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UniProtKB - Q8WWR8 (NEUR4_HUMAN)

Entry version 169 (25 May 2022)
Sequence version 3 (07 Mar 2006)
Previous versions | rss
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Protein

Sialidase-4

Gene

NEU4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228).

Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity).

May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691).

Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 3.2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei23SubstrateBy similarity1
Binding sitei43SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei47Proton acceptorBy similarity1
Active sitei48Proton acceptorBy similarity1
Binding sitei177SubstrateBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei222SubstrateBy similarity1
Binding sitei242SubstrateBy similarity1
Binding sitei389SubstrateBy similarity1
Active sitei419NucleophileBy similarity1
Active sitei440Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WWR8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660662, Glycosphingolipid metabolism [Q8WWR8-2]
R-HSA-4085001, Sialic acid metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q8WWR8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WWR8

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH33, Glycoside Hydrolase Family 33

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001400 [Q8WWR8-2]
SLP:000001401 [Q8WWR8-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialidase-4 (EC:3.2.1.184 Publications)
Alternative name(s):
N-acetyl-alpha-neuraminidase 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEU4
ORF Names:LP5125
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21328, NEU4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608527, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WWR8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204099

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Lysosome, Membrane, Microsome, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5R → A: Impairs mitochondrial targeting. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		129807

Open Targets

More...OpenTargetsi		ENSG00000204099

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134917116

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WWR8, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4174

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NEU4

Domain mapping of disease mutations (DMDM)

More...DMDMi		90110434

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002089061 – 484Sialidase-4Add BLAST484

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WWR8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WWR8

PeptideAtlas

More...PeptideAtlasi		Q8WWR8

PRoteomics IDEntifications database

More...PRIDEi		Q8WWR8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74925 [Q8WWR8-1]
74926 [Q8WWR8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8WWR8, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WWR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WWR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominant form in liver. Also expressed in brain, kidney and colon.2 Publications
Highly expressed in brain and at lower levels in kidney and liver.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated during monocyte to macrophage differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204099, Expressed in right lobe of liver and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WWR8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WWR8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204099, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126209, 63 interactors

Protein interaction database and analysis system

More...IntActi		Q8WWR8, 23 interactors

Molecular INTeraction database

More...MINTi		Q8WWR8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000320318

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8WWR8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WWR8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8WWR8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WWR8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati127 – 138BNR 1Add BLAST12
Repeati200 – 211BNR 2Add BLAST12
Repeati251 – 262BNR 3Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni284 – 357DisorderedSequence analysisAdd BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi22 – 25FRIP motif4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSFT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182944

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WWR8

Identification of Orthologs from Complete Genome Data

More...OMAi		GRTWHCG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WWR8

TreeFam database of animal gene trees

More...TreeFami		TF331063

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011040, Sialidase
IPR026946, Sialidase-4
IPR026856, Sialidase_fam
IPR036278, Sialidase_sf

The PANTHER Classification System

More...PANTHERi		PTHR10628, PTHR10628, 1 hit
PTHR10628:SF22, PTHR10628:SF22, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13088, BNR_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50939, SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVPRTPSRT VLFERERTGL TYRVPSLLPV PPGPTLLAFV EQRLSPDDSH 
        60         70         80         90        100
AHRLVLRRGT LAGGSVRWGA LHVLGTAALA EHRSMNPCPV HDAGTGTVFL 
       110        120        130        140        150
FFIAVLGHTP EAVQIATGRN AARLCCVASR DAGLSWGSAR DLTEEAIGGA 
       160        170        180        190        200
VQDWATFAVG PGHGVQLPSG RLLVPAYTYR VDRRECFGKI CRTSPHSFAF 
       210        220        230        240        250
YSDDHGRTWR CGGLVPNLRS GECQLAAVDG GQAGSFLYCN ARSPLGSRVQ 
       260        270        280        290        300
ALSTDEGTSF LPAERVASLP ETAWGCQGSI VGFPAPAPNR PRDDSWSVGP 
       310        320        330        340        350
GSPLQPPLLG PGVHEPPEEA AVDPRGGQVP GGPFSRLQPR GDGPRQPGPR 
       360        370        380        390        400
PGVSGDVGSW TLALPMPFAA PPQSPTWLLY SHPVGRRARL HMGIRLSQSP 
       410        420        430        440        450
LDPRSWTEPW VIYEGPSGYS DLASIGPAPE GGLVFACLYE SGARTSYDEI 
       460        470        480 
SFCTFSLREV LENVPASPKP PNLGDKPRGC CWPS
Length:484
Mass (Da):51,572
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14A878C2A9F18863
GO
Isoform 2 (identifier: Q8WWR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMSSAAFPRWLSM

