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UniProtKB - Q8WWW0 (RASF5_HUMAN)

Entry version 166 (10 Feb 2021)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
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Protein

Ras association domain-containing protein 5

Gene

RASSF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.3 Publications

Caution

Was termed (Ref. 3) RASSF3.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri122 – 170Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WWW0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WWW0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8WWW0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras association domain-containing protein 5
Alternative name(s):
New ras effector 1
Regulator for cell adhesion and polarization enriched in lymphoid tissues
Short name:
RAPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASSF5
Synonyms:NORE1, RAPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17609, RASSF5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607020, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WWW0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000266094.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		83593

Open Targets

More...OpenTargetsi		ENSG00000266094

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134958571

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WWW0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RASSF5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751587

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002404011 – 418Ras association domain-containing protein 5Add BLAST418
Isoform 2 (identifier: Q8WWW0-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei182PhosphoserineBy similarity1
Modified residuei279PhosphoserineCombined sources1
Modified residuei352PhosphothreonineCombined sources1
Isoform 2 (identifier: Q8WWW0-2)
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WWW0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WWW0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WWW0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WWW0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WWW0

PeptideAtlas

More...PeptideAtlasi		Q8WWW0

PRoteomics IDEntifications database

More...PRIDEi		Q8WWW0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74944 [Q8WWW0-1]
74945 [Q8WWW0-2]
74946 [Q8WWW0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WWW0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WWW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000266094, Expressed in blood and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WWW0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WWW0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000266094, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS (By similarity).

Interacts with KRAS (By similarity). Probably interacts with Ras-like GTPases RRAS, MRAS, RAP1B, RAP2A and RALA (By similarity).

Interacts with RRAS2 (PubMed:31130282). Can self-associate (By similarity).

Interacts with RSSF1 isoform A (By similarity). The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS (By similarity).

Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1 (PubMed:12845325, PubMed:15569673). Binds STK4/MST1, inhibiting STK4/MST1 autoactivation (PubMed:15109305).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8WWW0
With#Exp.IntAct
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-367390,EBI-10187270
BTRC [Q9Y297]4EBI-367390,EBI-307461
GABARAP [O95166]2EBI-367390,EBI-712001
GABARAPL1 [Q9H0R8]2EBI-367390,EBI-746969
GABARAPL2 [P60520]2EBI-367390,EBI-720116
HRAS [P01112]2EBI-367390,EBI-350145
KRT40 [Q6A162]3EBI-367390,EBI-10171697
KRTAP4-2 [Q9BYR5]3EBI-367390,EBI-10172511
MAP1LC3B [Q9GZQ8]5EBI-367390,EBI-373144
MAP1LC3C [Q9BXW4]2EBI-367390,EBI-2603996
MYLIP [Q8WY64]4EBI-367390,EBI-6952711
RABIF [P47224]3EBI-367390,EBI-713992
RAP1B [P61224]3EBI-367390,EBI-358143
RAP2B [P61225]3EBI-367390,EBI-750871
RASSF2 [P50749]3EBI-367390,EBI-960081
REL [Q04864]3EBI-367390,EBI-307352
SMAD4 [Q13485]5EBI-367390,EBI-347263
STK3 [Q13188]8EBI-367390,EBI-992580
STK4 [Q13043]8EBI-367390,EBI-367376
TRAF1 [Q13077]3EBI-367390,EBI-359224
TRAF2 [Q12933]3EBI-367390,EBI-355744
VPS28 [Q548N1]3EBI-367390,EBI-10243107
A8K9403EBI-367390,EBI-10174788
RASSF5 - isoform 1 [Q8WWW0-1]
With#Exp.IntAct
itself2EBI-960496,EBI-960496
STK3 [Q13188]6EBI-960496,EBI-992580
STK4 - isoform 1 [Q13043-1]3EBI-960496,EBI-15638366
Isoform 2 [Q8WWW0-2]
With#Exp.IntAct
BTRC [A0A0S2Z507]3EBI-960502,EBI-16429247
BTRC [Q9Y297]3EBI-960502,EBI-307461
GFAP [P14136]3EBI-960502,EBI-744302
HTT [P42858]3EBI-960502,EBI-466029
JPH3 [Q8WXH2]3EBI-960502,EBI-1055254
MECP2 [P51608]3EBI-960502,EBI-1189067
NDUFV2 [P19404]3EBI-960502,EBI-713665
RAP1A [P62834]3EBI-960502,EBI-491414
STK4 [Q13043]4EBI-960502,EBI-367376
VPS28 [Q9UK41]3EBI-960502,EBI-727424
Isoform 3 [Q8WWW0-3]
With#Exp.IntAct
STK4 [Q13043]2EBI-960507,EBI-367376

