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Entry version 137 (11 Dec 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Interactor protein for cytohesin exchange factors 1

Gene

IPCEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.By similarity

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Alternative name(s):
Phosphoinositide-binding protein PIP3-E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IPCEF1
Synonyms:KIAA0403
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000074706.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21204 IPCEF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWN9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26034

Open Targets

More...
OpenTargetsi
ENSG00000074706

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164721033

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WWN9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IPCEF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751582

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003266301 – 437Interactor protein for cytohesin exchange factors 1Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WWN9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WWN9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WWN9

PeptideAtlas

More...
PeptideAtlasi
Q8WWN9

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWN9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32242
74916 [Q8WWN9-1]
74917 [Q8WWN9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WWN9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074706 Expressed in 164 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWN9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WWN9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028708
HPA028710

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4 (By similarity).

Interacts (via C-terminus) with cytohesin-2 CYTH2 (PubMed:22085542).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117500, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WWN9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000394751

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WWN9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WWN9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 140PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni315 – 320CRAC domain6
Regioni339 – 348CRAC domain10
Regioni389 – 437Required for interaction with CYTH21 PublicationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi184 – 283Ser-richAdd BLAST100

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP6N Eukaryota
ENOG41121GN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154428

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082484

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WWN9

KEGG Orthology (KO)

More...
KOi
K23795

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHESTTK

Database of Orthologous Groups

More...
OrthoDBi
1121556at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWN9

TreeFam database of animal gene trees

More...
TreeFami
TF326495

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform IPCEF1-1 (identifier: Q8WWN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSYMAIDGS ALVPLRQKPR RKTQGFLTMS RRRISCKDLG HADCQGWLYK
60 70 80 90 100
KKEKGSFLSN KWKKFWVILK GSSLYWYSNQ MAEKADGFVN LPDFTVERAS
110 120 130 140 150
ECKKKHAFKI SHPQIKTFYF AAENVQEMNV WLNKLGSAVI HQESTTKDEE
160 170 180 190 200
CYSESEQEDP EIAAETPPPP HASQTQSLTA QQASSSSPSL SGTSYSFSSL
210 220 230 240 250
ENTVKTPSSF PSSLSKERQS LPDTVNSLSA AEDEGQPITF AVQVHSPVPS
260 270 280 290 300
EAGIHKALEN SFVTSESGFL NSLSSDDTSS LSSNHDHLTV PDKPAGSKIM
310 320 330 340 350
DKEETKVSED DEMEKLYKSL EQASLSPLGD RRPSTKKELR KSFVKRCKNP
360 370 380 390 400
SINEKLHKIR TLNSTLKCKE HDLAMINQLL DDPKLTARKY REWKVMNTLL
410 420 430
IQDIYQQQRA SPAPDDTDDT PQELKKSPSS PSVENSI
Length:437
Mass (Da):48,993
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60BC1790FBBD377C
GO
Isoform IPCEF1-2 (identifier: Q8WWN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LQ

Show »
Length:438
Mass (Da):49,121
Checksum:iC5AE0271EAF29540
GO
Isoform CNK3-IPCEF1-1 (identifier: G9CGD6-1) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Long-1
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:899
Mass (Da):100,365
GO
Isoform CNK3-IPCEF1-2 (identifier: G9CGD6-2) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Long-2
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:900
Mass (Da):100,493
GO
Isoform CNK3-IPCEF1-3 (identifier: G9CGD6-3) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Short
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:830
Mass (Da):92,057
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJQ7E5RJQ7_HUMAN
Interactor protein for cytohesin ex...
IPCEF1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Q2T6B6A0A2Q2T6B6_HUMAN
Interactor protein for cytohesin ex...
IPCEF1
409Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGB6E5RGB6_HUMAN
Interactor protein for cytohesin ex...
IPCEF1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGN6E5RGN6_HUMAN
Interactor protein for cytohesin ex...
IPCEF1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK08E5RK08_HUMAN
Interactor protein for cytohesin ex...
IPCEF1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti267S → G in CAI46054 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042410194S → P. Corresponds to variant dbSNP:rs1060390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03268212L → LQ in isoform IPCEF1-2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ310566 mRNA Translation: CAC83949.1
AK289917 mRNA Translation: BAF82606.1
BX647254 mRNA Translation: CAI46054.1
AL445220 Genomic DNA No translation available.
AL033376 Genomic DNA No translation available.
AL132774 Genomic DNA No translation available.
KF510943 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47701.1
CH471051 Genomic DNA Translation: EAW47702.1
BC105015 mRNA Translation: AAI05016.1
BC105043 mRNA Translation: AAI05044.1
BC143623 mRNA Translation: AAI43624.1
BC143629 mRNA Translation: AAI43630.1
AB007863 mRNA Translation: BAA23699.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47509.1 [Q8WWN9-2]
CCDS5245.1 [Q8WWN9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001124171.1, NM_001130699.1 [Q8WWN9-2]
NP_001124172.1, NM_001130700.1 [Q8WWN9-2]
NP_056368.1, NM_015553.2 [Q8WWN9-1]
XP_005266976.1, XM_005266919.4
XP_005266978.1, XM_005266921.4
XP_005266980.1, XM_005266923.3
XP_011534044.1, XM_011535742.2
XP_016866206.1, XM_017010717.1
XP_016866207.1, XM_017010718.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265198; ENSP00000265198; ENSG00000074706 [Q8WWN9-1]
ENST00000367220; ENSP00000356189; ENSG00000074706 [Q8WWN9-2]
ENST00000422970; ENSP00000394751; ENSG00000074706 [Q8WWN9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26034

