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Entry version 155 (31 Jul 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Gene

ARAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri504 – 527C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Centaurin-delta-3
Short name:
Cnt-d3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARAP3
Synonyms:CENTD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24097 ARAP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606647 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi307 – 308RR → AA: Loss of PtdIns(3,4,5)P3 binding. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
64411

Open Targets

More...
OpenTargetsi
ENSG00000120318

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164715983

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73619965

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000742151 – 1544Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3Add BLAST1544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1348PhosphothreonineBy similarity1
Modified residuei1403PhosphotyrosineBy similarity1
Modified residuei1408PhosphotyrosineBy similarity1
Modified residuei1444PhosphoserineCombined sources1
Modified residuei1480PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WWN8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WWN8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WWN8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WWN8

PeptideAtlas

More...
PeptideAtlasi
Q8WWN8

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWN8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
4328
74915 [Q8WWN8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WWN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120318 Expressed in 187 organ(s), highest expression level in apex of heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWN8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WWN8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042887

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SAM domain) with INPPL1/SHIP2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SH3KBP1Q96B972EBI-4402732,EBI-346595

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122163, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WWN8, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8WWN8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000239440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11544
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WWN8

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WWN8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 68SAMPROSITE-ProRule annotationAdd BLAST65
Domaini287 – 379PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini394 – 483PH 2PROSITE-ProRule annotationAdd BLAST90
Domaini480 – 611Arf-GAPPROSITE-ProRule annotationAdd BLAST132
Domaini907 – 1088Rho-GAPPROSITE-ProRule annotationAdd BLAST182
Domaini1117 – 1210Ras-associatingPROSITE-ProRule annotationAdd BLAST94
Domaini1223 – 1325PH 3PROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi81 – 139Pro-richAdd BLAST59
Compositional biasi1462 – 1542Pro-richAdd BLAST81

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri504 – 527C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1117 Eukaryota
COG5347 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246988

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WWN8

KEGG Orthology (KO)

More...
KOi
K12490

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRIFVFR

Database of Orthologous Groups

More...
OrthoDBi
98944at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWN8

TreeFam database of animal gene trees

More...
TreeFami
TF105769

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04385 RhoGAP_ARAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 3 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 2 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF54236 SSF54236, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 3 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPQDLDIA VWLATVHLEQ YADTFRRHGL ATAGAARGLG HEELKQLGIS
60 70 80 90 100
ATGHRKRILR LLQTGTEEGS LDPKSDSAME PSPSPAPQAQ PPKPVPKPRT
110 120 130 140 150
VFGGLSGPAT TQRPGLSPAL GGPGVSRSPE PSPRPPPLPT SSSEQSSALN
160 170 180 190 200
TVEMMPNSIY FGLDSRGRAQ AAQDKAPDSS QISAPTPALR PTTGTVHIMD
210 220 230 240 250
PGCLYYGVQP VGTPGAPDRR ESRGVCQGRA EHRLSRQDLE AREDAGYASL
260 270 280 290 300
ELPGDSTLLS PTLETEETSD DLISPYASFS FTADRLTPLL SGWLDKLSPQ
310 320 330 340 350
GNYVFQRRFV QFNGRSLMYF GSDKDPFPKG VIPLTAIEMT RSSKDNKFQV
360 370 380 390 400
ITGQRVFVFR TESEAQRDMW CSTLQSCLKE QRLLGHPRPP QPPRPLRTGM
410 420 430 440 450
LELRGHKAKV FAALSPGELA LYKSEQAFSL GIGICFIELQ GCSVRETKSR
460 470 480 490 500
SFDLLTPHRC FSFTAESGGA RQSWAAALQE AVTETLSDYE VAEKIWSNRA
510 520 530 540 550
NRQCADCGSS RPDWAAVNLG VVICKQCAGQ HRALGSGISK VQSLKLDTSV
560 570 580 590 600
WSNEIVQLFI VLGNDRANRF WAGTLPPGEG LHPDATPGPR GEFISRKYRL
610 620 630 640 650
GLFRKPHPQY PDHSQLLQAL CAAVARPNLL KNMTQLLCVE AFEGEEPWFP
660 670 680 690 700
PAPDGSCPGL LPSDPSPGVY NEVVVRATYS GFLYCSPVSN KAGPSPPRRG
710 720 730 740 750
RDAPPRLWCV LGAALEMFAS ENSPEPLSLI QPQDIVCLGV SPPPTDPGDR
760 770 780 790 800
FPFSFELILA GGRIQHFGTD GADSLEAWTS AVGKWFSPLS CHQLLGPGLL
810 820 830 840 850
RLGRLWLRSP SHTAPAPGLW LSGFGLLRGD HLFLCSAPGP GPPAPEDMVH
860 870 880 890 900
LRRLQEISVV SAADTPDKKE HLVLVETGRT LYLQGEGRLD FTAWNAAIGG
910 920 930 940 950
AAGGGGTGLQ EQQMSRGDIP IIVDACISFV TQHGLRLEGV YRKGGARARS
960 970 980 990 1000
LRLLAEFRRD ARSVKLRPGE HFVEDVTDTL KRFFRELDDP VTSARLLPRW
1010 1020 1030 1040 1050
REAAELPQKN QRLEKYKDVI GCLPRVNRRT LATLIGHLYR VQKCAALNQM
1060 1070 1080 1090 1100
CTRNLALLFA PSVFQTDGRG EHEVRVLQEL IDGYISVFDI DSDQVAQIDL
1110 1120 1130 1140 1150
EVSLITTWKD VQLSQAGDLI MEVYIEQQLP DNCVTLKVSP TLTAEELTNQ
1160 1170 1180 1190 1200
VLEMRGTAAG MDLWVTFEIR EHGELERPLH PKEKVLEQAL QWCQLPEPCS
1210 1220 1230 1240 1250
ASLLLKKVPL AQAGCLFTGI RRESPRVGLL RCREEPPRLL GSRFQERFFL
1260 1270 1280 1290 1300
LRGRCLLLLK EKKSSKPERE WPLEGAKVYL GIRKKLKPPT PWGFTLILEK
1310 1320 1330 1340 1350
MHLYLSCTDE DEMWDWTTSI LKAQHDDQQP VVLRRHSSSD LARQKFGTMP
1360 1370 1380 1390 1400
LLPIRGDDSG ATLLSANQTL RRLHNRRTLS MFFPMKSSQG SVEEQEELEE
1410 1420 1430 1440 1450
PVYEEPVYEE VGAFPELIQD TSTSFSTTRE WTVKPENPLT SQKSLDQPFL
1460 1470 1480 1490 1500
SKSSTLGQEE RPPEPPPGPP SKSSPQARGS LEEQLLQELS SLILRKGETT
1510 1520 1530 1540
AGLGSPSQPS SPQSPSPTGL PTQTPGFPTQ PPCTSSPPSS QPLT
Length:1,544
Mass (Da):169,844
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40C03A22591B2B6F
GO
Isoform 2 (identifier: Q8WWN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-338: Missing.
     1371-1383: Missing.

