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Protein

Serine-rich single-pass membrane protein 1

Gene

SSMEM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich single-pass membrane protein 1
Gene namesi
Name:SSMEM1
Synonyms:C7orf45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000165120.3
HGNCiHGNC:29580 SSMEM1
neXtProtiNX_Q8WWF3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165120
PharmGKBiPA162380490

Polymorphism and mutation databases

BioMutaiSSMEM1
DMDMi74730975

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713541 – 244Serine-rich single-pass membrane protein 1Add BLAST244

Proteomic databases

PaxDbiQ8WWF3
PeptideAtlasiQ8WWF3
PRIDEiQ8WWF3
ProteomicsDBi74880

PTM databases

iPTMnetiQ8WWF3
PhosphoSitePlusiQ8WWF3

Expressioni

Gene expression databases

BgeeiENSG00000165120 Expressed in 19 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_C7orf45
ExpressionAtlasiQ8WWF3 baseline and differential
GenevisibleiQ8WWF3 HS

Interactioni

Protein-protein interaction databases

BioGridi126451, 11 interactors
IntActiQ8WWF3, 87 interactors
STRINGi9606.ENSP00000297819

Structurei

3D structure databases

ProteinModelPortaliQ8WWF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKXI Eukaryota
ENOG4111EGG LUCA
GeneTreeiENSGT00390000015907
HOGENOMiHOG000252965
HOVERGENiHBG066015
InParanoidiQ8WWF3
OMAiQTMKKPK
OrthoDBiEOG091G0ISK
PhylomeDBiQ8WWF3
TreeFamiTF337221

Family and domain databases

InterProiView protein in InterPro
IPR027955 DUF4636
PANTHERiPTHR31822 PTHR31822, 1 hit
PfamiView protein in Pfam
PF15468 DUF4636, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WWF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDLFSLFWE VDPPPIPVNC AIPNQDYECW KDDSCGTIGS FLLWYFVIVF
60 70 80 90 100
VLMFFSRASV WMSEDKKDEG SGTSTSVRKA SKETSCKRQS KDSAWDPSQT
110 120 130 140 150
MKKPKQNQLT PVTNSEVALV NAYPEQRRAR RQSQFNEVNQ NQHDSDTTEY
160 170 180 190 200
GSEESNSEAS SWKESESEHH PSPDSIKRRK MAQRQRNLGS YQMSERHCLH
210 220 230 240
CKALRTNEWL AHHSRQKPSV TPPMKRDSQE ESSISDINKK FSKF
Length:244
Mass (Da):28,167
Last modified:March 1, 2002 - v1
Checksum:i14EB74E45FE0303D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02987388R → W. Corresponds to variant dbSNP:rs4728190Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097635 mRNA Translation: BAC05126.1
BC017587 mRNA Translation: AAH17587.1
CCDSiCCDS5816.1
RefSeqiNP_660311.1, NM_145268.3
UniGeneiHs.351816

Genome annotation databases

EnsembliENST00000297819; ENSP00000297819; ENSG00000165120
GeneIDi136263
KEGGihsa:136263
UCSCiuc003vpp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097635 mRNA Translation: BAC05126.1
BC017587 mRNA Translation: AAH17587.1
CCDSiCCDS5816.1
RefSeqiNP_660311.1, NM_145268.3
UniGeneiHs.351816

3D structure databases

ProteinModelPortaliQ8WWF3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126451, 11 interactors
IntActiQ8WWF3, 87 interactors
STRINGi9606.ENSP00000297819

PTM databases

iPTMnetiQ8WWF3
PhosphoSitePlusiQ8WWF3

Polymorphism and mutation databases

BioMutaiSSMEM1
DMDMi74730975

Proteomic databases

PaxDbiQ8WWF3
PeptideAtlasiQ8WWF3
PRIDEiQ8WWF3
ProteomicsDBi74880

Protocols and materials databases

DNASUi136263
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297819; ENSP00000297819; ENSG00000165120
GeneIDi136263
KEGGihsa:136263
UCSCiuc003vpp.4 human

Organism-specific databases

CTDi136263
EuPathDBiHostDB:ENSG00000165120.3
GeneCardsiSSMEM1
HGNCiHGNC:29580 SSMEM1
neXtProtiNX_Q8WWF3
OpenTargetsiENSG00000165120
PharmGKBiPA162380490
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKXI Eukaryota
ENOG4111EGG LUCA
GeneTreeiENSGT00390000015907
HOGENOMiHOG000252965
HOVERGENiHBG066015
InParanoidiQ8WWF3
OMAiQTMKKPK
OrthoDBiEOG091G0ISK
PhylomeDBiQ8WWF3
TreeFamiTF337221

Miscellaneous databases

GenomeRNAii136263
PROiPR:Q8WWF3

Gene expression databases

BgeeiENSG00000165120 Expressed in 19 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_C7orf45
ExpressionAtlasiQ8WWF3 baseline and differential
GenevisibleiQ8WWF3 HS

Family and domain databases

InterProiView protein in InterPro
IPR027955 DUF4636
PANTHERiPTHR31822 PTHR31822, 1 hit
PfamiView protein in Pfam
PF15468 DUF4636, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSMM1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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