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UniProtKB - Q8WW33 (GTSF1_HUMAN)

Entry version 136 (16 Oct 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Gametocyte-specific factor 1

Gene

GTSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri14 – 41CHHC U11-48K-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri48 – 75CHHC U11-48K-type 2PROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gametocyte-specific factor 1
Alternative name(s):
Protein FAM112B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTSF1
Synonyms:FAM112B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26565 GTSF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617484 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WW33

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		121355

Open Targets

More...OpenTargetsi		ENSG00000170627

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162390507

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WW33

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GTSF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002216211 – 167Gametocyte-specific factor 1Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WW33

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WW33

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WW33

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WW33

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WW33

PeptideAtlas

More...PeptideAtlasi		Q8WW33

PRoteomics IDEntifications database

More...PRIDEi		Q8WW33

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74854

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WW33

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WW33

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8WW33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170627 Expressed in 97 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WW33 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WW33 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA038876
HPA038877

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125724, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q8WW33, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000446485

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0224 (FAM112) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 41CHHC U11-48K-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri48 – 75CHHC U11-48K-type 2PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4376 Eukaryota
ENOG4111W8D LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000116230

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WW33

Database of Orthologous Groups

More...OrthoDBi		1359124at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WW33

TreeFam database of animal gene trees

More...TreeFami		TF323837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007917 GTSF1_vertebrate
IPR022776 TRM13/UPF0224_CHHC_Znf_dom
IPR036236 Znf_C2H2_sf

The PANTHER Classification System

More...PANTHERi		PTHR21402:SF9 PTHR21402:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05253 zf-U11-48K, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51800 ZF_CHHC_U11_48K, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WW33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEETYTDSLD PEKLLQCPYD KNHQIRACRF PYHLIKCRKN HPDVASKLAT 
        60         70         80         90        100
CPFNARHQVP RAEISHHISS CDDRSCIEQD VVNQTRSLRQ ETLAESTWQC 
       110        120        130        140        150
PPCDEDWDKD LWEQTSTPFV WGTTHYSDNN SPASNIVTEH KNNLASGMRV 
       160 
PKSLPYVLPW KNNGNAQ
Length:167
Mass (Da):19,266
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C39EF69263F495
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1V4G3V1V4_HUMAN
Family with sequence similarity 112...
GTSF1 FAM112B, hCG_1782630
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120V → A in AAH21179 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057504 mRNA Translation: BAG51922.1
AK098819 mRNA Translation: BAC05423.1
BC021179 mRNA Translation: AAH21179.1
BC105587 mRNA Translation: AAI05588.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8881.1

NCBI Reference Sequences

More...RefSeqi		NP_653195.2, NM_144594.2
XP_016874289.1, XM_017018800.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305879; ENSP00000304185; ENSG00000170627
ENST00000552397; ENSP00000446485; ENSG00000170627

Database of genes from NCBI RefSeq genomes

More...GeneIDi		121355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:121355

UCSC genome browser

More...UCSCi		uc001sgb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057504 mRNA Translation: BAG51922.1
AK098819 mRNA Translation: BAC05423.1
BC021179 mRNA Translation: AAH21179.1
BC105587 mRNA Translation: AAI05588.1
CCDSiCCDS8881.1
RefSeqiNP_653195.2, NM_144594.2
XP_016874289.1, XM_017018800.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi125724, 8 interactors
IntActiQ8WW33, 5 interactors
STRINGi9606.ENSP00000446485

PTM databases

iPTMnetiQ8WW33
PhosphoSitePlusiQ8WW33
SwissPalmiQ8WW33

Polymorphism and mutation databases

BioMutaiGTSF1
DMDMi116241359

Proteomic databases

EPDiQ8WW33
jPOSTiQ8WW33
MassIVEiQ8WW33
MaxQBiQ8WW33
PaxDbiQ8WW33
PeptideAtlasiQ8WW33
PRIDEiQ8WW33
ProteomicsDBi74854

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		121355

Genome annotation databases

EnsembliENST00000305879; ENSP00000304185; ENSG00000170627
ENST00000552397; ENSP00000446485; ENSG00000170627
GeneIDi121355
KEGGihsa:121355
UCSCiuc001sgb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		121355
DisGeNETi121355

GeneCards: human genes, protein and diseases

More...GeneCardsi		GTSF1
HGNCiHGNC:26565 GTSF1
HPAiHPA038876
HPA038877
MIMi617484 gene
neXtProtiNX_Q8WW33
OpenTargetsiENSG00000170627
PharmGKBiPA162390507

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4376 Eukaryota
ENOG4111W8D LUCA
GeneTreeiENSGT00940000156784
HOGENOMiHOG000116230
InParanoidiQ8WW33
OrthoDBi1359124at2759
PhylomeDBiQ8WW33
TreeFamiTF323837

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		121355
PharosiQ8WW33

Protein Ontology

More...PROi		PR:Q8WW33

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170627 Expressed in 97 organ(s), highest expression level in right testis
ExpressionAtlasiQ8WW33 baseline and differential
GenevisibleiQ8WW33 HS

Family and domain databases

InterProiView protein in InterPro
IPR007917 GTSF1_vertebrate
IPR022776 TRM13/UPF0224_CHHC_Znf_dom
IPR036236 Znf_C2H2_sf
PANTHERiPTHR21402:SF9 PTHR21402:SF9, 1 hit
PfamiView protein in Pfam
PF05253 zf-U11-48K, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51800 ZF_CHHC_U11_48K, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTSF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WW33
Secondary accession number(s): B3KQ60, Q0VGM4, Q8N778
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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