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Protein

G2/mitotic-specific cyclin-B3

Gene

CCNB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8WWL7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNB3
Synonyms:CYCB3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000147082.17

Human Gene Nomenclature Database

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HGNCi
HGNC:18709 CCNB3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300456 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8WWL7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60R → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-63 and A-68. 1
Mutagenesisi63F → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-60 and A-68. 1
Mutagenesisi68N → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-60 and A-63. 1

Organism-specific databases

DisGeNET

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DisGeNETi
85417

Open Targets

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OpenTargetsi
ENSG00000147082

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38653

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2094127

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CCNB3

Domain mapping of disease mutations (DMDM)

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DMDMi
209572596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000803731 – 1395G2/mitotic-specific cyclin-B3Add BLAST1395

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.Curated

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WWL7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WWL7

PeptideAtlas

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PeptideAtlasi
Q8WWL7

PRoteomics IDEntifications database

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PRIDEi
Q8WWL7

ProteomicsDB human proteome resource

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ProteomicsDBi
74902
74903 [Q8WWL7-2]
74904 [Q8WWL7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8WWL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8WWL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000147082 Expressed in 79 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_CCNB3

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WWL7 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA000496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK2 kinase.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124523, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2009 Cyclin B3-CDK2 complex

Protein interaction database and analysis system

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IntActi
Q8WWL7, 3 interactors

Molecular INTeraction database

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MINTi
Q8WWL7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000276014

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8WWL7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8WWL7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WWL7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi60 – 68D-box9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0653 Eukaryota
COG5024 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231355

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050835

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WWL7

KEGG Orthology (KO)

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KOi
K21771

Identification of Orthologs from Complete Genome Data

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OMAi
SHQVFFE

Database of Orthologous Groups

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OrthoDBi
EOG091G0L84

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWL7

TreeFam database of animal gene trees

More...
TreeFami
TF101001

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043 CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR015452 Cyclin_B3
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10177 PTHR10177, 1 hit
PTHR10177:SF214 PTHR10177:SF214, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WWL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPLPPQSS KPVPKKSQSS KIVPSHHDPS EKTGENCQTK ISPSSLQESP
60 70 80 90 100
SSLQGALKKR SAFEDLTNAS QCQPVQPKKE ANKEFVKVVS KKINRNTHAL
110 120 130 140 150
GLAKKNKRNL KWHKLEVTPV VASTTVVPNI MEKPLILDIS TTSKTPNTEE
160 170 180 190 200
ASLFRKPLVL KEEPTIEDET LINKSLSLKK CSNHEEVSLL EKLQPLQEES
210 220 230 240 250
DSDDAFVIEP MTFKKTHKTE EAAITKKTLS LKKKMCASQR KQSCQEESLA
260 270 280 290 300
VQDVNMEEDS FFMESMSFKK KPKTEESIPT HKLSSLKKKC TIYGKICHFR
310 320 330 340 350
KPPVLQTTIC GAMSSIKKPT TEKETLFQEL SVLQEKHTTE HEMSILKKSL
360 370 380 390 400
ALQKTNFKED SLVKESLAFK KKPSTEEAIM MPVILKEQCM TEGKRSRLKP
410 420 430 440 450
LVLQEITSGE KSLIMKPLSI KEKPSTEKES FSQEPSALQK KHTTQEEVSI
460 470 480 490 500
LKEPSSLLKS PTEESPFDEA LAFTKKCTIE EAPPTKKPLI LKRKHATQGT
510 520 530 540 550
MSHLKKPLIL QTTSGEKSLI KEPLPFKEEK VSLKKKCTTQ EMMSICPELL
560 570 580 590 600
DFQDMIGEDK NSFFMEPMSF RKNPTTEETV LTKTSLSLQE KKITQGKMSH
610 620 630 640 650
LKKPLVLQKI TSEEESFYKK LLPFKMKSTT EEKFLSQEPS ALKEKHTTLQ
660 670 680 690 700
EVSLSKESLA IQEKATTEEE FSQELFSLHV KHTNKSGSLF QEALVLQEKT
710 720 730 740 750
DAEEDSLKNL LALQEKSTME EESLINKLLA LKEELSAEAA TNIQTQLSLK
760 770 780 790 800
KKSTSHGKVF FLKKQLALNE TINEEEFLNK QPLALEGYPS IAEGETLFKK
810 820 830 840 850
LLAMQEEPSI EKEAVLKEPT IDTEAHFKEP LALQEEPSTE KEAVLKEPSV
860 870 880 890 900
DTEAHFKETL ALQEKPSIEQ EALFKRHSAL WEKPSTEKET IFKESLDLQE
910 920 930 940 950
KPSIKKETLL KKPLALKMST INEAVLFEDM IALNEKPTTG KELSFKEPLA
960 970 980 990 1000
LQESPTYKED TFLKTLLVPQ VGTSPNVSST APESITSKSS IATMTSVGKS
1010 1020 1030 1040 1050
GTINEAFLFE DMITLNEKPT TGKELSFKEP LALQESPTCK EDTFLETFLI
1060 1070 1080 1090 1100
PQIGTSPYVF STTPESITEK SSIATMTSVG KSRTTTESSA CESASDKPVS
1110 1120 1130 1140 1150
PQAKGTPKEI TPREDIDEDS SDPSFNPMYA KEIFSYMKER EEQFILTDYM
1160 1170 1180 1190 1200
NRQIEITSDM RAILVDWLVE VQVSFEMTHE TLYLAVKLVD LYLMKAVCKK
1210 1220 1230 1240 1250
DKLQLLGATA FMIAAKFEEH NSPRVDDFVY ICDDNYQRSE VLSMEINILN
1260 1270 1280 1290 1300
VLKCDINIPI AYHFLRRYAR CIHTNMKTLT LSRYICEMTL QEYHYVQEKA
1310 1320 1330 1340 1350
SKLAAASLLL ALYMKKLGYW VPFLEHYSGY SISELHPLVR QLNKLLTFSS
1360 1370 1380 1390
YDSLKAVYYK YSHPVFFEVA KIPALDMLKL EEILNCDCEA QGLVL
Length:1,395
Mass (Da):157,916
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i454552BC5A67E34E
GO
Isoform 2 (identifier: Q8WWL7-2) [UniParc]FASTAAdd to basket
Also known as: Variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     69-1172: Missing.

