transmembrane transport Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MSTAIREVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILIS 
        60         70         80         90        100
MMHPNKKYEE VPNIELNPMD KFTLSNLILG YTPVTNITSS IMQKVSTDHL 
       110        120        130        140        150
PDVIITEEYT NEKEMLTSSL SKPSNFVGVV FKDSMSYELR FFPDMIPVSS 
       160        170        180        190        200
IYMDSRAGCS KSCEAAQYWS SGFTVLQASI DAAIIQLKTN VSLWKELEST 
       210        220        230        240        250
KAVIMGETAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKIKE 
       260        270        280        290        300
FLKIMGLHDT AFWLSWVLLY TSLIFLMSLL MAVIATASLL FPQSSSIVIF 
       310        320        330        340        350
LLFFLYGLSS VFFALMLTPL FKKSKHVGIV EFFVTVAFGF IGLMIILIES 
       360        370        380        390        400
FPKSLVWLFS PFCHCTFVIG IAQVMHLEDF NEGASFSNLT AGPYPLIITI 
       410        420        430        440        450
IMLTLNSIFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKSKRNYEEL 
       460        470        480        490        500
SEGNVNGNIS FSEIIEPVSS EFVGKEAIRI SGIQKTYRKK GENVEALRNL 
       510        520        530        540        550
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE 
       560        570        580        590        600
MFEARKMIGI CPQLDIHFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL 
       610        620        630        640        650
DLDMQTIKDN QAKKLSGGQK RKLSLGIAVL GNPKILLLDE PTAGMDPCSR 
       660        670        680        690        700
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSMFL 
       710        720        730        740        750
KSKWGIGYRL SMYIDKYCAT ESLSSLVKQH IPGATLLQQN DQQLVYSLPF 
       760        770        780        790        800
KDMDKFSGLF SALDSHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS 
       810        820        830        840        850
VFTQQPLEEE MDSKSFDEME QSLLILSETK AALVSTMSLW KQQMYTIAKF 
       860        870        880        890        900
HFFTLKRESK SVRSVLLLLL IFFTVQIFMF LVHHSFKNAV VPIKLVPDLY 
       910        920        930        940        950
FLKPGDKPHK YKTSLLLQNS ADSDISDLIS FFTSQNIMVT MINDSDYVSV 
       960        970        980        990       1000
APHSAALNVM HSEKDYVFAA VFNSTMVYSL PILVNIISNY YLYHLNVTET 
      1010       1020       1030       1040       1050
IQIWSTPFFQ EITDIVFKIE LYFQAALLGI IVTAMPPYFA MENAENHKIK 
      1060       1070       1080       1090       1100
AYTQLKLSGL LPSAYWIGQA VVDIPLFFII LILMLGSLLA FHYGLYFYTV 
      1110       1120       1130       1140       1150
KFLAVVFCLI GYVPSVILFT YIASFTFKKI LNTKEFWSFI YSVAALACIA 
      1160       1170       1180       1190       1200
ITEITFFMGY TIATILHYAF CIIIPIYPLL GCLISFIKIS WKNVRKNVDT 
      1210       1220       1230       1240       1250
YNPWDRLSVA VISPYLQCVL WIFLLQYYEK KYGGRSIRKD PFFRNLSTKS 
      1260       1270       1280       1290       1300
KNRKLPEPPD NEDEDEDVKA ERLKVKELMG CQCCEEKPSI MVSNLHKEYD 
      1310       1320       1330       1340       1350
DKKDFLLSRK VKKVATKYIS FCVKKGEILG LLGPNGAGKS TIINILVGDI 
      1360       1370       1380       1390       1400
EPTSGQVFLG DYSSETSEDD DSLKCMGYCP QINPLWPDTT LQEHFEIYGA 
      1410       1420       1430       1440       1450
VKGMSASDMK EVISRITHAL DLKEHLQKTV KKLPAGIKRK LCFALSMLGN 
      1460       1470       1480       1490       1500
PQITLLDEPS TGMDPKAKQH MWRAIRTAFK NRKRAAILTT HYMEEAEAVC 
      1510       1520       1530       1540       1550
DRVAIMVSGQ LRCIGTVQHL KSKFGKGYFL EIKLKDWIEN LEVDRLQREI 
      1560       1570       1580       1590       1600
QYIFPNASRQ ESFSSILAYK IPKEDVQSLS QSFFKLEEAK HAFAIEEYSF 
      1610       1620       1630       1640 
SQATLEQVFV ELTKEQEEED NSCGTLNSTL WWERTQEDRV VF         

