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UniProtKB - Q8WWT9 (S13A3_HUMAN)

Protein

Solute carrier family 13 member 3

Gene

SLC13A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Protein family/group databases

TCDBi2.A.47.1.15 the divalent anion:na(+) symporter (dass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 3
Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name:
NaDC-3
Short name:
hNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2
Gene namesi
Name:SLC13A3
Synonyms:NADC3, SDCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000158296.13
HGNCiHGNC:14430 SLC13A3
MIMi606411 gene
neXtProtiNX_Q8WWT9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 55ExtracellularSequence analysisAdd BLAST18
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 82CytoplasmicSequence analysis6
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 137ExtracellularSequence analysisAdd BLAST34
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 229CytoplasmicSequence analysisAdd BLAST71
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 278ExtracellularSequence analysisAdd BLAST28
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 336CytoplasmicSequence analysisAdd BLAST37
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 372ExtracellularSequence analysisAdd BLAST15
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 422CytoplasmicSequence analysisAdd BLAST29
Intramembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461CytoplasmicSequence analysisAdd BLAST18
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 505ExtracellularSequence analysisAdd BLAST23
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 546CytoplasmicSequence analysisAdd BLAST20
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 602ExtracellularSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64849
OpenTargetsiENSG00000158296
PharmGKBiPA37881

Chemistry databases

ChEMBLiCHEMBL3712947
DrugBankiDB00139 Succinic acid

Polymorphism and mutation databases

BioMutaiSLC13A3
DMDMi23396845

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724921 – 602Solute carrier family 13 member 3Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8WWT9
PaxDbiQ8WWT9
PeptideAtlasiQ8WWT9
PRIDEiQ8WWT9
ProteomicsDBi74929
74930 [Q8WWT9-2]
74931 [Q8WWT9-3]
74932 [Q8WWT9-4]

PTM databases

iPTMnetiQ8WWT9
PhosphoSitePlusiQ8WWT9

Expressioni

Tissue specificityi

Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.

Gene expression databases

BgeeiENSG00000158296 Expressed in 171 organ(s), highest expression level in nephron tubule
ExpressionAtlasiQ8WWT9 baseline and differential
GenevisibleiQ8WWT9 HS

Organism-specific databases

HPAiHPA014333
HPA014353
HPA014736

Interactioni

Protein-protein interaction databases

BioGridi122322, 1 interactor
IntActiQ8WWT9, 9 interactors
STRINGi9606.ENSP00000279027

Chemistry databases

BindingDBiQ8WWT9

Structurei

3D structure databases

ProteinModelPortaliQ8WWT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
GeneTreeiENSGT00550000074480
HOGENOMiHOG000278432
HOVERGENiHBG055339
InParanoidiQ8WWT9
KOiK14445
OMAiKPSLKWW
OrthoDBiEOG091G092X
PhylomeDBiQ8WWT9
TreeFamiTF312913

Family and domain databases

InterProiView protein in InterPro
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8WWT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV 
        60         70         80         90        100
YWCTEALPLS VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA 
       110        120        130        140        150
SAIEEWNLHR RIALKILMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM 
       160        170        180        190        200
MLPIANAILK SLFGQKEVRK DPSQESEENT AAVRRNGLHT VPTEMQFLAS 
       210        220        230        240        250
TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY SASIGGTATL 
       260        270        280        290        300
TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL 
       310        320        330        340        350
YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC 
       360        370        380        390        400
MFAILLFTRD PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK 
       410        420        430        440        450
WWFDFKAPNT ETEPLLTWKK AQETVPWNII LLLGGGFAMA KGCEESGLSV 
       460        470        480        490        500
WIGGQLHPLE NVPPALAVLL ITVVIAFFTE FASNTATIII FLPVLAELAI 
       510        520        530        540        550
RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL VKDMVRTGLL 
       560        570        580        590        600
MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR 

TL
Length:602
Mass (Da):66,841
Last modified:March 1, 2002 - v1
Checksum:i611A50994BA37687
GO
Isoform 2 (identifier: Q8WWT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-297: AAVRRNGLHT...LFLLAGWLWI → GIEPNTFLSE...RVLSFLPGGM
     298-602: Missing.

