Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 178 (22 Apr 2020)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

LIM domain only protein 7

Gene

LMO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM domain only protein 7
Short name:
LMO-7
Alternative name(s):
F-box only protein 20
LOMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LMO7
Synonyms:FBX20, FBXO20, KIAA0858
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6646 LMO7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604362 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWI1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4008

Open Targets

More...
OpenTargetsi
ENSG00000136153

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30412

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WWI1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LMO7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758241 – 1683LIM domain only protein 7Add BLAST1683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei185PhosphotyrosineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei704PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei867PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei913PhosphothreonineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei932PhosphothreonineCombined sources1
Modified residuei949PhosphothreonineCombined sources1
Modified residuei956PhosphothreonineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei991PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei995PhosphoserineCombined sources1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1048PhosphothreonineCombined sources1
Modified residuei1177PhosphoserineCombined sources1
Modified residuei1304PhosphoserineCombined sources1
Modified residuei1307PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1423PhosphoserineCombined sources1
Modified residuei1454PhosphoserineCombined sources1
Modified residuei1493PhosphoserineCombined sources1
Modified residuei1510PhosphoserineCombined sources1
Modified residuei1516PhosphoserineCombined sources1
Modified residuei1563PhosphoserineCombined sources1
Modified residuei1586PhosphoserineCombined sources1
Modified residuei1593PhosphoserineCombined sources1
Modified residuei1595PhosphoserineCombined sources1
Modified residuei1597PhosphoserineCombined sources1
Modified residuei1601PhosphoserineCombined sources1
Isoform 5 (identifier: Q8WWI1-5)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 3 (identifier: Q8WWI1-3)
Modified residuei342PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WWI1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WWI1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WWI1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WWI1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WWI1

PeptideAtlas

More...
PeptideAtlasi
Q8WWI1

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWI1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
21797
74888 [Q8WWI1-1]
74889 [Q8WWI1-2]
74890 [Q8WWI1-3]
74891 [Q8WWI1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WWI1

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q8WWI1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWI1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WWI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136153 Expressed in lower esophagus mucosa and 153 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWI1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WWI1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136153 Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110193, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WWI1

Database of interacting proteins

More...
DIPi
DIP-33107N

Protein interaction database and analysis system

More...
IntActi
Q8WWI1, 40 interactors

Molecular INTeraction database

More...
MINTi
Q8WWI1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000433352

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WWI1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11683
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WWI1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WWI1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 181Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST118
Domaini1042 – 1128PDZPROSITE-ProRule annotationAdd BLAST87
Domaini1612 – 1678LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1704 Eukaryota
ENOG410XP0W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183159

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WWI1

KEGG Orthology (KO)

More...
KOi
K06084

Database of Orthologous Groups

More...
OrthoDBi
38375at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWI1

TreeFam database of animal gene trees

More...
TreeFami
TF332155

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR46767 PTHR46767, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00888 SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL
60 70 80 90 100
RDRVCSKKDI ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL
110 120 130 140 150
INKLKPGVIK KINRLSTPIA GLDNINVFLK ACEQIGLKEA QLFHPGDLQD
160 170 180 190 200
LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA QSNPYYNGPH LNLKAFENLL
210 220 230 240 250
GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH HKREDSFESL
260 270 280 290 300
DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS
310 320 330 340 350
AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE
360 370 380 390 400
ADGTFSSNQR RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD
410 420 430 440 450
LYVRKLSPVM PNPGNAFDQF LPKCWTPEDV NWKRIKRETY KPWYKEFQGF
460 470 480 490 500
SQFLLLQALQ TYSDDILSSE THTKIDPTSG PRLITRRKNL SYAPGYRRDD
510 520 530 540 550
LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS EQDDSVERDI
560 570 580 590 600
ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT
610 620 630 640 650
LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL
660 670 680 690 700
GTTVPPISFT PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN
710 720 730 740 750
GSKSMSDVSA EDVQNLRQLR YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK
760 770 780 790 800
SYTSDLQKKK EEREEIEKQA LEKSKRSSKT FKEMLQDRES QNQKSTVPSR
810 820 830 840 850
RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS EIPKEDSTTF
860 870 880 890 900
AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY
910 920 930 940 950
RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP
960 970 980 990 1000
NNVVSTPAPS PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ
1010 1020 1030 1040 1050
AATSKATLSS TSGLDLMSES GEGEISPQRE VSRSQDQFSD MRISINQTPG
1060 1070 1080 1090 1100
KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS QLQVDDEIIA INNTKFSYND
1110 1120 1130 1140 1150
SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG IYNSEKSSNL
1160 1170 1180 1190 1200
SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF
1210 1220 1230 1240 1250
EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ
1260 1270 1280 1290 1300
REQEKLREEW QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE
1310 1320 1330 1340 1350
ATWSEGSKSS DREGTRAGEE ERRQPQEEVV HEDQGKKPQD QLVIERERKW
1360 1370 1380 1390 1400
EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ AEIERETSVR IYQYRRPVDS
1410 1420 1430 1440 1450
YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY LDQIGNMTSS
1460 1470 1480 1490 1500
QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS
1510 1520 1530 1540 1550
LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL
1560 1570 1580 1590 1600
VSTSNRAYMR NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG
1610 1620 1630 1640 1650
SQLRNRSVSG KRICSYCNNI LGKGAAMIIE SLGLCYHLHC FKCVACECDL
1660 1670 1680
GGSSSGAEVR IRNHQLYCND CYLRFKSGRP TAM
Length:1,683
Mass (Da):192,696
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E79B2AEAC67F6F5
GO
Isoform 2 (identifier: Q8WWI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL

