UniProtKB - Q8WWX8 (SC5AB_HUMAN)
Sodium/myo-inositol cotransporter 2
SLC5A11
Functioni
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na+:MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
1 PublicationMiscellaneous
GO - Molecular functioni
- glucose:sodium symporter activity Source: GO_Central
- polyol transmembrane transporter activity Source: Reactome
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- myo-inositol transport Source: Reactome
- regulation of transporter activity Source: Ensembl
Keywordsi
Biological process | Apoptosis, Ion transport, Sodium transport, Sugar transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q8WWX8 |
Reactomei | R-HSA-429593, Inositol transporters |
SignaLinki | Q8WWX8 |
Protein family/group databases
TCDBi | 2.A.21.3.6, the solute:sodium symporter (sss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/myo-inositol cotransporter 2Short name: Na(+)/myo-inositol cotransporter 2 Alternative name(s): Sodium-dependent glucose cotransporter Sodium/glucose cotransporter KST1 Sodium/myo-inositol transporter 2 Short name: SMIT2 Solute carrier family 5 member 11 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23091, SLC5A11 |
MIMi | 610238, gene |
neXtProti | NX_Q8WWX8 |
VEuPathDBi | HostDB:ENSG00000158865 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 65 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 66 – 88 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 89 – 102 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 135 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 157 – 180 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 208 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 209 – 229 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 272 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 308 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 309 – 329 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 330 – 375 | ExtracellularSequence analysisAdd BLAST | 46 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 397 – 418 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 419 – 439 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 440 – 446 | ExtracellularSequence analysis | 7 | |
Transmembranei | 447 – 467 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 468 – 479 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 480 – 500 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 501 – 521 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 522 – 542 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 543 – 654 | CytoplasmicSequence analysisAdd BLAST | 112 | |
Transmembranei | 655 – 675 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 115584 |
OpenTargetsi | ENSG00000158865 |
PharmGKBi | PA134923660 |
Miscellaneous databases
Pharosi | Q8WWX8, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1744524 |
DrugCentrali | Q8WWX8 |
GuidetoPHARMACOLOGYi | 925 |
Genetic variation databases
BioMutai | SLC5A11 |
DMDMi | 74751588 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331568 | 1 – 675 | Sodium/myo-inositol cotransporter 2Add BLAST | 675 |
Proteomic databases
MassIVEi | Q8WWX8 |
PaxDbi | Q8WWX8 |
PeptideAtlasi | Q8WWX8 |
PRIDEi | Q8WWX8 |
ProteomicsDBi | 58368 6486 74950 [Q8WWX8-1] 74951 [Q8WWX8-2] 74952 [Q8WWX8-3] 74953 [Q8WWX8-4] |
PTM databases
GlyGeni | Q8WWX8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WWX8 |
PhosphoSitePlusi | Q8WWX8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000158865, Expressed in C1 segment of cervical spinal cord and 137 other tissues |
ExpressionAtlasi | Q8WWX8, baseline and differential |
Genevisiblei | Q8WWX8, HS |
Organism-specific databases
HPAi | ENSG00000158865, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Q8WWX8
With | #Exp. | IntAct |
---|---|---|
KPNA3 [O00505] | 3 | EBI-10277669,EBI-358297 |