Note: Gene prediction based on EST data.
Show »
Length:232
Mass (Da):25,684
Checksum:i7EEDA215B050ABEB
GO
Isoform 3 (identifier: Q8WWT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     340-374: Missing.

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):57,766
Checksum:iD9CB6E6BE1A5C936
GO
Isoform 4 (identifier: Q8WWT9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR
     375-388: FLSDAVTGVAIVTI → CKMGIISISTIQKM
     389-602: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:338
Mass (Da):37,669
Checksum:i022516BECC8D3961
GO
Isoform 5 (identifier: Q8WWT9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR

Note: No experimental confirmation available.
Show »
Length:552
Mass (Da):61,099
Checksum:iEF5734E90BBE2167
GO
Isoform 6 (identifier: Q8WWT9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:555
Mass (Da):61,757
Checksum:iE433B6A826BA4D77
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7L4C9J7L4_HUMAN
Solute carrier family 13 member 3
SLC13A3
408Annotation score:
C9J4A3C9J4A3_HUMAN
HCG2018530, isoform CRA_c
SLC13A3 hCG_2018530
185Annotation score:
H7C0C8H7C0C8_HUMAN
Solute carrier family 13 member 3
SLC13A3
236Annotation score:
X6RDV4X6RDV4_HUMAN
Solute carrier family 13 member 3
SLC13A3
301Annotation score:
A0A0A0MRQ6A0A0A0MRQ6_HUMAN
Solute carrier family 13 member 3
SLC13A3
248Annotation score:

Sequence cautioni

The sequence AAF73251 differs from that shown. Reason: Frameshift at positions 188 and 199.Curated
The sequence CAC09447 differs from that shown. erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94L → P in BAC04834 (PubMed:14702039).Curated1
Sequence conflicti364I → V in AAH35966 (PubMed:15489334).Curated1
Sequence conflicti572Q → P in BAB71262 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152911 – 47Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_006123181 – 297AAVRR…GWLWI → GIEPNTFLSEERLKLQAPLV IRLGQITESGQWNMSGNDVC NFRVLSFLPGGM in isoform 2. CuratedAdd BLAST117
Alternative sequenceiVSP_015292182 – 292AVRRN…LFLLA → KTTLGRQRFHWICRLTPGRR MNIVGTSGRASSSPSPTQPV LGAQPHSRAQPLTSSCLASS R in isoform 4 and isoform 5. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_006124298 – 602Missing in isoform 2. CuratedAdd BLAST305
Alternative sequenceiVSP_015293340 – 374Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_015294375 – 388FLSDA…AIVTI → CKMGIISISTIQKM in isoform 4. CuratedAdd BLAST14
Alternative sequenceiVSP_015295389 – 602Missing in isoform 4. CuratedAdd BLAST214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154121 mRNA Translation: AAF73251.1 Frameshift.
AY072810 mRNA Translation: AAL66762.1
AK056713 mRNA Translation: BAB71262.1
AK096658 mRNA Translation: BAC04834.1
AK295748 mRNA Translation: BAG58580.1
AL133520 Genomic DNA No translation available.
AL034424 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75725.1
CH471077 Genomic DNA Translation: EAW75726.1
BC035966 mRNA Translation: AAH35966.1
AL442082 mRNA Translation: CAC09447.2 Sequence problems.
CCDSiCCDS13400.1 [Q8WWT9-1]
CCDS42886.1 [Q8WWT9-6]
CCDS54469.1 [Q8WWT9-3]
CCDS54470.1 [Q8WWT9-5]
RefSeqiNP_001011554.1, NM_001011554.2 [Q8WWT9-6]
NP_001180268.1, NM_001193339.1 [Q8WWT9-5]
NP_001180269.1, NM_001193340.1 [Q8WWT9-3]
NP_073740.2, NM_022829.5 [Q8WWT9-1]
UniGeneiHs.655498
Hs.670365

