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UniProtKB - Q8WW38 (FOG2_HUMAN)

Protein

Zinc finger protein ZFPM2

Gene

ZFPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 277CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 357C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 575CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri681 – 714CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri848 – 881CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcription coactivator activity Source: BHF-UCL
  • transcription corepressor activity Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL
  • zinc ion binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Gonadal differentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiQ8WW38

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM2
Alternative name(s):
Friend of GATA protein 2
Short name:
FOG-2
Short name:
Friend of GATA 2
Short name:
hFOG-2
Zinc finger protein 89B
Zinc finger protein multitype 2
Gene namesi
Name:ZFPM2
Synonyms:FOG2, ZNF89B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169946.13
HGNCiHGNC:16700 ZFPM2
MIMi603693 gene
neXtProtiNX_Q8WW38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Tetralogy of Fallot (TOF)2 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
See also OMIM:187500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017943657S → G in TOF; slightly impairs its ability to interact with GATA4. 1 PublicationCorresponds to variant dbSNP:rs28374544EnsemblClinVar.1
Diaphragmatic hernia 3 (DIH3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionForm of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
See also OMIM:610187
46,XY sex reversal 9 (SRXY9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females or have ambiguous external genitalia.
See also OMIM:616067
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071104260R → Q in SRXY9; results in reduced transactivation activity on the AMH promoter; does not affect its ability to interact with GATA4. 1 PublicationCorresponds to variant dbSNP:rs200834568EnsemblClinVar.1
Natural variantiVAR_071105402S → R in SRXY9; results in reduced transactivation activity on the AMH promoter; abolished its ability to interact with GATA4. 1 PublicationCorresponds to variant dbSNP:rs606231252EnsemblClinVar.1
Conotruncal heart malformations (CTHM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.
See also OMIM:217095
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072074227I → V in CTHM. 1 PublicationCorresponds to variant dbSNP:rs202204708Ensembl.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi23414
MalaCardsiZFPM2
MIMi187500 phenotype
217095 phenotype
610187 phenotype
616067 phenotype
OpenTargetsiENSG00000169946
Orphaneti251510 46,XY partial gonadal dysgenesis
2140 Congenital diaphragmatic hernia
3303 Tetralogy of Fallot
PharmGKBiPA134947303

Polymorphism and mutation databases

BioMutaiZFPM2
DMDMi126302543

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210431 – 1151Zinc finger protein ZFPM2Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Modified residuei532PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Cross-linki915Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Modified residuei1014PhosphoserineCombined sources1

Post-translational modificationi

Sumoylation reduces transcriptional repression activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8WW38
PaxDbiQ8WW38
PeptideAtlasiQ8WW38
PRIDEiQ8WW38
ProteomicsDBi74858
74859 [Q8WW38-2]

PTM databases

iPTMnetiQ8WW38
PhosphoSitePlusiQ8WW38

Expressioni

Tissue specificityi

Widely expressed at low level.1 Publication

Gene expression databases

BgeeiENSG00000169946 Expressed in 188 organ(s), highest expression level in cerebellum
CleanExiHS_ZFPM2
ExpressionAtlasiQ8WW38 baseline and differential
GenevisibleiQ8WW38 HS

Organism-specific databases

HPAiHPA004094

Interactioni

Subunit structurei

Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Able to bind GATA1 in vitro. Interacts with NR2F2 and NR2F6 (By similarity). Interacts with ATOH8; mediates indirect interaction with GATA4 (By similarity).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116986, 15 interactors
ELMiQ8WW38
IntActiQ8WW38, 4 interactors
STRINGi9606.ENSP00000384179

Structurei

3D structure databases

ProteinModelPortaliQ8WW38
SMRiQ8WW38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni829 – 835Interaction with CTBP2Curated7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi736 – 740Nuclear localization signalBy similarity5

Domaini

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).By similarity

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 277CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 357C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 575CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri681 – 714CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri848 – 881CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000057275
HOVERGENiHBG048953
InParanoidiQ8WW38
KOiK17442
OMAiTICNYTA
OrthoDBiEOG091G00RC
PhylomeDBiQ8WW38
TreeFamiTF331342

