UniProtKB - Q8WWZ4 (ABCAA_HUMAN)
Protein
ATP-binding cassette sub-family A member 10
Gene
ABCA10
Organism
Homo sapiens (Human)
Status
Functioni
Probable transporter which may play a role in macrophage lipid transport and homeostasis.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 427 – 434 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1239 – 1246 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- lipid transporter activity Source: GO_Central
GO - Biological processi
- lipid transport Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WWZ4 |
Reactomei | R-HSA-1369062, ABC transporters in lipid homeostasis |
Protein family/group databases
TCDBi | 3.A.1.211.17, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ABCA10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30, ABCA10 |
MIMi | 612508, gene |
neXtProti | NX_Q8WWZ4 |
VEuPathDBi | HostDB:ENSG00000154263.17 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 310 – 330 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 774 – 794 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 890 – 910 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 926 – 946 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 985 – 1005 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1014 – 1034 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1046 – 1066 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1073 – 1093 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1113 – 1133 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10349 |
OpenTargetsi | ENSG00000154263 |
PharmGKBi | PA24374 |
Miscellaneous databases
Pharosi | Q8WWZ4, Tdark |
Genetic variation databases
BioMutai | ABCA10 |
DMDMi | 296439455 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253572 | 1 – 1543 | ATP-binding cassette sub-family A member 10Add BLAST | 1543 |
Proteomic databases
EPDi | Q8WWZ4 |
jPOSTi | Q8WWZ4 |
MassIVEi | Q8WWZ4 |
PaxDbi | Q8WWZ4 |
PeptideAtlasi | Q8WWZ4 |
PRIDEi | Q8WWZ4 |
ProteomicsDBi | 74965 [Q8WWZ4-1] 74966 [Q8WWZ4-2] 74967 [Q8WWZ4-3] 74968 [Q8WWZ4-4] 74969 [Q8WWZ4-5] |
PTM databases
iPTMneti | Q8WWZ4 |
PhosphoSitePlusi | Q8WWZ4 |
Expressioni
Tissue specificityi
Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.2 Publications
Inductioni
Down-regulated by cholesterol loading of macrophages.1 Publication
Gene expression databases
Bgeei | ENSG00000154263, Expressed in right ovary and 112 other tissues |
ExpressionAtlasi | Q8WWZ4, baseline and differential |
Organism-specific databases
HPAi | ENSG00000154263, Tissue enhanced (ovary) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115630, 2 interactors |
IntActi | Q8WWZ4, 2 interactors |
STRINGi | 9606.ENSP00000269081 |
Miscellaneous databases
RNActi | Q8WWZ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 391 – 626 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 236 | |
Domaini | 1206 – 1440 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0059, Eukaryota |
GeneTreei | ENSGT00940000162673 |
HOGENOMi | CLU_000604_19_1_1 |
InParanoidi | Q8WWZ4 |
OMAi | SDQGIMN |
OrthoDBi | 131191at2759 |
PhylomeDBi | Q8WWZ4 |
TreeFami | TF105192 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WWZ4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF
60 70 80 90 100
NWGYRIPVIK EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII
110 120 130 140 150
EVTTNHSVME ELTSVIGINM KIPPFISKGE IMNEWFHFTC LVSFSSFIYF
160 170 180 190 200
ASLNVARERG KFKKLMTVMG LRESAFWLSW GLTYICFIFI MSIFMALVIT
210 220 230 240 250
SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML AGLAGFLFTV
260 270 280 290 300
FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP
310 320 330 340 350
DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS
360 370 380 390 400
SFWSKHQNTH HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY
410 420 430 440 450
NGKTGKVEAL QGIFFDIYEG QITAILGHNG AGKSTLLNIL SGLSVSTEGS
460 470 480 490 500
ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ FDFLTVRENL RVFAKIKGIQ
510 520 530 540 550
PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI AILGDPQVLL
560 570 580 590 600
LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS
610 620 630 640 650
NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT
660 670 680 690 700
TESEEKLVYS LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN
710 720 730 740 750
LEGKSAIDEP DFDIGKQEKI HVTRNTGDES EMEQVLCSLP ETRKAVSSAA
760 770 780 790 800
LWRRQIYAVA TLRFLKLRRE RRALLCLLLV LGIAFIPIIL EKIMYKVTRE
810 820 830 840 850
THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV HSLKCQDIVL
860 870 880 890 900
EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV
910 920 930 940 950
SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI
960 970 980 990 1000
GMSSISDYKK NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY
1010 1020 1030 1040 1050
FIFLGFQLSW ELMFVLVVCI IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF
1060 1070 1080 1090 1100
GFFIILICVS TIMVSTQYEK LNLILCMIFI PSFTLLGYVM LLIQLDFMRN
1110 1120 1130 1140 1150
LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY GNEIMNKDPV
1160 1170 1180 1190 1200
FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC
1210 1220 1230 1240 1250
LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK
1260 1270 1280 1290 1300
MITGCTKPTA GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE
1310 1320 1330 1340 1350
HLELYAAVKG LGKEDAALSI SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF
1360 1370 1380 1390 1400
VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ ILQATVKNKE RGTLLTTHYM
1410 1420 1430 1440 1450
SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK MKEPTQVEAL
1460 1470 1480 1490 1500
HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE
1510 1520 1530 1540
EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFN6 | E5RFN6_HUMAN | ATP-binding cassette sub-family A m... | ABCA10 | 1,326 | Annotation score: | ||
E5RFP5 | E5RFP5_HUMAN | ATP-binding cassette sub-family A m... | ABCA10 | 340 | Annotation score: | ||
H0YBL8 | H0YBL8_HUMAN | ATP-binding cassette sub-family A m... | ABCA10 | 137 | Annotation score: | ||
K7EMH5 | K7EMH5_HUMAN | ATP-binding cassette sub-family A m... | ABCA10 | 76 | Annotation score: | ||
K7ERP5 | K7ERP5_HUMAN | ATP-binding cassette sub-family A m... | ABCA10 | 45 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 140 | C → Y in CAD89903 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 159 | R → G in CAD89903 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 187 | F → S in CAD89903 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 324 | L → S in CAD89903 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 364 | F → L in CAD89903 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1216 | R → I in AAO72160 (PubMed:12821155).Curated | 1 | |
Sequence conflicti | 1216 | R → I in AAO72161 (PubMed:12821155).Curated | 1 | |
Sequence conflicti | 1216 | R → I in AAH51320 (PubMed:16625196).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028384 | 203 | P → S3 PublicationsCorresponds to variant dbSNP:rs9909216Ensembl. | 1 | |
Natural variantiVAR_028385 | 287 | I → V3 PublicationsCorresponds to variant dbSNP:rs11657804Ensembl. | 1 | |
Natural variantiVAR_028386 | 916 | M → T1 PublicationCorresponds to variant dbSNP:rs4968849Ensembl. | 1 | |
Natural variantiVAR_055469 | 1322 | R → W. Corresponds to variant dbSNP:rs10491178Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021061 | 1 – 23 | Missing in isoform 2. CuratedAdd BLAST | 23 | |
Alternative sequenceiVSP_021062 | 67 | E → GHNKSFCNGGVDISYWNKYE DTTFHF in isoform 3. Curated | 1 | |
Alternative sequenceiVSP_021063 | 68 – 1543 | Missing in isoform 3. CuratedAdd BLAST | 1476 | |
Alternative sequenceiVSP_021064 | 413 – 452 | IFFDI…EGSAT → SEERLCPAAHRLRCGERLCP AAHHLGCEERPCPAATPSGN in isoform 5. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_021065 | 450 | S → KKNYNGIRHAKHSRHYC in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_021066 | 451 – 1543 | Missing in isoform 4. CuratedAdd BLAST | 1093 | |
Alternative sequenceiVSP_021067 | 453 – 1543 | Missing in isoform 5. 1 PublicationAdd BLAST | 1091 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028900 mRNA Translation: AAK30025.1 AY247065 mRNA Translation: AAO72161.1 AY247105 , AY247069, AY247070, AY247071, AY247072, AY247073, AY247074, AY247075, AY247076, AY247077, AY247078, AY247079, AY247080, AY247081, AY247082, AY247083, AY247084, AY247085, AY247086, AY247087, AY247088, AY247089, AY247090, AY247091, AY247092, AY247093, AY247094, AY247095, AY247096, AY247097, AY247098, AY247099, AY247100, AY247101, AY247102, AY247103, AY247104 Genomic DNA Translation: AAO72160.1 AL832004 mRNA Translation: CAD89903.1 AC005495 Genomic DNA No translation available. BC031026 mRNA Translation: AAH31026.1 BC051320 mRNA Translation: AAH51320.1 |
CCDSi | CCDS11684.1 [Q8WWZ4-1] |
RefSeqi | NP_525021.3, NM_080282.3 [Q8WWZ4-1] |
Genome annotation databases
Ensembli | ENST00000269081; ENSP00000269081; ENSG00000154263 [Q8WWZ4-1] ENST00000522406; ENSP00000429853; ENSG00000154263 [Q8WWZ4-5] ENST00000523512; ENSP00000429945; ENSG00000154263 [Q8WWZ4-3] |
GeneIDi | 10349 |
KEGGi | hsa:10349 |
UCSCi | uc010dfa.2, human [Q8WWZ4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
ABCMdb Database for mutations in ABC proteins |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028900 mRNA Translation: AAK30025.1 AY247065 mRNA Translation: AAO72161.1 AY247105 , AY247069, AY247070, AY247071, AY247072, AY247073, AY247074, AY247075, AY247076, AY247077, AY247078, AY247079, AY247080, AY247081, AY247082, AY247083, AY247084, AY247085, AY247086, AY247087, AY247088, AY247089, AY247090, AY247091, AY247092, AY247093, AY247094, AY247095, AY247096, AY247097, AY247098, AY247099, AY247100, AY247101, AY247102, AY247103, AY247104 Genomic DNA Translation: AAO72160.1 AL832004 mRNA Translation: CAD89903.1 AC005495 Genomic DNA No translation available. BC031026 mRNA Translation: AAH31026.1 BC051320 mRNA Translation: AAH51320.1 |
CCDSi | CCDS11684.1 [Q8WWZ4-1] |
RefSeqi | NP_525021.3, NM_080282.3 [Q8WWZ4-1] |
3D structure databases
SMRi | Q8WWZ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115630, 2 interactors |
IntActi | Q8WWZ4, 2 interactors |
STRINGi | 9606.ENSP00000269081 |
Protein family/group databases
TCDBi | 3.A.1.211.17, the atp-binding cassette (abc) superfamily |
PTM databases
iPTMneti | Q8WWZ4 |
PhosphoSitePlusi | Q8WWZ4 |
Genetic variation databases
BioMutai | ABCA10 |
DMDMi | 296439455 |
Proteomic databases
EPDi | Q8WWZ4 |
jPOSTi | Q8WWZ4 |
MassIVEi | Q8WWZ4 |
PaxDbi | Q8WWZ4 |
PeptideAtlasi | Q8WWZ4 |
PRIDEi | Q8WWZ4 |
ProteomicsDBi | 74965 [Q8WWZ4-1] 74966 [Q8WWZ4-2] 74967 [Q8WWZ4-3] 74968 [Q8WWZ4-4] 74969 [Q8WWZ4-5] |
Protocols and materials databases
Antibodypediai | 2899, 48 antibodies |
DNASUi | 10349 |
Genome annotation databases
Ensembli | ENST00000269081; ENSP00000269081; ENSG00000154263 [Q8WWZ4-1] ENST00000522406; ENSP00000429853; ENSG00000154263 [Q8WWZ4-5] ENST00000523512; ENSP00000429945; ENSG00000154263 [Q8WWZ4-3] |
GeneIDi | 10349 |
KEGGi | hsa:10349 |
UCSCi | uc010dfa.2, human [Q8WWZ4-1] |
Organism-specific databases
CTDi | 10349 |
DisGeNETi | 10349 |
GeneCardsi | ABCA10 |
HGNCi | HGNC:30, ABCA10 |
HPAi | ENSG00000154263, Tissue enhanced (ovary) |
MIMi | 612508, gene |
neXtProti | NX_Q8WWZ4 |
OpenTargetsi | ENSG00000154263 |
PharmGKBi | PA24374 |
VEuPathDBi | HostDB:ENSG00000154263.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0059, Eukaryota |
GeneTreei | ENSGT00940000162673 |
HOGENOMi | CLU_000604_19_1_1 |
InParanoidi | Q8WWZ4 |
OMAi | SDQGIMN |
OrthoDBi | 131191at2759 |
PhylomeDBi | Q8WWZ4 |
TreeFami | TF105192 |
Enzyme and pathway databases
PathwayCommonsi | Q8WWZ4 |
Reactomei | R-HSA-1369062, ABC transporters in lipid homeostasis |
Miscellaneous databases
BioGRID-ORCSi | 10349, 10 hits in 983 CRISPR screens |
ChiTaRSi | ABCA10, human |
GenomeRNAii | 10349 |
Pharosi | Q8WWZ4, Tdark |
PROi | PR:Q8WWZ4 |
RNActi | Q8WWZ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154263, Expressed in right ovary and 112 other tissues |
ExpressionAtlasi | Q8WWZ4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCAA_HUMAN | |
Accessioni | Q8WWZ4Primary (citable) accession number: Q8WWZ4 Secondary accession number(s): C9JZH2 Q86TD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families