UniProtKB - Q8WWM9 (CYGB_HUMAN)
Protein
Cytoglobin
Gene
CYGB
Organism
Homo sapiens (Human)
Status
Functioni
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 81 | Iron (heme distal ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 113 | Iron (heme proximal ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB
- peroxidase activity Source: UniProtKB
GO - Biological processi
- oxygen transport Source: Reactome
- regulation of nitric-oxide synthase activity Source: Reactome
- response to oxidative stress Source: UniProtKB
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WWM9 |
Reactomei | R-HSA-203615, eNOS activation R-HSA-8981607, Intracellular oxygen transport |
Protein family/group databases
TCDBi | 1.A.107.1.5, the pore-forming globin (globin) family |
Names & Taxonomyi
Protein namesi | Recommended name: CytoglobinAlternative name(s): Histoglobin Short name: HGb Stellate cell activation-associated protein |
Gene namesi | Name:CYGB Synonyms:STAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16505, CYGB |
MIMi | 608759, gene |
neXtProti | NX_Q8WWM9 |
VEuPathDBi | HostDB:ENSG00000161544.9 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 114757 |
OpenTargetsi | ENSG00000161544 |
PharmGKBi | PA27080 |
Miscellaneous databases
Pharosi | Q8WWM9, Tbio |
Genetic variation databases
BioMutai | CYGB |
DMDMi | 21263504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053384 | 1 – 190 | CytoglobinAdd BLAST | 190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 | Interchain (with C-83)1 Publication | ||
Disulfide bondi | 83 | Interchain (with C-38)1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | Q8WWM9 |
MassIVEi | Q8WWM9 |
MaxQBi | Q8WWM9 |
PaxDbi | Q8WWM9 |
PeptideAtlasi | Q8WWM9 |
PRIDEi | Q8WWM9 |
ProteomicsDBi | 74913 |
PTM databases
iPTMneti | Q8WWM9 |
PhosphoSitePlusi | Q8WWM9 |
Expressioni
Tissue specificityi
Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.1 Publication
Gene expression databases
Bgeei | ENSG00000161544, Expressed in cardiac muscle of right atrium and 185 other tissues |
ExpressionAtlasi | Q8WWM9, baseline and differential |
Genevisiblei | Q8WWM9, HS |
Organism-specific databases
HPAi | ENSG00000161544, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
1 PublicationBinary interactionsi
Hide detailsQ8WWM9
Protein-protein interaction databases
BioGRIDi | 125335, 8 interactors |
IntActi | Q8WWM9, 10 interactors |
STRINGi | 9606.ENSP00000293230 |
Miscellaneous databases
RNActi | Q8WWM9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8WWM9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WWM9 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 167 | GlobinAdd BLAST | 151 |
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000155004 |
HOGENOMi | CLU_003827_10_1_1 |
InParanoidi | Q8WWM9 |
OMAi | YFSQFRH |
PhylomeDBi | Q8WWM9 |
TreeFami | TF332967 |
Family and domain databases
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR013314, Globin_lamprey/hagfish |
PANTHERi | PTHR46783, PTHR46783, 1 hit |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR01906, FISHGLOBIN |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8WWM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PVYFKILSGV ILEVVAEEFA SDFPPETQRA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNATT PPATLPSSGP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EMC7 | K7EMC7_HUMAN | Cytoglobin | CYGB | 226 | Annotation score: | ||
