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Entry version 131 (18 Sep 2019)
Sequence version 3 (06 Feb 2007)
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Protein

Inactive heparanase-2

Gene

HPSE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2024096 HS-GAG degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WWQ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive heparanase-2
Short name:
Hpa2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HPSE2
Synonyms:HPA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18374 HPSE2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613469 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWQ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Urofacial syndrome 1 (UFS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
60495

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
HPSE2

MalaCards human disease database

More...
MalaCardsi
HPSE2
MIMi236730 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000172987

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2704 Ochoa syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38533

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HPSE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125987832

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Sequence analysisAdd BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000006814042 – 592Inactive heparanase-2Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WWQ2

PeptideAtlas

More...
PeptideAtlasi
Q8WWQ2

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWQ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74920 [Q8WWQ2-1]
74921 [Q8WWQ2-2]
74922 [Q8WWQ2-3]
74923 [Q8WWQ2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WWQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing forebrain, diencephalon, midbrain, hind brain and spinal cord at Carnagie stage 16 (CS16, 6 weeks of gestation) and CS21 (8 weeks).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172987 Expressed in 103 organ(s), highest expression level in lower esophagus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWQ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WWQ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044603

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HPSE.

Interacts with SDC1 (via glycan chains).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121926, 22 interactors

Protein interaction database and analysis system

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IntActi
Q8WWQ2, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000359583

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WWQ2

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 79 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHNV Eukaryota
ENOG410YDJW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000004874

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WWQ2

KEGG Orthology (KO)

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KOi
K07965

Identification of Orthologs from Complete Genome Data

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OMAi
HRNPDNS

Database of Orthologous Groups

More...
OrthoDBi
1132327at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWQ2

TreeFam database of animal gene trees

More...
TreeFami
TF328999

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005199 Glyco_hydro_79
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03662 Glyco_hydro_79n, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWQ2-1) [UniParc]FASTAAdd to basket
Also known as: HPA2c

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVLCAFPEA MPSSNSRPPA CLAPGALYLA LLLHLSLSSQ AGDRRPLPVD
60 70 80 90 100
RAAGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR
110 120 130 140 150
LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD
160 170 180 190 200
IVRSDVALDK QKGCKIAQHP DVMLELQREK AAQMHLVLLK EQFSNTYSNL
210 220 230 240 250
ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS
260 270 280 290 300
KKYNISWELG NEPNNYRTMH GRAVNGSQLG KDYIQLKSLL QPIRIYSRAS
310 320 330 340 350
LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK
360 370 380 390 400
TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG
410 420 430 440 450
FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR
460 470 480 490 500
LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF
510 520 530 540 550
IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV
560 570 580 590
DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR
Length:592
Mass (Da):66,596
Last modified:February 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95C384AD9A6C868E
GO
Isoform 2 (identifier: Q8WWQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-548: SVQLNGQPLV → TQRCQYCGII
     549-592: Missing.

Show »
Length:548
Mass (Da):61,816
Checksum:i2572C68423CD2C51
GO
Isoform 3 (identifier: Q8WWQ2-3) [UniParc]FASTAAdd to basket
Also known as: HPA2b

The sequence of this isoform differs from the canonical sequence as follows:
     204-261: Missing.

Show »
Length:534
Mass (Da):60,080
Checksum:iC3DE5E900CAB9BC4
GO
Isoform 4 (identifier: Q8WWQ2-4) [UniParc]FASTAAdd to basket
Also known as: HPA2a

The sequence of this isoform differs from the canonical sequence as follows:
     150-261: Missing.

Show »
Length:480
Mass (Da):53,917
Checksum:iF75F89F67AD95C83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X238A0A087X238_HUMAN
Inactive heparanase-2
HPSE2
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSB9A0A0A0MSB9_HUMAN
Inactive heparanase-2
HPSE2
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12P → L in CAC82492 (Ref. 2) Curated1
Sequence conflicti213F → S in CAC82491 (Ref. 2) Curated1
Sequence conflicti213F → S in CAC82492 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030472315A → T. Corresponds to variant dbSNP:rs17110744EnsemblClinVar.1
Natural variantiVAR_023601579Y → F2 PublicationsCorresponds to variant dbSNP:rs10883100Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015850150 – 261Missing in isoform 4. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_015851204 – 261Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_015852539 – 548SVQLNGQPLV → TQRCQYCGII in isoform 2. 1 Publication10
Alternative sequenceiVSP_015853549 – 592Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF282885 mRNA Translation: AAG23421.1
AF282886 mRNA Translation: AAG23422.1
AF282887 mRNA Translation: AAG23423.1
AJ299719 mRNA Translation: CAC82491.1
AJ299720 mRNA Translation: CAC82492.1
AL590036 Genomic DNA No translation available.
AL139243 Genomic DNA No translation available.
AL356268 Genomic DNA No translation available.
AL445251 Genomic DNA No translation available.
AL356220 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53566.1 [Q8WWQ2-4]
CCDS53567.1 [Q8WWQ2-3]
CCDS53568.1 [Q8WWQ2-2]
CCDS7477.1 [Q8WWQ2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7506