Show »
Length:291
Mass (Da):33,275
Checksum:iCC00FC3079181B7E
GO
Isoform 3 (identifier: Q8WWL7-3) [UniParc]FASTAAdd to basket
Also known as: Variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     112-1395: Missing.

Show »
Length:111
Mass (Da):12,195
Checksum:i0D8F2ACB1016D226
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295K → R in CAC40024 (PubMed:11846420).Curated1
Sequence conflicti331S → F in CAC94915 (PubMed:12185076).Curated1
Sequence conflicti396S → P in CAC40024 (PubMed:11846420).Curated1
Sequence conflicti493R → K in CAC40024 (PubMed:11846420).Curated1
Sequence conflicti573N → S in CAC40024 (PubMed:11846420).Curated1
Sequence conflicti597K → E in CAC40024 (PubMed:11846420).Curated1
Sequence conflicti774E → K in CAC94915 (PubMed:12185076).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036580597K → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0470271001G → R. Corresponds to variant dbSNP:rs6614336Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01051469 – 1172Missing in isoform 2. 1 PublicationAdd BLAST1104
Alternative sequenceiVSP_010515112 – 1395Missing in isoform 3. 1 PublicationAdd BLAST1284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ416458 mRNA Translation: CAC94915.1
AJ314764 mRNA Translation: CAC40024.1
AJ314765 mRNA Translation: CAC40025.1
AJ314766 mRNA Translation: CAC40026.1
AL591367 Genomic DNA No translation available.
BX323840 Genomic DNA No translation available.
CH471180 Genomic DNA Translation: EAW89922.1
CH471180 Genomic DNA Translation: EAW89923.1
AL137550 mRNA Translation: CAB70806.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14331.1 [Q8WWL7-1]
CCDS14332.1 [Q8WWL7-2]

Protein sequence database of the Protein Information Resource

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PIRi
T46391

NCBI Reference Sequences

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RefSeqi
NP_149020.2, NM_033031.2 [Q8WWL7-1]
NP_391990.1, NM_033670.2 [Q8WWL7-2]
XP_016885407.1, XM_017029918.1 [Q8WWL7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.130310
Hs.722420
Hs.722421
Hs.740165

