UniProtKB - Q8WW33 (GTSF1_HUMAN)
Protein
Gametocyte-specific factor 1
Gene
GTSF1
Organism
Homo sapiens (Human)
Status
Functioni
Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 14 – 41 | CHHC U11-48K-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 48 – 75 | CHHC U11-48K-type 2PROSITE-ProRule annotationAdd BLAST | 28 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation, Spermatogenesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8WW33 |
Names & Taxonomyi
Protein namesi | Recommended name: Gametocyte-specific factor 1Alternative name(s): Protein FAM112B |
Gene namesi | Name:GTSF1 Synonyms:FAM112B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26565, GTSF1 |
MIMi | 617484, gene |
neXtProti | NX_Q8WW33 |
VEuPathDBi | HostDB:ENSG00000170627.9 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 121355 |
OpenTargetsi | ENSG00000170627 |
PharmGKBi | PA162390507 |
Miscellaneous databases
Pharosi | Q8WW33, Tdark |
Genetic variation databases
BioMutai | GTSF1 |
DMDMi | 116241359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221621 | 1 – 167 | Gametocyte-specific factor 1Add BLAST | 167 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WW33 |
jPOSTi | Q8WW33 |
MassIVEi | Q8WW33 |
MaxQBi | Q8WW33 |
PaxDbi | Q8WW33 |
PeptideAtlasi | Q8WW33 |
PRIDEi | Q8WW33 |
ProteomicsDBi | 74854 |
PTM databases
GlyGeni | Q8WW33, 1 site |
iPTMneti | Q8WW33 |
PhosphoSitePlusi | Q8WW33 |
SwissPalmi | Q8WW33 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170627, Expressed in testis and 130 other tissues |
ExpressionAtlasi | Q8WW33, baseline and differential |
Genevisiblei | Q8WW33, HS |
Organism-specific databases
HPAi | ENSG00000170627, Group enriched (blood, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125724, 8 interactors |
IntActi | Q8WW33, 5 interactors |
STRINGi | 9606.ENSP00000446485 |
Miscellaneous databases
RNActi | Q8WW33, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0224 (FAM112) family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 14 – 41 | CHHC U11-48K-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 48 – 75 | CHHC U11-48K-type 2PROSITE-ProRule annotationAdd BLAST | 28 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4376, Eukaryota |
GeneTreei | ENSGT00940000156784 |
HOGENOMi | CLU_108762_0_0_1 |
InParanoidi | Q8WW33 |
OrthoDBi | 1359124at2759 |
PhylomeDBi | Q8WW33 |
TreeFami | TF323837 |
Family and domain databases
InterProi | View protein in InterPro IPR007917, GTSF1_vertebrate IPR022776, TRM13/UPF0224_CHHC_Znf_dom IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR21402:SF9, PTHR21402:SF9, 1 hit |
Pfami | View protein in Pfam PF05253, zf-U11-48K, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS51800, ZF_CHHC_U11_48K, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8WW33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEETYTDSLD PEKLLQCPYD KNHQIRACRF PYHLIKCRKN HPDVASKLAT
60 70 80 90 100
CPFNARHQVP RAEISHHISS CDDRSCIEQD VVNQTRSLRQ ETLAESTWQC
110 120 130 140 150
PPCDEDWDKD LWEQTSTPFV WGTTHYSDNN SPASNIVTEH KNNLASGMRV
160
PKSLPYVLPW KNNGNAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V1V4 | G3V1V4_HUMAN | Family with sequence similarity 112... | GTSF1 FAM112B, hCG_1782630 | 176 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 | V → A in AAH21179 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057504 mRNA Translation: BAG51922.1 AK098819 mRNA Translation: BAC05423.1 BC021179 mRNA Translation: AAH21179.1 BC105587 mRNA Translation: AAI05588.1 |
CCDSi | CCDS8881.1 |
RefSeqi | NP_653195.2, NM_144594.2 XP_016874289.1, XM_017018800.1 |
Genome annotation databases
Ensembli | ENST00000305879; ENSP00000304185; ENSG00000170627 ENST00000552397; ENSP00000446485; ENSG00000170627 |
GeneIDi | 121355 |
KEGGi | hsa:121355 |
UCSCi | uc001sgb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057504 mRNA Translation: BAG51922.1 AK098819 mRNA Translation: BAC05423.1 BC021179 mRNA Translation: AAH21179.1 BC105587 mRNA Translation: AAI05588.1 |
CCDSi | CCDS8881.1 |
RefSeqi | NP_653195.2, NM_144594.2 XP_016874289.1, XM_017018800.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125724, 8 interactors |
IntActi | Q8WW33, 5 interactors |
STRINGi | 9606.ENSP00000446485 |
PTM databases
GlyGeni | Q8WW33, 1 site |
iPTMneti | Q8WW33 |
PhosphoSitePlusi | Q8WW33 |
SwissPalmi | Q8WW33 |
Genetic variation databases
BioMutai | GTSF1 |
DMDMi | 116241359 |
Proteomic databases
EPDi | Q8WW33 |
jPOSTi | Q8WW33 |
MassIVEi | Q8WW33 |
MaxQBi | Q8WW33 |
PaxDbi | Q8WW33 |
PeptideAtlasi | Q8WW33 |
PRIDEi | Q8WW33 |
ProteomicsDBi | 74854 |
Protocols and materials databases
Antibodypediai | 48366, 92 antibodies |
DNASUi | 121355 |
Genome annotation databases
Ensembli | ENST00000305879; ENSP00000304185; ENSG00000170627 ENST00000552397; ENSP00000446485; ENSG00000170627 |
GeneIDi | 121355 |
KEGGi | hsa:121355 |
UCSCi | uc001sgb.4, human |
Organism-specific databases
CTDi | 121355 |
DisGeNETi | 121355 |
GeneCardsi | GTSF1 |
HGNCi | HGNC:26565, GTSF1 |
HPAi | ENSG00000170627, Group enriched (blood, testis) |
MIMi | 617484, gene |
neXtProti | NX_Q8WW33 |
OpenTargetsi | ENSG00000170627 |
PharmGKBi | PA162390507 |
VEuPathDBi | HostDB:ENSG00000170627.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4376, Eukaryota |
GeneTreei | ENSGT00940000156784 |
HOGENOMi | CLU_108762_0_0_1 |
InParanoidi | Q8WW33 |
OrthoDBi | 1359124at2759 |
PhylomeDBi | Q8WW33 |
TreeFami | TF323837 |
Enzyme and pathway databases
PathwayCommonsi | Q8WW33 |
Miscellaneous databases
BioGRID-ORCSi | 121355, 3 hits in 873 CRISPR screens |
GenomeRNAii | 121355 |
Pharosi | Q8WW33, Tdark |
PROi | PR:Q8WW33 |
RNActi | Q8WW33, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170627, Expressed in testis and 130 other tissues |
ExpressionAtlasi | Q8WW33, baseline and differential |
Genevisiblei | Q8WW33, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007917, GTSF1_vertebrate IPR022776, TRM13/UPF0224_CHHC_Znf_dom IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR21402:SF9, PTHR21402:SF9, 1 hit |
Pfami | View protein in Pfam PF05253, zf-U11-48K, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS51800, ZF_CHHC_U11_48K, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GTSF1_HUMAN | |
Accessioni | Q8WW33Primary (citable) accession number: Q8WW33 Secondary accession number(s): B3KQ60, Q0VGM4, Q8N778 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries