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UniProtKB - Q8WWT9 (S13A3_HUMAN)

Entry version 174 (07 Apr 2021)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
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Protein

Solute carrier family 13 member 3

Gene

SLC13A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate (PubMed:30635937). The stoichiometry is probably 3 Na+ for 1 divalent succinate.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WWT9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-433137, Sodium-coupled sulphate, di- and tri-carboxylate transporters

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q8WWT9

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.47.1.15, the divalent anion:na(+) symporter (dass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 13 member 3
Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name:
NaDC-3
Short name:
hNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC13A3
Synonyms:NADC3, SDCT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14430, SLC13A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606411, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WWT9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000158296.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 55ExtracellularSequence analysisAdd BLAST18
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 82CytoplasmicSequence analysis6
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 137ExtracellularSequence analysisAdd BLAST34
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 229CytoplasmicSequence analysisAdd BLAST71
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 278ExtracellularSequence analysisAdd BLAST28
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 336CytoplasmicSequence analysisAdd BLAST37
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 372ExtracellularSequence analysisAdd BLAST15
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 422CytoplasmicSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461CytoplasmicSequence analysisAdd BLAST18
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 505ExtracellularSequence analysisAdd BLAST23
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 546CytoplasmicSequence analysisAdd BLAST20
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 602ExtracellularSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate (ARLIAK)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by acute, reversible neurological deterioration during febrile illness. Patients exhibit reversible leukoencephalopathy and increased urinary excretion of alpha-ketoglutarate.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082121254A → D in ARLIAK; unable to transport succinate, alpha-ketoglutarate and N-acetylaspartate. 1 PublicationCorresponds to variant dbSNP:rs1568927501EnsemblClinVar.1
Natural variantiVAR_082122548G → S in ARLIAK; severely decreased transport of succinate, alpha-ketoglutarate and N-acetylaspartate. 1 PublicationCorresponds to variant dbSNP:rs1568904872EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		64849

MalaCards human disease database

More...MalaCardsi		SLC13A3
MIMi618384, phenotype

Open Targets

More...OpenTargetsi		ENSG00000158296

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37881

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WWT9, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3712947

Drug and drug target database

More...DrugBanki		DB00139, Succinic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC13A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		23396845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001724921 – 602Solute carrier family 13 member 3Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WWT9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WWT9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WWT9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WWT9

PeptideAtlas

More...PeptideAtlasi		Q8WWT9

PRoteomics IDEntifications database

More...PRIDEi		Q8WWT9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		28114
4325
74929 [Q8WWT9-1]
74930 [Q8WWT9-2]
74931 [Q8WWT9-3]
74932 [Q8WWT9-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8WWT9, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WWT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WWT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000158296, Expressed in nephron tubule and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WWT9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WWT9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000158296, Tissue enriched (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122322, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q8WWT9, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000279027

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8WWT9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WWT9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1281, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005170_9_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WWT9

Identification of Orthologs from Complete Genome Data

More...OMAi		IWWMTEA

Database of Orthologous Groups

More...OrthoDBi		389981at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WWT9

TreeFam database of animal gene trees

More...TreeFami		TF312913

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001898, SLC13A/DASS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00939, Na_sulph_symp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV 
        60         70         80         90        100
YWCTEALPLS VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA 
       110        120        130        140        150
SAIEEWNLHR RIALKILMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM 
       160        170        180        190        200
MLPIANAILK SLFGQKEVRK DPSQESEENT AAVRRNGLHT VPTEMQFLAS 
       210        220        230        240        250
TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY SASIGGTATL 
       260        270        280        290        300
TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL 
       310        320        330        340        350
YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC 
       360        370        380        390        400
MFAILLFTRD PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK 
       410        420        430        440        450
WWFDFKAPNT ETEPLLTWKK AQETVPWNII LLLGGGFAMA KGCEESGLSV 
       460        470        480        490        500
WIGGQLHPLE NVPPALAVLL ITVVIAFFTE FASNTATIII FLPVLAELAI 
       510        520        530        540        550
RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL VKDMVRTGLL 
       560        570        580        590        600
MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR 

TL
Length:602
Mass (Da):66,841
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i611A50994BA37687
GO
Isoform 2 (identifier: Q8WWT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-297: AAVRRNGLHT...LFLLAGWLWI → GIEPNTFLSE...RVLSFLPGGM
     298-602: Missing.

Show »
Length:232
Mass (Da):25,684
Checksum:i7EEDA215B050ABEB
GO
Isoform 3 (identifier: Q8WWT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     340-374: Missing.

