Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q8WWZ4 (ABCAA_HUMAN)

Entry version 145 (25 May 2022)
Sequence version 3 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

ATP-binding cassette sub-family A member 10

Gene

ABCA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transporter which may play a role in macrophage lipid transport and homeostasis.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi427 – 434ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1239 – 1246ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WWZ4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1369062, ABC transporters in lipid homeostasis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WWZ4

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.211.17, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 10Curated (EC:7.6.2.-1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30, ABCA10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612508, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WWZ4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000154263

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Transmembranei890 – 910HelicalSequence analysisAdd BLAST21
Transmembranei926 – 946HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1005HelicalSequence analysisAdd BLAST21
Transmembranei1014 – 1034HelicalSequence analysisAdd BLAST21
Transmembranei1046 – 1066HelicalSequence analysisAdd BLAST21
Transmembranei1073 – 1093HelicalSequence analysisAdd BLAST21
Transmembranei1113 – 1133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10349

Open Targets

More...OpenTargetsi		ENSG00000154263

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24374

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WWZ4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABCA10

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535721 – 1543ATP-binding cassette sub-family A member 10Add BLAST1543

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WWZ4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WWZ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WWZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WWZ4

PeptideAtlas

More...PeptideAtlasi		Q8WWZ4

PRoteomics IDEntifications database

More...PRIDEi		Q8WWZ4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74965 [Q8WWZ4-1]
74966 [Q8WWZ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WWZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WWZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by cholesterol loading of macrophages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154263, Expressed in right ovary and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WWZ4, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154263, Tissue enhanced (ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115630, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q8WWZ4, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000269081

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WWZ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8WWZ4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WWZ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini391 – 626ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1206 – 1440ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1153 – 1177DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCA family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0059, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WWZ4

Identification of Orthologs from Complete Genome Data

More...OMAi		SDQGIMN

Database of Orthologous Groups

More...OrthoDBi		131191at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WWZ4

TreeFam database of animal gene trees

More...TreeFami		TF105192

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like_ATP-bd
IPR017871, ABC_transporter-like_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF 
        60         70         80         90        100
NWGYRIPVIK EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII 
       110        120        130        140        150
EVTTNHSVME ELTSVIGINM KIPPFISKGE IMNEWFHFTC LVSFSSFIYF 
       160        170        180        190        200
ASLNVARERG KFKKLMTVMG LRESAFWLSW GLTYICFIFI MSIFMALVIT 
       210        220        230        240        250
SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML AGLAGFLFTV 
       260        270        280        290        300
FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP 
       310        320        330        340        350
DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS 
       360        370        380        390        400
SFWSKHQNTH HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY 
       410        420        430        440        450
NGKTGKVEAL QGIFFDIYEG QITAILGHNG AGKSTLLNIL SGLSVSTEGS 
       460        470        480        490        500
ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ FDFLTVRENL RVFAKIKGIQ 
       510        520        530        540        550
PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI AILGDPQVLL 
       560        570        580        590        600
LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS 
       610        620        630        640        650
NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT 
       660        670        680        690        700
TESEEKLVYS LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN 
       710        720        730        740        750
LEGKSAIDEP DFDIGKQEKI HVTRNTGDES EMEQVLCSLP ETRKAVSSAA 
       760        770        780        790        800
LWRRQIYAVA TLRFLKLRRE RRALLCLLLV LGIAFIPIIL EKIMYKVTRE 
       810        820        830        840        850
THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV HSLKCQDIVL 
       860        870        880        890        900
EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV 
       910        920        930        940        950
SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI 
       960        970        980        990       1000
GMSSISDYKK NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY 
      1010       1020       1030       1040       1050
FIFLGFQLSW ELMFVLVVCI IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF 
      1060       1070       1080       1090       1100
GFFIILICVS TIMVSTQYEK LNLILCMIFI PSFTLLGYVM LLIQLDFMRN 
      1110       1120       1130       1140       1150
LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY GNEIMNKDPV 
      1160       1170       1180       1190       1200
FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC 
      1210       1220       1230       1240       1250
LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK 
      1260       1270       1280       1290       1300
MITGCTKPTA GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE 
      1310       1320       1330       1340       1350
HLELYAAVKG LGKEDAALSI SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF 
      1360       1370       1380       1390       1400
VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ ILQATVKNKE RGTLLTTHYM 
      1410       1420       1430       1440       1450
SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK MKEPTQVEAL 
      1460       1470       1480       1490       1500
HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE 
      1510       1520       1530       1540 
EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP
Length:1,543
Mass (Da):175,790
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E932434314B538
GO
Isoform 2 (identifier: Q8WWZ4-2) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta+82

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:1,520
Mass (Da):173,280
Checksum:i53F733EF3885790F
GO
Isoform 3 (identifier: Q8WWZ4-3) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta-104

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: E → GHNKSFCNGGVDISYWNKYEDTTFHF
     68-1543: Missing.

Show »
Length:92
Mass (Da):10,828
Checksum:i947A319F99231651
GO
Isoform 4 (identifier: Q8WWZ4-4) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta-176

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: S → KKNYNGIRHAKHSRHYC
     451-1543: Missing.

Show »
Length:466
Mass (Da):53,113
Checksum:i636FB6EEBF278210
GO
Isoform 5 (identifier: Q8WWZ4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-452: IFFDIYEGQI...LSVSTEGSAT → SEERLCPAAH...PCPAATPSGN
     453-1543: Missing.

Show »
Length:452
Mass (Da):51,478
Checksum:iD3583F1419B5AC38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFN6E5RFN6_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
1,326Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFP5E5RFP5_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBL8H0YBL8_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMH5K7EMH5_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERP5K7ERP5_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140C → Y in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti159R → G in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti187F → S in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti324L → S in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti364F → L in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti1216R → I in AAO72160 (PubMed:12821155).Curated1
Sequence conflicti1216R → I in AAO72161 (PubMed:12821155).Curated1
Sequence conflicti1216R → I in AAH51320 (PubMed:16625196).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028384203P → S3 PublicationsCorresponds to variant dbSNP:rs9909216Ensembl.1
Natural variantiVAR_028385287I → V3 PublicationsCorresponds to variant dbSNP:rs11657804Ensembl.1
Natural variantiVAR_028386916M → T1 PublicationCorresponds to variant dbSNP:rs4968849Ensembl.1
Natural variantiVAR_0554691322R → W. Corresponds to variant dbSNP:rs10491178Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0210611 – 23Missing in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_02106267E → GHNKSFCNGGVDISYWNKYE DTTFHF in isoform 3. Curated1
Alternative sequenceiVSP_02106368 – 1543Missing in isoform 3. CuratedAdd BLAST1476
Alternative sequenceiVSP_021064413 – 452IFFDI…EGSAT → SEERLCPAAHRLRCGERLCP AAHHLGCEERPCPAATPSGN in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_021065450S → KKNYNGIRHAKHSRHYC in isoform 4. Curated1
Alternative sequenceiVSP_021066451 – 1543Missing in isoform 4. CuratedAdd BLAST1093
Alternative sequenceiVSP_021067453 – 1543Missing in isoform 5. 1 PublicationAdd BLAST1091

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY028900 mRNA Translation: AAK30025.1
AY247065 mRNA Translation: AAO72161.1
AY247105 AY247104 Genomic DNA Translation: AAO72160.1
AL832004 mRNA Translation: CAD89903.1
AC005495 Genomic DNA No translation available.
BC031026 mRNA Translation: AAH31026.1
BC051320 mRNA Translation: AAH51320.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11684.1 [Q8WWZ4-1]

