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Entry version 122 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein

PIH1 domain-containing protein 2

Gene

PIH1D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WWB5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PIH1 domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIH1D2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000150773.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25210, PIH1D2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WWB5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
120379

Open Targets

More...
OpenTargetsi
ENSG00000150773

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399536

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WWB5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIH1D2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730959

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073341 – 315PIH1 domain-containing protein 2Add BLAST315

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WWB5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WWB5

PeptideAtlas

More...
PeptideAtlasi
Q8WWB5

PRoteomics IDEntifications database

More...
PRIDEi
Q8WWB5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19604
5149
74873 [Q8WWB5-1]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WWB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150773, Expressed in testis and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WWB5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WWB5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000150773, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8WWB5
With#Exp.IntAct
ANKRD11 [X5D778]3EBI-10232538,EBI-17183751
BAG3 [O95817]3EBI-10232538,EBI-747185
BANP - isoform 2 [Q8N9N5-2]3EBI-10232538,EBI-11524452
CBLL2 [Q8N7E2]3EBI-10232538,EBI-12196065
CBX8 [Q9HC52]3EBI-10232538,EBI-712912
CCNL2 - isoform 5 [Q96S94-5]3EBI-10232538,EBI-12024864
CDC23 [Q9UJX2]3EBI-10232538,EBI-396137
CDCA8 [Q53HL2]3EBI-10232538,EBI-979174
CDKL3 [Q8IVW4]3EBI-10232538,EBI-3919850
CFAP206 [Q8IYR0]3EBI-10232538,EBI-749051
COMMD3 [Q9UBI1]5EBI-10232538,EBI-714979
CT55 [Q8WUE5]3EBI-10232538,EBI-6873363
CTAG1B [P78358]3EBI-10232538,EBI-1188472
DES [P17661]3EBI-10232538,EBI-1055572
DPH3 [Q96FX2]6EBI-10232538,EBI-465363
DSCAM [O60469]3EBI-10232538,EBI-19949317
EIF4A2 - isoform 2 [Q14240-2]3EBI-10232538,EBI-10232522
ENKD1 [Q9H0I2]3EBI-10232538,EBI-744099
EXOSC5 [Q9NQT4]3EBI-10232538,EBI-371876
FRS3 [O43559]3EBI-10232538,EBI-725515
GFAP [P14136]4EBI-10232538,EBI-744302
GMCL1 [Q96IK5]3EBI-10232538,EBI-2548508
GPRASP2 [Q96D09]3EBI-10232538,EBI-473189
HES7 [Q9BYE0]3EBI-10232538,EBI-12163087
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-10232538,EBI-12056251
IQUB [Q8NA54]3EBI-10232538,EBI-10220600
ITGB3BP [Q13352]7EBI-10232538,EBI-712105
ITGB3BP - isoform 5 [Q13352-5]3EBI-10232538,EBI-10175826
KRTAP12-2 [P59991]3EBI-10232538,EBI-10176379
KRTAP12-4 [P60329]6EBI-10232538,EBI-10176396
LAP3 [P28838]3EBI-10232538,EBI-2339312
LMNB1 [P20700]3EBI-10232538,EBI-968218
MCCD1 [P59942]3EBI-10232538,EBI-11987923
MDFI [Q99750]6EBI-10232538,EBI-724076
MED20 [Q9H944]3EBI-10232538,EBI-394644
MISP [Q8IVT2]3EBI-10232538,EBI-2555085
MRFAP1L1 [Q96HT8]8EBI-10232538,EBI-748896
NFIL3 [Q16649]3EBI-10232538,EBI-3951858
NHSL2 [Q5HYW2]3EBI-10232538,EBI-2859639
NOTO [A8MTQ0]3EBI-10232538,EBI-17490746
NXF1 [Q9UBU9]3EBI-10232538,EBI-398874
PBX4 [Q9BYU1]6EBI-10232538,EBI-10302990
PLEKHJ1 [Q9NW61]3EBI-10232538,EBI-1057560
POLR1C [O15160]3EBI-10232538,EBI-1055079
PRDM6 [Q9NQX0]3EBI-10232538,EBI-11320284
PRMT3 [O60678]3EBI-10232538,EBI-2809009
REL [Q04864]4EBI-10232538,EBI-307352
RSPO4 [Q2I0M5]3EBI-10232538,EBI-12821217
SDCBP [O00560]3EBI-10232538,EBI-727004
SERTAD1 [Q9UHV2]3EBI-10232538,EBI-748601
SLPI [P03973]3EBI-10232538,EBI-355293
SPRED1 [Q7Z699]5EBI-10232538,EBI-5235340
SSX3 [Q99909]3EBI-10232538,EBI-10295431
SUOX [P51687]3EBI-10232538,EBI-3921347
TAF6 - isoform 3 [P49848-3]3EBI-10232538,EBI-12940148
TASOR2 [Q5VWN6]5EBI-10232538,EBI-745958
TBATA [Q96M53]3EBI-10232538,EBI-24203456
TCEA2 [Q15560]3EBI-10232538,EBI-710310
TNNI1 [P19237]3EBI-10232538,EBI-746692
TTC23 - isoform 3 [Q5W5X9-3]3EBI-10232538,EBI-9090990
WDYHV1 [Q96HA8]3EBI-10232538,EBI-741158
ZBTB1 [Q9Y2K1]3EBI-10232538,EBI-2682961
ZMAT5 [Q9UDW3]3EBI-10232538,EBI-7850213
ZNF185 [O15231]3EBI-10232538,EBI-6874731
ZNF417 [Q8TAU3]3EBI-10232538,EBI-740727
ZNF438 [Q7Z4V0]3EBI-10232538,EBI-11962468
ZNF688 [P0C7X2]3EBI-10232538,EBI-4395732

