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Protein

Intelectin-1

Gene

ITLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).Curated4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi87Calcium 2Combined sources1 Publication1
Metal bindingi89Calcium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi92Calcium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi97Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi98Calcium 2Combined sources1 Publication1
Metal bindingi133Calcium 1Combined sources1 Publication1
Metal bindingi260Calcium 3Combined sources1 Publication1
Metal bindingi262Calcium 3Combined sources1 Publication1
Metal bindingi274Calcium 3Combined sources1 Publication1
Binding sitei274CarbohydrateCombined sources1 Publication1
Metal bindingi282Calcium 1Combined sources1 Publication1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • oligosaccharide binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Protein family/group databases

UniLectiniQ8WWA0

Names & Taxonomyi

Protein namesi
Recommended name:
Intelectin-1
Short name:
ITLN-1
Alternative name(s):
Endothelial lectin HL-1
Galactofuranose-binding lectin
Intestinal lactoferrin receptor1 Publication
Omentin1 Publication
Gene namesi
Name:ITLN1
Synonyms:INTL, ITLN, LFR
ORF Names:UNQ640/PRO1270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179914.4
HGNCiHGNC:18259 ITLN1
MIMi609873 gene
neXtProtiNX_Q8WWA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31C → S: Forms mainly monomers; when associated with S-48. 1 Publication1
Mutagenesisi48C → S: Forms mainly dimers. Forms mainly monomers; when associated with S-31. 1 Publication1

Organism-specific databases

DisGeNETi55600
OpenTargetsiENSG00000179914
PharmGKBiPA134870726

Polymorphism and mutation databases

BioMutaiITLN1
DMDMi55976553

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000000914319 – 298Intelectin-1Add BLAST280
PropeptideiPRO_0000009144299 – 313Sequence analysisAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31Interchain (with C-48)PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi41 ↔ 70Combined sources1 Publication
Disulfide bondi48Interchain (with C-31)PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi94 ↔ 280Combined sources1 Publication
Glycosylationi163N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi199 ↔ 259Combined sources1 Publication
Disulfide bondi251 ↔ 265Combined sources1 Publication
Lipidationi298GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8WWA0
PeptideAtlasiQ8WWA0
PRIDEiQ8WWA0
ProteomicsDBi74869

PTM databases

iPTMnetiQ8WWA0
PhosphoSitePlusiQ8WWA0

Expressioni

Tissue specificityi

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level) (PubMed:16531507). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.4 Publications

Developmental stagei

Found in fetal small intestine and thymus.

Gene expression databases

BgeeiENSG00000179914 Expressed in 107 organ(s), highest expression level in parietal pleura
CleanExiHS_ITLN1
GenevisibleiQ8WWA0 HS

Organism-specific databases

HPAiCAB012652
HPA063275
HPA067326

Interactioni

Subunit structurei

Homotrimer; disulfide-linked (PubMed:11313366, PubMed:17621593, PubMed:26148048). May interact with LTF (PubMed:11747454, PubMed:23921499).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-16163679,EBI-16163679

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120741, 14 interactors
DIPiDIP-61704N
STRINGi9606.ENSP00000323587

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WWA0
SMRiQ8WWA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 255Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni262 – 263Carbohydrate bindingCombined sources1 Publication2

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGEB Eukaryota
ENOG4110R6N LUCA
GeneTreeiENSGT00390000008567
HOGENOMiHOG000026788
HOVERGENiHBG052157
InParanoidiQ8WWA0
KOiK17527
OMAiWITDEAN
OrthoDBiEOG091G0QYK
PhylomeDBiQ8WWA0
TreeFamiTF328530

Family and domain databases

Gene3Di3.90.215.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR002181 Fibrinogen_a/b/g_C_dom
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WWA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQLSFLLFL IATTRGWSTD EANTYFKEWT CSSSPSLPRS CKEIKDECPS
60 70 80 90 100
AFDGLYFLRT ENGVIYQTFC DMTSGGGGWT LVASVHENDM RGKCTVGDRW
110 120 130 140 150
SSQQGSKAVY PEGDGNWANY NTFGSAEAAT SDDYKNPGYY DIQAKDLGIW
160 170 180 190 200
HVPNKSPMQH WRNSSLLRYR TDTGFLQTLG HNLFGIYQKY PVKYGEGKCW
210 220 230 240 250
TDNGPVIPVV YDFGDAQKTA SYYSPYGQRE FTAGFVQFRV FNNERAANAL
260 270 280 290 300
CAGMRVTGCN TEHHCIGGGG YFPEASPQQC GDFSGFDWSG YGTHVGYSSS
310
REITEAAVLL FYR
Length:313
Mass (Da):34,962
Last modified:March 1, 2002 - v1
Checksum:i56219FE937FC802E
GO