Show »
Length:496
Mass (Da):52,938
Checksum:i1DE1395862011A36
GO
Isoform 3 (identifier: Q8WWR8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMSSAAFPRWLQSM

Show »
Length:497
Mass (Da):53,066
Checksum:iC933EFAEC7383F69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JRN9C9JRN9_HUMAN
Exo-alpha-sialidase
NEU4
260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5X2C9J5X2_HUMAN
Exo-alpha-sialidase
NEU4
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE58F8WE58_HUMAN
Exo-alpha-sialidase
NEU4
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2R4C9J2R4_HUMAN
Sialidase-4
NEU4
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2V4C9J2V4_HUMAN
Sialidase-4
NEU4
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZG9C9IZG9_HUMAN
Sialidase-4
NEU4
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEA3C9JEA3_HUMAN
Sialidase-4
NEU4
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J295C9J295_HUMAN
Sialidase-4
NEU4
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP34475 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184R → L in CAC81904 (PubMed:14962670).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067458301G → R3 PublicationsCorresponds to variant dbSNP:rs11545301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0374911M → MMSSAAFPRWLSM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0471231M → MMSSAAFPRWLQSM in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ277883 mRNA Translation: CAC81904.1
AK289421 mRNA Translation: BAF82110.1
AY203952 mRNA Translation: AAP34475.1 Frameshift.
AC114730 Genomic DNA Translation: AAX82022.1
CH471063 Genomic DNA Translation: EAW71296.1
BC012899 mRNA Translation: AAH12899.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2553.1 [Q8WWR8-2]
CCDS54441.1 [Q8WWR8-3]
CCDS54442.1 [Q8WWR8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001161071.1, NM_001167599.2 [Q8WWR8-3]
NP_001161072.1, NM_001167600.2 [Q8WWR8-1]
NP_001161073.1, NM_001167601.2 [Q8WWR8-1]
NP_001161074.1, NM_001167602.2 [Q8WWR8-1]
NP_542779.2, NM_080741.3 [Q8WWR8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325935.10; ENSP00000320318.6; ENSG00000204099.12 [Q8WWR8-3]
ENST00000391969.6; ENSP00000375830.2; ENSG00000204099.12
ENST00000404257.5; ENSP00000385149.1; ENSG00000204099.12 [Q8WWR8-2]
ENST00000405370.5; ENSP00000384804.1; ENSG00000204099.12
ENST00000407683.6; ENSP00000385402.1; ENSG00000204099.12
ENST00000616490.3; ENSP00000482722.2; ENSG00000277926.4 [Q8WWR8-2]
ENST00000618866.4; ENSP00000483726.1; ENSG00000277926.4
ENST00000621851.4; ENSP00000478409.1; ENSG00000277926.4
ENST00000626600.2; ENSP00000485701.1; ENSG00000277926.4 [Q8WWR8-3]
ENST00000630923.2; ENSP00000486602.1; ENSG00000277926.4

Database of genes from NCBI RefSeq genomes

More...GeneIDi		129807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:129807

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000407683.6; ENSP00000385402.1; NM_001167600.3; NP_001161072.1

UCSC genome browser

More...UCSCi		uc002wcm.4, human [Q8WWR8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277883 mRNA Translation: CAC81904.1
AK289421 mRNA Translation: BAF82110.1
AY203952 mRNA Translation: AAP34475.1 Frameshift.
AC114730 Genomic DNA Translation: AAX82022.1
CH471063 Genomic DNA Translation: EAW71296.1
BC012899 mRNA Translation: AAH12899.2
CCDSiCCDS2553.1 [Q8WWR8-2]
CCDS54441.1 [Q8WWR8-3]
CCDS54442.1 [Q8WWR8-1]
RefSeqiNP_001161071.1, NM_001167599.2 [Q8WWR8-3]
NP_001161072.1, NM_001167600.2 [Q8WWR8-1]
NP_001161073.1, NM_001167601.2 [Q8WWR8-1]
NP_001161074.1, NM_001167602.2 [Q8WWR8-1]
NP_542779.2, NM_080741.3 [Q8WWR8-2]