Note: No experimental confirmation available.
Show »
Length:1,193
Mass (Da):131,986
Checksum:i8E101A95C1FB7D24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9Y3G5E9Y3_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP3 CENTD3, hCG_1980706
1,375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q05CH1Q05CH1_HUMAN
ARAP3 protein
ARAP3
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048330218D → H. Corresponds to variant dbSNP:rs1031904Ensembl.1
Natural variantiVAR_036180471R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0361811085I → M in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0361821428T → P in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs61749636Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0562141 – 338Missing in isoform 2. 1 PublicationAdd BLAST338
Alternative sequenceiVSP_0562151371 – 1383Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ310567 mRNA Translation: CAC83946.1
AK295768 mRNA Translation: BAG58593.1
AC022420 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61904.1
CH471062 Genomic DNA Translation: EAW61905.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4266.1 [Q8WWN8-1]

Protein sequence database of the Protein Information Resource

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PIRi
E59431

NCBI Reference Sequences

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RefSeqi
NP_071926.4, NM_022481.5 [Q8WWN8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000239440; ENSP00000239440; ENSG00000120318 [Q8WWN8-1]
ENST00000513878; ENSP00000421468; ENSG00000120318 [Q8WWN8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64411

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64411

UCSC genome browser

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UCSCi
uc003llm.4 human [Q8WWN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310567 mRNA Translation: CAC83946.1
AK295768 mRNA Translation: BAG58593.1
AC022420 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61904.1
CH471062 Genomic DNA Translation: EAW61905.1
CCDSiCCDS4266.1 [Q8WWN8-1]
PIRiE59431
RefSeqiNP_071926.4, NM_022481.5 [Q8WWN8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KG5NMR-A1-80[»]
2LNWNMR-B1404-1412[»]
5JCPX-ray2.10A/B906-1107[»]
5JD0X-ray2.30A/B906-1107[»]
SMRiQ8WWN8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122163, 17 interactors
IntActiQ8WWN8, 4 interactors
MINTiQ8WWN8
STRINGi9606.ENSP00000239440

PTM databases

iPTMnetiQ8WWN8
PhosphoSitePlusiQ8WWN8

Polymorphism and mutation databases

BioMutaiARAP3
DMDMi73619965

Proteomic databases

EPDiQ8WWN8
jPOSTiQ8WWN8
MaxQBiQ8WWN8
PaxDbiQ8WWN8
PeptideAtlasiQ8WWN8
PRIDEiQ8WWN8
ProteomicsDBi4328
74915 [Q8WWN8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239440; ENSP00000239440; ENSG00000120318 [Q8WWN8-1]
ENST00000513878; ENSP00000421468; ENSG00000120318 [Q8WWN8-2]
GeneIDi64411
KEGGihsa:64411
UCSCiuc003llm.4 human [Q8WWN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64411
DisGeNETi64411

GeneCards: human genes, protein and diseases

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GeneCardsi
ARAP3
HGNCiHGNC:24097 ARAP3
HPAiHPA042887
MIMi606647 gene
neXtProtiNX_Q8WWN8
OpenTargetsiENSG00000120318
PharmGKBiPA164715983

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00940000158869
HOGENOMiHOG000246988
InParanoidiQ8WWN8
KOiK12490
OMAiHRIFVFR
OrthoDBi98944at2759
PhylomeDBiQ8WWN8
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARAP3 human
EvolutionaryTraceiQ8WWN8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CENTD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64411

Protein Ontology

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PROi
PR:Q8WWN8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120318 Expressed in 187 organ(s), highest expression level in apex of heart
ExpressionAtlasiQ8WWN8 baseline and differential
GenevisibleiQ8WWN8 HS

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 3 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 2 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF54236 SSF54236, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 3 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWN8
Secondary accession number(s): B4DIT1, D3DQE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: July 31, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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