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Protein

Cytoglobin

Gene

CYGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi113Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • catalase activity Source: Ensembl
  • fatty acid peroxidase activity Source: Ensembl
  • heme binding Source: Ensembl
  • iron ion binding Source: InterPro
  • nitric oxide dioxygenase activity Source: Reactome
  • oxygen binding Source: InterPro
  • oxygen carrier activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-203615 eNOS activation
R-HSA-8981607 Intracellular oxygen transport

Protein family/group databases

TCDBi1.A.107.1.5 the pore-forming globin (globin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Stellate cell activation-associated protein
Gene namesi
Name:CYGB
Synonyms:STAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161544.9
HGNCiHGNC:16505 CYGB
MIMi608759 gene
neXtProtiNX_Q8WWM9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi114757
OpenTargetsiENSG00000161544
PharmGKBiPA27080

Polymorphism and mutation databases

BioMutaiCYGB
DMDMi21263504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000533841 – 190CytoglobinAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38Interchain (with C-83)1 Publication
Disulfide bondi83Interchain (with C-38)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8WWM9
PaxDbiQ8WWM9
PeptideAtlasiQ8WWM9
PRIDEiQ8WWM9
ProteomicsDBi74913

PTM databases

iPTMnetiQ8WWM9
PhosphoSitePlusiQ8WWM9

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000161544 Expressed in 172 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_CYGB
ExpressionAtlasiQ8WWM9 baseline and differential
GenevisibleiQ8WWM9 HS

Organism-specific databases

HPAiHPA017757
HPA061642

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDI1Q8WTU05EBI-6309037,EBI-748248

Protein-protein interaction databases

BioGridi125335, 4 interactors
IntActiQ8WWM9, 5 interactors
STRINGi9606.ENSP00000293230

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WWM9
SMRiQ8WWM9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWM9

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 167GlobinAdd BLAST151

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000112127
HOVERGENiHBG100250
InParanoidiQ8WWM9
KOiK21894
OMAiTHVTAAY
PhylomeDBiQ8WWM9
TreeFamiTF332967

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR013314 Globin_lamprey/hagfish
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR01906 FISHGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8WWM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PVYFKILSGV ILEVVAEEFA SDFPPETQRA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNATT PPATLPSSGP
Length:190
Mass (Da):21,405
Last modified:March 1, 2002 - v1
Checksum:iB5D7F9976D0BA118
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMC7K7EMC7_HUMAN
Cytoglobin
CYGB
226Annotation score:
K7EIM9K7EIM9_HUMAN
Cytoglobin
CYGB
125Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37N → S in AAH29798 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315162 mRNA Translation: CAC86186.1
AB057769 mRNA Translation: BAB87840.1
AK098057 mRNA Translation: BAC05223.1
CH471099 Genomic DNA Translation: EAW89406.1
BC029798 mRNA Translation: AAH29798.1
CCDSiCCDS11746.1
RefSeqiNP_599030.1, NM_134268.4
UniGeneiHs.95120

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544
GeneIDi114757
KEGGihsa:114757
UCSCiuc002jru.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315162 mRNA Translation: CAC86186.1
AB057769 mRNA Translation: BAB87840.1
AK098057 mRNA Translation: BAC05223.1
CH471099 Genomic DNA Translation: EAW89406.1
BC029798 mRNA Translation: AAH29798.1
CCDSiCCDS11746.1
RefSeqiNP_599030.1, NM_134268.4
UniGeneiHs.95120

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortaliQ8WWM9
SMRiQ8WWM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125335, 4 interactors
IntActiQ8WWM9, 5 interactors
STRINGi9606.ENSP00000293230

Protein family/group databases

TCDBi1.A.107.1.5 the pore-forming globin (globin) family

PTM databases

iPTMnetiQ8WWM9
PhosphoSitePlusiQ8WWM9

Polymorphism and mutation databases

BioMutaiCYGB
DMDMi21263504

Proteomic databases

MaxQBiQ8WWM9
PaxDbiQ8WWM9
PeptideAtlasiQ8WWM9
PRIDEiQ8WWM9
ProteomicsDBi74913

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544
GeneIDi114757
KEGGihsa:114757
UCSCiuc002jru.3 human

Organism-specific databases

CTDi114757
DisGeNETi114757
EuPathDBiHostDB:ENSG00000161544.9
GeneCardsiCYGB
HGNCiHGNC:16505 CYGB
HPAiHPA017757
HPA061642
MIMi608759 gene
neXtProtiNX_Q8WWM9
OpenTargetsiENSG00000161544
PharmGKBiPA27080
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000112127
HOVERGENiHBG100250
InParanoidiQ8WWM9
KOiK21894
OMAiTHVTAAY
PhylomeDBiQ8WWM9
TreeFamiTF332967

Enzyme and pathway databases

ReactomeiR-HSA-203615 eNOS activation
R-HSA-8981607 Intracellular oxygen transport

Miscellaneous databases

EvolutionaryTraceiQ8WWM9
GeneWikiiCytoglobin
GenomeRNAii114757
PROiPR:Q8WWM9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161544 Expressed in 172 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_CYGB
ExpressionAtlasiQ8WWM9 baseline and differential
GenevisibleiQ8WWM9 HS

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR013314 Globin_lamprey/hagfish
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR01906 FISHGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYGB_HUMAN
AccessioniPrimary (citable) accession number: Q8WWM9
Secondary accession number(s): Q541Y7, Q8N2X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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