UniProtKB - Q8WWV3 (RT4I1_HUMAN)
Reticulon-4-interacting protein 1, mitochondrial
RTN4IP1
Functioni
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
By similarityGO - Molecular functioni
- oxidoreductase activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- nervous system development Source: UniProtKB-KW
- regulation of dendrite development Source: UniProtKB
Keywordsi
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q8WWV3 |
SignaLinki | Q8WWV3 |
Names & Taxonomyi
Protein namesi | Recommended name: Reticulon-4-interacting protein 1, mitochondrialAlternative name(s): NOGO-interacting mitochondrial protein |
Gene namesi | Name:RTN4IP1 Synonyms:NIMP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18647, RTN4IP1 |
MIMi | 610502, gene |
neXtProti | NX_Q8WWV3 |
VEuPathDBi | HostDB:ENSG00000130347 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 2 Publications
Note: Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.1 Publication
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Involvement in diseasei
Optic atrophy 10 with or without ataxia, mental retardation, and seizures (OPA10)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076369 | 103 | R → H in OPA10. 1 PublicationCorresponds to variant dbSNP:rs372054380EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 84816 |
MalaCardsi | RTN4IP1 |
MIMi | 616732, phenotype |
OpenTargetsi | ENSG00000130347 |
Orphaneti | 98676, Autosomal recessive isolated optic atrophy |
PharmGKBi | PA38619 |
Miscellaneous databases
Pharosi | Q8WWV3, Tbio |
Genetic variation databases
BioMutai | RTN4IP1 |
DMDMi | 76789669 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 40 | MitochondrionSequence analysisCombined sourcesAdd BLAST | 40 | |
ChainiPRO_0000042114 | 41 – 396 | Reticulon-4-interacting protein 1, mitochondrialAdd BLAST | 356 |
Proteomic databases
EPDi | Q8WWV3 |
jPOSTi | Q8WWV3 |
MassIVEi | Q8WWV3 |
MaxQBi | Q8WWV3 |
PaxDbi | Q8WWV3 |
PeptideAtlasi | Q8WWV3 |
PRIDEi | Q8WWV3 |
ProteomicsDBi | 74937 [Q8WWV3-1] 74938 [Q8WWV3-2] 74939 [Q8WWV3-3] |
PTM databases
GlyGeni | Q8WWV3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WWV3 |
PhosphoSitePlusi | Q8WWV3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130347, Expressed in muscle tissue and 192 other tissues |
ExpressionAtlasi | Q8WWV3, baseline and differential |
Genevisiblei | Q8WWV3, HS |
Organism-specific databases
HPAi | ENSG00000130347, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RTN4, UQCRC1 and UQCRC2.
By similarityBinary interactionsi
Q8WWV3
Protein-protein interaction databases
BioGRIDi | 124276, 87 interactors |
IntActi | Q8WWV3, 36 interactors |
MINTi | Q8WWV3 |
STRINGi | 9606.ENSP00000358059 |
Miscellaneous databases
RNActi | Q8WWV3, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8WWV3 |
SMRi | Q8WWV3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WWV3 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1198, Eukaryota |
GeneTreei | ENSGT00880000138028 |
HOGENOMi | CLU_026673_3_3_1 |
InParanoidi | Q8WWV3 |
OMAi | TSWQALK |
OrthoDBi | 727365at2759 |
PhylomeDBi | Q8WWV3 |
TreeFami | TF313919 |
Family and domain databases
CDDi | cd08248, RTN4I1, 1 hit |
InterProi | View protein in InterPro IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS IPR037397, RTN4I1 |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEFLKTCVLR RNACTAVCFW RSKVVQKPSV RRISTTSPRS TVMPAWVIDK
60 70 80 90 100
YGKNEVLRFT QNMMMPIIHY PNEVIVKVHA ASVNPIDVNM RSGYGATALN
110 120 130 140 150
MKRDPLHVKI KGEEFPLTLG RDVSGVVMEC GLDVKYFKPG DEVWAAVPPW
160 170 180 190 200
KQGTLSEFVV VSGNEVSHKP KSLTHTQAAS LPYVALTAWS AINKVGGLND
210 220 230 240 250
KNCTGKRVLI LGASGGVGTF AIQVMKAWDA HVTAVCSQDA SELVRKLGAD
260 270 280 290 300
DVIDYKSGSV EEQLKSLKPF DFILDNVGGS TETWAPDFLK KWSGATYVTL
310 320 330 340 350
VTPFLLNMDR LGIADGMLQT GVTVGSKALK HFWKGVHYRW AFFMASGPCL
360 370 380 390
DDIAELVDAG KIRPVIEQTF PFSKVPEAFL KVERGHARGK TVINVV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V1R2 | G3V1R2_HUMAN | Reticulon-4-interacting protein 1, ... | RTN4IP1 | 226 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | M → V in AAL34525 (Ref. 1) Curated | 1 | |
Sequence conflicti | 84 | N → Y in AAL40856 (Ref. 1) Curated | 1 | |
Sequence conflicti | 164 | N → S in BAC04499 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 182 | P → S in AAL34525 (Ref. 1) Curated | 1 | |
