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Protein

Potassium voltage-gated channel subfamily E member 4

Gene

KCNE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
  • voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene namesi
Name:KCNE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152049.6
HGNCiHGNC:6244 KCNE4
MIMi607775 gene
neXtProtiNX_Q8WWG9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86ExtracellularSequence analysisAdd BLAST86
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 221CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23704
OpenTargetsiENSG00000152049
PharmGKBiPA30032

Polymorphism and mutation databases

DMDMi311033433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442921 – 221Potassium voltage-gated channel subfamily E member 4Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WWG9
PeptideAtlasiQ8WWG9
PRIDEiQ8WWG9
ProteomicsDBi74885

PTM databases

iPTMnetiQ8WWG9
PhosphoSitePlusiQ8WWG9

Expressioni

Tissue specificityi

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication

Gene expression databases

BgeeiENSG00000152049 Expressed in 160 organ(s), highest expression level in myometrium
CleanExiHS_KCNE4
GenevisibleiQ8WWG9 HS

Organism-specific databases

HPAiHPA011420

Interactioni

Subunit structurei

Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117217, 5 interactors
CORUMiQ8WWG9
IntActiQ8WWG9, 4 interactors
STRINGi9606.ENSP00000281830

Structurei

3D structure databases

ProteinModelPortaliQ8WWG9
SMRiQ8WWG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 123Poly-Leu4

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWSX Eukaryota
ENOG41129VY LUCA
GeneTreeiENSGT00390000013776
HOGENOMiHOG000237340
HOVERGENiHBG052229
InParanoidiQ8WWG9
KOiK04898
OMAiLWGEAMK
OrthoDBiEOG091G0QZW
TreeFamiTF333025

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR00168 KCNECHANNEL

Sequencei

Sequence statusi: Complete.

Q8WWG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA
60 70 80 90 100
SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF
110 120 130 140 150
LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP
160 170 180 190 200
LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE
210 220
TSETPLNESS EGSSENIHQN S
Length:221
Mass (Da):23,806
Last modified:September 3, 2014 - v4
Checksum:iF601434C18E82CFE
GO

Sequence cautioni

The sequence AAH14429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL49979 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47V → A in BAH11761 (PubMed:14702039).Curated1
Sequence conflicti105M → V in AAL49979 (Ref. 4) Curated1
Sequence conflicti137P → S in AAL49979 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03062098G → S. Corresponds to variant dbSNP:rs13409084Ensembl.1
Natural variantiVAR_024411196D → E2 PublicationsCorresponds to variant dbSNP:rs12621643Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294423 mRNA Translation: BAH11761.1
AC017014 Genomic DNA Translation: AAX93228.1
BC014429 mRNA Translation: AAH14429.1 Different initiation.
AY065987 mRNA Translation: AAL49979.1 Different initiation.
CCDSiCCDS2456.2
RefSeqiNP_542402.3, NM_080671.3
UniGeneiHs.348522

Genome annotation databases

EnsembliENST00000281830; ENSP00000281830; ENSG00000152049
GeneIDi23704
KEGGihsa:23704
UCSCiuc002vnl.7 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294423 mRNA Translation: BAH11761.1
AC017014 Genomic DNA Translation: AAX93228.1
BC014429 mRNA Translation: AAH14429.1 Different initiation.
AY065987 mRNA Translation: AAL49979.1 Different initiation.
CCDSiCCDS2456.2
RefSeqiNP_542402.3, NM_080671.3
UniGeneiHs.348522

3D structure databases

ProteinModelPortaliQ8WWG9
SMRiQ8WWG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117217, 5 interactors
CORUMiQ8WWG9
IntActiQ8WWG9, 4 interactors
STRINGi9606.ENSP00000281830

PTM databases

iPTMnetiQ8WWG9
PhosphoSitePlusiQ8WWG9

Polymorphism and mutation databases

DMDMi311033433

Proteomic databases

PaxDbiQ8WWG9
PeptideAtlasiQ8WWG9
PRIDEiQ8WWG9
ProteomicsDBi74885

Protocols and materials databases

DNASUi23704
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281830; ENSP00000281830; ENSG00000152049
GeneIDi23704
KEGGihsa:23704
UCSCiuc002vnl.7 human

Organism-specific databases

CTDi23704
DisGeNETi23704
EuPathDBiHostDB:ENSG00000152049.6
GeneCardsiKCNE4
HGNCiHGNC:6244 KCNE4
HPAiHPA011420
MIMi607775 gene
neXtProtiNX_Q8WWG9
OpenTargetsiENSG00000152049
PharmGKBiPA30032
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWSX Eukaryota
ENOG41129VY LUCA
GeneTreeiENSGT00390000013776
HOGENOMiHOG000237340
HOVERGENiHBG052229
InParanoidiQ8WWG9
KOiK04898
OMAiLWGEAMK
OrthoDBiEOG091G0QZW
TreeFamiTF333025

Enzyme and pathway databases

ReactomeiR-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase

Miscellaneous databases

GeneWikiiKCNE4
GenomeRNAii23704
PROiPR:Q8WWG9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152049 Expressed in 160 organ(s), highest expression level in myometrium
CleanExiHS_KCNE4
GenevisibleiQ8WWG9 HS

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR00168 KCNECHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE4_HUMAN
AccessioniPrimary (citable) accession number: Q8WWG9
Secondary accession number(s): B7Z275, Q53SM4, Q96CC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: September 3, 2014
Last modified: September 12, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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