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123689, 42 interactors

Database of interacting proteins

More...DIPi		DIP-32490N

Protein interaction database and analysis system

More...IntActi		Q8WWW0, 51 interactors

Molecular INTeraction database

More...MINTi		Q8WWW0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000462099

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WWW0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WWW0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini274 – 364Ras-associatingPROSITE-ProRule annotationAdd BLAST91
Domaini366 – 413SARAHPROSITE-ProRule annotationAdd BLAST48

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri122 – 170Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4239, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159288

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045544_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WWW0

Database of Orthologous Groups

More...OrthoDBi		1120975at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WWW0

TreeFam database of animal gene trees

More...TreeFami		TF319243

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00631

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033614, C-RASSF
IPR002219, PE/DAG-bd
IPR000159, RA_dom
IPR033623, RASSF5
IPR011524, SARAH_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR22738, PTHR22738, 1 hit
PTHR22738:SF9, PTHR22738:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 1 hit
PF16517, Nore1-SARAH, 1 hit
PF00788, RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 1 hit
SM00314, RA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50200, RA, 1 hit
PS50951, SARAH, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWW0-1) [UniParc]FASTAAdd to basket
Also known as: A, NORE1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMASPAIGQ RPYPLLLDPE PPRYLQSLSG PELPPPPPDR SSRLCVPAPL 
        60         70         80         90        100
STAPGAREGR SARRAARGNL EPPPRASRPA RPLRPGLQQR LRRRPGAPRP 
       110        120        130        140        150
RDVRSIFEQP QDPRVPAERG EGHCFAELVL PGGPGWCDLC GREVLRQALR 
       160        170        180        190        200
CTNCKFTCHP ECRSLIQLDC SQQEGLSRDR PSPESTLTVT FSQNVCKPVE 
       210        220        230        240        250
ETQRPPTLQE IKQKIDSYNT REKNCLGMKL SEDGTYTGFI KVHLKLRRPV 
       260        270        280        290        300
TVPAGIRPQS IYDAIKEVNL AATTDKRTSF YLPLDAIKQL HISSTTTVSE 
       310        320        330        340        350
VIQGLLKKFM VVDNPQKFAL FKRIHKDGQV LFQKLSIADR PLYLRLLAGP 
       360        370        380        390        400
DTEVLSFVLK ENETGEVEWD AFSIPELQNF LTILEKEEQD KIQQVQKKYD 
       410 
KFRQKLEEAL RESQGKPG
Length:418
Mass (Da):47,090
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AFBC69B1325CC9E
GO
Isoform 2 (identifier: Q8WWW0-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-193: CKFTCHPECR...ESTLTVTFSQ → MTVDSSMSSG...RNAQSKHLSK

Show »
Length:265
Mass (Da):30,359
Checksum:i66AD5D84EFA6D6CB
GO
Isoform 3 (identifier: Q8WWW0-3) [UniParc]FASTAAdd to basket
Also known as: C, NORE1B

The sequence of this isoform differs from the canonical sequence as follows:
     331-336: LFQKLS → GCLLHP
     337-418: Missing.