        10         20         30         40         50
MSTAIREVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILIS 
        60         70         80         90        100
MMHPNKKYEE VPNIELNPMD KFTLSNLILG YTPVTNITSS IMQKVSTDHL 
       110        120        130        140        150
PDVIITEEYT NEKEMLTSSL SKPSNFVGVV FKDSMSYELR FFPDMIPVSS 
       160        170        180        190        200
IYMDSRAGCS KSCEAAQYWS SGFTVLQASI DAAIIQLKTN VSLWKELEST 
       210        220        230        240        250
KAVIMGETAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKIKE 
       260        270        280        290        300
FLKIMGLHDT AFWLSWVLLY TSLIFLMSLL MAVIATASLL FPQSSSIVIF 
       310        320        330        340        350
LLFFLYGLSS VFFALMLTPL FKKSKHVGIV EFFVTVAFGF IGLMIILIES 
       360        370        380        390        400
FPKSLVWLFS PFCHCTFVIG IAQVMHLEDF NEGASFSNLT AGPYPLIITI 
       410        420        430        440        450
IMLTLNSIFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKSKRNYEEL 
       460        470        480        490        500
SEGNVNGNIS FSEIIEPVSS EFVGKEAIRI SGIQKTYRKK GENVEALRNL 
       510        520        530        540        550
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE 
       560        570        580        590        600
MFEARKMIGI CPQLDIHFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL 
       610        620        630        640        650
DLDMQTIKDN QAKKLSGGQK RKLSLGIAVL GNPKILLLDE PTAGMDPCSR 
       660        670        680        690        700
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSMFL 
       710        720        730        740        750
KSKWGIGYRL SMYIDKYCAT ESLSSLVKQH IPGATLLQQN DQQLVYSLPF 
       760        770        780        790        800
KDMDKFSGLF SALDSHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS 
       810        820        830        840        850
VFTQQPLEEE MDSKSFDEME QSLLILSETK AALVSTMSLW KQQMYTIAKF 
       860        870        880        890        900
HFFTLKRESK SVRSVLLLLL IFFTVQIFMF LVHHSFKNAV VPIKLVPDLY 
       910        920 
FLKPGDKPHK YKTSLLLQNS AGESV                            

        10         20         30         40         50
MTTLEDVFLK LEVEAEIDQA DYSVFTQQPL EEEMDSKSFD EMEQSLLILS 
        60         70         80         90        100
ETKAALVSTM SLWKQQMYTI AKFHFFTLKR ESKSVRSVLL LLLIFFTVQI 
       110        120        130        140        150
FMFLVHHSFK NAVVPIKLVP DLYFLKPGDK PHKYKTSLLL QNSADSDISD 
       160        170        180        190        200
LISFFTSQNI MVTMINDSDY VSVAPHSAAL NVMHSEKDYV FAAVFNSTMV 
       210        220        230        240        250
YSLPILVNII SNYYLYHLNV TETIQIWSTP FFQEITDIVF KIELYFQAAL 
       260        270        280        290        300
LGIIVTAMPP YFAMENAENH KIKAYTQLKL SGLLPSAYWI GQAVVDIPLF 
       310        320        330        340        350
FIILILMLGS LLAFHYGLYF YTVKFLAVVF CLIGYVPSVI LFTYIASFTF 
       360        370        380        390        400
KKILNTKEFW SFIYSVAALA CIAITEITFF MGYTIATILH YAFCIIIPIY 
       410        420        430        440        450
PLLGCLISFI KISWKNVRKN VDTYNPWDRL SVAVISPYLQ CVLWIFLLQY 
       460        470        480        490        500
YEKKYGGRSI RKDPFFRNLS TKSKNRKLPE PPDNEDEDED VKAERLKVKE 
       510        520        530        540        550
LMGCQCCEEK PSIMVSNLHK EYDDKKDFLL SRKVKKVATK YISFCVKKGE 
       560        570        580        590        600
ILGLLGPNGA GKSTIINILV GDIEPTSGQV FLGDYSSETS EDDDSLKCMG 
       610        620        630        640        650
YCPQINPLWP DTTLQEHFEI YGAVKGMSAS DMKEVISRIT HALDLKEHLQ 
       660        670        680        690        700
KTVKKLPAGI KRKLCFALSM LGNPQITLLD EPSTGMDPKA KQHMWRAIRT 
       710        720        730        740        750
AFKNRKRAAI LTTHYMEEAE AVCDRVAIMV SGQLRCIGTV QHLKSKFGKG 
       760        770        780        790        800
YFLEIKLKDW IENLEVDRLQ REIQYIFPNA SRQESFSSIL AYKIPKEDVQ 
       810        820        830        840        850
SLSQSFFKLE EAKHAFAIEE YSFSQATLEQ VFVELTKEQE EEDNSCGTLN 
       860 
STLWWERTQE DRVVF                                       

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families