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Protein

Choline transporter-like protein 1

Gene

SLC44A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Choline transporter. May be involved in membrane synthesis and myelin production.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • choline transmembrane transporter activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483191 Synthesis of PC
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-6798163 Choline catabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.92.1.6 the choline transporter-like (ctl) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Choline transporter-like protein 1
Alternative name(s):
CDw92
Solute carrier family 44 member 1
CD_antigen: CD92
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC44A1
Synonyms:CD92, CDW92, CTL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000070214.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18798 SLC44A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606105 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWI5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 30CytoplasmicSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 212Mitochondrial intermembraneSequence analysisAdd BLAST161
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 238CytoplasmicSequence analysis5
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 288Mitochondrial intermembraneSequence analysisAdd BLAST29
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 315CytoplasmicSequence analysis6
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 338Mitochondrial intermembraneSequence analysis2
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 380CytoplasmicSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 537Mitochondrial intermembraneSequence analysisAdd BLAST136
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 566CytoplasmicSequence analysis8
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21
Topological domaini588 – 653Mitochondrial intermembraneSequence analysisAdd BLAST66

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23446

Open Targets

More...
OpenTargetsi
ENSG00000070214

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134958011

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00122 Choline

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1204

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC44A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73918923

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917122 – 657Choline transporter-like protein 1Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei652PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WWI5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WWI5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WWI5

PeptideAtlas

More...
PeptideAtlasi
Q8WWI5

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWI5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74892
74893 [Q8WWI5-2]
74894 [Q8WWI5-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1110

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WWI5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWI5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WWI5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various cells of the hematopoietic system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000070214 Expressed in 232 organ(s), highest expression level in inferior vagus X ganglion

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC44A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWI5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WWI5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064714

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117012, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WWI5, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8WWI5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363852

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WWI5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi474 – 492Cys-richAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1362 Eukaryota
ENOG410XS0P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157174

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231655

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080361

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WWI5

KEGG Orthology (KO)

More...
KOi
K06515

Identification of Orthologs from Complete Genome Data

More...
OMAi
TYYFTRE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CMQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWI5

TreeFam database of animal gene trees

More...
TreeFami
TF313325

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007603 Choline_transptr-like

The PANTHER Classification System

More...
PANTHERi
PTHR12385 PTHR12385, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04515 Choline_transpo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WWI5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI
60 70 80 90 100
ATGAAARLVS GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL
110 120 130 140 150
DLINRKIKSV ALCVAACPRQ ELKTLSDVQK FAEINGSALC SYNLKPSEYT
160 170 180 190 200
TSPKSSVLCP KLPVPASAPI PFFHRCAPVN ISCYAKFAEA LITFVSDNSV
210 220 230 240 250
LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL VWILTILVIL
260 270 280 290 300
GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT
310 320 330 340 350
VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV
360 370 380 390 400
YWIMTLLFLG TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL
410 420 430 440 450
ACQQMTVAGA VVTYYFTRDK RNLPFTPILA SVNRLIRYHL GTVAKGSFII
460 470 480 490 500
TLVKIPRMIL MYIHSQLKGK ENACARCVLK SCICCLWCLE KCLNYLNQNA
510 520 530 540 550
YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML FLGKVLIVCS
560 570 580 590 600
TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC
610 620 630 640 650
FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM

ASGASSA
Length:657
Mass (Da):73,302
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10D70CAB8E33E3AC
GO
Isoform 2 (identifier: Q8WWI5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: ASGA → LKKR
     655-657: Missing.

Show »
Length:654
Mass (Da):73,296
Checksum:i625565695C5DA9F0
GO
Isoform 3 (identifier: Q8WWI5-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     651-652: AS → IK
     653-657: Missing.

Show »
Length:652
Mass (Da):73,012
Checksum:iD56E2C5DA9F0188A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79I → V in CAC82175 (PubMed:11698453).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048837644S → A1 PublicationCorresponds to variant dbSNP:rs3199966Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015424651 – 654ASGA → LKKR in isoform 2. Curated4
Alternative sequenceiVSP_015426651 – 652AS → IK in isoform 3. 1 Publication2
Alternative sequenceiVSP_015427653 – 657Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_015425655 – 657Missing in isoform 2. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ245620 Genomic DNA Translation: CAB75541.2
AJ272365 mRNA Translation: CAC82175.1
AJ420812 mRNA Translation: CAD12764.1
AL161627 Genomic DNA No translation available.
AL450265 Genomic DNA No translation available.
AL590368 Genomic DNA No translation available.
BC018213 mRNA Translation: AAH18213.1
BC049203 mRNA Translation: AAH49203.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6763.1 [Q8WWI5-1]
CCDS75868.1 [Q8WWI5-3]
CCDS83390.1 [Q8WWI5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273659.1, NM_001286730.1 [Q8WWI5-3]
NP_001317660.1, NM_001330731.1 [Q8WWI5-2]
NP_536856.2, NM_080546.4 [Q8WWI5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.573495