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WW38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI EDEEEECPSE ETDIISKGDF PLEESFSTEF 
        60         70         80         90        100
GPENLSCEEV EYFCNKGDDE GIQETAESDG DTQSEKPGQP GVETDDWDGP 
       110        120        130        140        150
GELEVFQKDG ERKIQSRQQL PVGTTWGPFP GKMDLNNNSL KTKAQVPMVL 
       160        170        180        190        200
TAGPKWLLDV TWQGVEDNKN NCIVYSKGGQ LWCTTTKAIS EGEELIAFVV 
       210        220        230        240        250
DFDSRLQAAS QMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF 
       260        270        280        290        300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDS AHQISSLCPF 
       310        320        330        340        350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF 
       360        370        380        390        400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS 
       410        420        430        440        450
PSATEDSLQP ATDLLTRSEL PQSQKAMQTK DASSDTELDK CEKKTQLFLT 
       460        470        480        490        500
NQRPEIQPTT NKQSFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ 
       510        520        530        540        550
FSFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC 
       560        570        580        590        600
FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEALSPNTG 
       610        620        630        640        650
QTSINLLNPA AHSADPENPL LQTSCINSST VLDLIGPNGK GHDKDFSTQT 
       660        670        680        690        700
KKLSTSSNND DKINGKPVDV KNPSVPLVDG ESDPNKTTCE ACNITFSRHE 
       710        720        730        740        750
TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE 
       760        770        780        790        800
QRPPLVQQRF LDVANLNNPC TSTQEPTEGL GECYHPRCDI FPGIVSKHLE 
       810        820        830        840        850
TSLTINKCVP VSKCDTTHSS VSCLEMDVPI DLSKKCLSQS ERTTTSPKRL 
       860        870        880        890        900
LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES 
       910        920        930        940        950
ERNSPDVSYE RSIIKCEKNG NLKQPSPNGN LFSSHLATLQ GLKVFSEAAQ 
       960        970        980        990       1000
LIATKEENRH LFLPQCLYPG AIKKAKGADQ LSPYYGIKPS DYISGSLVIH 
      1010       1020       1030       1040       1050
NTDIEQSRNA ENESPKGQAS SNGCAALKKD SLPLLPKNRG MVIVNGGLKQ 
      1060       1070       1080       1090       1100
DERPAANPQQ ENISQNPQHE DDHKSPSWIS ENPLAANENV SPGIPSAEEQ 
      1110       1120       1130       1140       1150
LSSIAKGVNG SSQAPTSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV 

K
Length:1,151
Mass (Da):128,159
Last modified:February 20, 2007 - v3
Checksum:i680E31BA1D044C35
GO
Isoform 2 (identifier: Q8WW38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     247-287: KDIFPCKSCG...REAAPVSEEN → SKCSVLCSPA...FFLQKKKKKK

Note: Sequence incomplete. No experimental confirmation available.
Show »
Length:1,019
Mass (Da):113,229
Checksum:iA4365593BE3B4476
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ET52E7ET52_HUMAN
Zinc finger protein ZFPM2
ZFPM2
1,019Annotation score:
E5RJX0E5RJX0_HUMAN
Zinc finger protein ZFPM2
ZFPM2
26Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198F → L in CAB97541 (Ref. 3) Curated1
Sequence conflicti939L → P in AAD49558 (PubMed:10438528).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01794230E → G in TOF and CTHM; does not affect its ability to interact with GATA4. 2 PublicationsCorresponds to variant dbSNP:rs121908601EnsemblClinVar.1
Natural variantiVAR_072074227I → V in CTHM. 1 PublicationCorresponds to variant dbSNP:rs202204708Ensembl.1
Natural variantiVAR_071104260R → Q in SRXY9; results in reduced transactivation activity on the AMH promoter; does not affect its ability to interact with GATA4. 1 PublicationCorresponds to variant dbSNP:rs200834568EnsemblClinVar.1
Natural variantiVAR_071105402S → R in SRXY9; results in reduced transactivation activity on the AMH promoter; abolished its ability to interact with GATA4. 1 PublicationCorresponds to variant dbSNP:rs606231252EnsemblClinVar.1
Natural variantiVAR_024178403A → G1 PublicationCorresponds to variant dbSNP:rs11993776EnsemblClinVar.1
Natural variantiVAR_072075544M → I in SRXY9 and TOF; reduced its ability to interact with GATA4. 2 PublicationsCorresponds to variant dbSNP:rs187043152EnsemblClinVar.1
Natural variantiVAR_017943657S → G in TOF; slightly impairs its ability to interact with GATA4. 1 PublicationCorresponds to variant dbSNP:rs28374544EnsemblClinVar.1
Natural variantiVAR_017944782E → D1 PublicationCorresponds to variant dbSNP:rs2920048EnsemblClinVar.1
Natural variantiVAR_0307601055A → V. Corresponds to variant dbSNP:rs16873741EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0097011 – 132Missing in isoform 2. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_009702247 – 287KDIFP…VSEEN → SKCSVLCSPALEVMGIYGRK KCLLTRNQEQTFFLQKKKKK K in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119334 mRNA Translation: AAD49558.1
BC020928 mRNA Translation: AAH20928.1
BC109222 mRNA Translation: AAI09223.1
AL389987 mRNA Translation: CAB97539.1
AL389989 mRNA Translation: CAB97541.1
CCDSiCCDS47908.1 [Q8WW38-1]
RefSeqiNP_036214.2, NM_012082.3 [Q8WW38-1]
UniGeneiHs.431009