Show »
Length:1,670
Mass (Da):190,876
Checksum:iFC84DAB0587D1AB6
GO
Isoform 3 (identifier: Q8WWI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-690: Missing.

Show »
Length:1,349
Mass (Da):153,670
Checksum:iE5A0EBC6A4894751
GO
Isoform 4 (identifier: Q8WWI1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

Show »
Length:1,614
Mass (Da):185,216
Checksum:iE0212DE11E059A39
GO
Isoform 5 (identifier: Q8WWI1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.
     1606-1670: RSVSGKRICS...IRNHQLYCND → SVLPVSVTSE...EEVVAAHVDL
     1671-1683: Missing.

Show »
Length:1,385
Mass (Da):158,265
Checksum:iBD1DCE8F29152AFC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WD26F8WD26_HUMAN
LIM domain only protein 7
LMO7
1,631Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMS6E9PMS6_HUMAN
LIM domain only protein 7
LMO7
1,275Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMT2E9PMT2_HUMAN
LIM domain only protein 7
LMO7
1,398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP06J3KP06_HUMAN
LIM domain only protein 7
LMO7
1,668Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTE2A0A0A0MTE2_HUMAN
LIM domain only protein 7
LMO7
1,385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMP7E9PMP7_HUMAN
LIM domain only protein 7
LMO7
1,045Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y424H0Y424_HUMAN
LIM domain only protein 7
LMO7
1,055Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDG6H0YDG6_HUMAN
LIM domain only protein 7
LMO7
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRE3E9PRE3_HUMAN
LIM domain only protein 7
LMO7
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRJ0E9PRJ0_HUMAN
LIM domain only protein 7
LMO7
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC96299 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAC96300 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAD33924 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti522V → A in AAF04521 (PubMed:10531035).Curated1
Sequence conflicti613F → L in AAF04521 (PubMed:10531035).Curated1
Sequence conflicti891R → C in AAD33924 (Ref. 6) Curated1
Sequence conflicti943V → I in AAL37480 (PubMed:11935316).Curated1
Sequence conflicti943V → I in AAD33924 (Ref. 6) Curated1
Sequence conflicti1447M → T in AAD33924 (Ref. 6) Curated1
Sequence conflicti1447M → T in AAB86592 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036189354T → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036190785L → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0561631547P → Q. Corresponds to variant dbSNP:rs7988661Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0556831 – 285Missing in isoform 5. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_009718357 – 690Missing in isoform 3. 2 PublicationsAdd BLAST334
Alternative sequenceiVSP_0097191606 – 1683RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_0097201606 – 1683RSVSG…RPTAM → SWTANRHVM in isoform 4. CuratedAdd BLAST78
Alternative sequenceiVSP_0556841606 – 1670RSVSG…LYCND → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 5. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0556851671 – 1683Missing in isoform 5. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF330045 mRNA Translation: AAL37480.1
AL137121 Genomic DNA No translation available.
AL137244 Genomic DNA No translation available.
AL137782 Genomic DNA No translation available.
AL359392 Genomic DNA No translation available.
AB020665 mRNA Translation: BAA74881.2
AF174600 mRNA Translation: AAF04521.1
AF144237 mRNA Translation: AAD33924.1 Sequence problems.
U90654 mRNA Translation: AAB86592.1
AF092557 AF092556 Genomic DNA Translation: AAC96299.1 Different initiation.
AF092557, AF092554 Genomic DNA Translation: AAC96300.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53876.1 [Q8WWI1-5]
CCDS9454.1 [Q8WWI1-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0325

