UniProtKB - Q8WWG9 (KCNE4_HUMAN)
Protein
Potassium voltage-gated channel subfamily E member 4
Gene
KCNE4
Organism
Homo sapiens (Human)
Status
Functioni
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
GO - Molecular functioni
- ion channel binding Source: UniProtKB
- potassium channel regulator activity Source: GO_Central
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- membrane repolarization during action potential Source: GO_Central
- membrane repolarization during ventricular cardiac muscle cell action potential Source: GOC
- negative regulation of delayed rectifier potassium channel activity Source: GO_Central
- potassium ion export across plasma membrane Source: GO_Central
- regulation of heart rate by cardiac conduction Source: GO_Central
- regulation of ventricular cardiac muscle cell membrane repolarization Source: GO_Central
- ventricular cardiac muscle cell action potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q8WWG9 |
Reactomei | R-HSA-5576890, Phase 3 - rapid repolarisation R-HSA-5576893, Phase 2 - plateau phase |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily E member 4Alternative name(s): MinK-related peptide 3 Minimum potassium ion channel-related peptide 3 Potassium channel subunit beta MiRP3 |
Gene namesi | Name:KCNE4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6244, KCNE4 |
MIMi | 607775, gene |
neXtProti | NX_Q8WWG9 |
VEuPathDBi | HostDB:ENSG00000152049.6 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Plasma Membrane
- apical plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 86 | ExtracellularSequence analysisAdd BLAST | 86 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 221 | CytoplasmicSequence analysisAdd BLAST | 114 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23704 |
OpenTargetsi | ENSG00000152049 |
PharmGKBi | PA30032 |
Miscellaneous databases
Pharosi | Q8WWG9, Tbio |
Chemistry databases
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
Genetic variation databases
BioMutai | KCNE4 |
DMDMi | 311033433 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144292 | 1 – 221 | Potassium voltage-gated channel subfamily E member 4Add BLAST | 221 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q8WWG9 |
PaxDbi | Q8WWG9 |
PeptideAtlasi | Q8WWG9 |
PRIDEi | Q8WWG9 |
ProteomicsDBi | 74885 |
PTM databases
GlyGeni | Q8WWG9, 1 site |
iPTMneti | Q8WWG9 |
PhosphoSitePlusi | Q8WWG9 |
Expressioni
Tissue specificityi
Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication
Gene expression databases
Bgeei | ENSG00000152049, Expressed in myometrium and 173 other tissues |
Genevisiblei | Q8WWG9, HS |
Organism-specific databases
HPAi | ENSG00000152049, Tissue enhanced (smooth) |
Interactioni
Subunit structurei
Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.
3 PublicationsBinary interactionsi
Hide detailsQ8WWG9
With | #Exp. | IntAct |
---|---|---|
CAMLG [P49069] | 3 | EBI-11750916,EBI-1748958 |
GET3 [O43681] | 3 | EBI-11750916,EBI-2515857 |
TRDN - isoform 2 [Q13061-2] | 3 | EBI-11750916,EBI-17257686 |
GO - Molecular functioni
- ion channel binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117217, 10 interactors |
CORUMi | Q8WWG9 |
IntActi | Q8WWG9, 4 interactors |
STRINGi | 9606.ENSP00000281830 |
Miscellaneous databases
RNActi | Q8WWG9, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 120 – 123 | Poly-Leu | 4 |
Sequence similaritiesi
Belongs to the potassium channel KCNE family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZ36, Eukaryota |
GeneTreei | ENSGT00390000013776 |
HOGENOMi | CLU_109412_0_0_1 |
InParanoidi | Q8WWG9 |
OMAi | HFTIQEE |
OrthoDBi | 1418062at2759 |
TreeFami | TF333025 |
Family and domain databases
InterProi | View protein in InterPro IPR000369, K_chnl_KCNE |
PANTHERi | PTHR15282, PTHR15282, 1 hit |
Pfami | View protein in Pfam PF02060, ISK_Channel, 1 hit |
PRINTSi | PR00168, KCNECHANNEL |
i Sequence
Sequence statusi: Complete.