Show »
Length:520
Mass (Da):57,766
Checksum:iD9CB6E6BE1A5C936
GO
Isoform 4 (identifier: Q8WWT9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR
     375-388: FLSDAVTGVAIVTI → CKMGIISISTIQKM
     389-602: Missing.

Show »
Length:338
Mass (Da):37,669
Checksum:i022516BECC8D3961
GO
Isoform 5 (identifier: Q8WWT9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR

Show »
Length:552
Mass (Da):61,099
Checksum:iEF5734E90BBE2167
GO
Isoform 6 (identifier: Q8WWT9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:555
Mass (Da):61,757
Checksum:iE433B6A826BA4D77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7L4C9J7L4_HUMAN
Solute carrier family 13 member 3
SLC13A3
408Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRQ6A0A0A0MRQ6_HUMAN
Solute carrier family 13 member 3
SLC13A3
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RDV4X6RDV4_HUMAN
Solute carrier family 13 member 3
SLC13A3
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4A3C9J4A3_HUMAN
HCG2018530, isoform CRA_c
SLC13A3 hCG_2018530
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0C8H7C0C8_HUMAN
Solute carrier family 13 member 3
SLC13A3
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF73251 differs from that shown. Reason: Frameshift.Curated
The sequence CAC09447 differs from that shown. erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94L → P in BAC04834 (PubMed:14702039).Curated1
Sequence conflicti364I → V in AAH35966 (PubMed:15489334).Curated1
Sequence conflicti572Q → P in BAB71262 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082121254A → D in ARLIAK; unable to transport succinate, alpha-ketoglutarate and N-acetylaspartate. 1 PublicationCorresponds to variant dbSNP:rs1568927501EnsemblClinVar.1
Natural variantiVAR_082122548G → S in ARLIAK; severely decreased transport of succinate, alpha-ketoglutarate and N-acetylaspartate. 1 PublicationCorresponds to variant dbSNP:rs1568904872EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152911 – 47Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_006123181 – 297AAVRR…GWLWI → GIEPNTFLSEERLKLQAPLV IRLGQITESGQWNMSGNDVC NFRVLSFLPGGM in isoform 2. CuratedAdd BLAST117
Alternative sequenceiVSP_015292182 – 292AVRRN…LFLLA → KTTLGRQRFHWICRLTPGRR MNIVGTSGRASSSPSPTQPV LGAQPHSRAQPLTSSCLASS R in isoform 4 and isoform 5. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_006124298 – 602Missing in isoform 2. CuratedAdd BLAST305
Alternative sequenceiVSP_015293340 – 374Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_015294375 – 388FLSDA…AIVTI → CKMGIISISTIQKM in isoform 4. CuratedAdd BLAST14
Alternative sequenceiVSP_015295389 – 602Missing in isoform 4. CuratedAdd BLAST214

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF154121 mRNA Translation: AAF73251.1 Frameshift.
AY072810 mRNA Translation: AAL66762.1
AK056713 mRNA Translation: BAB71262.1
AK096658 mRNA Translation: BAC04834.1
AK295748 mRNA Translation: BAG58580.1
AL133520 Genomic DNA No translation available.
AL034424 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75725.1
CH471077 Genomic DNA Translation: EAW75726.1
BC035966 mRNA Translation: AAH35966.1
AL442082 mRNA Translation: CAC09447.2 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13400.1 [Q8WWT9-1]
CCDS42886.1 [Q8WWT9-6]
CCDS54469.1 [Q8WWT9-3]
CCDS54470.1 [Q8WWT9-5]

NCBI Reference Sequences

More...RefSeqi		NP_001011554.1, NM_001011554.2 [Q8WWT9-6]
NP_001180268.1, NM_001193339.1 [Q8WWT9-5]
NP_001180269.1, NM_001193340.1 [Q8WWT9-3]
NP_073740.2, NM_022829.5 [Q8WWT9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000279027; ENSP00000279027; ENSG00000158296 [Q8WWT9-1]
ENST00000290317; ENSP00000290317; ENSG00000158296 [Q8WWT9-6]
ENST00000413164; ENSP00000415852; ENSG00000158296 [Q8WWT9-5]
ENST00000472148; ENSP00000420177; ENSG00000158296 [Q8WWT9-3]
ENST00000495082; ENSP00000419621; ENSG00000158296 [Q8WWT9-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64849