NCBI Reference Sequences

More...
RefSeqi
NP_001293009.1, NM_001306080.1
NP_001317512.1, NM_001330583.1
NP_005349.3, NM_005358.5 [Q8WWI1-3]
NP_056667.2, NM_015842.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341547; ENSP00000342112; ENSG00000136153 [Q8WWI1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4008

UCSC genome browser

More...
UCSCi
uc010thv.4 human [Q8WWI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330045 mRNA Translation: AAL37480.1
AL137121 Genomic DNA No translation available.
AL137244 Genomic DNA No translation available.
AL137782 Genomic DNA No translation available.
AL359392 Genomic DNA No translation available.
AB020665 mRNA Translation: BAA74881.2
AF174600 mRNA Translation: AAF04521.1
AF144237 mRNA Translation: AAD33924.1 Sequence problems.
U90654 mRNA Translation: AAB86592.1
AF092557 AF092556 Genomic DNA Translation: AAC96299.1 Different initiation.
AF092557, AF092554 Genomic DNA Translation: AAC96300.1 Different initiation.
CCDSiCCDS53876.1 [Q8WWI1-5]
CCDS9454.1 [Q8WWI1-3]
PIRiJE0325
RefSeqiNP_001293009.1, NM_001306080.1
NP_001317512.1, NM_001330583.1
NP_005349.3, NM_005358.5 [Q8WWI1-3]
NP_056667.2, NM_015842.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAQX-ray1.46A1037-1126[»]
SMRiQ8WWI1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110193, 70 interactors
CORUMiQ8WWI1
DIPiDIP-33107N
IntActiQ8WWI1, 40 interactors
MINTiQ8WWI1
STRINGi9606.ENSP00000433352

PTM databases

iPTMnetiQ8WWI1
MetOSiteiQ8WWI1
PhosphoSitePlusiQ8WWI1
SwissPalmiQ8WWI1

Polymorphism and mutation databases

BioMutaiLMO7
DMDMi308153585

Proteomic databases

EPDiQ8WWI1
jPOSTiQ8WWI1
MassIVEiQ8WWI1
MaxQBiQ8WWI1
PaxDbiQ8WWI1
PeptideAtlasiQ8WWI1
PRIDEiQ8WWI1
ProteomicsDBi21797
74888 [Q8WWI1-1]
74889 [Q8WWI1-2]
74890 [Q8WWI1-3]
74891 [Q8WWI1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10122 110 antibodies

Genome annotation databases

EnsembliENST00000341547; ENSP00000342112; ENSG00000136153 [Q8WWI1-3]
GeneIDi4008
KEGGihsa:4008
UCSCiuc010thv.4 human [Q8WWI1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4008
DisGeNETi4008

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LMO7
HGNCiHGNC:6646 LMO7
HPAiENSG00000136153 Tissue enhanced (heart)
MIMi604362 gene
neXtProtiNX_Q8WWI1
OpenTargetsiENSG00000136153
PharmGKBiPA30412

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00950000183159
InParanoidiQ8WWI1
KOiK06084
OrthoDBi38375at2759
PhylomeDBiQ8WWI1
TreeFamiTF332155

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LMO7 human
EvolutionaryTraceiQ8WWI1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LMO7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4008
PharosiQ8WWI1 Tbio

Protein Ontology

More...
PROi
PR:Q8WWI1
RNActiQ8WWI1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136153 Expressed in lower esophagus mucosa and 153 other tissues
ExpressionAtlasiQ8WWI1 baseline and differential
GenevisibleiQ8WWI1 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM
PANTHERiPTHR46767 PTHR46767, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMO7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWI1
Secondary accession number(s): E9PLH4
, O15462, O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 5, 2010
Last modified: April 22, 2020
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again