Genome annotation databases

EnsembliENST00000279027; ENSP00000279027; ENSG00000158296 [Q8WWT9-1]
ENST00000290317; ENSP00000290317; ENSG00000158296 [Q8WWT9-6]
ENST00000413164; ENSP00000415852; ENSG00000158296 [Q8WWT9-5]
ENST00000472148; ENSP00000420177; ENSG00000158296 [Q8WWT9-3]
ENST00000495082; ENSP00000419621; ENSG00000158296 [Q8WWT9-6]
GeneIDi64849
KEGGihsa:64849
UCSCiuc002xsf.3 human [Q8WWT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154121 mRNA Translation: AAF73251.1 Frameshift.
AY072810 mRNA Translation: AAL66762.1
AK056713 mRNA Translation: BAB71262.1
AK096658 mRNA Translation: BAC04834.1
AK295748 mRNA Translation: BAG58580.1
AL133520 Genomic DNA No translation available.
AL034424 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75725.1
CH471077 Genomic DNA Translation: EAW75726.1
BC035966 mRNA Translation: AAH35966.1
AL442082 mRNA Translation: CAC09447.2 Sequence problems.
CCDSiCCDS13400.1 [Q8WWT9-1]
CCDS42886.1 [Q8WWT9-6]
CCDS54469.1 [Q8WWT9-3]
CCDS54470.1 [Q8WWT9-5]
RefSeqiNP_001011554.1, NM_001011554.2 [Q8WWT9-6]
NP_001180268.1, NM_001193339.1 [Q8WWT9-5]
NP_001180269.1, NM_001193340.1 [Q8WWT9-3]
NP_073740.2, NM_022829.5 [Q8WWT9-1]
UniGeneiHs.655498
Hs.670365

3D structure databases

ProteinModelPortaliQ8WWT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122322, 1 interactor
IntActiQ8WWT9, 9 interactors
STRINGi9606.ENSP00000279027

Chemistry databases

BindingDBiQ8WWT9
ChEMBLiCHEMBL3712947
DrugBankiDB00139 Succinic acid

Protein family/group databases

TCDBi2.A.47.1.15 the divalent anion:na(+) symporter (dass) family

PTM databases

iPTMnetiQ8WWT9
PhosphoSitePlusiQ8WWT9

Polymorphism and mutation databases

BioMutaiSLC13A3
DMDMi23396845

Proteomic databases

MaxQBiQ8WWT9
PaxDbiQ8WWT9
PeptideAtlasiQ8WWT9
PRIDEiQ8WWT9
ProteomicsDBi74929
74930 [Q8WWT9-2]
74931 [Q8WWT9-3]
74932 [Q8WWT9-4]

Protocols and materials databases

DNASUi64849
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279027; ENSP00000279027; ENSG00000158296 [Q8WWT9-1]
ENST00000290317; ENSP00000290317; ENSG00000158296 [Q8WWT9-6]
ENST00000413164; ENSP00000415852; ENSG00000158296 [Q8WWT9-5]
ENST00000472148; ENSP00000420177; ENSG00000158296 [Q8WWT9-3]
ENST00000495082; ENSP00000419621; ENSG00000158296 [Q8WWT9-6]
GeneIDi64849
KEGGihsa:64849
UCSCiuc002xsf.3 human [Q8WWT9-1]

Organism-specific databases

CTDi64849
DisGeNETi64849
EuPathDBiHostDB:ENSG00000158296.13
GeneCardsiSLC13A3
HGNCiHGNC:14430 SLC13A3
HPAiHPA014333
HPA014353
HPA014736
MIMi606411 gene
neXtProtiNX_Q8WWT9
OpenTargetsiENSG00000158296
PharmGKBiPA37881
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
GeneTreeiENSGT00550000074480
HOGENOMiHOG000278432
HOVERGENiHBG055339
InParanoidiQ8WWT9
KOiK14445
OMAiKPSLKWW
OrthoDBiEOG091G092X
PhylomeDBiQ8WWT9
TreeFamiTF312913

Enzyme and pathway databases

ReactomeiR-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Miscellaneous databases

ChiTaRSiSLC13A3 human
GeneWikiiSLC13A3
GenomeRNAii64849
PROiPR:Q8WWT9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158296 Expressed in 171 organ(s), highest expression level in nephron tubule
ExpressionAtlasiQ8WWT9 baseline and differential
GenevisibleiQ8WWT9 HS

Family and domain databases

InterProiView protein in InterPro
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS13A3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWT9
Secondary accession number(s): B4DIR8
, E1P5U4, F6WI18, Q5JYC9, Q5JYD0, Q5JYD1, Q5TCQ2, Q8IVB1, Q8N8K4, Q96MM5, Q9BR25, Q9H1G1, Q9H3W4, Q9NQN5, Q9NS04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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