MBD3L1

Functionⁱ

Transcriptional repressor.1 Publication

Miscellaneous

Does not bind methylated DNA.

The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

GO - Molecular functionⁱ

methyl-CpG binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

methylation-dependent chromatin silencing
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Methyl-CpG-binding domain protein 3-like 1 Short name: MBD3-like protein 1
Gene namesⁱ	Name:MBD3L1 Synonyms:MBD3L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170948.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15774 MBD3L1
MIMⁱ	607963 gene
neXtProtⁱ	NX_Q8WWY6

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170948
PharmGKBⁱ	PA30662

Polymorphism and mutation databases

BioMutaⁱ	MBD3L1
DMDMⁱ	296436435

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096251	1 – 194	Methyl-CpG-binding domain protein 3-like 1Add BLAST		194

Proteomic databases

PaxDbⁱ	Q8WWY6
PeptideAtlas More...PeptideAtlasⁱ	Q8WWY6
PRIDEⁱ	Q8WWY6
ProteomicsDBⁱ	74958

PTM databases

iPTMnetⁱ	Q8WWY6
PhosphoSitePlusⁱ	Q8WWY6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis. Detected at low levels in pancreas. Not detected in the other tissues tested.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170948 Expressed in 26 organ(s), highest expression level in left testis
CleanExⁱ	HS_MBD3L1
Genevisibleⁱ	Q8WWY6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043121 HPA046753

HPAⁱ

HPA043121
HPA046753

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GTF2IRD1	Q9UHL9	3	EBI-12516603,EBI-372530

With

Entry

#Exp.

IntAct

Notes

GTF2IRD1

Q9UHL9

3

EBI-12516603,EBI-372530

Protein-protein interaction databases

BioGridⁱ	124569, 24 interactors
IntActⁱ	Q8WWY6, 34 interactors
STRINGⁱ	9606.ENSP00000304198

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WWY6
SMRⁱ	Q8WWY6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 104	Transcription repressorAdd BLAST		104

Domainⁱ

The N-terminal half of the protein mediates transcription repression.

Sequence similaritiesⁱ

Belongs to the MBD3L family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4161 Eukaryota ENOG4111HPQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025376
HOGENOMⁱ	HOG000013073
HOVERGENⁱ	HBG052417
InParanoidⁱ	Q8WWY6
OMAⁱ	PQQVCWQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I05
PhylomeDBⁱ	Q8WWY6
TreeFamⁱ	TF325032

Family and domain databases

InterProⁱ	View protein in InterPro IPR032343 MBD2/MBD3_p55-bd IPR025884 MeCpG-bd_2/3_C_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14048 MBD_C, 1 hit PF16564 MBDa, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WWY6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKSSQRKQR DCVNQCKSKP GLSTSIPLRM SSYTFKRPVT RITPHPGNEV 
        60         70         80         90        100
RYHQWEESLE KPQQVCWQRR LQGLQAYSSA GELSSTLDLA NTLQKLVPSY 
       110        120        130        140        150
TGGSLLEDLA SGLEHSCPMP HLACSSDAVE IIPAEGVGIS QLLCKQFLVT 
       160        170        180        190 
EEDIRKQEGK VKTVRERLAI ALIADGLANE AEKVRDQEGR PEKR

Length:194

Mass (Da):21,616

Last modified:May 18, 2010 - v2

Checksum:ⁱF9EC132573A45DC9

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051155	190	R → C3 PublicationsCorresponds to variant dbSNP:rs2972588Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY038022 mRNA Translation: AAK72591.1 AB451462 mRNA Translation: BAG70276.1 AC008734 Genomic DNA No translation available. BC112064 mRNA Translation: AAI12065.1 BC112058 mRNA Translation: AAI12059.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12209.1
NCBI Reference Sequences More...RefSeqⁱ	NP_660209.2, NM_145208.2
UniGeneⁱ	Hs.133912

