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Protein

DPY30 domain-containing protein 1

Gene

DYDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a crucial role during acrosome biogenesis.1 Publication

Caution

Sequence AAQ84766 was incorrectly indicated as originating from mouse.Curated

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DPY30 domain-containing protein 1
Gene namesi
Name:DYDC1
Synonyms:DPY30D1
ORF Names:RSD-9, RSD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000170788.13
HGNCiHGNC:23460 DYDC1
MIMi615154 gene
neXtProtiNX_Q8WWB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170788
PharmGKBiPA134972260

Polymorphism and mutation databases

BioMutaiDYDC1
DMDMi74751572

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475561 – 177DPY30 domain-containing protein 1Add BLAST177

Proteomic databases

PaxDbiQ8WWB3
PeptideAtlasiQ8WWB3
PRIDEiQ8WWB3
ProteomicsDBi74872

PTM databases

PhosphoSitePlusiQ8WWB3

Expressioni

Tissue specificityi

Brain and testis. Accumulates during late stage of spermiogenesis.1 Publication

Gene expression databases

BgeeiENSG00000170788
CleanExiHS_DYDC1
ExpressionAtlasiQ8WWB3 baseline and differential
GenevisibleiQ8WWB3 HS

Organism-specific databases

HPAiHPA037790
HPA037791

Interactioni

Subunit structurei

Interacts with SH3GL3.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126791, 20 interactors
IntActiQ8WWB3, 39 interactors
STRINGi9606.ENSP00000361276

Structurei

3D structure databases

ProteinModelPortaliQ8WWB3
SMRiQ8WWB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-30 family.Curated

Phylogenomic databases

eggNOGiENOG410J0SH Eukaryota
ENOG410XYYJ LUCA
GeneTreeiENSGT00530000063857
HOGENOMiHOG000013181
HOVERGENiHBG081469
InParanoidiQ8WWB3
OMAiDEPMFSD
OrthoDBiEOG091G17ZL
PhylomeDBiQ8WWB3
TreeFamiTF330747

Family and domain databases

InterProiView protein in InterPro
IPR007858 Dpy-30_motif
PfamiView protein in Pfam
PF05186 Dpy-30, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESIYLQKHL GACLTQGLAE VARVRPVDPI EYLALWIYKY KENVTMEQLR
60 70 80 90 100
QKEMAKLERE RELALMEQEM MERLKAEELL LQQQQLALQL ELEMQEKERQ
110 120 130 140 150
RIQELQRAQE QLGKEMRMNM ENLVRNEDIL HSEEATLDSG KTLAEISDRY
160 170
GAPNLSRVEE LDEPMFSDIA LNIDQDL
Length:177
Mass (Da):20,893
Last modified:March 1, 2002 - v1
Checksum:iFB3DA4290972C623
GO
Isoform 2 (identifier: Q8WWB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-177: IALNIDQDL → VSISVFCEKTRFCFCF

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):21,795
Checksum:iB8559B607228C22D
GO

Sequence cautioni

The sequence BAC86339 differs from that shown. Intron retention.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056983169 – 177IALNIDQDL → VSISVFCEKTRFCFCF in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278322 mRNA Translation: AAQ84766.1
AK125908 mRNA Translation: BAC86339.1 Sequence problems.
AK292542 mRNA Translation: BAF85231.1
AL359195 Genomic DNA No translation available.
BC019250 mRNA Translation: AAH19250.1
CCDSiCCDS7366.1 [Q8WWB3-1]
RefSeqiNP_001255982.1, NM_001269053.1 [Q8WWB3-1]
NP_620167.1, NM_138812.3 [Q8WWB3-1]
XP_005269606.1, XM_005269549.4 [Q8WWB3-2]
XP_005269607.1, XM_005269550.4 [Q8WWB3-2]
XP_011537636.1, XM_011539334.2 [Q8WWB3-2]
XP_011537637.1, XM_011539335.1 [Q8WWB3-1]
UniGeneiHs.407751

Genome annotation databases

EnsembliENST00000372202; ENSP00000361276; ENSG00000170788 [Q8WWB3-1]
ENST00000372204; ENSP00000361278; ENSG00000170788 [Q8WWB3-1]
ENST00000421924; ENSP00000402890; ENSG00000170788 [Q8WWB3-1]
GeneIDi143241
KEGGihsa:143241
UCSCiuc001kbx.6 human [Q8WWB3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDYDC1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWB3
Secondary accession number(s): A8K927
, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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