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64849

UCSC genome browser

More...UCSCi		uc002xsf.3, human [Q8WWT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154121 mRNA Translation: AAF73251.1 Frameshift.
AY072810 mRNA Translation: AAL66762.1
AK056713 mRNA Translation: BAB71262.1
AK096658 mRNA Translation: BAC04834.1
AK295748 mRNA Translation: BAG58580.1
AL133520 Genomic DNA No translation available.
AL034424 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75725.1
CH471077 Genomic DNA Translation: EAW75726.1
BC035966 mRNA Translation: AAH35966.1
AL442082 mRNA Translation: CAC09447.2 Sequence problems.
CCDSiCCDS13400.1 [Q8WWT9-1]
CCDS42886.1 [Q8WWT9-6]
CCDS54469.1 [Q8WWT9-3]
CCDS54470.1 [Q8WWT9-5]
RefSeqiNP_001011554.1, NM_001011554.2 [Q8WWT9-6]
NP_001180268.1, NM_001193339.1 [Q8WWT9-5]
NP_001180269.1, NM_001193340.1 [Q8WWT9-3]
NP_073740.2, NM_022829.5 [Q8WWT9-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122322, 10 interactors
IntActiQ8WWT9, 10 interactors
STRINGi9606.ENSP00000279027

Chemistry databases

BindingDBiQ8WWT9
ChEMBLiCHEMBL3712947
DrugBankiDB00139, Succinic acid

Protein family/group databases

TCDBi2.A.47.1.15, the divalent anion:na(+) symporter (dass) family

PTM databases

GlyGeniQ8WWT9, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ8WWT9
PhosphoSitePlusiQ8WWT9

Genetic variation databases

BioMutaiSLC13A3
DMDMi23396845

Proteomic databases

jPOSTiQ8WWT9
MassIVEiQ8WWT9
MaxQBiQ8WWT9
PaxDbiQ8WWT9
PeptideAtlasiQ8WWT9
PRIDEiQ8WWT9
ProteomicsDBi28114
4325
74929 [Q8WWT9-1]
74930 [Q8WWT9-2]
74931 [Q8WWT9-3]
74932 [Q8WWT9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13229, 127 antibodies

The DNASU plasmid repository

More...DNASUi		64849

Genome annotation databases

EnsembliENST00000279027; ENSP00000279027; ENSG00000158296 [Q8WWT9-1]
ENST00000290317; ENSP00000290317; ENSG00000158296 [Q8WWT9-6]
ENST00000413164; ENSP00000415852; ENSG00000158296 [Q8WWT9-5]
ENST00000472148; ENSP00000420177; ENSG00000158296 [Q8WWT9-3]
ENST00000495082; ENSP00000419621; ENSG00000158296 [Q8WWT9-6]
GeneIDi64849
KEGGihsa:64849
UCSCiuc002xsf.3, human [Q8WWT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64849
DisGeNETi64849

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC13A3
HGNCiHGNC:14430, SLC13A3
HPAiENSG00000158296, Tissue enriched (kidney)
MalaCardsiSLC13A3
MIMi606411, gene
618384, phenotype
neXtProtiNX_Q8WWT9
OpenTargetsiENSG00000158296
PharmGKBiPA37881
VEuPathDBiHostDB:ENSG00000158296.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1281, Eukaryota
GeneTreeiENSGT01000000214423
HOGENOMiCLU_005170_9_1_1
InParanoidiQ8WWT9
OMAiIWWMTEA
OrthoDBi389981at2759
PhylomeDBiQ8WWT9
TreeFamiTF312913

Enzyme and pathway databases

PathwayCommonsiQ8WWT9
ReactomeiR-HSA-433137, Sodium-coupled sulphate, di- and tri-carboxylate transporters
SABIO-RKiQ8WWT9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64849, 4 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC13A3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC13A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64849
PharosiQ8WWT9, Tbio

Protein Ontology

More...PROi		PR:Q8WWT9
RNActiQ8WWT9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000158296, Expressed in nephron tubule and 191 other tissues
ExpressionAtlasiQ8WWT9, baseline and differential
GenevisibleiQ8WWT9, HS

Family and domain databases

InterProiView protein in InterPro
IPR001898, SLC13A/DASS
PfamiView protein in Pfam
PF00939, Na_sulph_symp, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS13A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWT9
Secondary accession number(s): B4DIR8
, E1P5U4, F6WI18, Q5JYC9, Q5JYD0, Q5JYD1, Q5TCQ2, Q8IVB1, Q8N8K4, Q96MM5, Q9BR25, Q9H1G1, Q9H3W4, Q9NQN5, Q9NS04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: April 7, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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