Genome annotation databases

Ensemblⁱ	ENST00000305625; ENSP00000304198; ENSG00000170948 ENST00000595891; ENSP00000471575; ENSG00000170948
GeneIDⁱ	85509
KEGGⁱ	hsa:85509
UCSC genome browser More...UCSCⁱ	uc002mko.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8WWY6	Methyl-CpG binding domain protein 3 like 1		MACMU		200	UniRef90_Q8WWY6
Uncharacterized protein		MACFA		200
Uncharacterized protein		MANLE		200
MBD3L1 isoform 1 (Fragment)		PONAB		195
Methyl-CpG binding domain protein 3 like 1		CHLSB		194
+13

Protein	Similar proteins		Species	Score	Length	Source
Q8WWY6	Uncharacterized protein		MANLE		200	UniRef50_Q8WWY6
Methyl-CpG binding domain protein 3 like 1		MACMU		200
Uncharacterized protein		MACFA		200
MBD3L1 isoform 1 (Fragment)		PONAB		195
MBD3L1 isoform 1		PANTR		194
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY038022 mRNA Translation: AAK72591.1 AB451462 mRNA Translation: BAG70276.1 AC008734 Genomic DNA No translation available. BC112064 mRNA Translation: AAI12065.1 BC112058 mRNA Translation: AAI12059.1
CCDSⁱ	CCDS12209.1
RefSeqⁱ	NP_660209.2, NM_145208.2
UniGeneⁱ	Hs.133912

3D structure databases

ProteinModelPortalⁱ	Q8WWY6
SMRⁱ	Q8WWY6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124569, 24 interactors
IntActⁱ	Q8WWY6, 34 interactors
STRINGⁱ	9606.ENSP00000304198

PTM databases

iPTMnetⁱ	Q8WWY6
PhosphoSitePlusⁱ	Q8WWY6

Polymorphism and mutation databases

BioMutaⁱ	MBD3L1
DMDMⁱ	296436435

Proteomic databases

PaxDbⁱ	Q8WWY6
PeptideAtlasⁱ	Q8WWY6
PRIDEⁱ	Q8WWY6
ProteomicsDBⁱ	74958

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000305625; ENSP00000304198; ENSG00000170948 ENST00000595891; ENSP00000471575; ENSG00000170948
GeneIDⁱ	85509
KEGGⁱ	hsa:85509
UCSCⁱ	uc002mko.2 human

Organism-specific databases

CTDⁱ	85509
EuPathDBⁱ	HostDB:ENSG00000170948.3
GeneCardsⁱ	MBD3L1
H-InvDBⁱ	HIX0040045
HGNCⁱ	HGNC:15774 MBD3L1
HPAⁱ	HPA043121 HPA046753
MIMⁱ	607963 gene
neXtProtⁱ	NX_Q8WWY6
OpenTargetsⁱ	ENSG00000170948
PharmGKBⁱ	PA30662
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4161 Eukaryota ENOG4111HPQ LUCA
GeneTreeⁱ	ENSGT00410000025376
HOGENOMⁱ	HOG000013073
HOVERGENⁱ	HBG052417
InParanoidⁱ	Q8WWY6
OMAⁱ	PQQVCWQ
OrthoDBⁱ	EOG091G0I05
PhylomeDBⁱ	Q8WWY6
TreeFamⁱ	TF325032

Miscellaneous databases

GenomeRNAiⁱ	85509
Protein Ontology More...PROⁱ	PR:Q8WWY6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170948 Expressed in 26 organ(s), highest expression level in left testis
CleanExⁱ	HS_MBD3L1
Genevisibleⁱ	Q8WWY6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR032343 MBD2/MBD3_p55-bd IPR025884 MeCpG-bd_2/3_C_dom
Pfamⁱ	View protein in Pfam PF14048 MBD_C, 1 hit PF16564 MBDa, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MB3L1_HUMAN
Accessionⁱ	Q8WWY6Primary (citable) accession number: Q8WWY6 Secondary accession number(s): B5BUM6, Q2M291
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q8WWY6 (MB3L1_HUMAN)

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Methyl-CpG-binding domain protein 3-like 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