UCSC genome browser

More...
UCSCi
uc003qpw.4 human [Q8WWN9-1]
uc063skh.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310566 mRNA Translation: CAC83949.1
AK289917 mRNA Translation: BAF82606.1
BX647254 mRNA Translation: CAI46054.1
AL445220 Genomic DNA No translation available.
AL033376 Genomic DNA No translation available.
AL132774 Genomic DNA No translation available.
KF510943 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47701.1
CH471051 Genomic DNA Translation: EAW47702.1
BC105015 mRNA Translation: AAI05016.1
BC105043 mRNA Translation: AAI05044.1
BC143623 mRNA Translation: AAI43624.1
BC143629 mRNA Translation: AAI43630.1
AB007863 mRNA Translation: BAA23699.1
CCDSiCCDS47509.1 [Q8WWN9-2]
CCDS5245.1 [Q8WWN9-1]
RefSeqiNP_001124171.1, NM_001130699.1 [Q8WWN9-2]
NP_001124172.1, NM_001130700.1 [Q8WWN9-2]
NP_056368.1, NM_015553.2 [Q8WWN9-1]
XP_005266976.1, XM_005266919.4
XP_005266978.1, XM_005266921.4
XP_005266980.1, XM_005266923.3
XP_011534044.1, XM_011535742.2
XP_016866206.1, XM_017010717.1
XP_016866207.1, XM_017010718.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MR1X-ray1.20A42-142[»]
SMRiQ8WWN9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117500, 7 interactors
IntActiQ8WWN9, 7 interactors
STRINGi9606.ENSP00000394751

PTM databases

iPTMnetiQ8WWN9
PhosphoSitePlusiQ8WWN9

Polymorphism and mutation databases

BioMutaiIPCEF1
DMDMi74751582

Proteomic databases

jPOSTiQ8WWN9
MassIVEiQ8WWN9
PaxDbiQ8WWN9
PeptideAtlasiQ8WWN9
PRIDEiQ8WWN9
ProteomicsDBi32242
74916 [Q8WWN9-1]
74917 [Q8WWN9-2]

Genome annotation databases

EnsembliENST00000265198; ENSP00000265198; ENSG00000074706 [Q8WWN9-1]
ENST00000367220; ENSP00000356189; ENSG00000074706 [Q8WWN9-2]
ENST00000422970; ENSP00000394751; ENSG00000074706 [Q8WWN9-2]
GeneIDi26034
KEGGihsa:26034
UCSCiuc003qpw.4 human [Q8WWN9-1]
uc063skh.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26034
DisGeNETi26034
EuPathDBiHostDB:ENSG00000074706.13

GeneCards: human genes, protein and diseases

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GeneCardsi
IPCEF1
HGNCiHGNC:21204 IPCEF1
HPAiHPA028708
HPA028710
neXtProtiNX_Q8WWN9
OpenTargetsiENSG00000074706
PharmGKBiPA164721033

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IP6N Eukaryota
ENOG41121GN LUCA
GeneTreeiENSGT00940000154428
HOGENOMiHOG000082484
InParanoidiQ8WWN9
KOiK23795
OMAiHHESTTK
OrthoDBi1121556at2759
PhylomeDBiQ8WWN9
TreeFamiTF326495

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IPCEF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26034
PharosiQ8WWN9 Tbio

Protein Ontology

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PROi
PR:Q8WWN9
RNActiQ8WWN9 protein

Gene expression databases

BgeeiENSG00000074706 Expressed in 164 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ8WWN9 baseline and differential
GenevisibleiQ8WWN9 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICEF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWN9
Secondary accession number(s): A8K1K2
, B7ZL78, B7ZL80, G3V132, O43153, Q5HYL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2002
Last modified: December 11, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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