KCNE4

Functionⁱ

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

GO - Molecular functionⁱ

ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19687231
voltage-gated potassium channel activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Potassium channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5576890 Phase 3 - rapid repolarisation R-HSA-5576893 Phase 2 - plateau phase

Reactomeⁱ

R-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium voltage-gated channel subfamily E member 4 Alternative name(s): MinK-related peptide 3 Minimum potassium ion channel-related peptide 3 Potassium channel subunit beta MiRP3
Gene namesⁱ	Name:KCNE4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152049.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6244 KCNE4
MIMⁱ	607775 gene
neXtProtⁱ	NX_Q8WWG9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 86	ExtracellularSequence analysisAdd BLAST	86
Transmembraneⁱ	87 – 107	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	108 – 221	CytoplasmicSequence analysisAdd BLAST	114

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23704
Open Targets More...OpenTargetsⁱ	ENSG00000152049
PharmGKBⁱ	PA30032

Polymorphism and mutation databases

DMDMⁱ	311033433

DMDMⁱ

311033433

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144292	1 – 221	Potassium voltage-gated channel subfamily E member 4Add BLAST		221

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	9	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8WWG9
PeptideAtlas More...PeptideAtlasⁱ	Q8WWG9
PRIDEⁱ	Q8WWG9
ProteomicsDBⁱ	74885

PTM databases

iPTMnetⁱ	Q8WWG9
PhosphoSitePlusⁱ	Q8WWG9

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000152049 Expressed in 160 organ(s), highest expression level in myometrium
CleanExⁱ	HS_KCNE4
Genevisibleⁱ	Q8WWG9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011420

HPAⁱ

HPA011420

Interactionⁱ

Subunit structureⁱ

Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.3 Publications

GO - Molecular functionⁱ

ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19687231

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117217, 5 interactors
CORUMⁱ	Q8WWG9
IntActⁱ	Q8WWG9, 4 interactors
STRINGⁱ	9606.ENSP00000281830

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WWG9
SMRⁱ	Q8WWG9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	120 – 123	Poly-Leu		4

Sequence similaritiesⁱ

Belongs to the potassium channel KCNE family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWSX Eukaryota ENOG41129VY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013776
HOGENOMⁱ	HOG000237340
HOVERGENⁱ	HBG052229
InParanoidⁱ	Q8WWG9
KEGG Orthology (KO) More...KOⁱ	K04898
OMAⁱ	LWGEAMK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QZW
TreeFamⁱ	TF333025

Family and domain databases

InterProⁱ	View protein in InterPro IPR000369 K_chnl_KCNE
PANTHERⁱ	PTHR15282 PTHR15282, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02060 ISK_Channel, 1 hit
PRINTSⁱ	PR00168 KCNECHANNEL

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WWG9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA 
        60         70         80         90        100
SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF 
       110        120        130        140        150
LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP 
       160        170        180        190        200
LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE 
       210        220 
TSETPLNESS EGSSENIHQN S

Length:221

Mass (Da):23,806

Last modified:September 3, 2014 - v4

Checksum:ⁱF601434C18E82CFE

GO

Sequence cautionⁱ

The sequence AAH14429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAL49979 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	47	V → A in BAH11761 (PubMed:14702039).Curated	1
Sequence conflictⁱ	105	M → V in AAL49979 (Ref. 4) Curated	1
Sequence conflictⁱ	137	P → S in AAL49979 (Ref. 4) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030620	98	G → S. Corresponds to variant dbSNP:rs13409084Ensembl.		1
Natural variantⁱVAR_024411	196	D → E2 PublicationsCorresponds to variant dbSNP:rs12621643Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK294423 mRNA Translation: BAH11761.1 AC017014 Genomic DNA Translation: AAX93228.1 BC014429 mRNA Translation: AAH14429.1 Different initiation. AY065987 mRNA Translation: AAL49979.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2456.2
NCBI Reference Sequences More...RefSeqⁱ	NP_542402.3, NM_080671.3
UniGeneⁱ	Hs.348522

Genome annotation databases

Ensemblⁱ	ENST00000281830; ENSP00000281830; ENSG00000152049
GeneIDⁱ	23704
KEGGⁱ	hsa:23704
UCSC genome browser More...UCSCⁱ	uc002vnl.7 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WWG9	Potassium voltage-gated channel subfamily E member 4		HUMAN		170	UniRef100_Q8WWG9
Cardiac voltage-gated potassium channel accessory subunit 4 (Fragment)		HUMAN		119