K7EIM9 | K7EIM9_HUMAN | Cytoglobin | CYGB | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | N → S in AAH29798 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ315162 mRNA Translation: CAC86186.1 AB057769 mRNA Translation: BAB87840.1 AK098057 mRNA Translation: BAC05223.1 CH471099 Genomic DNA Translation: EAW89406.1 BC029798 mRNA Translation: AAH29798.1 |
CCDSi | CCDS11746.1 |
RefSeqi | NP_599030.1, NM_134268.4 |
Genome annotation databases
Ensembli | ENST00000293230; ENSP00000293230; ENSG00000161544 |
GeneIDi | 114757 |
KEGGi | hsa:114757 |
UCSCi | uc002jru.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ315162 mRNA Translation: CAC86186.1 AB057769 mRNA Translation: BAB87840.1 AK098057 mRNA Translation: BAC05223.1 CH471099 Genomic DNA Translation: EAW89406.1 BC029798 mRNA Translation: AAH29798.1 |
CCDSi | CCDS11746.1 |
RefSeqi | NP_599030.1, NM_134268.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UMO | X-ray | 2.59 | A/B | 1-190 | [»] | |
1URV | X-ray | 2.00 | A/B | 1-190 | [»] | |
1URY | X-ray | 2.40 | A/B | 1-190 | [»] | |
1UT0 | X-ray | 2.10 | A/B | 1-190 | [»] | |
1UX9 | X-ray | 2.40 | A/B | 1-190 | [»] | |
1V5H | X-ray | 2.40 | A | 1-190 | [»] | |
2DC3 | X-ray | 1.68 | A/B | 1-190 | [»] | |
3AG0 | X-ray | 2.60 | A | 1-190 | [»] | |
4B3W | X-ray | 2.80 | A/B | 1-190 | [»] | |
SMRi | Q8WWM9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125335, 8 interactors |
IntActi | Q8WWM9, 10 interactors |
STRINGi | 9606.ENSP00000293230 |
Protein family/group databases
TCDBi | 1.A.107.1.5, the pore-forming globin (globin) family |
PTM databases
iPTMneti | Q8WWM9 |
PhosphoSitePlusi | Q8WWM9 |
Genetic variation databases
BioMutai | CYGB |
DMDMi | 21263504 |
Proteomic databases
jPOSTi | Q8WWM9 |
MassIVEi | Q8WWM9 |
MaxQBi | Q8WWM9 |
PaxDbi | Q8WWM9 |
PeptideAtlasi | Q8WWM9 |
PRIDEi | Q8WWM9 |
ProteomicsDBi | 74913 |
Protocols and materials databases
Antibodypediai | 2901, 307 antibodies |
Genome annotation databases
Ensembli | ENST00000293230; ENSP00000293230; ENSG00000161544 |
GeneIDi | 114757 |
KEGGi | hsa:114757 |
UCSCi | uc002jru.3, human |
Organism-specific databases
CTDi | 114757 |
DisGeNETi | 114757 |
GeneCardsi | CYGB |
HGNCi | HGNC:16505, CYGB |
HPAi | ENSG00000161544, Low tissue specificity |
MIMi | 608759, gene |
neXtProti | NX_Q8WWM9 |
OpenTargetsi | ENSG00000161544 |
PharmGKBi | PA27080 |
VEuPathDBi | HostDB:ENSG00000161544.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000155004 |
HOGENOMi | CLU_003827_10_1_1 |
InParanoidi | Q8WWM9 |
OMAi | YFSQFRH |
PhylomeDBi | Q8WWM9 |
TreeFami | TF332967 |
Enzyme and pathway databases
PathwayCommonsi | Q8WWM9 |
Reactomei | R-HSA-203615, eNOS activation R-HSA-8981607, Intracellular oxygen transport |
Miscellaneous databases
BioGRID-ORCSi | 114757, 6 hits in 984 CRISPR screens |
ChiTaRSi | CYGB, human |
EvolutionaryTracei | Q8WWM9 |
GeneWikii | Cytoglobin |
GenomeRNAii | 114757 |
Pharosi | Q8WWM9, Tbio |
PROi | PR:Q8WWM9 |
RNActi | Q8WWM9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161544, Expressed in cardiac muscle of right atrium and 185 other tissues |
ExpressionAtlasi | Q8WWM9, baseline and differential |
Genevisiblei | Q8WWM9, HS |
Family and domain databases
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR013314, Globin_lamprey/hagfish |
PANTHERi | PTHR46783, PTHR46783, 1 hit |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR01906, FISHGLOBIN |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYGB_HUMAN | |
Accessioni | Q8WWM9Primary (citable) accession number: Q8WWM9 Secondary accession number(s): Q541Y7, Q8N2X5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families