UniProtKB - Q8WW34 (TM239_HUMAN)
Protein
Transmembrane protein 239
Gene
TMEM239
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 239 |
Gene namesi | Name:TMEM239 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:40044, TMEM239 |
neXtProti | NX_Q8WW34 |
VEuPathDBi | HostDB:ENSG00000198326.9 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 145 – 171 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 100288797 |
OpenTargetsi | ENSG00000198326 |
Miscellaneous databases
Pharosi | Q8WW34, Tdark |
Genetic variation databases
BioMutai | TMEM239 |
DMDMi | 353558900 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000413694 | 1 – 195 | Transmembrane protein 239Add BLAST | 195 |
Proteomic databases
MassIVEi | Q8WW34 |
PaxDbi | Q8WW34 |
PeptideAtlasi | Q8WW34 |
PRIDEi | Q8WW34 |
ProteomicsDBi | 68307 74855 [Q8WW34-1] |
PTM databases
iPTMneti | Q8WW34 |
PhosphoSitePlusi | Q8WW34 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198326, Expressed in left testis and 50 other tissues |
Genevisiblei | Q8WW34, HS |
Organism-specific databases
HPAi | ENSG00000198326, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q8WW34
Isoform 2 [Q8WW34-2]
Protein-protein interaction databases
BioGRIDi | 940453, 70 interactors |
IntActi | Q8WW34, 66 interactors |
MINTi | Q8WW34 |
Miscellaneous databases
RNActi | Q8WW34, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 67 – 97 | Trp-richAdd BLAST | 31 | |
Compositional biasi | 101 – 181 | Leu-richAdd BLAST | 81 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R18E, Eukaryota |
GeneTreei | ENSGT00390000005090 |
HOGENOMi | CLU_125766_0_0_1 |
InParanoidi | Q8WW34 |
OMAi | PQRAVPW |
OrthoDBi | 1571659at2759 |
PhylomeDBi | Q8WW34 |
TreeFami | TF337840 |
Family and domain databases
InterProi | View protein in InterPro IPR031694, TMEM239 |
PANTHERi | PTHR37356, PTHR37356, 1 hit |
Pfami | View protein in Pfam PF15841, TMEM239, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8WW34-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRVGTWICLP GRPGRCRKQH DLGNCPEVPG IFKTLALSPG APDMMQQPRV
60 70 80 90 100
ETDTIGAGEG PQQAVPWSAW VTRHGWVRWW VSHMPPSWIQ WWSTSNWRQP
110 120 130 140 150
LQRLLWGLEG ILYLLLALML CHALFTTGSH LLSSLWPVVA AVWRHLLPAL
160 170 180 190
LLLVLSALPA LLFTASFLLL FSTLLSLVGL LTSMTHPGDT QDLDQ
Sequence cautioni
The sequence AAH21178 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053737 | 1 – 43 | Missing in isoform 2. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126033 mRNA Translation: BAC86404.1 AL035460 Genomic DNA No translation available. AL161656 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10573.1 BC021178 mRNA Translation: AAH21178.1 Different initiation. |
CCDSi | CCDS54444.1 [Q8WW34-2] CCDS82595.1 [Q8WW34-1] |
RefSeqi | NP_001161142.1, NM_001167670.2 [Q8WW34-2] NP_001305136.1, NM_001318207.1 [Q8WW34-1] XP_011527431.1, XM_011529129.2 [Q8WW34-2] |
Genome annotation databases
Ensembli | ENST00000361033; ENSP00000354312; ENSG00000198326 [Q8WW34-1] ENST00000380585; ENSP00000369959; ENSG00000198326 [Q8WW34-2] |
GeneIDi | 100288797 |
KEGGi | hsa:100288797 |
UCSCi | uc002wgx.3, human [Q8WW34-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126033 mRNA Translation: BAC86404.1 AL035460 Genomic DNA No translation available. AL161656 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10573.1 BC021178 mRNA Translation: AAH21178.1 Different initiation. |
CCDSi | CCDS54444.1 [Q8WW34-2] CCDS82595.1 [Q8WW34-1] |
RefSeqi | NP_001161142.1, NM_001167670.2 [Q8WW34-2] NP_001305136.1, NM_001318207.1 [Q8WW34-1] XP_011527431.1, XM_011529129.2 [Q8WW34-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 940453, 70 interactors |
IntActi | Q8WW34, 66 interactors |
MINTi | Q8WW34 |
PTM databases
iPTMneti | Q8WW34 |
PhosphoSitePlusi | Q8WW34 |
Genetic variation databases
BioMutai | TMEM239 |
DMDMi | 353558900 |
Proteomic databases
MassIVEi | Q8WW34 |
PaxDbi | Q8WW34 |
PeptideAtlasi | Q8WW34 |
PRIDEi | Q8WW34 |
ProteomicsDBi | 68307 74855 [Q8WW34-1] |
Protocols and materials databases
Antibodypediai | 74574, 5 antibodies |
Genome annotation databases
Ensembli | ENST00000361033; ENSP00000354312; ENSG00000198326 [Q8WW34-1] ENST00000380585; ENSP00000369959; ENSG00000198326 [Q8WW34-2] |
GeneIDi | 100288797 |
KEGGi | hsa:100288797 |
UCSCi | uc002wgx.3, human [Q8WW34-1] |
Organism-specific databases
CTDi | 100288797 |
DisGeNETi | 100288797 |
GeneCardsi | TMEM239 |
HGNCi | HGNC:40044, TMEM239 |
HPAi | ENSG00000198326, Tissue enriched (testis) |
neXtProti | NX_Q8WW34 |
OpenTargetsi | ENSG00000198326 |
VEuPathDBi | HostDB:ENSG00000198326.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R18E, Eukaryota |
GeneTreei | ENSGT00390000005090 |
HOGENOMi | CLU_125766_0_0_1 |
InParanoidi | Q8WW34 |
OMAi | PQRAVPW |
OrthoDBi | 1571659at2759 |
PhylomeDBi | Q8WW34 |
TreeFami | TF337840 |
Enzyme and pathway databases
PathwayCommonsi | Q8WW34 |
Miscellaneous databases
BioGRID-ORCSi | 100288797, 4 hits in 866 CRISPR screens |
GenomeRNAii | 100288797 |
Pharosi | Q8WW34, Tdark |
PROi | PR:Q8WW34 |
RNActi | Q8WW34, protein |
Gene expression databases
Bgeei | ENSG00000198326, Expressed in left testis and 50 other tissues |
Genevisiblei | Q8WW34, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031694, TMEM239 |
PANTHERi | PTHR37356, PTHR37356, 1 hit |
Pfami | View protein in Pfam PF15841, TMEM239, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM239_HUMAN | |
Accessioni | Q8WW34Primary (citable) accession number: Q8WW34 Secondary accession number(s): Q5JY54, Q6ZU23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2011 |
Last sequence update: | February 19, 2014 | |
Last modified: | February 10, 2021 | |
This is version 118 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM