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Entry version 135 (26 Feb 2020)
Sequence version 3 (18 May 2010)
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Protein

ATP-binding cassette sub-family A member 10

Gene

ABCA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transporter which may play a role in macrophage lipid homeostasis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi427 – 434ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1239 – 1246ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1369062 ABC transporters in lipid homeostasis

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.211.17 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30 ABCA10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612508 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWZ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Transmembranei890 – 910HelicalSequence analysisAdd BLAST21
Transmembranei926 – 946HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1005HelicalSequence analysisAdd BLAST21
Transmembranei1014 – 1034HelicalSequence analysisAdd BLAST21
Transmembranei1046 – 1066HelicalSequence analysisAdd BLAST21
Transmembranei1073 – 1093HelicalSequence analysisAdd BLAST21
Transmembranei1113 – 1133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10349

Open Targets

More...
OpenTargetsi
ENSG00000154263

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24374

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WWZ4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCA10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535721 – 1543ATP-binding cassette sub-family A member 10Add BLAST1543

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WWZ4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WWZ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WWZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WWZ4

PeptideAtlas

More...
PeptideAtlasi
Q8WWZ4

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWZ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74965 [Q8WWZ4-1]
74966 [Q8WWZ4-2]
74967 [Q8WWZ4-3]
74968 [Q8WWZ4-4]
74969 [Q8WWZ4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WWZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by cholesterol loading of macrophages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154263 Expressed in right ovary and 86 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWZ4 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014535

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115630, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000269081

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WWZ4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WWZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini391 – 626ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1206 – 1440ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WWZ4

KEGG Orthology (KO)

More...
KOi
K05652

Identification of Orthologs from Complete Genome Data

More...
OMAi
SDQGIMN

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWZ4

TreeFam database of animal gene trees

More...
TreeFami
TF105192

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF
60 70 80 90 100
NWGYRIPVIK EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII
110 120 130 140 150
EVTTNHSVME ELTSVIGINM KIPPFISKGE IMNEWFHFTC LVSFSSFIYF
160 170 180 190 200
ASLNVARERG KFKKLMTVMG LRESAFWLSW GLTYICFIFI MSIFMALVIT
210 220 230 240 250
SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML AGLAGFLFTV
260 270 280 290 300
FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP
310 320 330 340 350
DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS
360 370 380 390 400
SFWSKHQNTH HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY
410 420 430 440 450
NGKTGKVEAL QGIFFDIYEG QITAILGHNG AGKSTLLNIL SGLSVSTEGS
460 470 480 490 500
ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ FDFLTVRENL RVFAKIKGIQ
510 520 530 540 550
PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI AILGDPQVLL
560 570 580 590 600
LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS
610 620 630 640 650
NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT
660 670 680 690 700
TESEEKLVYS LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN
710 720 730 740 750
LEGKSAIDEP DFDIGKQEKI HVTRNTGDES EMEQVLCSLP ETRKAVSSAA
760 770 780 790 800
LWRRQIYAVA TLRFLKLRRE RRALLCLLLV LGIAFIPIIL EKIMYKVTRE
810 820 830 840 850
THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV HSLKCQDIVL
860 870 880 890 900
EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV
910 920 930 940 950
SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI
960 970 980 990 1000
GMSSISDYKK NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY
1010 1020 1030 1040 1050
FIFLGFQLSW ELMFVLVVCI IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF
1060 1070 1080 1090 1100
GFFIILICVS TIMVSTQYEK LNLILCMIFI PSFTLLGYVM LLIQLDFMRN
1110 1120 1130 1140 1150
LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY GNEIMNKDPV
1160 1170 1180 1190 1200
FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC
1210 1220 1230 1240 1250
LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK
1260 1270 1280 1290 1300
MITGCTKPTA GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE
1310 1320 1330 1340 1350
HLELYAAVKG LGKEDAALSI SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF
1360 1370 1380 1390 1400
VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ ILQATVKNKE RGTLLTTHYM
1410 1420 1430 1440 1450
SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK MKEPTQVEAL
1460 1470 1480 1490 1500
HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE
1510 1520 1530 1540
EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP
Length:1,543
Mass (Da):175,790
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E932434314B538
GO
Isoform 2 (identifier: Q8WWZ4-2) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta+82

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:1,520
Mass (Da):173,280
Checksum:i53F733EF3885790F
GO
Isoform 3 (identifier: Q8WWZ4-3) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta-104

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: E → GHNKSFCNGGVDISYWNKYEDTTFHF
     68-1543: Missing.

Show »
Length:92
Mass (Da):10,828
Checksum:i947A319F99231651
GO
Isoform 4 (identifier: Q8WWZ4-4) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta-176

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: S → KKNYNGIRHAKHSRHYC
     451-1543: Missing.

Show »
Length:466
Mass (Da):53,113
Checksum:i636FB6EEBF278210
GO
Isoform 5 (identifier: Q8WWZ4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-452: IFFDIYEGQI...LSVSTEGSAT → SEERLCPAAH...PCPAATPSGN
     453-1543: Missing.

Show »
Length:452
Mass (Da):51,478
Checksum:iD3583F1419B5AC38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFN6E5RFN6_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
1,326Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFP5E5RFP5_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBL8H0YBL8_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMH5K7EMH5_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERP5K7ERP5_HUMAN
ATP-binding cassette sub-family A m...
ABCA10
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140C → Y in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti159R → G in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti187F → S in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti324L → S in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti364F → L in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti1216R → I in AAO72160 (PubMed:12821155).Curated1
Sequence conflicti1216R → I in AAO72161 (PubMed:12821155).Curated1
Sequence conflicti1216R → I in AAH51320 (PubMed:16625196).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028384203P → S3 PublicationsCorresponds to variant dbSNP:rs9909216Ensembl.1
Natural variantiVAR_028385287I → V3 PublicationsCorresponds to variant dbSNP:rs11657804Ensembl.1
Natural variantiVAR_028386916M → T1 PublicationCorresponds to variant dbSNP:rs4968849Ensembl.1
Natural variantiVAR_0554691322R → W. Corresponds to variant dbSNP:rs10491178Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0210611 – 23Missing in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_02106267E → GHNKSFCNGGVDISYWNKYE DTTFHF in isoform 3. Curated1
Alternative sequenceiVSP_02106368 – 1543Missing in isoform 3. CuratedAdd BLAST1476
Alternative sequenceiVSP_021064413 – 452IFFDI…EGSAT → SEERLCPAAHRLRCGERLCP AAHHLGCEERPCPAATPSGN in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_021065450S → KKNYNGIRHAKHSRHYC in isoform 4. Curated1
Alternative sequenceiVSP_021066451 – 1543Missing in isoform 4. CuratedAdd BLAST1093
Alternative sequenceiVSP_021067453 – 1543Missing in isoform 5. 1 PublicationAdd BLAST1091

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY028900 mRNA Translation: AAK30025.1
AY247065 mRNA Translation: AAO72161.1
AY247105 AY247104 Genomic DNA Translation: AAO72160.1
AL832004 mRNA Translation: CAD89903.1
AC005495 Genomic DNA No translation available.
BC031026 mRNA Translation: AAH31026.1
BC051320 mRNA Translation: AAH51320.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11684.1 [Q8WWZ4-1]

NCBI Reference Sequences

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RefSeqi
NP_525021.3, NM_080282.3 [Q8WWZ4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269081; ENSP00000269081; ENSG00000154263 [Q8WWZ4-1]
ENST00000522406; ENSP00000429853; ENSG00000154263 [Q8WWZ4-5]
ENST00000523512; ENSP00000429945; ENSG00000154263 [Q8WWZ4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10349

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10349

UCSC genome browser

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UCSCi
uc010dfa.2 human [Q8WWZ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028900 mRNA Translation: AAK30025.1
AY247065 mRNA Translation: AAO72161.1
AY247105 AY247104 Genomic DNA Translation: AAO72160.1
AL832004 mRNA Translation: CAD89903.1
AC005495 Genomic DNA No translation available.
BC031026 mRNA Translation: AAH31026.1
BC051320 mRNA Translation: AAH51320.1
CCDSiCCDS11684.1 [Q8WWZ4-1]
RefSeqiNP_525021.3, NM_080282.3 [Q8WWZ4-1]

3D structure databases

SMRiQ8WWZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115630, 2 interactors
STRINGi9606.ENSP00000269081

Protein family/group databases

TCDBi3.A.1.211.17 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ8WWZ4
PhosphoSitePlusiQ8WWZ4

Polymorphism and mutation databases

BioMutaiABCA10
DMDMi296439455

Proteomic databases

EPDiQ8WWZ4
jPOSTiQ8WWZ4
MassIVEiQ8WWZ4
PaxDbiQ8WWZ4
PeptideAtlasiQ8WWZ4
PRIDEiQ8WWZ4
ProteomicsDBi74965 [Q8WWZ4-1]
74966 [Q8WWZ4-2]
74967 [Q8WWZ4-3]
74968 [Q8WWZ4-4]
74969 [Q8WWZ4-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10349

Genome annotation databases

EnsembliENST00000269081; ENSP00000269081; ENSG00000154263 [Q8WWZ4-1]
ENST00000522406; ENSP00000429853; ENSG00000154263 [Q8WWZ4-5]
ENST00000523512; ENSP00000429945; ENSG00000154263 [Q8WWZ4-3]
GeneIDi10349
KEGGihsa:10349
UCSCiuc010dfa.2 human [Q8WWZ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10349
DisGeNETi10349

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCA10
HGNCiHGNC:30 ABCA10
HPAiHPA014535
MIMi612508 gene
neXtProtiNX_Q8WWZ4
OpenTargetsiENSG00000154263
PharmGKBiPA24374

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00940000162673
HOGENOMiCLU_000604_19_1_1
InParanoidiQ8WWZ4
KOiK05652
OMAiSDQGIMN
OrthoDBi131191at2759
PhylomeDBiQ8WWZ4
TreeFamiTF105192

Enzyme and pathway databases

ReactomeiR-HSA-1369062 ABC transporters in lipid homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCA10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10349
PharosiQ8WWZ4 Tdark

Protein Ontology

More...
PROi
PR:Q8WWZ4
RNActiQ8WWZ4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154263 Expressed in right ovary and 86 other tissues
ExpressionAtlasiQ8WWZ4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCAA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWZ4
Secondary accession number(s): C9JZH2
, C9K035, Q6PIQ6, Q7Z2I9, Q7Z7P7, Q86TD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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