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125683, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WWB5, 68 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280350

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WWB5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WWB5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIH1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4356, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048581

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_075974_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WWB5

Identification of Orthologs from Complete Genome Data

More...
OMAi
ADQNEKP

Database of Orthologous Groups

More...
OrthoDBi
1394603at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WWB5

TreeFam database of animal gene trees

More...
TreeFami
TF324376

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012981, PIH1_N
IPR041442, PIH1D1/2/3_CS-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08190, PIH1, 1 hit
PF18201, PIH1_CS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WWB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METSSKGLLT QVTQFWNLLD DLAQSDPEGY EKFIQQQLKE GKQLCAAPEP
60 70 80 90 100
QLCLQTRILK PKEKILFINL CQWTRIPAPQ STTHPVPLTV GKPEDTTEIS
110 120 130 140 150
DAYTVIDVAY NPDVLHAAEK DQVKKNQLIQ MAMKCIEEKF QFTLSHSYHI
160 170 180 190 200
TKFRIKGSIQ RMKQNLMGIQ TDSIDLREKM RRELTLGQIR SSTMSNPDHF
210 220 230 240 250
PQLLLPKDQV SGKAVCLIEE ISSTEIQVEM KMPAYELKIV HDHSEKPLKI
260 270 280 290 300
ELKVELPGIN SVSLCDLSVS EDDLLIEVSE KYRLHLNLPK LIDTEMTTAK
310
FIKEKSTLII TMPLV
Length:315
Mass (Da):35,957
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF136BA2D0B28182C
GO
Isoform 2 (identifier: Q8WWB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-288: DDLLIEVSEKYRLHLNL → GTTEPQALAKDELSLKF
     289-315: Missing.

Show »
Length:288
Mass (Da):32,690
Checksum:i97750CD21CD107CB
GO
Isoform 3 (identifier: Q8WWB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-273: DD → VS
     274-315: Missing.