Sequence conflicti | 317 | M → T in AAL40856 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076369 | 103 | R → H in OPA10. 1 PublicationCorresponds to variant dbSNP:rs372054380EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015742 | 1 – 100 | Missing in isoform 2. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_015743 | 208 – 226 | VLILG…IQVMK → ISGKESIIAGHFSWPVAH in isoform 3. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_015744 | 227 – 396 | Missing in isoform 3. 1 PublicationAdd BLAST | 170 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF439711 mRNA Translation: AAL34525.1 AY063761 mRNA Translation: AAL40856.1 AK095207 mRNA Translation: BAC04499.1 AL390074 Genomic DNA No translation available. BC006399 mRNA Translation: AAH06399.2 |
CCDSi | CCDS5056.1 [Q8WWV3-1] |
RefSeqi | NP_001305675.1, NM_001318746.1 [Q8WWV3-2] NP_116119.2, NM_032730.5 [Q8WWV3-1] |
Genome annotation databases
Ensembli | ENST00000369063.8; ENSP00000358059.3; ENSG00000130347.13 |
GeneIDi | 84816 |
KEGGi | hsa:84816 |
MANE-Selecti | ENST00000369063.8; ENSP00000358059.3; NM_032730.5; NP_116119.2 |
UCSCi | uc003prj.4, human [Q8WWV3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF439711 mRNA Translation: AAL34525.1 AY063761 mRNA Translation: AAL40856.1 AK095207 mRNA Translation: BAC04499.1 AL390074 Genomic DNA No translation available. BC006399 mRNA Translation: AAH06399.2 |
CCDSi | CCDS5056.1 [Q8WWV3-1] |
RefSeqi | NP_001305675.1, NM_001318746.1 [Q8WWV3-2] NP_116119.2, NM_032730.5 [Q8WWV3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VN8 | X-ray | 2.10 | A/B | 45-396 | [»] | |
AlphaFoldDBi | Q8WWV3 | |||||
SMRi | Q8WWV3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124276, 87 interactors |
IntActi | Q8WWV3, 36 interactors |
MINTi | Q8WWV3 |
STRINGi | 9606.ENSP00000358059 |
PTM databases
GlyGeni | Q8WWV3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WWV3 |
PhosphoSitePlusi | Q8WWV3 |
Genetic variation databases
BioMutai | RTN4IP1 |
DMDMi | 76789669 |
Proteomic databases
EPDi | Q8WWV3 |
jPOSTi | Q8WWV3 |
MassIVEi | Q8WWV3 |
MaxQBi | Q8WWV3 |
PaxDbi | Q8WWV3 |
PeptideAtlasi | Q8WWV3 |
PRIDEi | Q8WWV3 |
ProteomicsDBi | 74937 [Q8WWV3-1] 74938 [Q8WWV3-2] 74939 [Q8WWV3-3] |
Protocols and materials databases
Antibodypediai | 32150, 233 antibodies from 22 providers |
DNASUi | 84816 |
Genome annotation databases
Ensembli | ENST00000369063.8; ENSP00000358059.3; ENSG00000130347.13 |
GeneIDi | 84816 |
KEGGi | hsa:84816 |
MANE-Selecti | ENST00000369063.8; ENSP00000358059.3; NM_032730.5; NP_116119.2 |
UCSCi | uc003prj.4, human [Q8WWV3-1] |
Organism-specific databases
CTDi | 84816 |
DisGeNETi | 84816 |
GeneCardsi | RTN4IP1 |
HGNCi | HGNC:18647, RTN4IP1 |
HPAi | ENSG00000130347, Low tissue specificity |
MalaCardsi | RTN4IP1 |
MIMi | 610502, gene 616732, phenotype |
neXtProti | NX_Q8WWV3 |
OpenTargetsi | ENSG00000130347 |
Orphaneti | 98676, Autosomal recessive isolated optic atrophy |
PharmGKBi | PA38619 |
VEuPathDBi | HostDB:ENSG00000130347 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1198, Eukaryota |
GeneTreei | ENSGT00880000138028 |
HOGENOMi | CLU_026673_3_3_1 |
InParanoidi | Q8WWV3 |
OMAi | TSWQALK |
OrthoDBi | 727365at2759 |
PhylomeDBi | Q8WWV3 |
TreeFami | TF313919 |
Enzyme and pathway databases
PathwayCommonsi | Q8WWV3 |
SignaLinki | Q8WWV3 |
Miscellaneous databases
BioGRID-ORCSi | 84816, 85 hits in 1081 CRISPR screens |
ChiTaRSi | RTN4IP1, human |
EvolutionaryTracei | Q8WWV3 |
GenomeRNAii | 84816 |
Pharosi | Q8WWV3, Tbio |
PROi | PR:Q8WWV3 |
RNActi | Q8WWV3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130347, Expressed in muscle tissue and 192 other tissues |
ExpressionAtlasi | Q8WWV3, baseline and differential |
Genevisiblei | Q8WWV3, HS |
Family and domain databases
CDDi | cd08248, RTN4I1, 1 hit |
InterProi | View protein in InterPro IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS IPR037397, RTN4I1 |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RT4I1_HUMAN | |
Accessioni | Q8WWV3Primary (citable) accession number: Q8WWV3 Secondary accession number(s): Q8N9B3, Q8WZ66, Q9BRA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | September 27, 2005 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families