NCBI Reference Sequences

More...
RefSeqi
NP_001159716.1, NM_001166244.1 [Q8WWQ2-3]
NP_001159717.1, NM_001166245.1 [Q8WWQ2-4]
NP_001159718.1, NM_001166246.1 [Q8WWQ2-2]
NP_068600.4, NM_021828.4 [Q8WWQ2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370546; ENSP00000359577; ENSG00000172987 [Q8WWQ2-2]
ENST00000370549; ENSP00000359580; ENSG00000172987 [Q8WWQ2-3]
ENST00000370552; ENSP00000359583; ENSG00000172987 [Q8WWQ2-1]
ENST00000628193; ENSP00000485916; ENSG00000172987 [Q8WWQ2-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60495

UCSC genome browser

More...
UCSCi
uc001kpn.3 human [Q8WWQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282885 mRNA Translation: AAG23421.1
AF282886 mRNA Translation: AAG23422.1
AF282887 mRNA Translation: AAG23423.1
AJ299719 mRNA Translation: CAC82491.1
AJ299720 mRNA Translation: CAC82492.1
AL590036 Genomic DNA No translation available.
AL139243 Genomic DNA No translation available.
AL356268 Genomic DNA No translation available.
AL445251 Genomic DNA No translation available.
AL356220 Genomic DNA No translation available.
CCDSiCCDS53566.1 [Q8WWQ2-4]
CCDS53567.1 [Q8WWQ2-3]
CCDS53568.1 [Q8WWQ2-2]
CCDS7477.1 [Q8WWQ2-1]
PIRiJC7506
RefSeqiNP_001159716.1, NM_001166244.1 [Q8WWQ2-3]
NP_001159717.1, NM_001166245.1 [Q8WWQ2-4]
NP_001159718.1, NM_001166246.1 [Q8WWQ2-2]
NP_068600.4, NM_021828.4 [Q8WWQ2-1]

3D structure databases

SMRiQ8WWQ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121926, 22 interactors
IntActiQ8WWQ2, 1 interactor
STRINGi9606.ENSP00000359583

PTM databases

iPTMnetiQ8WWQ2
PhosphoSitePlusiQ8WWQ2

Polymorphism and mutation databases

BioMutaiHPSE2
DMDMi125987832

Proteomic databases

PaxDbiQ8WWQ2
PeptideAtlasiQ8WWQ2
PRIDEiQ8WWQ2
ProteomicsDBi74920 [Q8WWQ2-1]
74921 [Q8WWQ2-2]
74922 [Q8WWQ2-3]
74923 [Q8WWQ2-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
60495
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370546; ENSP00000359577; ENSG00000172987 [Q8WWQ2-2]
ENST00000370549; ENSP00000359580; ENSG00000172987 [Q8WWQ2-3]
ENST00000370552; ENSP00000359583; ENSG00000172987 [Q8WWQ2-1]
ENST00000628193; ENSP00000485916; ENSG00000172987 [Q8WWQ2-4]
GeneIDi60495
KEGGihsa:60495
UCSCiuc001kpn.3 human [Q8WWQ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
60495
DisGeNETi60495

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HPSE2
GeneReviewsiHPSE2
HGNCiHGNC:18374 HPSE2
HPAiHPA044603
MalaCardsiHPSE2
MIMi236730 phenotype
613469 gene
neXtProtiNX_Q8WWQ2
OpenTargetsiENSG00000172987
Orphaneti2704 Ochoa syndrome
PharmGKBiPA38533

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHNV Eukaryota
ENOG410YDJW LUCA
GeneTreeiENSGT00390000004874
InParanoidiQ8WWQ2
KOiK07965
OMAiHRNPDNS
OrthoDBi1132327at2759
PhylomeDBiQ8WWQ2
TreeFamiTF328999

Enzyme and pathway databases

ReactomeiR-HSA-2024096 HS-GAG degradation
SIGNORiQ8WWQ2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HPSE2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HPSE2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60495

Pharos

More...
Pharosi
Q8WWQ2

Protein Ontology

More...
PROi
PR:Q8WWQ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172987 Expressed in 103 organ(s), highest expression level in lower esophagus
ExpressionAtlasiQ8WWQ2 baseline and differential
GenevisibleiQ8WWQ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR005199 Glyco_hydro_79
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF03662 Glyco_hydro_79n, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHPSE2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWQ2
Secondary accession number(s): Q5VUH4
, Q5VUH5, Q5VUH6, Q8WWQ1, Q9HB37, Q9HB38, Q9HB39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 6, 2007
Last modified: September 18, 2019
This is version 131 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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