NCBI Reference Sequences

More...RefSeqi		NP_525021.3, NM_080282.3 [Q8WWZ4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000269081.8; ENSP00000269081.4; ENSG00000154263.18
ENST00000522406.5; ENSP00000429853.1; ENSG00000154263.18 [Q8WWZ4-5]
ENST00000523512.5; ENSP00000429945.1; ENSG00000154263.18 [Q8WWZ4-3]
ENST00000690296.1; ENSP00000509702.1; ENSG00000154263.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10349

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10349

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000690296.1; ENSP00000509702.1; NM_001377321.1; NP_001364250.1

UCSC genome browser

More...UCSCi		uc010dfa.2, human [Q8WWZ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028900 mRNA Translation: AAK30025.1
AY247065 mRNA Translation: AAO72161.1
AY247105 AY247104 Genomic DNA Translation: AAO72160.1
AL832004 mRNA Translation: CAD89903.1
AC005495 Genomic DNA No translation available.
BC031026 mRNA Translation: AAH31026.1
BC051320 mRNA Translation: AAH51320.1
CCDSiCCDS11684.1 [Q8WWZ4-1]
RefSeqiNP_525021.3, NM_080282.3 [Q8WWZ4-1]

3D structure databases

AlphaFoldDBiQ8WWZ4
SMRiQ8WWZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115630, 5 interactors
IntActiQ8WWZ4, 2 interactors
STRINGi9606.ENSP00000269081

Protein family/group databases

TCDBi3.A.1.211.17, the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ8WWZ4
PhosphoSitePlusiQ8WWZ4

Genetic variation databases

BioMutaiABCA10
DMDMi296439455

Proteomic databases

EPDiQ8WWZ4
jPOSTiQ8WWZ4
MassIVEiQ8WWZ4
PaxDbiQ8WWZ4
PeptideAtlasiQ8WWZ4
PRIDEiQ8WWZ4
ProteomicsDBi74965 [Q8WWZ4-1]
74966 [Q8WWZ4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2899, 49 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		10349

Genome annotation databases

EnsembliENST00000269081.8; ENSP00000269081.4; ENSG00000154263.18
ENST00000522406.5; ENSP00000429853.1; ENSG00000154263.18 [Q8WWZ4-5]
ENST00000523512.5; ENSP00000429945.1; ENSG00000154263.18 [Q8WWZ4-3]
ENST00000690296.1; ENSP00000509702.1; ENSG00000154263.18
GeneIDi10349
KEGGihsa:10349
MANE-SelectiENST00000690296.1; ENSP00000509702.1; NM_001377321.1; NP_001364250.1
UCSCiuc010dfa.2, human [Q8WWZ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10349
DisGeNETi10349

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABCA10
HGNCiHGNC:30, ABCA10
HPAiENSG00000154263, Tissue enhanced (ovary)
MIMi612508, gene
neXtProtiNX_Q8WWZ4
OpenTargetsiENSG00000154263
PharmGKBiPA24374
VEuPathDBiHostDB:ENSG00000154263

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000162673
HOGENOMiCLU_000604_19_1_1
InParanoidiQ8WWZ4
OMAiSDQGIMN
OrthoDBi131191at2759
PhylomeDBiQ8WWZ4
TreeFamiTF105192

Enzyme and pathway databases

PathwayCommonsiQ8WWZ4
ReactomeiR-HSA-1369062, ABC transporters in lipid homeostasis
SignaLinkiQ8WWZ4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10349, 12 hits in 1064 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABCA10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10349
PharosiQ8WWZ4, Tdark

Protein Ontology

More...PROi		PR:Q8WWZ4
RNActiQ8WWZ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154263, Expressed in right ovary and 113 other tissues
ExpressionAtlasiQ8WWZ4, baseline and differential

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like_ATP-bd
IPR017871, ABC_transporter-like_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCAA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWZ4
Secondary accession number(s): C9JZH2
, C9K035, Q6PIQ6, Q7Z2I9, Q7Z7P7, Q86TD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again