3D structure databases

AlphaFoldDBiQ8WWR8
SMRiQ8WWR8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126209, 63 interactors
IntActiQ8WWR8, 23 interactors
MINTiQ8WWR8
STRINGi9606.ENSP00000320318

Chemistry databases

BindingDBiQ8WWR8
ChEMBLiCHEMBL4174
SwissLipidsiSLP:000001400 [Q8WWR8-2]
SLP:000001401 [Q8WWR8-1]

Protein family/group databases

CAZyiGH33, Glycoside Hydrolase Family 33

PTM databases

GlyGeniQ8WWR8, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8WWR8
PhosphoSitePlusiQ8WWR8

Genetic variation databases

BioMutaiNEU4
DMDMi90110434

Proteomic databases

MassIVEiQ8WWR8
PaxDbiQ8WWR8
PeptideAtlasiQ8WWR8
PRIDEiQ8WWR8
ProteomicsDBi74925 [Q8WWR8-1]
74926 [Q8WWR8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34580, 171 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		129807

Genome annotation databases

EnsembliENST00000325935.10; ENSP00000320318.6; ENSG00000204099.12 [Q8WWR8-3]
ENST00000391969.6; ENSP00000375830.2; ENSG00000204099.12
ENST00000404257.5; ENSP00000385149.1; ENSG00000204099.12 [Q8WWR8-2]
ENST00000405370.5; ENSP00000384804.1; ENSG00000204099.12
ENST00000407683.6; ENSP00000385402.1; ENSG00000204099.12
ENST00000616490.3; ENSP00000482722.2; ENSG00000277926.4 [Q8WWR8-2]
ENST00000618866.4; ENSP00000483726.1; ENSG00000277926.4
ENST00000621851.4; ENSP00000478409.1; ENSG00000277926.4
ENST00000626600.2; ENSP00000485701.1; ENSG00000277926.4 [Q8WWR8-3]
ENST00000630923.2; ENSP00000486602.1; ENSG00000277926.4
GeneIDi129807
KEGGihsa:129807
MANE-SelectiENST00000407683.6; ENSP00000385402.1; NM_001167600.3; NP_001161072.1
UCSCiuc002wcm.4, human [Q8WWR8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		129807
DisGeNETi129807

GeneCards: human genes, protein and diseases

More...GeneCardsi		NEU4
HGNCiHGNC:21328, NEU4
HPAiENSG00000204099, Tissue enriched (liver)
MIMi608527, gene
neXtProtiNX_Q8WWR8
OpenTargetsiENSG00000204099
PharmGKBiPA134917116
VEuPathDBiHostDB:ENSG00000204099

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSFT, Eukaryota
GeneTreeiENSGT00950000182944
InParanoidiQ8WWR8
OMAiGRTWHCG
PhylomeDBiQ8WWR8
TreeFamiTF331063

Enzyme and pathway databases

BRENDAi3.2.1.18, 2681
PathwayCommonsiQ8WWR8
ReactomeiR-HSA-1660662, Glycosphingolipid metabolism [Q8WWR8-2]
R-HSA-4085001, Sialic acid metabolism
SABIO-RKiQ8WWR8
SignaLinkiQ8WWR8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		129807, 12 hits in 1069 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NEU4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		129807
PharosiQ8WWR8, Tchem

Protein Ontology

More...PROi		PR:Q8WWR8
RNActiQ8WWR8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204099, Expressed in right lobe of liver and 155 other tissues
ExpressionAtlasiQ8WWR8, baseline and differential
GenevisibleiQ8WWR8, HS

Family and domain databases

InterProiView protein in InterPro
IPR011040, Sialidase
IPR026946, Sialidase-4
IPR026856, Sialidase_fam
IPR036278, Sialidase_sf
PANTHERiPTHR10628, PTHR10628, 1 hit
PTHR10628:SF22, PTHR10628:SF22, 1 hit
PfamiView protein in Pfam
PF13088, BNR_2, 1 hit
SUPFAMiSSF50939, SSF50939, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUR4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWR8
Secondary accession number(s): A8K056, J3KNJ5, Q96D64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 7, 2006
Last modified: May 25, 2022
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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