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UniProtKB - Q8WWP7 (GIMA1_HUMAN)
Protein
GTPase IMAP family member 1
Gene
GIMAP1
Organism
Homo sapiens (Human)
Status
Functioni
May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 55 | GTPBy similarity | 1 | |
Binding sitei | 190 | GTPCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 42 | GTPCombined sources1 Publication | 9 | |
Nucleotide bindingi | 153 – 155 | GTPCombined sources1 Publication | 3 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WWP7 |
SignaLinki | Q8WWP7 |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase IMAP family member 1Alternative name(s): Immunity-associated protein 1 Short name: hIMAP1 |
Gene namesi | Name:GIMAP1 Synonyms:IMAP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23237, GIMAP1 |
MIMi | 608084, gene |
neXtProti | NX_Q8WWP7 |
VEuPathDBi | HostDB:ENSG00000213203 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type IV membrane protein Curated
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type IV membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 272 | CytoplasmicSequence analysisAdd BLAST | 272 | |
Transmembranei | 273 – 292 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 20 | |
Topological domaini | 293 – 306 | LumenalSequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 170575 |
OpenTargetsi | ENSG00000213203 |
PharmGKBi | PA134978698 |
Miscellaneous databases
Pharosi | Q8WWP7, Tbio |
Genetic variation databases
BioMutai | GIMAP1 |
DMDMi | 38372377 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190984 | 1 – 306 | GTPase IMAP family member 1Add BLAST | 306 |
Proteomic databases
EPDi | Q8WWP7 |
jPOSTi | Q8WWP7 |
MassIVEi | Q8WWP7 |
PaxDbi | Q8WWP7 |
PeptideAtlasi | Q8WWP7 |
PRIDEi | Q8WWP7 |
ProteomicsDBi | 74918 |
PTM databases
iPTMneti | Q8WWP7 |
MetOSitei | Q8WWP7 |
PhosphoSitePlusi | Q8WWP7 |
Expressioni
Tissue specificityi
Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells.2 Publications
Gene expression databases
Bgeei | ENSG00000213203, Expressed in blood and 209 other tissues |
ExpressionAtlasi | Q8WWP7, baseline and differential |
Genevisiblei | Q8WWP7, HS |
Organism-specific databases
HPAi | ENSG00000213203, Tissue enhanced (lymphoid) |
Interactioni
Binary interactionsi
Q8WWP7
Protein-protein interaction databases
BioGRIDi | 128063, 43 interactors |
IntActi | Q8WWP7, 47 interactors |
STRINGi | 9606.ENSP00000302833 |
Miscellaneous databases
RNActi | Q8WWP7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8WWP7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WWP7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 229 | AIG1-type GPROSITE-ProRule annotationAdd BLAST | 205 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 34 – 41 | G1PROSITE-ProRule annotation | 8 | |
Regioni | 61 – 65 | G2PROSITE-ProRule annotation | 5 | |
Regioni | 82 – 85 | G3PROSITE-ProRule annotation | 4 | |
Regioni | 152 – 155 | G4PROSITE-ProRule annotation | 4 | |
Regioni | 189 – 191 | G5PROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SN36, Eukaryota |
GeneTreei | ENSGT00940000161272 |
HOGENOMi | CLU_010468_1_2_1 |
InParanoidi | Q8WWP7 |
OMAi | HDYVSNT |
PhylomeDBi | Q8WWP7 |
TreeFami | TF330845 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR045058, GIMA/IAN/Toc IPR027417, P-loop_NTPase |
PANTHERi | PTHR10903, PTHR10903, 1 hit |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WWP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ
60 70 80 90 100
RRFFSRLGAT SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE
110 120 130 140 150
RGHCYLLSAP GPHALLLVTQ LGRFTAQDQQ AVRQVRDMFG EDVLKWMVIV