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276014; ENSP00000276014; ENSG00000147082 [Q8WWL7-1]
ENST00000348603; ENSP00000338682; ENSG00000147082 [Q8WWL7-2]
ENST00000376038; ENSP00000365206; ENSG00000147082 [Q8WWL7-2]
ENST00000376042; ENSP00000365210; ENSG00000147082 [Q8WWL7-1]
ENST00000476167; ENSP00000431645; ENSG00000147082 [Q8WWL7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85417

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85417

UCSC genome browser

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UCSCi
uc004dox.5 human [Q8WWL7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ416458 mRNA Translation: CAC94915.1
AJ314764 mRNA Translation: CAC40024.1
AJ314765 mRNA Translation: CAC40025.1
AJ314766 mRNA Translation: CAC40026.1
AL591367 Genomic DNA No translation available.
BX323840 Genomic DNA No translation available.
CH471180 Genomic DNA Translation: EAW89922.1
CH471180 Genomic DNA Translation: EAW89923.1
AL137550 mRNA Translation: CAB70806.1
CCDSiCCDS14331.1 [Q8WWL7-1]
CCDS14332.1 [Q8WWL7-2]
PIRiT46391
RefSeqiNP_149020.2, NM_033031.2 [Q8WWL7-1]
NP_391990.1, NM_033670.2 [Q8WWL7-2]
XP_016885407.1, XM_017029918.1 [Q8WWL7-1]
UniGeneiHs.130310
Hs.722420
Hs.722421
Hs.740165

3D structure databases

ProteinModelPortaliQ8WWL7
SMRiQ8WWL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124523, 3 interactors
ComplexPortaliCPX-2009 Cyclin B3-CDK2 complex
IntActiQ8WWL7, 3 interactors
MINTiQ8WWL7
STRINGi9606.ENSP00000276014

Chemistry databases

BindingDBiQ8WWL7
ChEMBLiCHEMBL2094127

PTM databases

iPTMnetiQ8WWL7
PhosphoSitePlusiQ8WWL7

Polymorphism and mutation databases

BioMutaiCCNB3
DMDMi209572596

Proteomic databases

EPDiQ8WWL7
PaxDbiQ8WWL7
PeptideAtlasiQ8WWL7
PRIDEiQ8WWL7
ProteomicsDBi74902
74903 [Q8WWL7-2]
74904 [Q8WWL7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85417
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276014; ENSP00000276014; ENSG00000147082 [Q8WWL7-1]
ENST00000348603; ENSP00000338682; ENSG00000147082 [Q8WWL7-2]
ENST00000376038; ENSP00000365206; ENSG00000147082 [Q8WWL7-2]
ENST00000376042; ENSP00000365210; ENSG00000147082 [Q8WWL7-1]
ENST00000476167; ENSP00000431645; ENSG00000147082 [Q8WWL7-3]
GeneIDi85417
KEGGihsa:85417
UCSCiuc004dox.5 human [Q8WWL7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85417
DisGeNETi85417
EuPathDBiHostDB:ENSG00000147082.17

GeneCards: human genes, protein and diseases

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GeneCardsi
CCNB3
HGNCiHGNC:18709 CCNB3
HPAiHPA000496
MIMi300456 gene
neXtProtiNX_Q8WWL7
OpenTargetsiENSG00000147082
PharmGKBiPA38653

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00940000160459
HOGENOMiHOG000231355
HOVERGENiHBG050835
InParanoidiQ8WWL7
KOiK21771
OMAiSHQVFFE
OrthoDBiEOG091G0L84
PhylomeDBiQ8WWL7
TreeFamiTF101001

Enzyme and pathway databases

SignaLinkiQ8WWL7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCNB3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85417

Protein Ontology

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PROi
PR:Q8WWL7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147082 Expressed in 79 organ(s), highest expression level in secondary oocyte
CleanExiHS_CCNB3
GenevisibleiQ8WWL7 HS

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR015452 Cyclin_B3
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF214 PTHR10177:SF214, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWL7
Secondary accession number(s): B1AQI5
, B1AQI6, Q96SB5, Q96SB6, Q96SB7, Q9NT38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 14, 2008
Last modified: December 5, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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