Isoform 3 [Q8WWX8-3]
With | #Exp. | IntAct |
---|---|---|
KPNA3 [O00505] | 3 | EBI-12697471,EBI-358297 |
Protein-protein interaction databases
BioGRIDi | 125441, 10 interactors |
IntActi | Q8WWX8, 3 interactors |
STRINGi | 9606.ENSP00000289932 |
Chemistry databases
BindingDBi | Q8WWX8 |
Miscellaneous databases
RNActi | Q8WWX8, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000157690 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | Q8WWX8 |
OMAi | GWWGMRR |
OrthoDBi | 243316at2759 |
PhylomeDBi | Q8WWX8 |
TreeFami | TF352855 |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS50283, NA_SOLUT_SYMP_3, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESGTSSPQP PQLDPLDAFP QKGLEPGDIA VLVLYFLFVL AVGLWSTVKT
60 70 80 90 100
KRDTVKGYFL AGGDMVWWPV GASLFASNVG SGHFIGLAGS GAATGISVSA
110 120 130 140 150
YELNGLFSVL MLAWIFLPIY IAGQVTTMPE YLRKRFGGIR IPIILAVLYL
160 170 180 190 200
FIYIFTKISV DMYAGAIFIQ QSLHLDLYLA IVGLLAITAV YTVAGGLAAV
210 220 230 240 250
IYTDALQTLI MLIGALTLMG YSFAAVGGME GLKEKYFLAL ASNRSENSSC
260 270 280 290 300
GLPREDAFHI FRDPLTSDLP WPGVLFGMSI PSLWYWCTDQ VIVQRTLAAK
310 320 330 340 350
NLSHAKGGAL MAAYLKVLPL FIMVFPGMVS RILFPDQVAC ADPEICQKIC
360 370 380 390 400
SNPSGCSDIA YPKLVLELLP TGLRGLMMAV MVAALMSSLT SIFNSASTIF
410 420 430 440 450
TMDLWNHLRP RASEKELMIV GRVFVLLLVL VSILWIPVVQ ASQGGQLFIY
460 470 480 490 500
IQSISSYLQP PVAVVFIMGC FWKRTNEKGA FWGLISGLLL GLVRLVLDFI
510 520 530 540 550
YVQPRCDQPD ERPVLVKSIH YLYFSMILST VTLITVSTVS WFTEPPSKEM
560 570 580 590 600
VSHLTWFTRH DPVVQKEQAP PAAPLSLTLS QNGMPEASSS SSVQFEMVQE
610 620 630 640 650
NTSKTHSCDM TPKQSKVVKA ILWLCGIQEK GKEELPARAE AIIVSLEENP
660 670
LVKTLLDVNL IFCVSCAIFI WGYFA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BN85 | H3BN85_HUMAN | Sodium/myo-inositol cotransporter 2 | SLC5A11 | 91 | Annotation score: | ||
I3L1G0 | I3L1G0_HUMAN | Sodium/myo-inositol cotransporter 2 | SLC5A11 | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | A → T in AAK97053 (Ref. 2) Curated | 1 | |
Sequence conflicti | 371 | T → P in CAC83728 (Ref. 3) Curated | 1 | |
Sequence conflicti | 547 | S → P in BAC86105 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052494 | 47 | T → P. Corresponds to variant dbSNP:rs36048966Ensembl. | 1 | |
Natural variantiVAR_042896 | 182 | V → A Reduces serum myo-inositol concentration. 4 PublicationsCorresponds to variant dbSNP:rs11074656Ensembl. | 1 | |
Natural variantiVAR_042897 | 258 | F → L1 PublicationCorresponds to variant dbSNP:rs35993597Ensembl. | 1 | |
Natural variantiVAR_042898 | 452 | Q → R1 PublicationCorresponds to variant dbSNP:rs17854935Ensembl. | 1 | |
Natural variantiVAR_042899 | 526 | M → I1 Publication | 1 | |
Natural variantiVAR_061877 | 539 | V → M. Corresponds to variant dbSNP:rs35038575Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052789 | 1 – 64 | Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_033259 | 45 | W → WVGSPSVAQGTRTQWWQSWL TPASTSWAQVILSPRLPDTE EVLSTRNRLSPDTKPLGALI LNFQVSRI in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_045034 | 70 – 104 | Missing in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_052790 | 125 – 159 | Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST | 35 | |
Alternative sequenceiVSP_045035 | 223 – 302 | FAAVG…AAKNL → DCPADSGCQEPVPCQRRCSD GCIPEGAAPLHNGVPWDGQP HPLPRSSGLCRSRDLPEDLQ QPLRLFGHRVSQTRAGTPAH in isoform 6. 1 PublicationAdd BLAST | 80 | |
Alternative sequenceiVSP_045036 | 303 – 394 | Missing in isoform 6. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY044906 mRNA Translation: AAK97784.1 AF292385 mRNA Translation: AAK97053.1 AJ305237 mRNA Translation: CAC83728.1 AK125267 mRNA Translation: BAC86105.1 AK295427 mRNA Translation: BAH12065.1 AC008731 Genomic DNA No translation available. CH471145 Genomic DNA Translation: EAW55781.1 BC049385 mRNA Translation: AAH49385.1 BC057780 mRNA Translation: AAH57780.1 |