Genome annotation databases

EnsembliENST00000407775; ENSP00000384179; ENSG00000169946 [Q8WW38-1]
GeneIDi23414
KEGGihsa:23414
UCSCiuc003ymd.4 human [Q8WW38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119334 mRNA Translation: AAD49558.1
BC020928 mRNA Translation: AAH20928.1
BC109222 mRNA Translation: AAI09223.1
AL389987 mRNA Translation: CAB97539.1
AL389989 mRNA Translation: CAB97541.1
CCDSiCCDS47908.1 [Q8WW38-1]
RefSeqiNP_036214.2, NM_012082.3 [Q8WW38-1]
UniGeneiHs.431009

3D structure databases

ProteinModelPortaliQ8WW38
SMRiQ8WW38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116986, 15 interactors
ELMiQ8WW38
IntActiQ8WW38, 4 interactors
STRINGi9606.ENSP00000384179

PTM databases

iPTMnetiQ8WW38
PhosphoSitePlusiQ8WW38

Polymorphism and mutation databases

BioMutaiZFPM2
DMDMi126302543

Proteomic databases

MaxQBiQ8WW38
PaxDbiQ8WW38
PeptideAtlasiQ8WW38
PRIDEiQ8WW38
ProteomicsDBi74858
74859 [Q8WW38-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407775; ENSP00000384179; ENSG00000169946 [Q8WW38-1]
GeneIDi23414
KEGGihsa:23414
UCSCiuc003ymd.4 human [Q8WW38-1]

Organism-specific databases

CTDi23414
DisGeNETi23414
EuPathDBiHostDB:ENSG00000169946.13
GeneCardsiZFPM2
HGNCiHGNC:16700 ZFPM2
HPAiHPA004094
MalaCardsiZFPM2
MIMi187500 phenotype
217095 phenotype
603693 gene
610187 phenotype
616067 phenotype
neXtProtiNX_Q8WW38
OpenTargetsiENSG00000169946
Orphaneti251510 46,XY partial gonadal dysgenesis
2140 Congenital diaphragmatic hernia
3303 Tetralogy of Fallot
PharmGKBiPA134947303
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000057275
HOVERGENiHBG048953
InParanoidiQ8WW38
KOiK17442
OMAiTICNYTA
OrthoDBiEOG091G00RC
PhylomeDBiQ8WW38
TreeFamiTF331342

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiQ8WW38

Miscellaneous databases

ChiTaRSiZFPM2 human
GeneWikiiZFPM2
GenomeRNAii23414
PROiPR:Q8WW38
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169946 Expressed in 188 organ(s), highest expression level in cerebellum
CleanExiHS_ZFPM2
ExpressionAtlasiQ8WW38 baseline and differential
GenevisibleiQ8WW38 HS

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFOG2_HUMAN
AccessioniPrimary (citable) accession number: Q8WW38
Secondary accession number(s): Q32MA6
, Q9NPL7, Q9NPS4, Q9UNI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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