Show »
Length:336
Mass (Da):37,433
Checksum:i2657B6DAECD8D6A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B763A0A075B763_HUMAN
Ras association domain-containing p...
RASSF5
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTG4A0A1B0GTG4_HUMAN
Ras association domain-containing p...
RASSF5
318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8TEK8Q8TEK8_HUMAN
FLJ00186 protein
RASSF5 FLJ00186
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04270 differs from that shown. Aberrant splicing.Curated
The sequence AAH04270 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH07203 differs from that shown. Aberrant splicing.Curated
The sequence AAH07203 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0193631 – 153Missing in isoform 2. 5 PublicationsAdd BLAST153
Alternative sequenceiVSP_019364154 – 193CKFTC…VTFSQ → MTVDSSMSSGYCSLDEELED CFFTAKTTFFRNAQSKHLSK in isoform 2. 5 PublicationsAdd BLAST40
Alternative sequenceiVSP_019365331 – 336LFQKLS → GCLLHP in isoform 3. 1 Publication6
Alternative sequenceiVSP_019366337 – 418Missing in isoform 3. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF445801 mRNA Translation: AAL38592.1
AY261332 mRNA Translation: AAP83360.1
AY062002 mRNA Translation: AAL40388.1
AY062003 mRNA Translation: AAL40389.1
AY216268 mRNA Translation: AAO61668.1
AK289861 mRNA Translation: BAF82550.1
AL832784 mRNA Translation: CAI46164.1
AL591846, AL354681 Genomic DNA Translation: CAI13536.1
AL591846, AL354681 Genomic DNA Translation: CAI13538.1
AL354681, AL591846 Genomic DNA Translation: CAI15252.1
AL591846, AL354681 Genomic DNA Translation: CAI13537.1
AL591846, AL354681 Genomic DNA Translation: CAI13542.1
AL354681, AL591846 Genomic DNA Translation: CAI15253.1
AL354681, AL591846 Genomic DNA Translation: CAI15254.1
AL354681, AL591846 Genomic DNA Translation: CAI15256.1
CH471100 Genomic DNA Translation: EAW93544.1
BC004270 mRNA Translation: AAH04270.1 Sequence problems.
BC007203 mRNA Translation: AAH07203.1 Sequence problems.
BC042651 mRNA Translation: AAH42651.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1463.1 [Q8WWW0-3]
CCDS1464.1 [Q8WWW0-2]
CCDS30998.1 [Q8WWW0-1]

NCBI Reference Sequences

More...RefSeqi		NP_872604.1, NM_182663.3 [Q8WWW0-1]
NP_872605.1, NM_182664.3 [Q8WWW0-3]
NP_872606.1, NM_182665.3 [Q8WWW0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000577571; ENSP00000462576; ENSG00000266094 [Q8WWW0-2]
ENST00000579436; ENSP00000462099; ENSG00000266094 [Q8WWW0-1]
ENST00000580449; ENSP00000462544; ENSG00000266094 [Q8WWW0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83593