Mass spectrometryi

Molecular mass is 35500 Da from positions 19 - 298. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019924109V → D1 PublicationCorresponds to variant dbSNP:rs2274907Ensembl.1
Natural variantiVAR_019925313R → P2 PublicationsCorresponds to variant dbSNP:rs8144Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271386 mRNA Translation: AAM20741.1
AY065972 mRNA Translation: AAL58073.1
AB036706 mRNA Translation: BAA96094.1
AY157361 mRNA Translation: AAO17800.1
AY157362 mRNA Translation: AAO17801.1
AY549722 mRNA Translation: AAS49907.1
AY619692 mRNA Translation: AAU88048.1
AY358359 mRNA Translation: AAQ88725.1
AK000029 mRNA Translation: BAA90893.1
CR457224 mRNA Translation: CAG33505.1
AL354714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52690.1
BC020664 mRNA Translation: AAH20664.1
CCDSiCCDS1211.1
RefSeqiNP_060095.2, NM_017625.2
UniGeneiHs.50813

Genome annotation databases

EnsembliENST00000326245; ENSP00000323587; ENSG00000179914
GeneIDi55600
KEGGihsa:55600
UCSCiuc001fxc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271386 mRNA Translation: AAM20741.1
AY065972 mRNA Translation: AAL58073.1
AB036706 mRNA Translation: BAA96094.1
AY157361 mRNA Translation: AAO17800.1
AY157362 mRNA Translation: AAO17801.1
AY549722 mRNA Translation: AAS49907.1
AY619692 mRNA Translation: AAU88048.1
AY358359 mRNA Translation: AAQ88725.1
AK000029 mRNA Translation: BAA90893.1
CR457224 mRNA Translation: CAG33505.1
AL354714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52690.1
BC020664 mRNA Translation: AAH20664.1
CCDSiCCDS1211.1
RefSeqiNP_060095.2, NM_017625.2
UniGeneiHs.50813

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WMQX-ray1.80A/B29-313[»]
4WMYX-ray1.60A/B29-313[»]
ProteinModelPortaliQ8WWA0
SMRiQ8WWA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120741, 14 interactors
DIPiDIP-61704N
STRINGi9606.ENSP00000323587

Protein family/group databases

UniLectiniQ8WWA0

PTM databases

iPTMnetiQ8WWA0
PhosphoSitePlusiQ8WWA0

Polymorphism and mutation databases

BioMutaiITLN1
DMDMi55976553

Proteomic databases

PaxDbiQ8WWA0
PeptideAtlasiQ8WWA0
PRIDEiQ8WWA0
ProteomicsDBi74869

Protocols and materials databases

DNASUi55600
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326245; ENSP00000323587; ENSG00000179914
GeneIDi55600
KEGGihsa:55600
UCSCiuc001fxc.4 human

Organism-specific databases

CTDi55600
DisGeNETi55600
EuPathDBiHostDB:ENSG00000179914.4
GeneCardsiITLN1
HGNCiHGNC:18259 ITLN1
HPAiCAB012652
HPA063275
HPA067326
MIMi609873 gene
neXtProtiNX_Q8WWA0
OpenTargetsiENSG00000179914
PharmGKBiPA134870726
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGEB Eukaryota
ENOG4110R6N LUCA
GeneTreeiENSGT00390000008567
HOGENOMiHOG000026788
HOVERGENiHBG052157
InParanoidiQ8WWA0
KOiK17527
OMAiWITDEAN
OrthoDBiEOG091G0QYK
PhylomeDBiQ8WWA0
TreeFamiTF328530

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRSiITLN1 human
GeneWikiiITLN1
GenomeRNAii55600
PROiPR:Q8WWA0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179914 Expressed in 107 organ(s), highest expression level in parietal pleura
CleanExiHS_ITLN1
GenevisibleiQ8WWA0 HS

Family and domain databases

Gene3Di3.90.215.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR002181 Fibrinogen_a/b/g_C_dom
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITLN1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWA0
Secondary accession number(s): Q5IWS4
, Q5VYI4, Q6YDJ3, Q9NP67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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