Note: May be due to a competing donor splice site.Curated
Show »
Length:273
Mass (Da):31,046
Checksum:i23F4C764433AD8C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCC0H0YCC0_HUMAN
PIH1 domain-containing protein 2
PIH1D2
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTE1A0A0A0MTE1_HUMAN
PIH1 domain-containing protein 2
PIH1D2
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035415117A → V. Corresponds to variant dbSNP:rs1425917Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054022272 – 288DDLLI…LHLNL → GTTEPQALAKDELSLKF in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_054023272 – 273DD → VS in isoform 3. 1 Publication2
Alternative sequenceiVSP_054024274 – 315Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_054025289 – 315Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK300496 mRNA Translation: BAG62210.1
AP000907 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67177.1
BC019238 mRNA Translation: AAH19238.1
BP369833 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44730.1 [Q8WWB5-2]
CCDS8355.1 [Q8WWB5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001076088.1, NM_001082619.1 [Q8WWB5-2]
NP_620144.1, NM_138789.3 [Q8WWB5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280350; ENSP00000280350; ENSG00000150773 [Q8WWB5-1]
ENST00000431456; ENSP00000388209; ENSG00000150773 [Q8WWB5-2]
ENST00000528775; ENSP00000434275; ENSG00000150773 [Q8WWB5-2]
ENST00000530641; ENSP00000431147; ENSG00000150773 [Q8WWB5-3]
ENST00000532211; ENSP00000431841; ENSG00000150773 [Q8WWB5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
120379

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:120379

UCSC genome browser

More...
UCSCi
uc001pmp.5, human [Q8WWB5-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300496 mRNA Translation: BAG62210.1
AP000907 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67177.1
BC019238 mRNA Translation: AAH19238.1
BP369833 mRNA No translation available.
CCDSiCCDS44730.1 [Q8WWB5-2]
CCDS8355.1 [Q8WWB5-1]
RefSeqiNP_001076088.1, NM_001082619.1 [Q8WWB5-2]
NP_620144.1, NM_138789.3 [Q8WWB5-1]

3D structure databases

SMRiQ8WWB5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125683, 12 interactors
IntActiQ8WWB5, 68 interactors
STRINGi9606.ENSP00000280350

PTM databases

PhosphoSitePlusiQ8WWB5

Polymorphism and mutation databases

BioMutaiPIH1D2
DMDMi74730959

Proteomic databases

MassIVEiQ8WWB5
PaxDbiQ8WWB5
PeptideAtlasiQ8WWB5
PRIDEiQ8WWB5
ProteomicsDBi19604
5149
74873 [Q8WWB5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
51744, 152 antibodies

The DNASU plasmid repository

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DNASUi
120379

Genome annotation databases

EnsembliENST00000280350; ENSP00000280350; ENSG00000150773 [Q8WWB5-1]
ENST00000431456; ENSP00000388209; ENSG00000150773 [Q8WWB5-2]
ENST00000528775; ENSP00000434275; ENSG00000150773 [Q8WWB5-2]
ENST00000530641; ENSP00000431147; ENSG00000150773 [Q8WWB5-3]
ENST00000532211; ENSP00000431841; ENSG00000150773 [Q8WWB5-1]
GeneIDi120379
KEGGihsa:120379
UCSCiuc001pmp.5, human [Q8WWB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
120379
DisGeNETi120379
EuPathDBiHostDB:ENSG00000150773.10

GeneCards: human genes, protein and diseases

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GeneCardsi
PIH1D2
HGNCiHGNC:25210, PIH1D2
HPAiENSG00000150773, Tissue enhanced (testis)
neXtProtiNX_Q8WWB5
OpenTargetsiENSG00000150773
PharmGKBiPA162399536

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4356, Eukaryota
GeneTreeiENSGT00510000048581
HOGENOMiCLU_075974_0_0_1
InParanoidiQ8WWB5
OMAiADQNEKP
OrthoDBi1394603at2759
PhylomeDBiQ8WWB5
TreeFamiTF324376

Enzyme and pathway databases

PathwayCommonsiQ8WWB5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
120379, 13 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIH1D2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
120379
PharosiQ8WWB5, Tdark

Protein Ontology

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PROi
PR:Q8WWB5
RNActiQ8WWB5, protein

Gene expression databases

BgeeiENSG00000150773, Expressed in testis and 126 other tissues
ExpressionAtlasiQ8WWB5, baseline and differential
GenevisibleiQ8WWB5, HS

Family and domain databases

InterProiView protein in InterPro
IPR012981, PIH1_N
IPR041442, PIH1D1/2/3_CS-like
PfamiView protein in Pfam
PF08190, PIH1, 1 hit
PF18201, PIH1_CS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIHD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WWB5
Secondary accession number(s): B4DU48, E9PD82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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