Protein	Similar proteins		Species	Score	Length	Source
Q8WWG9	Potassium voltage-gated channel subfamily E member 4		HUMAN		170	UniRef90_Q8WWG9
KCNE4 isoform 2		PANTR		221
Potassium voltage-gated channel subfamily E regulatory subunit 4		SAIBB		221
Potassium voltage-gated channel subfamily E regulatory subunit 4		Cebus capucinus imitator		221
KCNE4 isoform 1		PONAB		221
+28

Protein	Similar proteins		Species	Score	Length	Source
Q8WWG9	Potassium voltage-gated channel subfamily E member 4		MOUSE		170	UniRef50_Q8WWG9
Potassium voltage-gated channel subfamily E member 4		HUMAN		170
Potassium voltage-gated channel subfamily E regulatory subunit 4		PANPA		221
Potassium voltage-gated channel subfamily E regulatory subunit 4		SAIBB		221
KCNE4 isoform 1		PONAB		221
+89

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK294423 mRNA Translation: BAH11761.1 AC017014 Genomic DNA Translation: AAX93228.1 BC014429 mRNA Translation: AAH14429.1 Different initiation. AY065987 mRNA Translation: AAL49979.1 Different initiation.
CCDSⁱ	CCDS2456.2
RefSeqⁱ	NP_542402.3, NM_080671.3
UniGeneⁱ	Hs.348522

3D structure databases

ProteinModelPortalⁱ	Q8WWG9
SMRⁱ	Q8WWG9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117217, 5 interactors
CORUMⁱ	Q8WWG9
IntActⁱ	Q8WWG9, 4 interactors
STRINGⁱ	9606.ENSP00000281830

PTM databases

iPTMnetⁱ	Q8WWG9
PhosphoSitePlusⁱ	Q8WWG9

Polymorphism and mutation databases

DMDMⁱ	311033433

DMDMⁱ

311033433

Proteomic databases

PaxDbⁱ	Q8WWG9
PeptideAtlasⁱ	Q8WWG9
PRIDEⁱ	Q8WWG9
ProteomicsDBⁱ	74885

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23704
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000281830; ENSP00000281830; ENSG00000152049
GeneIDⁱ	23704
KEGGⁱ	hsa:23704
UCSCⁱ	uc002vnl.7 human

Organism-specific databases

CTDⁱ	23704
DisGeNETⁱ	23704
EuPathDBⁱ	HostDB:ENSG00000152049.6
GeneCardsⁱ	KCNE4
HGNCⁱ	HGNC:6244 KCNE4
HPAⁱ	HPA011420
MIMⁱ	607775 gene
neXtProtⁱ	NX_Q8WWG9
OpenTargetsⁱ	ENSG00000152049
PharmGKBⁱ	PA30032
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWSX Eukaryota ENOG41129VY LUCA
GeneTreeⁱ	ENSGT00390000013776
HOGENOMⁱ	HOG000237340
HOVERGENⁱ	HBG052229
InParanoidⁱ	Q8WWG9
KOⁱ	K04898
OMAⁱ	LWGEAMK
OrthoDBⁱ	EOG091G0QZW
TreeFamⁱ	TF333025

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5576890 Phase 3 - rapid repolarisation R-HSA-5576893 Phase 2 - plateau phase

Reactomeⁱ

R-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase

Miscellaneous databases

GeneWikiⁱ	KCNE4
GenomeRNAiⁱ	23704
Protein Ontology More...PROⁱ	PR:Q8WWG9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152049 Expressed in 160 organ(s), highest expression level in myometrium
CleanExⁱ	HS_KCNE4
Genevisibleⁱ	Q8WWG9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000369 K_chnl_KCNE
PANTHERⁱ	PTHR15282 PTHR15282, 1 hit
Pfamⁱ	View protein in Pfam PF02060 ISK_Channel, 1 hit
PRINTSⁱ	PR00168 KCNECHANNEL
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNE4_HUMAN
Accessionⁱ	Q8WWG9Primary (citable) accession number: Q8WWG9 Secondary accession number(s): B7Z275, Q53SM4, Q96CC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
	Last sequence update:	September 3, 2014
	Last modified:	September 12, 2018
	This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WWG9 (KCNE4_HUMAN)

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Potassium voltage-gated channel subfamily E member 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