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374720; ENSP00000363852; ENSG00000070214 [Q8WWI5-1]
ENST00000374723; ENSP00000363855; ENSG00000070214 [Q8WWI5-3]
ENST00000374724; ENSP00000363856; ENSG00000070214 [Q8WWI5-2]
ENST00000470972; ENSP00000433072; ENSG00000070214 [Q8WWI5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23446

UCSC genome browser

More...
UCSCi
uc004bcn.5 human [Q8WWI5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245620 Genomic DNA Translation: CAB75541.2
AJ272365 mRNA Translation: CAC82175.1
AJ420812 mRNA Translation: CAD12764.1
AL161627 Genomic DNA No translation available.
AL450265 Genomic DNA No translation available.
AL590368 Genomic DNA No translation available.
BC018213 mRNA Translation: AAH18213.1
BC049203 mRNA Translation: AAH49203.1
CCDSiCCDS6763.1 [Q8WWI5-1]
CCDS75868.1 [Q8WWI5-3]
CCDS83390.1 [Q8WWI5-2]
RefSeqiNP_001273659.1, NM_001286730.1 [Q8WWI5-3]
NP_001317660.1, NM_001330731.1 [Q8WWI5-2]
NP_536856.2, NM_080546.4 [Q8WWI5-1]
UniGeneiHs.573495

3D structure databases

ProteinModelPortaliQ8WWI5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117012, 19 interactors
IntActiQ8WWI5, 4 interactors
MINTiQ8WWI5
STRINGi9606.ENSP00000363852

Chemistry databases

DrugBankiDB00122 Choline
GuidetoPHARMACOLOGYi1204

Protein family/group databases

TCDBi2.A.92.1.6 the choline transporter-like (ctl) family

PTM databases

GlyConnecti1110
iPTMnetiQ8WWI5
PhosphoSitePlusiQ8WWI5
SwissPalmiQ8WWI5

Polymorphism and mutation databases

BioMutaiSLC44A1
DMDMi73918923

Proteomic databases

EPDiQ8WWI5
MaxQBiQ8WWI5
PaxDbiQ8WWI5
PeptideAtlasiQ8WWI5
PRIDEiQ8WWI5
ProteomicsDBi74892
74893 [Q8WWI5-2]
74894 [Q8WWI5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374720; ENSP00000363852; ENSG00000070214 [Q8WWI5-1]
ENST00000374723; ENSP00000363855; ENSG00000070214 [Q8WWI5-3]
ENST00000374724; ENSP00000363856; ENSG00000070214 [Q8WWI5-2]
ENST00000470972; ENSP00000433072; ENSG00000070214 [Q8WWI5-1]
GeneIDi23446
KEGGihsa:23446
UCSCiuc004bcn.5 human [Q8WWI5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23446
DisGeNETi23446
EuPathDBiHostDB:ENSG00000070214.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC44A1
HGNCiHGNC:18798 SLC44A1
HPAiHPA064714
MIMi606105 gene
neXtProtiNX_Q8WWI5
OpenTargetsiENSG00000070214
PharmGKBiPA134958011

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1362 Eukaryota
ENOG410XS0P LUCA
GeneTreeiENSGT00940000157174
HOGENOMiHOG000231655
HOVERGENiHBG080361
InParanoidiQ8WWI5
KOiK06515
OMAiTYYFTRE
OrthoDBiEOG091G0CMQ
PhylomeDBiQ8WWI5
TreeFamiTF313325

Enzyme and pathway databases

ReactomeiR-HSA-1483191 Synthesis of PC
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-6798163 Choline catabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC44A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC44A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23446

Protein Ontology

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PROi
PR:Q8WWI5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000070214 Expressed in 232 organ(s), highest expression level in inferior vagus X ganglion
CleanExiHS_SLC44A1
ExpressionAtlasiQ8WWI5 baseline and differential
GenevisibleiQ8WWI5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007603 Choline_transptr-like
PANTHERiPTHR12385 PTHR12385, 1 hit
PfamiView protein in Pfam
PF04515 Choline_transpo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWI5
Secondary accession number(s): A6NLZ9
, Q5VUB3, Q8WVB0, Q96KU3, Q9NY69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: December 5, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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