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Protein

DnaJ homolog subfamily B member 3

Gene

DNAJB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.Curated

Caution

Due to a premature stop codon, the human protein is truncated and lacks the DNAJB3 canonical C-terminal domain. However, expression studies suggest the existence of the mRNA and protein in human.Curated

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 3
Gene namesi
Name:DNAJB3
Synonyms:HCG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32397 DNAJB3
neXtProtiNX_Q8WWF6

Pathology & Biotechi

Organism-specific databases

DisGeNETi414061
PharmGKBiPA162383828

Polymorphism and mutation databases

BioMutaiDNAJB3
DMDMi74730976

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003864721 – 145DnaJ homolog subfamily B member 3Add BLAST145

Proteomic databases

EPDiQ8WWF6
MaxQBiQ8WWF6
PeptideAtlasiQ8WWF6
PRIDEiQ8WWF6
ProteomicsDBi74882

PTM databases

iPTMnetiQ8WWF6
PhosphoSitePlusiQ8WWF6

Expressioni

Tissue specificityi

Expressed in sperm (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi135928, 18 interactors
IntActiQ8WWF6, 7 interactors

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Helixi16 – 27Combined sources12
Turni32 – 34Combined sources3
Helixi39 – 56Combined sources18
Helixi61 – 67Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EJ7NMR-A1-69[»]
ProteinModelPortaliQ8WWF6
SMRiQ8WWF6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWF6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69JPROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

InParanoidiQ8WWF6
KOiK09509
PhylomeDBiQ8WWF6

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR026901 DNAJB3
IPR036869 J_dom_sf
PANTHERiPTHR43948:SF1 PTHR43948:SF1, 1 hit
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WWF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYYEVLDV PRQASSEAIK KAYRKLALKW HPDKNPENKE EAERRFKQVA
60 70 80 90 100
EAYEVLSDAK KRDIYDRYGE AGAEGGCTGG RPFEDPFEYV FSFRDPADVF
110 120 130 140
REFFGGQDPF SFDLLGNPLE NILGGSEELL GKQKQSVCTP FLCLQ
Length:145
Mass (Da):16,559
Last modified:March 1, 2002 - v1
Checksum:i065CD71109B6F0DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06114285D → E. Corresponds to variant dbSNP:rs34622615Ensembl.1
Natural variantiVAR_06114398D → E. Corresponds to variant dbSNP:rs34150486Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083665 mRNA Translation: AAM08934.1
AC114812 Genomic DNA Translation: AAY24024.1
BC017590 mRNA Translation: AAH17590.1
BC024013 mRNA Translation: AAH24013.1
RefSeqiNP_001001394.1, NM_001001394.3
UniGeneiHs.725533

Genome annotation databases

GeneIDi414061
KEGGihsa:414061

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDNJB3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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