Q8WWG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA
60 70 80 90 100
SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF
110 120 130 140 150
LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP
160 170 180 190 200
LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE
210 220
TSETPLNESS EGSSENIHQN S
Sequence cautioni
The sequence AAH14429 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL49979 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | V → A in BAH11761 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 105 | M → V in AAL49979 (Ref. 4) Curated | 1 | |
Sequence conflicti | 137 | P → S in AAL49979 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030620 | 98 | G → S. Corresponds to variant dbSNP:rs13409084Ensembl. | 1 | |
Natural variantiVAR_024411 | 196 | D → E2 PublicationsCorresponds to variant dbSNP:rs12621643Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294423 mRNA Translation: BAH11761.1 AC017014 Genomic DNA Translation: AAX93228.1 BC014429 mRNA Translation: AAH14429.1 Different initiation. AY065987 mRNA Translation: AAL49979.1 Different initiation. |
RefSeqi | NP_542402.3, NM_080671.3 |
Genome annotation databases
Ensembli | ENST00000281830; ENSP00000281830; ENSG00000152049 |
GeneIDi | 23704 |
KEGGi | hsa:23704 |
UCSCi | uc002vnl.7, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294423 mRNA Translation: BAH11761.1 AC017014 Genomic DNA Translation: AAX93228.1 BC014429 mRNA Translation: AAH14429.1 Different initiation. AY065987 mRNA Translation: AAL49979.1 Different initiation. |
RefSeqi | NP_542402.3, NM_080671.3 |
3D structure databases
SMRi | Q8WWG9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117217, 10 interactors |
CORUMi | Q8WWG9 |
IntActi | Q8WWG9, 4 interactors |
STRINGi | 9606.ENSP00000281830 |
Chemistry databases
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
PTM databases
GlyGeni | Q8WWG9, 1 site |
iPTMneti | Q8WWG9 |
PhosphoSitePlusi | Q8WWG9 |
Genetic variation databases
BioMutai | KCNE4 |
DMDMi | 311033433 |
Proteomic databases
jPOSTi | Q8WWG9 |
PaxDbi | Q8WWG9 |
PeptideAtlasi | Q8WWG9 |
PRIDEi | Q8WWG9 |
ProteomicsDBi | 74885 |
Protocols and materials databases
Antibodypediai | 2515, 134 antibodies |
DNASUi | 23704 |
Genome annotation databases
Ensembli | ENST00000281830; ENSP00000281830; ENSG00000152049 |
GeneIDi | 23704 |
KEGGi | hsa:23704 |
UCSCi | uc002vnl.7, human |
Organism-specific databases
CTDi | 23704 |
DisGeNETi | 23704 |
GeneCardsi | KCNE4 |
HGNCi | HGNC:6244, KCNE4 |
HPAi | ENSG00000152049, Tissue enhanced (smooth) |
MIMi | 607775, gene |
neXtProti | NX_Q8WWG9 |
OpenTargetsi | ENSG00000152049 |
PharmGKBi | PA30032 |
VEuPathDBi | HostDB:ENSG00000152049.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZ36, Eukaryota |
GeneTreei | ENSGT00390000013776 |
HOGENOMi | CLU_109412_0_0_1 |
InParanoidi | Q8WWG9 |
OMAi | HFTIQEE |
OrthoDBi | 1418062at2759 |
TreeFami | TF333025 |
Enzyme and pathway databases
PathwayCommonsi | Q8WWG9 |
Reactomei | R-HSA-5576890, Phase 3 - rapid repolarisation R-HSA-5576893, Phase 2 - plateau phase |
Miscellaneous databases
BioGRID-ORCSi | 23704, 4 hits in 876 CRISPR screens |
GeneWikii | KCNE4 |
GenomeRNAii | 23704 |
Pharosi | Q8WWG9, Tbio |
PROi | PR:Q8WWG9 |
RNActi | Q8WWG9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152049, Expressed in myometrium and 173 other tissues |
Genevisiblei | Q8WWG9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000369, K_chnl_KCNE |
PANTHERi | PTHR15282, PTHR15282, 1 hit |
Pfami | View protein in Pfam PF02060, ISK_Channel, 1 hit |
PRINTSi | PR00168, KCNECHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNE4_HUMAN | |
Accessioni | Q8WWG9Primary (citable) accession number: Q8WWG9 Secondary accession number(s): B7Z275, Q53SM4, Q96CC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | September 3, 2014 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families