160 170 180 190 200
FTRKEDLAGG SLHDYVSNTE NRALRELVAE CGGRVCAFDN RATGREQEAQ
210 220 230 240 250
VEQLLGMVEG LVLEHKGAHY SNEVYELAQV LRWAGPEERL RRVAERVAAR
260 270 280 290 300
VQRRPWGAWL SARLWKWLKS PRSWRLGLAL LLGGALLFWV LLHRRWSEAV
AEVGPD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 235 | G → V in BAC03754 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036301 | 166 | V → E in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_049530 | 254 | R → S. Corresponds to variant dbSNP:rs7811263Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306287 mRNA Translation: CAC83740.1 AK091818 mRNA Translation: BAC03754.1 AK315127 mRNA Translation: BAG37580.1 CH471173 Genomic DNA Translation: EAW54095.1 BC040736 mRNA Translation: AAH40736.1 |
CCDSi | CCDS5906.1 |
RefSeqi | NP_570115.1, NM_130759.3 |
Genome annotation databases
Ensembli | ENST00000307194; ENSP00000302833; ENSG00000213203 |
GeneIDi | 170575 |
KEGGi | hsa:170575 |
MANE-Selecti | ENST00000307194.6; ENSP00000302833.5; NM_130759.4; NP_570115.1 |
UCSCi | uc003whq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306287 mRNA Translation: CAC83740.1 AK091818 mRNA Translation: BAC03754.1 AK315127 mRNA Translation: BAG37580.1 CH471173 Genomic DNA Translation: EAW54095.1 BC040736 mRNA Translation: AAH40736.1 |
CCDSi | CCDS5906.1 |
RefSeqi | NP_570115.1, NM_130759.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3V70 | X-ray | 2.21 | A/B | 25-253 | [»] | |
SMRi | Q8WWP7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128063, 43 interactors |
IntActi | Q8WWP7, 47 interactors |
STRINGi | 9606.ENSP00000302833 |
PTM databases
iPTMneti | Q8WWP7 |
MetOSitei | Q8WWP7 |
PhosphoSitePlusi | Q8WWP7 |
Genetic variation databases
BioMutai | GIMAP1 |
DMDMi | 38372377 |
Proteomic databases
EPDi | Q8WWP7 |
jPOSTi | Q8WWP7 |
MassIVEi | Q8WWP7 |
PaxDbi | Q8WWP7 |
PeptideAtlasi | Q8WWP7 |
PRIDEi | Q8WWP7 |
ProteomicsDBi | 74918 |
Protocols and materials databases
Antibodypediai | 32894, 57 antibodies from 14 providers |
DNASUi | 170575 |
Genome annotation databases
Ensembli | ENST00000307194; ENSP00000302833; ENSG00000213203 |
GeneIDi | 170575 |
KEGGi | hsa:170575 |
MANE-Selecti | ENST00000307194.6; ENSP00000302833.5; NM_130759.4; NP_570115.1 |
UCSCi | uc003whq.4, human |
Organism-specific databases
CTDi | 170575 |
DisGeNETi | 170575 |
GeneCardsi | GIMAP1 |
HGNCi | HGNC:23237, GIMAP1 |
HPAi | ENSG00000213203, Tissue enhanced (lymphoid) |
MIMi | 608084, gene |
neXtProti | NX_Q8WWP7 |
OpenTargetsi | ENSG00000213203 |
PharmGKBi | PA134978698 |
VEuPathDBi | HostDB:ENSG00000213203 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SN36, Eukaryota |
GeneTreei | ENSGT00940000161272 |
HOGENOMi | CLU_010468_1_2_1 |
InParanoidi | Q8WWP7 |
OMAi | HDYVSNT |
PhylomeDBi | Q8WWP7 |
TreeFami | TF330845 |
Enzyme and pathway databases
PathwayCommonsi | Q8WWP7 |
SignaLinki | Q8WWP7 |
Miscellaneous databases
BioGRID-ORCSi | 170575, 4 hits in 1035 CRISPR screens |
EvolutionaryTracei | Q8WWP7 |
GenomeRNAii | 170575 |
Pharosi | Q8WWP7, Tbio |
PROi | PR:Q8WWP7 |
RNActi | Q8WWP7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213203, Expressed in blood and 209 other tissues |
ExpressionAtlasi | Q8WWP7, baseline and differential |
Genevisiblei | Q8WWP7, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR045058, GIMA/IAN/Toc IPR027417, P-loop_NTPase |
PANTHERi | PTHR10903, PTHR10903, 1 hit |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GIMA1_HUMAN | |
Accessioni | Q8WWP7Primary (citable) accession number: Q8WWP7 Secondary accession number(s): B2RCI3, Q8NAZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families