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Protein

Selenoprotein M

Gene

SELENOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45NucleophileBy similarity1
Active sitei48NucleophileBy similarity1

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein M1 Publication
Short name:
SelM1 Publication
Gene namesi
Name:SELENOM1 PublicationImported
Synonyms:SELM2 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:30397 SELENOM
MIMi610918 gene
neXtProtiNX_Q8WWX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140606
OpenTargetsiENSG00000198832

Polymorphism and mutation databases

BioMutaiSELM
DMDMi189034058

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002229824 – 145Selenoprotein MAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki45 ↔ 48Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Proteomic databases

EPDiQ8WWX9
MaxQBiQ8WWX9
PaxDbiQ8WWX9
PeptideAtlasiQ8WWX9
PRIDEiQ8WWX9
ProteomicsDBi74954

PTM databases

PhosphoSitePlusiQ8WWX9

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ExpressionAtlasiQ8WWX9 baseline and differential

Organism-specific databases

HPAiHPA019601

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126635, 4 interactors
IntActiQ8WWX9, 10 interactors
STRINGi9606.ENSP00000383155

Structurei

3D structure databases

ProteinModelPortaliQ8WWX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZY6 Eukaryota
ENOG4112CA8 LUCA
GeneTreeiENSGT00390000001255
HOGENOMiHOG000168390
HOVERGENiHBG108468
InParanoidiQ8WWX9
OMAiTFRPDWN
PhylomeDBiQ8WWX9

Family and domain databases

Gene3Di3.40.30.50, 1 hit
InterProiView protein in InterPro
IPR038219 Sep15/SelM_sf
IPR014912 Sep15_SelM
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF08806 Sep15_SelM, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WWX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLPPLAL LLLLAALVAP ATAATAYRPD WNRLSGLTRA RVETCGGUQL
60 70 80 90 100
NRLKEVKAFV TQDIPFYHNL VMKHLPGADP ELVLLGRRYE ELERIPLSEM
110 120 130 140
TREEINALVQ ELGFYRKAAP DAQVPPEYVW APAKPPEETS DHADL
Length:145
Mass (Da):16,232
Last modified:February 26, 2008 - v3
Checksum:i556A41B02EF694BE
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei48Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043487 mRNA Translation: AAK95397.1
AC005005 Genomic DNA No translation available.
BC013421 mRNA Translation: AAH13421.1
BC030236 mRNA Translation: AAH30236.1
BC068004 mRNA Translation: AAH68004.1
CCDSiCCDS43003.1
RefSeqiNP_536355.1, NM_080430.3
UniGeneiHs.55940

Genome annotation databases

EnsembliENST00000400299; ENSP00000383155; ENSG00000198832
ENST00000402395; ENSP00000384564; ENSG00000198832
GeneIDi140606
KEGGihsa:140606

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELM_HUMAN
AccessioniPrimary (citable) accession number: Q8WWX9
Secondary accession number(s): A8MPZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: February 26, 2008
Last modified: July 18, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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