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83593

UCSC genome browser

More...UCSCi		uc031vlp.2, human [Q8WWW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445801 mRNA Translation: AAL38592.1
AY261332 mRNA Translation: AAP83360.1
AY062002 mRNA Translation: AAL40388.1
AY062003 mRNA Translation: AAL40389.1
AY216268 mRNA Translation: AAO61668.1
AK289861 mRNA Translation: BAF82550.1
AL832784 mRNA Translation: CAI46164.1
AL591846, AL354681 Genomic DNA Translation: CAI13536.1
AL591846, AL354681 Genomic DNA Translation: CAI13538.1
AL354681, AL591846 Genomic DNA Translation: CAI15252.1
AL591846, AL354681 Genomic DNA Translation: CAI13537.1
AL591846, AL354681 Genomic DNA Translation: CAI13542.1
AL354681, AL591846 Genomic DNA Translation: CAI15253.1
AL354681, AL591846 Genomic DNA Translation: CAI15254.1
AL354681, AL591846 Genomic DNA Translation: CAI15256.1
CH471100 Genomic DNA Translation: EAW93544.1
BC004270 mRNA Translation: AAH04270.1 Sequence problems.
BC007203 mRNA Translation: AAH07203.1 Sequence problems.
BC042651 mRNA Translation: AAH42651.1
CCDSiCCDS1463.1 [Q8WWW0-3]
CCDS1464.1 [Q8WWW0-2]
CCDS30998.1 [Q8WWW0-1]
RefSeqiNP_872604.1, NM_182663.3 [Q8WWW0-1]
NP_872605.1, NM_182664.3 [Q8WWW0-3]
NP_872606.1, NM_182665.3 [Q8WWW0-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LGDX-ray3.05E/F/G/H365-413[»]
4OH8X-ray2.28B366-418[»]
SMRiQ8WWW0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123689, 42 interactors
DIPiDIP-32490N
IntActiQ8WWW0, 51 interactors
MINTiQ8WWW0
STRINGi9606.ENSP00000462099

PTM databases

iPTMnetiQ8WWW0
PhosphoSitePlusiQ8WWW0

Genetic variation databases

BioMutaiRASSF5
DMDMi74751587

Proteomic databases

EPDiQ8WWW0
jPOSTiQ8WWW0
MassIVEiQ8WWW0
MaxQBiQ8WWW0
PaxDbiQ8WWW0
PeptideAtlasiQ8WWW0
PRIDEiQ8WWW0
ProteomicsDBi74944 [Q8WWW0-1]
74945 [Q8WWW0-2]
74946 [Q8WWW0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		73646, 266 antibodies

The DNASU plasmid repository

More...DNASUi		83593

Genome annotation databases

EnsembliENST00000577571; ENSP00000462576; ENSG00000266094 [Q8WWW0-2]
ENST00000579436; ENSP00000462099; ENSG00000266094 [Q8WWW0-1]
ENST00000580449; ENSP00000462544; ENSG00000266094 [Q8WWW0-3]
GeneIDi83593
KEGGihsa:83593
UCSCiuc031vlp.2, human [Q8WWW0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83593
DisGeNETi83593

GeneCards: human genes, protein and diseases

More...GeneCardsi		RASSF5
HGNCiHGNC:17609, RASSF5
HPAiENSG00000266094, Tissue enhanced (blood, lymphoid tissue)
MIMi607020, gene
neXtProtiNX_Q8WWW0
OpenTargetsiENSG00000266094
PharmGKBiPA134958571
VEuPathDBiHostDB:ENSG00000266094.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4239, Eukaryota
GeneTreeiENSGT00940000159288
HOGENOMiCLU_045544_0_0_1
InParanoidiQ8WWW0
OrthoDBi1120975at2759
PhylomeDBiQ8WWW0
TreeFamiTF319243

Enzyme and pathway databases

PathwayCommonsiQ8WWW0
SignaLinkiQ8WWW0
SIGNORiQ8WWW0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83593, 4 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RASSF5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RASSF5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83593
PharosiQ8WWW0, Tbio

Protein Ontology

More...PROi		PR:Q8WWW0
RNActiQ8WWW0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000266094, Expressed in blood and 216 other tissues
ExpressionAtlasiQ8WWW0, baseline and differential
GenevisibleiQ8WWW0, HS

Family and domain databases

CDDicd00029, C1, 1 hit
IDEALiIID00631
InterProiView protein in InterPro
IPR033614, C-RASSF
IPR002219, PE/DAG-bd
IPR000159, RA_dom
IPR033623, RASSF5
IPR011524, SARAH_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR22738, PTHR22738, 1 hit
PTHR22738:SF9, PTHR22738:SF9, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF16517, Nore1-SARAH, 1 hit
PF00788, RA, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00314, RA, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200, RA, 1 hit
PS50951, SARAH, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASF5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWW0
Secondary accession number(s): A8K1E6
, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2002
Last modified: February 10, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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