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Entry version 121 (10 Apr 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Zinc finger CCHC domain-containing protein 13

Gene

ZCCHC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4 – 21CCHC-type 1; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri45 – 62CCHC-type 2; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri89 – 106CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri110 – 127CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri128 – 145CCHC-type 6PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCCHC13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000187969.5

Human Gene Nomenclature Database

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HGNCi
HGNC:31749 ZCCHC13

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WW36

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000187969

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134926925

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCCHC13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152962

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509741 – 166Zinc finger CCHC domain-containing protein 13Add BLAST166

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WW36

PeptideAtlas

More...
PeptideAtlasi
Q8WW36

PRoteomics IDEntifications database

More...
PRIDEi
Q8WW36

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74857

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WW36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WW36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187969 Expressed in 13 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WW36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003382

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-954111,EBI-747107

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
133309, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WW36, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345633

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WW36

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WW36

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri45 – 62CCHC-type 2; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri89 – 106CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri110 – 127CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri128 – 145CCHC-type 6PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4400 Eukaryota
COG5082 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183041

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186262

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000397

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WW36

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEDSICY

Database of Orthologous Groups

More...
OrthoDBi
1535084at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WW36

TreeFam database of animal gene trees

More...
TreeFami
TF316974

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00098 zf-CCHC, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756 SSF57756, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WW36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKDFFACG HSGHWARGCP RGGAGGRRGG GHGRGSQCGS TTLSYTCYCC
60 70 80 90 100
GESGRNAKNC VLLGNICYNC GRSGHIAKDC KDPKRERRQH CYTCGRLGHL
110 120 130 140 150
ARDCDRQKEQ KCYSCGKLGH IQKDCAQVKC YRCGEIGHVA INCSKARPGQ
160
LLPLRQIPTS SQGMSQ
Length:166
Mass (Da):18,005
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40CC28B9FF3F64C3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC021176 mRNA Translation: AAH21176.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14425.1

NCBI Reference Sequences

More...
RefSeqi
NP_976048.1, NM_203303.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.157231

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339534; ENSP00000345633; ENSG00000187969

Database of genes from NCBI RefSeq genomes

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GeneIDi
389874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389874

UCSC genome browser

More...
UCSCi
uc004ebs.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021176 mRNA Translation: AAH21176.1
CCDSiCCDS14425.1
RefSeqiNP_976048.1, NM_203303.2
UniGeneiHs.157231

3D structure databases

ProteinModelPortaliQ8WW36
SMRiQ8WW36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133309, 2 interactors
IntActiQ8WW36, 6 interactors
STRINGi9606.ENSP00000345633

PTM databases

iPTMnetiQ8WW36
PhosphoSitePlusiQ8WW36

Polymorphism and mutation databases

BioMutaiZCCHC13
DMDMi71152962

Proteomic databases

PaxDbiQ8WW36
PeptideAtlasiQ8WW36
PRIDEiQ8WW36
ProteomicsDBi74857

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
389874
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339534; ENSP00000345633; ENSG00000187969
GeneIDi389874
KEGGihsa:389874
UCSCiuc004ebs.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389874
EuPathDBiHostDB:ENSG00000187969.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZCCHC13
HGNCiHGNC:31749 ZCCHC13
HPAiHPA003382
neXtProtiNX_Q8WW36
OpenTargetsiENSG00000187969
PharmGKBiPA134926925

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4400 Eukaryota
COG5082 LUCA
GeneTreeiENSGT00950000183041
HOGENOMiHOG000186262
HOVERGENiHBG000397
InParanoidiQ8WW36
OMAiGEDSICY
OrthoDBi1535084at2759
PhylomeDBiQ8WW36
TreeFamiTF316974

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389874

Protein Ontology

More...
PROi
PR:Q8WW36

Gene expression databases

BgeeiENSG00000187969 Expressed in 13 organ(s), highest expression level in testis
GenevisibleiQ8WW36 HS

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 4 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 6 hits
SUPFAMiSSF57756 SSF57756, 3 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCH13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WW36
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2002
Last modified: April 10, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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