CCDSi | CCDS10625.1 [Q8WWX8-1] CCDS58437.1 [Q8WWX8-2] CCDS58438.1 [Q8WWX8-5] CCDS58439.1 [Q8WWX8-3] CCDS58440.1 [Q8WWX8-6] |
RefSeqi | NP_001245340.1, NM_001258411.2 [Q8WWX8-2] NP_001245341.1, NM_001258412.2 [Q8WWX8-5] NP_001245342.1, NM_001258413.2 [Q8WWX8-3] NP_001245343.1, NM_001258414.1 [Q8WWX8-6] NP_443176.2, NM_052944.4 [Q8WWX8-1] XP_005255137.1, XM_005255080.2 XP_016878389.1, XM_017022900.1 XP_016878390.1, XM_017022901.1 XP_016878391.1, XM_017022902.1 XP_016878392.1, XM_017022903.1 [Q8WWX8-1] XP_016878394.1, XM_017022905.1 XP_016878395.1, XM_017022906.1 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY044906 mRNA Translation: AAK97784.1 AF292385 mRNA Translation: AAK97053.1 AJ305237 mRNA Translation: CAC83728.1 AK125267 mRNA Translation: BAC86105.1 AK295427 mRNA Translation: BAH12065.1 AC008731 Genomic DNA No translation available. CH471145 Genomic DNA Translation: EAW55781.1 BC049385 mRNA Translation: AAH49385.1 BC057780 mRNA Translation: AAH57780.1 |
CCDSi | CCDS10625.1 [Q8WWX8-1] CCDS58437.1 [Q8WWX8-2] CCDS58438.1 [Q8WWX8-5] CCDS58439.1 [Q8WWX8-3] CCDS58440.1 [Q8WWX8-6] |
RefSeqi | NP_001245340.1, NM_001258411.2 [Q8WWX8-2] NP_001245341.1, NM_001258412.2 [Q8WWX8-5] NP_001245342.1, NM_001258413.2 [Q8WWX8-3] NP_001245343.1, NM_001258414.1 [Q8WWX8-6] NP_443176.2, NM_052944.4 [Q8WWX8-1] XP_005255137.1, XM_005255080.2 XP_016878389.1, XM_017022900.1 XP_016878390.1, XM_017022901.1 XP_016878391.1, XM_017022902.1 XP_016878392.1, XM_017022903.1 [Q8WWX8-1] XP_016878394.1, XM_017022905.1 XP_016878395.1, XM_017022906.1 |
3D structure databases
AlphaFoldDBi | Q8WWX8 |
SMRi | Q8WWX8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125441, 10 interactors |
IntActi | Q8WWX8, 3 interactors |
STRINGi | 9606.ENSP00000289932 |
Chemistry databases
BindingDBi | Q8WWX8 |
ChEMBLi | CHEMBL1744524 |
DrugCentrali | Q8WWX8 |
GuidetoPHARMACOLOGYi | 925 |
Protein family/group databases
TCDBi | 2.A.21.3.6, the solute:sodium symporter (sss) family |
PTM databases
GlyGeni | Q8WWX8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WWX8 |
PhosphoSitePlusi | Q8WWX8 |
Genetic variation databases
BioMutai | SLC5A11 |
DMDMi | 74751588 |
Proteomic databases
MassIVEi | Q8WWX8 |
PaxDbi | Q8WWX8 |
PeptideAtlasi | Q8WWX8 |
PRIDEi | Q8WWX8 |
ProteomicsDBi | 58368 6486 74950 [Q8WWX8-1] 74951 [Q8WWX8-2] 74952 [Q8WWX8-3] 74953 [Q8WWX8-4] |
Protocols and materials databases
Antibodypediai | 12746, 142 antibodies from 27 providers |
DNASUi | 115584 |
Genome annotation databases
Organism-specific databases
CTDi | 115584 |
DisGeNETi | 115584 |
GeneCardsi | SLC5A11 |
HGNCi | HGNC:23091, SLC5A11 |
HPAi | ENSG00000158865, Tissue enriched (brain) |
MIMi | 610238, gene |
neXtProti | NX_Q8WWX8 |
OpenTargetsi | ENSG00000158865 |
PharmGKBi | PA134923660 |
VEuPathDBi | HostDB:ENSG00000158865 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000157690 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | Q8WWX8 |
OMAi | GWWGMRR |
OrthoDBi | 243316at2759 |
PhylomeDBi | Q8WWX8 |
TreeFami | TF352855 |
Enzyme and pathway databases
PathwayCommonsi | Q8WWX8 |
Reactomei | R-HSA-429593, Inositol transporters |
SignaLinki | Q8WWX8 |
Miscellaneous databases
BioGRID-ORCSi | 115584, 15 hits in 1063 CRISPR screens |
ChiTaRSi | SLC5A11, human |
GenomeRNAii | 115584 |
Pharosi | Q8WWX8, Tchem |
PROi | PR:Q8WWX8 |
RNActi | Q8WWX8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158865, Expressed in C1 segment of cervical spinal cord and 137 other tissues |
ExpressionAtlasi | Q8WWX8, baseline and differential |
Genevisiblei | Q8WWX8, HS |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS50283, NA_SOLUT_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC5AB_HUMAN | |
Accessioni | Q8WWX8Primary (citable) accession number: Q8WWX8 Secondary accession number(s): B7Z329 Q96PP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families